{"title":"In vitro models for human neuroglia.","authors":"Bas Lendemeijer, Femke M S de Vrij","doi":"10.1016/B978-0-443-19104-6.00015-2","DOIUrl":"https://doi.org/10.1016/B978-0-443-19104-6.00015-2","url":null,"abstract":"<p><p>Neuroglia are a heterogenous population of cells in the nervous system. In the central nervous system, this group is classified into astrocytes, oligodendrocytes, and microglia. Neuroglia in the peripheral nervous system are divided into Schwann cells and enteric glia. These groups of cells display considerable differences in their developmental origin, morphology, function, and regional abundance. Compared to animal models, human neuroglia differ in their transcriptomic profile, morphology, and function. Investigating the physiology of healthy or diseased human neuroglia in vivo is challenging due to the inaccessibility of the tissue. Therefore, researchers have developed numerous in vitro models attempting to replicate the natural tissue environment. Earlier models made use of postmortem, postsurgical, or fetal tissue to establish human neuroglial cells in vitro, either as a pure population of the desired cell type or as organotypic slice cultures. Advancements in human stem cell differentiation techniques have greatly enhanced the possibilities for creating in vitro models of human neuroglia. This chapter provides an overview of the current models used to study the functioning and development of human neuroglia in vitro, both in health and disease.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"209 ","pages":"213-227"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neuroglia in epilepsy.","authors":"Manolia R Ghouli, Devin K Binder","doi":"10.1016/B978-0-443-19102-2.00016-8","DOIUrl":"https://doi.org/10.1016/B978-0-443-19102-2.00016-8","url":null,"abstract":"<p><p>Epilepsy is a group of neurologic diseases characterized by spontaneous, repetitive disruption to neuronal activity. Neurons have been at the core of epilepsy research efforts, and pharmacotherapies historically have been generated by targeting neuronal mechanisms. As a result, most currently available antiseizure drugs (ASDs) work to either decrease excitatory glutamatergic neurotransmission or to increase inhibitory GABAergic neurotransmission. However, ASDs may have undesirable side effects on cognition and also fail to control seizures in approximately 30% of epilepsy patients. In recent years, glia have surfaced as essential modulators of neuronal function in health and disease. The redirection of focus onto neuroglia provides new perspectives and opportunities to generate novel therapeutic targets that may treat refractory epilepsy and diminish the unwanted side effect profile of current treatments. In this chapter, we discuss the contribution of astroglia, oligodendroglia, and microglia to the genesis, development, and progression of epilepsy, and we highlight key enzymes, receptors, transporters, and channels that may be pursued as nonneuronal targets for novel ASDs.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"210 ","pages":"69-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain asymmetries in figurative language comprehension.","authors":"Costanza Papagno","doi":"10.1016/B978-0-443-15646-5.00013-0","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00013-0","url":null,"abstract":"<p><p>This chapter reviews the literature concerning the neural basis of three types of figurative expressions, namely, idioms, metaphors, and irony. Besides these three forms of language, which are the most investigated, many other types exist, differing in their linguistic structure and, consequently, in the corresponding comprehension processes. After defining the most common figurative expressions and showing how they differ in terms of linguistic properties, the chapter presents early studies that focused on the role of the right hemisphere (RH) in figurative language comprehension in general, without a clear distinction among different forms. Later literature shows how evidence has been accumulated, suggesting that both hemispheres are involved in figurative language processing. Therefore, a sharp distinction between the left hemisphere (LH) and the RH, the first involved in literal language and the second in figurative language, is not tenable. Idioms, metaphors, and irony will be considered separately, demonstrating that different expressions rely on the LH and RH to a different degree.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"289-299"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlo Semenza, Silvia Benavides-Varela, Elena Salillas
{"title":"Brain laterality of numbers and calculation: Complex networks and their development.","authors":"Carlo Semenza, Silvia Benavides-Varela, Elena Salillas","doi":"10.1016/B978-0-443-15646-5.00017-8","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00017-8","url":null,"abstract":"<p><p>This chapter reviews notions about the lateralization of numbers and calculation in the brain, including its developmental pattern. Such notions have changed dramatically in recent decades. What was once considered a function almost exclusively located in the left hemisphere has been found to be sustained by complex brain networks encompassing both hemispheres. Depending on the specific task, however, each hemisphere has its own role. Much of this progress was determined by the convergency of investigations conducted with different methods. Contrary to traditional wisdom, the right hemisphere is not involved in arithmetic just as far as generic spatial aspects are concerned. Very specific arithmetic functions like remembering the spatial templates for complex operations, or processing of zero in complex numbers, are indeed sustained in specific right-sided areas. The system used in the typical adult appears to be the result of a complex pattern of development. The numerical brain clearly evolved from less mature to more advanced brain networks because of growth and education. Children seem to be equipped with the ability to represent the number nonverbally from a very early age. The bilateral processing of number-related tasks is however a late acquisition.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"461-480"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left- and right-side unilateral spatial neglect: Hemispheric differences.","authors":"Laura Veronelli, Giuseppe Vallar","doi":"10.1016/B978-0-443-15646-5.00025-7","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00025-7","url":null,"abstract":"<p><p>Neglect of one side of space, typically contralateral to a lesion of one cerebral hemisphere, is a multicomponent neurologic syndrome. In humans, left neglect after right brain damage is more frequent, severe, or both, than right neglect after left brain damage. Right neglect is behaviorally like left neglect. In the monkey, such a functional asymmetry is not present. In humans, left hemisphere-based spatial systems are weaker, likely due to the coexistence of language and spatial processes. This may account for the lateral asymmetry of neglect, which is present at birth. Except in a few patients, there is no global functional reversal of language and spatial cognition. Left brain-damaged patients often show both aphasia and right neglect, as many right brain-damaged patients with crossed aphasia show left neglect. Lateralized sensory stimulations temporarily improve both left and right neglect. Damage to the posterior parietal lobe (inferior parietal lobule), the temporo-parietal junction, the superior and middle temporal, and to the premotor and prefrontal cortices is associated with contralateral neglect; also, lesions in white matter fiber tracts and subcortical nuclei bring about neglect, with no definite left-right asymmetries.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"127-154"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preface.","authors":"Costanza Papagno, Paul Corballis","doi":"10.1016/B978-0-443-15646-5.09995-4","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.09995-4","url":null,"abstract":"","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"xiii-xiv"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The arts and hemispheric specialization.","authors":"D W Zaidel","doi":"10.1016/B978-0-443-15646-5.00002-6","DOIUrl":"https://doi.org/10.1016/B978-0-443-15646-5.00002-6","url":null,"abstract":"<p><p>Art was initially thought of as a single function linked mainly to spatial perception and right hemisphere functional specialization. Art was also considered to be diametrically opposed to language, further solidifying the right hemisphere specialization model. This view remained dominant for many decades. However, increase in published observations of artworks by professional artists following acquired unilateral hemispheric damage showed that quality artistic works can be produced when there is damage in either the left or the right hemisphere. With the advent of neuroimaging such as functional magnetic resonance imaging (fMRI), light was shed on the neural underpinning of the esthetics of artworks revealing activation in multiple regions across both hemispheres. The bulk of recent data suggests complementary hemispheric contributions to art production and esthetic evaluation of numerous art expressions. Similarly, creativity and imagination, upon which art expression depends, both appear to recruit interhemispheric processes. Culturally, the early evolutionary origin of art is associated mainly with Homo sapiens (HS) but, despite evidence for cerebral asymmetry based on fossil skulls, their emergence did not coincide with visual art making. A significant lag of hundreds of thousands of years intervened before humans produced art consistently and abundantly. By now, the arts are practiced ubiquitously throughout the globe, in all human societies.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"409-419"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Palagini, Pierre-Alexis Geoffroy, Raffaele Manni, Angelo Gemignani
{"title":"Circadian aspects in nonpharmacologic and pharmacologic treatment of insomnia.","authors":"Laura Palagini, Pierre-Alexis Geoffroy, Raffaele Manni, Angelo Gemignani","doi":"10.1016/B978-0-323-90918-1.00010-1","DOIUrl":"https://doi.org/10.1016/B978-0-323-90918-1.00010-1","url":null,"abstract":"<p><p>Insomnia disorder is a frequent sleep disorder leading to significant health and economic consequences. It has been proposed that individuals with insomnia may experience compromised deactivation systems of arousal, leading to a chronic state of hyperactivation of arousal known as hyperarousal, along with instability in the flip-flop system. Such disruptions may have a primarily impact on the sleep homeostatic drive process. Insomnia may indeed be associated with a disruption in the body's internal clock, known as chronodisruption. Despite the differentiation established in diagnostic nosology between insomnia disorder and circadian rhythm disorders, there is a significant body of evidence suggesting a complex interplay and frequent co-occurrence between these two conditions. In particular, circadian factors can predispose individuals to insomnia disorders, as well as precipitate and perpetuate their symptoms. Accordingly numerous pieces of evidence suggest that both pharmacologic and nonpharmacologic options for treating insomnia can have a resynchronization effect on circadian rhythms. The first-line treatment for chronic insomnia, according to current guidelines, is cognitive behavioral therapy for insomnia while pharmacologic interventions comprise of benzodiazepine receptor agonists also known as Z-drugs and short- to medium-acting benzodiazepines, melatonergic agonists such as ramelteon and melatonin 2mg prolonged release, and dual orexin receptor antagonists such as daridorexant, suvorexant, and lemborexant. At the same time, certain therapies recommended for circadian rhythm disorders can be utilized as adjunctive treatments for insomnia. Therefore, this chapter will discuss the circadian aspects of insomnia disorder and of its therapeutic approach. Furthermore, the effects of chronobiologic interventions, recommended for the treatment of circadian rhythm sleep-wake disorders, will be examined in individuals afflicted with chronic insomnia.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"206 ","pages":"161-179"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac arrest and disorders of consciousness.","authors":"Nefize Turan, Romergryko G Geocadin","doi":"10.1016/B978-0-443-13408-1.00015-4","DOIUrl":"https://doi.org/10.1016/B978-0-443-13408-1.00015-4","url":null,"abstract":"<p><p>As the second most common cause of coma and disorders of consciousness, cardiac arrest is defined as a cessation of cardiac mechanical activity and absence of circulation. Cardiac arrest can happen due to an intrinsic cardiac condition or secondary to noncardiac causes such as respiratory, neurologic, metabolic causes or external causes such as toxic ingestion, asphyxia, drowning, trauma, and other environmental exposures. While cardiac arrest resuscitation research and practice has evolved over decades, the overall survival to hospital discharge remains low across different types of cardiac arrest (about 9%-29%). This chapter focuses on disorders of consciousness after cardiac arrest and how it is different from other etiologies. It also discusses advances and controversies in diagnosis, management, prognostication and research.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"207 ","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical and surgical treatments in disorders of consciousness.","authors":"Marwan H Othman, Moshgan Amiri, Daniel Kondziella","doi":"10.1016/B978-0-443-13408-1.00004-X","DOIUrl":"https://doi.org/10.1016/B978-0-443-13408-1.00004-X","url":null,"abstract":"<p><p>Ever since a 2012 landmark study showed positive effects of amantadine in people with disorders of consciousness (DOC), there has been a shift in research efforts from merely improving diagnostics and prognostication of DOC to also include therapeutic trials, in the quest to improve consciousness recovery after brain injury. Stimulation of residual consciousness in the intensive care unit is critical because failure to do so may lead to unwarranted pessimistic prognosis and premature withdrawal of life-sustaining therapies. Similarly, it is crucial to harvest the potential of chronic DOC patients for late consciousness recovery, which is increasingly reported. To this end, medical and nonpharmacologic, including surgical, treatment strategies are being tested. These include dopaminergic and GABAergic drugs (medical), vagal nerve stimulation (noninvasive or surgical), and deep brain stimulation (surgical). In addition, transcranial magnetic stimulation, transcranial direct current stimulation, and low-intensity ultrasound (nonpharmacologic and nonsurgical) are covered in another chapter in this volume of the Handbook. Although overall, DOC treatment studies are subject to small sample sizes, unblinded protocols, and limited follow-up, this will likely change in the foreseeable future with the advent of adequately powered multicenter studies, randomized, double-blind, placebo-controlled designs, and standardized outcome measures. This chapter discusses the present state and outlooks of the field of medical and surgical options to boost arousal and awareness in patients with DOC, indicating the future of DOC treatment is bright.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"207 ","pages":"183-196"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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