{"title":"Hemispheric asymmetries in episodic memory.","authors":"Gian Daniele Zannino, Giovanni Augusto Carlesimo","doi":"10.1016/B978-0-443-15646-5.00023-3","DOIUrl":null,"url":null,"abstract":"<p><p>The term \"episodic memory\" refers to our ability to remember past personal experiences. This ability is severely disrupted following bilateral damage to a dedicated neural substrate located symmetrically in the mesial temporal lobes. Milder deficits are also observed following unilateral damage to the same structures. In this chapter, we contrast memory deficits after left and right mesiotemporal damage and review some of the hypotheses proposed to account for the observed differences. As proposed by other authors (e.g., Binder et al., 2010), the observed lesion side effects in memory profiles after unilateral brain damage do not directly reflect specialization across the two symmetric memory substrates. Rather, they depend on the different kinds of information each of the two mesiotemporal structures receives from the ipsilateral hemisphere where other non-memory-specific cognitive systems are asymmetrically housed. In particular, this chapter outlines the role of language, working memory, and visuospatial processes in accounting for side effects in memory profiles. This is because all these systems greatly contribute to the functioning of episodic memory and also show a variable extent of lateralization in the human brain.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"208 ","pages":"449-460"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Handbook of clinical neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/B978-0-443-15646-5.00023-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The term "episodic memory" refers to our ability to remember past personal experiences. This ability is severely disrupted following bilateral damage to a dedicated neural substrate located symmetrically in the mesial temporal lobes. Milder deficits are also observed following unilateral damage to the same structures. In this chapter, we contrast memory deficits after left and right mesiotemporal damage and review some of the hypotheses proposed to account for the observed differences. As proposed by other authors (e.g., Binder et al., 2010), the observed lesion side effects in memory profiles after unilateral brain damage do not directly reflect specialization across the two symmetric memory substrates. Rather, they depend on the different kinds of information each of the two mesiotemporal structures receives from the ipsilateral hemisphere where other non-memory-specific cognitive systems are asymmetrically housed. In particular, this chapter outlines the role of language, working memory, and visuospatial processes in accounting for side effects in memory profiles. This is because all these systems greatly contribute to the functioning of episodic memory and also show a variable extent of lateralization in the human brain.
期刊介绍：
The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.
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