Neuroglia in suicide.

Q2 Medicine

Handbook of clinical neurology Pub Date : 2025-01-01 DOI:10.1016/B978-0-443-19102-2.00018-1

Lin Zhang, Dick F Swaab

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引用次数: 0

Abstract

Suicide is the worst outcome for many neuropsychiatric disorders having a high social and economic burden. There is a great need to determine the neurobiologic background of the etiopathogenesis and resilience toward suicide and to find novel pharmacologic strategies to treat suicidal behaviors. Neuroglia have been found to actively participate in the regulation of many cerebral functions, but it is debated whether these cells are structurally or functionally involved in the neuropathology of suicide, or merely follow the changes of comorbid psychiatric disorders. The purpose of this chapter is to review the scattered literature on the involvement of neuroglia in suicide and to describe how these cells might be responsive to the current pharmacologic interventions. We describe the different biological features of neuroglia in relation to suicide and the underlying psychiatric disorders, the molecular commonalities of neuroglial alterations in suicide across different psychiatric disorders, and the evidence for morphologic neuroglia changes in relation to the severity and resilience of suicide. Illuminating the mechanisms by which neuroglia are involved in suicide may ultimately lead to the development of suicide-related biomarkers and novel therapies for suicide prevention.

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来源期刊

Handbook of clinical neurology Medicine-Neurology (clinical)

CiteScore

4.10

自引率

0.00%

发文量

302

期刊介绍： The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.