Hearing Research最新文献

{"title":"Exploring applications of electrically evoked compound action potentials using the vestibulo-cochlear implant","authors":"Stan C.J. van Boxel ,&nbsp;Bernd L. Vermorken ,&nbsp;Benjamin Volpe ,&nbsp;Nils Guinand ,&nbsp;Angélica Perez-Fornos ,&nbsp;Elke M.J. Devocht ,&nbsp;Raymond van de Berg","doi":"10.1016/j.heares.2025.109326","DOIUrl":"10.1016/j.heares.2025.109326","url":null,"abstract":"<div><h3>Objectives</h3><div>Vestibulo-cochlear implants are a potential treatment approach for patients with loss of vestibular function. A critical aspect is the development of reliable and objective outcome measures, to assess their efficacy and optimize their performance. As in cochlear implant care and other neural prostheses, electrically evoked compound action potentials (eCAP) can be used to measure the neural response to implant stimulation. eCAPs might provide information about the presence and misalignment of the electrically evoked vestibulo-ocular reflex, and potential vestibulo-cochlear interactions. This could be valuable in intra-operative functionality assessment, as input for fitting, and to measure spread of excitation. This study aimed to explore the potential role of eCAPs in vestibulo-cochlear implant research.</div></div><div><h3>Design</h3><div>eCAPs were measured in ten subjects with a vestibulo-cochlear implant. Different configurations were used, i.e., trans-canal, vestibulo-cochlear and cochleo-vestibular. The predictive value of eCAPs was evaluated for four outcomes: presence of an electrically evoked vestibulo-ocular reflex (eVOR), degree of misalignment of the eVOR, auditory perception due to vestibular stimulation, and the prevalence of vestibular activation due to cochlear stimulation.</div></div><div><h3>Results</h3><div>The results demonstrated a high positive predictive value of the eCAP for the presence of an eVOR (i.e., 1.0), while the negative predictive value was low (i.e., 0.54). The presence of trans-canal eCAP did not correspond with the degree of misalignment in the eVOR. Furthermore, the predictive values for auditory perception were low (i.e., ≤0.5). eCAP recordings in the cochlea to vestibular configuration imply a high likelihood of cochlear to vestibular interaction (i.e., 67% of electrodes).</div></div><div><h3>Conclusions</h3><div>The presence of a vestibular eCAP was demonstrated to be a predictor of the presence of the eVOR. However, the low negative predictive value prevents the eCAP from providing a reliable indicator for intra-operative electrode position evaluation. eCAP measurements in vestibulo-cochlear configurations indicated that spread of excitation between the cochlea and canals is already possible at stimulation levels within the clinical fitting range of both the vestibular and cochlear electrodes. Measured eCAPs did not correspond with misalignment of the eVOR or the presence of an auditory percept as result of vestibular stimulation. Future research is needed to elucidate the full potential of vestibulo-cochlear implant eCAP measurements.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109326"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of phase-locked neural responses to cochlear-implant stimulation from multiple stages of the auditory system","authors":"Dorothée Arzounian ,&nbsp;François Guérit ,&nbsp;John M. Deeks ,&nbsp;Charlotte Garcia ,&nbsp;Evelien de Groote ,&nbsp;Manohar Bance ,&nbsp;Robert P. Carlyon","doi":"10.1016/j.heares.2025.109338","DOIUrl":"10.1016/j.heares.2025.109338","url":null,"abstract":"<div><div>Studies investigating objective measures of auditory perception when using cochlear implants (CIs) differ in the stimuli used and in the neural response measured. The present study aims to disentangle the effects of response type and of stimulus type on neural response properties. We report three measures corresponding with separate neural latencies, all collected from the same 19 CI recipients and with the same stimulus, consisting of a continuous low-rate electrical pulse train of about 40 pulses per second (pps). These measures comprise the electrically evoked compound action potential (eCAP), auditory brainstem response (eABR), and auditory steady-state response (eASSR), having putative neural generators in peripheral (auditory nerve), subcortical (brainstem), and thalamo-cortical auditory regions, respectively. When assessing correlations across CI recipients, we found that the growth of eASSR amplitude with stimulus level was correlated with that of eCAP amplitude and predictive of the just-noticeable-to-comfortable electrical dynamic range, as measured through behavioral loudness scaling. Additionally, we compared eASSRs measured with the ∼40-pps stimulus and with a high-rate (500-pps) pulse train modulated in amplitude at rates around 40 Hz, and found that both showed similar recipient-specific effects of stimulation rate on response phase and amplitude. Our results highlight that neural responses to different electrical stimuli and at different central processing stages share common idiosyncratic properties, and support the validity of eASSRs for loudness-growth estimation in CI recipients.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109338"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digitizing audiograms with deep learning: structured data extraction and pseudonymization for hearing big data","authors":"Sunghwa You ,&nbsp;Chanbeom Kwak ,&nbsp;Chul Young Yoon ,&nbsp;Young Joon Seo","doi":"10.1016/j.heares.2025.109337","DOIUrl":"10.1016/j.heares.2025.109337","url":null,"abstract":"<div><h3>Purpose</h3><div>hearing loss relies on pure-tone audiometry (PTA); however, audiograms are often stored as unstructured images, limiting their integration into electronic medical records (EMRs) and common data models (CDMs). This study developed a deep learning-based system to digitize audiograms, enabling the structured and numerical conversion of data for large-scale hearing big data collection.</div></div><div><h3>Methods</h3><div>A convolutional neural network (CNN) was trained to extract numerical frequency and threshold values from audiograms. The system consists of four modules: preprocessing, pattern classification, image analysis, and post-processing. Optical character recognition (OCR) was employed to extract patient data, which were then pseudonymized to prevent leakage of personal and sensitive information. The model was trained using 8847 audiometric symbols and tested using 2443 symbols.</div></div><div><h3>Results</h3><div>The model achieved accuracy of 95.01 % and 98.18 % for the right and left ears, respectively. It processed audiograms 17.72 times faster than manual digitization, reducing processing time from 63.27 s to 3.57 s per audiogram. The structured data format allows seamless integration into big data and CDMs, ensuring compliance with pseudonymization and anonymization protocols.</div></div><div><h3>Discussion</h3><div>The model improves data accessibility and scalability for both clinical and research applications. Unlike previous studies that primarily focused on classification or prediction, this framework ensures a structured numerical data output while adhering to data pseudonymization regulations.</div></div><div><h3>Conclusion</h3><div>This deep learning-based system enhanced the efficiency and accuracy of audiogram digitization, facilitating the construction of hearing big data, integration with CDMs, AI-driven diagnostics, and large-scale hearing data analysis.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109337"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the cocktail-party problem: Do children use their exquisite hearing at frequencies above 8 kHz?","authors":"Anu Nair ,&nbsp;Srikanta K Mishra ,&nbsp;Sajana Aryal ,&nbsp;Qian-jie Fu ,&nbsp;John J. Galvin 3rd","doi":"10.1016/j.heares.2025.109327","DOIUrl":"10.1016/j.heares.2025.109327","url":null,"abstract":"<div><div>The ability to segregate speech streams in challenging listening environments, often referred to as the \"cocktail party effect,\" is critical for children learning effective communication, especially in noisy classroom settings. This developmental process, influenced by factors such as hearing sensitivity, cognitive abilities, and acoustic cues, has not been thoroughly examined in relation to hearing at frequencies above 8 kHz, to which children are exquisitely more sensitive than adults. This represents a critical gap, as emerging studies reveal the significant detrimental effects of filtering out this information. The present study investigated the functional role of extended high-frequency (EHF) sensitivity in speech stream segregation in normal-hearing children aged 4–14 years. Using digit triplets to reduce cognitive load, performance on speech tasks were measured across four segregation cue conditions: baseline (co-located, talker-sex matched), talker-sex cue (talker-sex mismatched), spatial cue (spatially separated target and maskers), and combined (talker-sex cue and spatial cue). Results demonstrate that EHF sensitivity uniquely contributes to improved SRTs in baseline and talker-sex cue conditions, underscoring its importance in situations where talker-specific cues are crucial for stream segregation. However, EHF sensitivity did not influence SRTs in the spatial or combined cue conditions, nor did it significantly affect release from masking in any conditions. These findings suggest that while EHF sensitivity plays a key role in segregating speech streams, its contribution may be less prominent when salient spatial cues are available. This research highlights the importance of EHF sensitivity in children for utilization of talker-specific cues when segregating competing speech in complex listening environments.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109327"},"PeriodicalIF":2.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does simple impedance reflect intrascalar tissue in the implanted cochlea?","authors":"Deborah J. Colesa,&nbsp;Katie L. Colesa,&nbsp;Yuki Low,&nbsp;Donald L. Swiderski,&nbsp;Yehoash Raphael,&nbsp;Bryan E. Pfingst","doi":"10.1016/j.heares.2025.109336","DOIUrl":"10.1016/j.heares.2025.109336","url":null,"abstract":"<div><div>A potential threat to the long-term preservation of electrical and acoustical hearing in cochlear implant patients is the development of fibrous tissue and bone in the scala tympani. Simple impedance measures (impedance = voltage/current; <em>Z</em> = <em>V</em>/I), which are commonly used as a non-invasive test of implant integrity, might also be useful for monitoring the environment of the implanted cochlea. Increases in impedance might reflect growth of tissue that impedes current flow. Subsequently then in this study in guinea pigs, impedances for sinusoidal and pulsatile stimuli were measured with cochlear implants for up to 21 months and compared to histology at termination. Histology revealed variable distributions and amounts of scala tympani tissue near the primary measurement electrode. Impedances measured in the first 4 months after implantation increased and decreased over time, suggesting they were influenced by factors other than, or in addition to, tissue growth within the scala tympani. The magnitude of change in impedance for the sinusoidal stimuli was a moderate, statistically significant, predictor of the percentage of new bone and not fibrous or the total tissue in the long term. The extent of new bone was associated with long-term trends of increasing impedance. End-point impedances were highly correlated between bipolar and monopolar sinusoids, and monopolar sinusoids and pulses. Impedances for both stimuli and configurations showed that the amount of fibrosis was not predicted by impedance, but the presence of new bone was. The results should be helpful in determining the underlying causes of functional changes following cochlear implantation.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109336"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic tinnitus is quietened by sound therapy using a novel cross-frequency de-correlating stimulus modulation","authors":"E.A. Yukhnovich ,&nbsp;S. Harrison ,&nbsp;N. Wray ,&nbsp;K. Alter ,&nbsp;W. Sedley","doi":"10.1016/j.heares.2025.109335","DOIUrl":"10.1016/j.heares.2025.109335","url":null,"abstract":"<div><div>We introduce a novel modulation of broadband sounds which eliminates correlations between all frequency pairs close to the tinnitus frequency, to reduce cross-frequency neural synchrony and thereby quieten tinnitus. Fifty-three unselected participants completed a blinded randomised crossover trial, which was run completely online using their computers or smartphones, comparing active to perceptually-near-identical sham stimuli, comprising two 6-week listening periods and 3-week washout periods. Results showed a significant, persisting, reduction in self-rated tinnitus loudness after the active (<em>p</em> = 0.012), but not sham (<em>p</em> = 0.916) intervention. Tinnitus distress scores decreased in both listening periods, indicating tolerability of the intervention and trial process. Due to its automation, generalisability across tinnitus types, and deliverability with generic hardware, this intervention could be made available to most of the worldwide tinnitus community at minimal cost. Next steps involve optimising the intervention parameters to maximise efficacy, and development of a software package for wholescale delivery.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109335"},"PeriodicalIF":2.5,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active control of transverse viscoelastic damping in the tectorial membrane: A second mechanism for traveling-wave amplification?","authors":"François Deloche ,&nbsp;Morgan Thienpont ,&nbsp;Arturo Moleti ,&nbsp;Renata Sisto ,&nbsp;Sarah Verhulst","doi":"10.1016/j.heares.2025.109320","DOIUrl":"10.1016/j.heares.2025.109320","url":null,"abstract":"<div><div>Observations from optical coherence tomography (OCT) have revealed a velocity gradient across the reticular lamina in response to sounds (Cho and Puria, 2022). Since viscoelastic forces depend on velocity gradients, this finding suggests that OHC activity may influence viscous loss in the cochlea. Here, we propose a candidate mechanism for regulating traveling-wave viscous dissipation which involves the tectorial membrane (TM). We hypothesize that the velocity gradient generated in the OHC region, combined with TM structural properties, can reduce transverse deformations in the TM and, subsequently, transverse viscous damping. Based on this hypothesis and a simplified mechanical model, we derive a formula for an equivalent basilar membrane (BM) admittance in both passive and active scenarios. We use the WKB approximation to simulate traveling waves in response to tones at different stimulation levels. The calibration of the model is based on OCT data from mice, including data on TM motion. Our simulations show that modulating the viscous load affects the traveling wave in the peak region, with changes in BM velocity magnitude of up to 10 dB. The inclusion of a more classical anti-damping term is necessary to capture the full dynamic range of the response gain. With the textbook view of OHCs acting directly on the BM under re-evaluation in light of recent OCT data, the control of viscous damping in the TM emerges as a viable candidate for a second mechanism governing traveling-wave amplification.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109320"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine-learning-based approach to predict early hallmarks of progressive hearing loss","authors":"Federico Ceriani ,&nbsp;Joshua Giles ,&nbsp;Neil J Ingham ,&nbsp;Jing-Yi Jeng ,&nbsp;Morag A Lewis ,&nbsp;Karen P Steel ,&nbsp;Mahnaz Arvaneh ,&nbsp;Walter Marcotti","doi":"10.1016/j.heares.2025.109328","DOIUrl":"10.1016/j.heares.2025.109328","url":null,"abstract":"<div><div>Machine learning (ML) techniques are increasingly being used to improve disease diagnosis and treatment. However, the application of these computational approaches to the early diagnosis of age-related hearing loss (ARHL), the most common sensory deficit in adults, remains underexplored. Here, we demonstrate the potential of ML for identifying early signs of ARHL in adult mice. We used auditory brainstem responses (ABRs), which are non-invasive electrophysiological recordings that can be performed in both mice and humans, as a readout of hearing function. We recorded ABRs from C57BL/6N mice (6N), which develop early-onset ARHL due to a hypomorphic allele of <em>Cadherin23</em> (<em>Cdh23^ahl</em>), and from co-isogenic C57BL/6NTac<em>^Cdh23+</em> mice (6N-Repaired), which do not harbour the <em>Cdh23^ahl</em> allele and maintain good hearing until later in life. We evaluated several ML classifiers across different metrics for their ability to distinguish between the two mouse strains based on ABRs. Remarkably, the models accurately identified mice carrying the <em>Cdh23^ahl</em> allele even in the absence of obvious signs of hearing loss at 1 month of age, surpassing the classification accuracy of human experts. Feature importance analysis using Shapley values indicated that subtle differences in ABR wave 1 were critical for distinguishing between the two genotypes. This superior performance underscores the potential of ML approaches in detecting subtle phenotypic differences that may elude manual classification. Additionally, we successfully trained regression models capable of predicting ARHL progression rate at older ages from ABRs recorded in younger mice. We propose that ML approaches are suitable for the early diagnosis of ARHL and could potentially improve the success of future treatments in humans by predicting the progression of hearing dysfunction.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109328"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of the reticular lamina motion to the traveling wave: a WKB approach","authors":"Renata Sisto ,&nbsp;Arturo Moleti","doi":"10.1016/j.heares.2025.109324","DOIUrl":"10.1016/j.heares.2025.109324","url":null,"abstract":"<div><div>Optical coherence tomography (OCT) experiments showed that, in the peak region, at low stimulus levels, the motion of the reticular lamina (RL) may be larger than that of the basilar membrane (BM), suggesting that the contribution of the RL motion to the development of a slow traveling wave (TW) could be a relevant one. In this study, a transmission-line cochlear model with two mechanical degrees of freedom at each tonotopic place is used, in which the outer hair cell (OHC) force is represented by a low-pass filtered elastic term proportional to the OHC elongation. The hydrodynamic effects of fluid focusing and viscous damping in the peak region are also included in the model. In the simulations, the contribution of the RL motion to the traveling wave is due to the volume change of the Organ of Corti (OoC), which adds up to the antisymmetric volume change of the two scalae associated with the BM motion. Including the RL motion in the computation of the local wavenumber in the Wentzel-Kramers-Brillouin (WKB) framework implies a change of both the focusing factor and of the real part of the admittance, dependent on the phase of the relative RL-BM motion. To make the RL contribution on focusing the most effective, the BM and the RL should be approximately in phase in the peak region, which, in the model, is consistent with a dominant gain effect of fluid focusing over OHC internal force in the peak region. The negative/positive sign of the RL-BM local phase shift would imply an additional damping/antidamping effect, which is more difficult to predict, and model-dependent.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109324"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological markers of early auditory temporal resolution deterioration with aging","authors":"Thomas M.D. Augereau ,&nbsp;Daniel Paromov ,&nbsp;Adriana B.M. Lacerda ,&nbsp;Victoria Duda ,&nbsp;François Champoux","doi":"10.1016/j.heares.2025.109325","DOIUrl":"10.1016/j.heares.2025.109325","url":null,"abstract":"<div><div>Aging significantly impacts auditory perception, particularly temporal resolution, which is the ability to detect rapid changes in sounds. Temporal resolution is often studied using gap detection methods, where a silent gap is inserted into a longer noise duration. Previous research indicates that aging negatively affects gap detection at the behavioral level. To objectively examine this process, electrophysiological correlates can be studied using a multi-deviant oddball paradigm. Existing data show reduced Deviant-Related Negativity (DRN) amplitudes and increased latencies in older adults compared to younger adults, suggesting a pre-attentive decline in processing basic temporal stimulus features. The effects of aging on gap detection have not been extensively investigated, making it uncertain whether changes can be detected in groups with smaller age differences. This study aims to investigate DRN and P2/P3a components in healthy, normal-hearing young (18-25 years) and middle-aged (30-45 years) adults using a multi-deviant paradigm combined with a behavioral gap audibility task with fixed gap durations. While behavioral task results were inconclusive, DRN latency analysis revealed significant differences during adaptation to deviant stimuli between age groups at various gap durations, displaying opposite slopes between both groups. Specifically, middle-aged participants exhibited increasing slopes, while younger participants showed decreasing slopes. Additionally, middle-aged adults exhibited significantly increased P2/P3a latencies compared to younger adults. These findings not only confirm the impact of aging on DRN during temporal resolution tasks but also suggest that examining the P2/P3a component could be valuable for early detection of age-related auditory decline.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109325"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}