Hearing Research最新文献

{"title":"Vocal control and speech production in cochlear implant listeners: A review within auditory-motor processing framework","authors":"Samin Ashjaei ,&nbsp;Roozbeh Behroozmand ,&nbsp;Shaivee Fozdar ,&nbsp;Reed Farrar ,&nbsp;Meisam Arjmandi","doi":"10.1016/j.heares.2024.109132","DOIUrl":"10.1016/j.heares.2024.109132","url":null,"abstract":"<div><div>A comprehensive literature review is conducted to summarize and discuss prior findings on how cochlear implants (CI) affect the users’ abilities to produce and control vocal and articulatory movements within the auditory-motor integration framework of speech. Patterns of speech production pre- versus post-implantation, post-implantation adjustments, deviations from the typical ranges of speakers with normal hearing (NH), the effects of switching the CI on and off, as well as the impact of altered auditory feedback on vocal and articulatory speech control are discussed. Overall, findings indicate that CIs enhance the vocal and articulatory control aspects of speech production at both segmental and suprasegmental levels. While many CI users achieve speech quality comparable to NH individuals, some features still deviate in a group of CI users even years post-implantation. More specifically, contracted vowel space, increased vocal jitter and shimmer, longer phoneme and utterance durations, shorter voice onset time, decreased contrast in fricative production, limited prosodic patterns, and reduced intelligibility have been reported in subgroups of CI users compared to NH individuals. Significant individual variations among CI users have been observed in both the pace of speech production adjustments and long-term speech outcomes. Few controlled studies have explored how the implantation age and the duration of CI use influence speech features, leaving substantial gaps in our understanding about the effects of spectral resolution, auditory rehabilitation, and individual auditory-motor processing abilities on vocal and articulatory speech outcomes in CI users. Future studies under the auditory-motor integration framework are warranted to determine how suboptimal CI auditory feedback impacts auditory-motor processing and precise vocal and articulatory control in CI users.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109132"},"PeriodicalIF":2.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic tinnitus is associated with aging but not dementia","authors":"Lisa Reisinger ,&nbsp;Nathan Weisz","doi":"10.1016/j.heares.2024.109135","DOIUrl":"10.1016/j.heares.2024.109135","url":null,"abstract":"<div><h3>Aim</h3><div>Aging is related to deterioration of bodily and neural functions, leading to various disorders and symptoms, including the development of dementia, hearing loss, or tinnitus. Understanding how these phenomena are intertwined and how aging affects those is crucial for prevention and the future development of interventions.</div></div><div><h3>Methods</h3><div>We utilized the UK Biobank which includes a total of 502,382 participants between 40 and 70 years old. We used logistic regression models and cox proportional hazard models and compared hazard ratios.</div></div><div><h3>Results</h3><div>The odds of reporting tinnitus in the older age group (i.e., older than 58 years) were increased by 53.6 % and a one decibel increase in the speech-reception thresholds enhanced the odds for tinnitus by 13.0 %. For our second analysis regarding hearing loss, the risk of dementia increased by 14.0 % with an increase by one decibel in the speech-reception threshold score. In terms of aging, each additional year increased the risk by 17.3 %. Tinnitus alone showed a significant influence with a hazard ratio of 52.1 %, however, when adding hearing loss, age and various covariates, the effect vanished.</div></div><div><h3>Conclusion</h3><div>Findings confirm that tinnitus is indeed related to aging, but presumably independent of the aging processes accompanying the development of dementia. This highlights the urge to further investigate the impact of aging on neural processes that are relevant for alterations in the auditory systems (e.g., leading to the development of tinnitus or hearing loss) as well as for increased vulnerability in terms of neurodegenerative diseases.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109135"},"PeriodicalIF":2.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical role of hepsin/TMPRSS1 in hearing and tectorial membrane morphogenesis: Insights from transgenic mouse models","authors":"Ting-Hua Yang ,&nbsp;Yu-Chen Hsu ,&nbsp;Peng Yeh ,&nbsp;Chia-Jui Hung ,&nbsp;Yu-Fei Tsai ,&nbsp;Mo-Chu Fang ,&nbsp;Alice Chih Chia Yen ,&nbsp;Li-Fu Chen ,&nbsp;Jhih-Yu Pan ,&nbsp;Chen-Chi Wu ,&nbsp;Tien-Chen Liu ,&nbsp;Fong-Ling Chung ,&nbsp;Wei-Ming Yu ,&nbsp;Shu-Wha Lin","doi":"10.1016/j.heares.2024.109134","DOIUrl":"10.1016/j.heares.2024.109134","url":null,"abstract":"<div><div>Mutations in various type II transmembrane serine protease (TMPRSS) family members are associated with non-syndromic hearing loss, with some mechanisms still unclear. For instance, the mechanism underlying profound hearing loss and tectorial membrane (TM) malformations in hepsin/TMPRSS1 knockout (KO) mice remains elusive. In this study, we confirmed significantly elevated hearing thresholds and abnormal TM morphology in hepsin KO mice, characterized by enlarged TM with gaps and detachment from the spiral limbus. Transgenic mouse lines were created to express either wild-type or a serine protease-dead mutant of human hepsin in the KO background. The Tg68;KO line, expressing moderate levels of wild-type human hepsin in the cochlea, showed partial restoration of hearing function. Conversely, the Tg5;KO or TgRS;KO lines, with undetectable hepsin or protease-dead hepsin, did not show such improvement. Histological analyses revealed that Tg68;KO mice, but not Tg5;KO or TgRS;KO mice, had a more compact TM structure, partially attached to the spiral limbus. These results indicate that hepsin expression levels correlate with improvements in hearing and TM morphology, and its protease activity is critical for these effects. Hepsin's role was further examined by studying its relationship with α-tectorin (TECTA) and β-tectorin (TECTB), non-collagenous proteins crucial for TM formation. Hepsin was co-expressed with TECTA and TECTB in the developing cochlear epithelium. Immunostaining showed decreased levels of TECTA and TECTB in hepsin KO TM, partially restored in Tg68;KO mice. These findings suggest that hepsin is essential for proper TM morphogenesis and auditory function, potentially by proteolytic processing/maturation of TECTA and TECTB and their incorporation into the TM.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109134"},"PeriodicalIF":2.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy for hearing loss: Current status and future prospects of non-viral vector delivery systems","authors":"Jean-Christophe Leclère ,&nbsp;Remi Marianowski ,&nbsp;Tristan Montier","doi":"10.1016/j.heares.2024.109130","DOIUrl":"10.1016/j.heares.2024.109130","url":null,"abstract":"<div><div>Current therapeutic options for hearing loss rely on hearing aids, ossiculoplasty or cochlear implants. These devices have limitations, particularly in noisy acoustic environments. Therefore, interest in exploring aetiological treatments to improve not only auditory perception but also the quality of life of those affected is increasing. Gene therapy is a promising aetiological treatment that can fully restore auditory function. The success of gene therapy relies on the efficient delivery of therapeutic genes or genetic modifications to the cells of the inner ear that are designed to repair or replace defective genes and restore normal hearing function. Two main strategies for gene therapy involve the use of recombinant viral vectors and nonviral delivery vehicles.</div><div>Owing to their excellent diffusion properties and compatibility with sensory cells, recombinant viral vectors, particularly adeno-associated viruses (AAVs), have dominated gene therapy in the cochlea. However, recombinant viral vectors have several drawbacks, such as limited transgene size, immunogenicity (particularly in neonates), and potential need for repeat administration.</div><div>Nonviral vectors, such as cationic lipids and polymeric nanoparticles, are potential attractive alternatives. Nonviral vectors have several advantages, including low immunogenicity and unlimited transgene size. Recent studies have demonstrated significant auditory recovery in vivo using nonviral vectors in murine models. However, nonviral vectors are not as efficient as viral vectors in transferring genetic material.</div><div>An alternative to nanoparticles is the use of other methods, such as electroporation. The main advantage of electroporation is that it can be used in combination with cochlear implantation and can target surface cells, but this method has a risk of cell damage.</div><div>The goal of this review is to provide valuable insights into the current state of research on nonviral vectors for inner ear gene therapy and propose the exploration of innovative and effective gene therapy strategies for the treatment of hearing loss.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109130"},"PeriodicalIF":2.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of voice cues and speech-in-speech by children with prelingual single-sided deafness and a cochlear implant","authors":"Tine Arras ,&nbsp;Laura Rachman ,&nbsp;Astrid van Wieringen ,&nbsp;Deniz Başkent","doi":"10.1016/j.heares.2024.109133","DOIUrl":"10.1016/j.heares.2024.109133","url":null,"abstract":"<div><div>Voice cues, such as fundamental frequency (F0) and vocal tract length (VTL), help listeners identify the speaker's gender, perceive the linguistic and emotional prosody, and segregate competing talkers. Postlingually implanted adult cochlear implant (CI) users seem to have difficulty in perceiving and making use of voice cues, especially of VTL. Early implanted child CI users, in contrast, perceive and make use of both voice cues better than CI adults, and in patterns similar to their peers with normal hearing (NH).</div><div>In our study, we investigated the perception and use of voice cues in children with single-sided deafness (SSD) who received their CI at an early age (SSD+CI), in an attempt to bridge the gap between these two groups. The SSD+CI children have access to bilateral auditory information and often receive their CI at an early age, similar to CI children. They may also have dominant acoustic representations, similar to CI adults who acquired hearing loss at a later age. As such, the current study aimed to investigate the perception and use of voice cues by a group of nine early-implanted children with prelingual SSD. The study consisted of three experiments: F0 and VTL discrimination, voice gender categorization, and speech-in-speech perception. In each experiment, the results of the SSD group are compared to children and adults with CIs (for their CI ear) and with typical hearing (for their NH ear).</div><div>Overall, the SSD+CI children had poorer VTL detection thresholds with their CI compared to their NH ear, while their F0 perception was similar across ears. Detection thresholds for both F0 and VTL with their CI ear was comparable to those of bilaterally implanted CI children, suggesting that SSD+CI children do not only rely on their NH ear, but actually make use of their CI. SSD+CI children relied more heavily on F0 cues than on VTL cues for voice gender categorization, with cue weighting patterns comparable to those of CI adults. In contrast to CI children, the SSD+CI children showed limited speech perception benefit based on F0 and VTL differences between the target and masker speaker, which again corresponded to the results of CI adults. Altogether, the SSD+CI children make good use of their CI, despite a good-hearing ear, however, the perceptual patterns seem to fall in-between those of CI children and CI adults. Perhaps a combination of childhood neuroplasticity, limited experience with relying only on the CI, and a dominant acoustic representation of voice gender explain these results.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"454 ","pages":"Article 109133"},"PeriodicalIF":2.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of intraoperative electric field and neural excitation patterns of the cochlear implant with patient-related factors of age, gender, cochlear diameter, and postoperative speech measures","authors":"Priyanka Mohan,&nbsp;Saku T. Sinkkonen,&nbsp;Ville Sivonen","doi":"10.1016/j.heares.2024.109131","DOIUrl":"10.1016/j.heares.2024.109131","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the relationships between the electric field (EF) and neural excitation patterns in cochlear implants (CIs) and explore their associations with the cochlear diameter, patient age and gender, and postoperative speech recognition.</div></div><div><h3>Method</h3><div>The intraoperative transimpedance matrix (TIM) and spread of excitation (SOE) measures were computed to obtain their 50 % widths corresponding to six electrode contacts of a lateral-wall electrode array. The measures were then analyzed for intercorrelations, associations with the cochlear diameter, as well as age and gender-related differences. The relationships between the computed intraoperative measures and postimplant speech recognition were also studied.</div></div><div><h3>Results</h3><div>The TIM and SOE 50 % widths present moderate correlations and exhibit differences between adults and children. The TIM 50 % widths show additional associations with the cochlear diameter and partly vary with the implantee's gender. Speech recognition was found to have a significant relationship with the exponential spread coefficients (ESCs) obtained for individual electrode contacts.</div></div><div><h3>Conclusion</h3><div>Although interrelated, the EF and neural excitation measures of the CI are associated with different variables. The ESC, derived from computations of the TIM_, is the only measure linked to postoperative speech recognition.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109131"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in brain activity and functional connectivity originating residual inhibition of tinnitus induced by tailor-made notched music training","authors":"Min Zhu ,&nbsp;Qin Gong","doi":"10.1016/j.heares.2024.109129","DOIUrl":"10.1016/j.heares.2024.109129","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Tinnitus arises from the intricate interplay of multiple, parallel but overlapping networks, involving neuroplastic changes in both auditory and non-auditory activity. Tailor-made notched music training (TMNMT) has emerged as a promising therapeutic approach for tinnitus. Residual inhibition (RI) represents one of the rare interventions capable of temporarily alleviating tinnitus, offering a valuable tool that can be applied to tinnitus research to explore underlying tinnitus mechanisms. To our knowledge, this study is the first to investigate the neural mechanisms underlying the RI effect of TMNMT through analysis of neural source activity and functional connectivity of EEG. Forty-four participants with tinnitus were divided into TMNMT group (twenty-two participants; ECnm, NMnm, RInm represented that EEG recordings with eyes closed stimuli-pre, stimuli-ing, stimuli-post by TMNMT music, respectively) and Placebo control group (twenty-two participants; ECpb, PBpb, RIpb represented that EEG recordings with eyes closed stimuli-pre, stimuli-ing, stimuli-post by Placebo music, respectively) in a single-blind manner. Source localization analysis revealed that RI effect of TMNMT significantly increased in current density at the delta band in the insula, subgenual anterior cingulate cortex (sgACC), parahippocampus (PHC), and secondary auditory cortex (AⅡ), and significantly increased in current density at the theta band in the sgACC, and significantly decreased in current density at the alpha band in the precuneus, PHC, primary (AI) and secondary (AII) auditory cortex. Meanwhile, RI effect of Placebo significantly decreased in current density at the alpha band in the PHC. Functional connectivity analysis demonstrated that RI effect of TMNMT significantly increased in phase coherence between the left AⅡ and the right sgACC; and between the left PHC and the left retrosplenial cortex (RSC) at the theta band. It significantly decreased in phase coherence between the left PHC and the right precuneus, the right posterior cingulate cortex (PCC), the right AⅡ; between the right PHC and the right PCC; and between the right PCC and the right AⅡ at the alpha band. RI effect of Placebo significantly increased in phase coherence between the left insula and the right precuneus, the left PHC, the right PHC, the left AⅠ, the left AⅡ; between the left sgACC and the right PHC; between the left AⅡ and the right PHC, the left PCC at the delta band. It was found that the current density of sgACC was significantly positively correlated with the tinnitus evaluation indicators (Loudness, VAS, THI, TFI) at the alpha band in TMNMT group. These findings indicated that TMNMT, a novel music therapy for tinnitus, revealed a robust RI effect, and RI effect of TMNMT was not only involved in the activity of auditory networks (AⅠ, AⅡ), but also extended to non-auditory networks, particularly higher-level auditory association cortices, such as the sgACC, PHC and PCC. The current","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"457 ","pages":"Article 109129"},"PeriodicalIF":2.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the cochlear partition’s flexibility on the macro mechanisms in the inner ear","authors":"Simon Kersten ,&nbsp;Henning Taschke ,&nbsp;Michael Vorländer","doi":"10.1016/j.heares.2024.109127","DOIUrl":"10.1016/j.heares.2024.109127","url":null,"abstract":"<div><div>Recent studies have highlighted the anatomy of the cochlear partition (CP), revealing insights into the flexible nature of the osseous spiral lamina (OSL) and the existence of a flexible cochlear partition bridge (CPB) between the OSL and the basilar membrane (BM). However, most existing inner ear models treat the OSL as a rigid structure and ignore the CPB, neglecting their potential impact on intracochlear sound pressure and motion of the BM. In this paper, we investigate the effect of the CP’s flexibility by including the OSL and CPB as either rigid or flexible structures in a numerical anatomical model of the human inner ear. Our findings demonstrate that the flexibility of the OSL and the presence of the CPB significantly affect cochlear macro mechanisms, including differential intracochlear sound pressure, resistive behavior in cochlear impedances, CP stiffness, and BM velocity. These results emphasize the importance of considering the flexibility of the entire CP to enhance our understanding of cochlear function and to accurately interpret experimental data on inner ear mechanics.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109127"},"PeriodicalIF":2.5,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple electrical circuit model for impedance spectroscopy with cochlear implant electrodes","authors":"Merle Sehlmeyer ,&nbsp;Mit B. Bhavsar ,&nbsp;Stefan Zimmermann ,&nbsp;Hannes Maier","doi":"10.1016/j.heares.2024.109125","DOIUrl":"10.1016/j.heares.2024.109125","url":null,"abstract":"<div><div>Although cochlear implants are an established method of restoring hearing, they can have limitations such as increasing current spread and decreasing frequency resolution due to tissue growth around the electrode array. Impedance measurements in cochlear implants have become a versatile tool for intra- and post-operative diagnosis of cochlear implant state. However, most clinical devices use current pulse stimulation already available in the implants and analyze the voltage response in the time-domain and spread along the cochlea. To use the full potential of impedance spectroscopy in differentiating cell types, measurement over an extended frequency range is required. This study presents a simple electrical equivalent circuit for impedance spectroscopy with cochlear implants in a 2-pole configuration. The electrical equivalent circuit describes the electrical properties of the cochlear implant electrode and its electrochemical behavior at the electrode-electrolyte interface by comparing two non-linear bilayer models, Cole-Cole and Schwan-Faraday. The model is validated for four cochlear implant electrodes from four different manufacturers (MED-EL FlexSoft, AB HiFocus SlimJ, Oticon EVO, Cochlear Nucleus CI622) characterized by impedance spectroscopy between 5 Hz and 13 MHz. In the future, this electrical equivalent circuit may help to extract parameters for differentiating cell types around the cochlear implant electrode from an impedance spectroscopic measurement.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109125"},"PeriodicalIF":2.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state networks in chronic tinnitus: Increased connectivity between thalamus and visual areas","authors":"Tori Kok ,&nbsp;Rosemary Varley ,&nbsp;Chris Clark ,&nbsp;Madeleine Verriotis ,&nbsp;Kiran Seunarine ,&nbsp;Giriraj Singh Shekhawat","doi":"10.1016/j.heares.2024.109122","DOIUrl":"10.1016/j.heares.2024.109122","url":null,"abstract":"<div><div>Tinnitus is thought to be associated with aberrant spontaneous activity in the central nervous system. Previous resting-state fMRI findings support this hypothesis and have shown a variety of alterations in neural activity in people with tinnitus compared to people without tinnitus. However, there is little replication of findings. Therefore, the current study aimed to extend on previous findings by investigating eight common resting-state networks (i.e. auditory, default mode, sensorimotor, visual, salience, dorsal attention, frontoparietal and language networks) using a control group (<em>n</em> = 36) and a group of tinnitus patients (<em>n</em> = 46) matched for age, sex and years of education. Hearing profiles matched up to 2 kHz and had a small but significant difference between groups in the high frequency range. Functional connectivity (FC) with dorsolateral prefrontal cortex (DLPFC) was also investigated separately for the first time, as this region is proposed to be core to tinnitus distress symptoms and most often used as a stimulation target in transcranial direct current stimulation (tDCS) research. The results showed that tinnitus patients had increased FC between bilateral thalamus and right visual association cortex compared to control participants. No differences were found with DLPFC, or with any of the resting-state networks (RSN), contrary to previous studies which have reported alterations in several RSNs.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"453 ","pages":"Article 109122"},"PeriodicalIF":2.5,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}