Optimizing the stimulus used to elicit the acoustic change complex: Evaluation of the pre-transition stimulus duration and stimulus complexity in normal hearing adults

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research Pub Date : 2025-03-19 DOI:10.1016/j.heares.2025.109251

Laura I.A. Schellekens , Marloes L. Adank , Sarah Meehan , Marc P. van der Schroeff , Jantien L. Vroegop

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引用次数: 0

Abstract

Introduction

The Acoustic Change Complex (ACC), a cortical auditory evoked potential elicited by sound changes, is a promising measure of speech discrimination for populations unable to perform speech perception tests. However, its clinical utility is limited by long measurement times, which could be reduced by optimizing the signalto-noise ratio (SNR).

Objectives

To study the effect of 1) varying the pre-transition duration (PTD) and 2) tonal complexity on ACC outcomes, including N1-P2 amplitude, baseline noise, SNR, and efficiency (SNR divided by measurement time).

Methods

ACC responses were measured in 18 normal-hearing adults using pure-tone stimuli with a frequency change (1 to 1.1 kHz) and PTDs of 0.25, 0.5, 1, 2 and 3 s, as well as a complex tone with a 1-second PTD.

Results

N1-P2 amplitude increased with PTD up to 2 s. PTD 0.25 s was excluded due to response overlap. Increasing PTD from 0.5 s to 1 s increased efficiency and SNR, reducing estimated measurement time by 78.8 %. ACC presence increased with PTD (100 % for PTD 3 s), but SNR and efficiency gains were absent beyond PTD 1 s. The complex tone showed no difference in N1-P2 amplitude or SNR compared to the pure tone, but increased ACC presence by 22.5 % points.

Conclusion

A PTD of 1 s is recommended over 0.5 s. Increasing tonal complexity and the PTD beyond 1 s seems promising to enhance ACC specificity without compromising SNR or efficiency. These findings support stimulus optimization to improve clinical feasibility of ACC measurements.

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来源期刊

Hearing Research 医学-耳鼻喉科学

CiteScore

5.30

自引率

14.30%

发文量

163

审稿时长

75 days

期刊介绍： The aim of the journal is to provide a forum for papers concerned with basic peripheral and central auditory mechanisms. Emphasis is on experimental and clinical studies, but theoretical and methodological papers will also be considered. The journal publishes original research papers, review and mini- review articles, rapid communications, method/protocol and perspective articles. Papers submitted should deal with auditory anatomy, physiology, psychophysics, imaging, modeling and behavioural studies in animals and humans, as well as hearing aids and cochlear implants. Papers dealing with the vestibular system are also considered for publication. Papers on comparative aspects of hearing and on effects of drugs and environmental contaminants on hearing function will also be considered. Clinical papers will be accepted when they contribute to the understanding of normal and pathological hearing functions.