Hearing Research最新文献

{"title":"Structural brain pattern abnormalities in tinnitus with and without hearing loss","authors":"Li Qin ,&nbsp;Qiu Ge ,&nbsp;Chaoqi Shi ,&nbsp;Jiayu Ni ,&nbsp;Zili Yin ,&nbsp;Enli Jin ,&nbsp;Jiaying Wang ,&nbsp;Yu-Feng Zang ,&nbsp;Yuan Li","doi":"10.1016/j.heares.2025.109274","DOIUrl":"10.1016/j.heares.2025.109274","url":null,"abstract":"<div><h3>Objective</h3><div>Subjective tinnitus often coexists with hearing loss, and they share common pathophysiological mechanisms. This comorbidity induces whole-brain gray matter volume (GMV) alterations, manifesting as distributed structural changes in neural networks rather than isolated regional modifications. Multivariate analysis of structural brain patterns is therefore essential to differentiate their underlying mechanisms.</div></div><div><h3>Methods</h3><div>Fifty tinnitus patients and 50 age-/gender-matched controls underwent structural MRI and audiometry. Patients were stratified by hearing level into 22 with hearing loss (T+HL) and 28 without (T-HL). To investigate structural brain patterns specific to tinnitus and hearing loss, Source-Based Morphometry (SBM), a multivariate analytical approach based on Independent Component Analysis (ICA), was applied to identify covarying patterns of GMV. The associations between these structural covariance patterns and clinical characteristics were examined using Spearman's correlation analysis.</div></div><div><h3>Results</h3><div>Our results showed that in T-HL patients, structural abnormalities in the medial prefrontal cortex, precuneus, and auditory cortex were negatively correlated with tinnitus distress. In contrast, in T+HL patients, abnormalities in the insular structural brain pattern were negatively associated with depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Our findings revealed that tinnitus-related structural brain patterns involve regions such as the middle frontal gyrus, supplementary motor area (SMA), and anterior cingulate cortex (ACC), with these changes negatively correlating with tinnitus distress, suggesting adaptive mechanisms in tinnitus perception. Moreover, the structural brain pattern involving the insula, putamen, and superior temporal gyrus appears to be primarily driven by hearing loss. These findings support audiometric-based subgrouping in tinnitus management.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109274"},"PeriodicalIF":2.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle-aged CBA/CaJ mice exhibit auditory dysfunction in background noise","authors":"E. Fabrizio-Stover ,&nbsp;J. Wu ,&nbsp;H. Lang ,&nbsp;K.C. Harris","doi":"10.1016/j.heares.2025.109259","DOIUrl":"10.1016/j.heares.2025.109259","url":null,"abstract":"<div><div>Aging is associated with deficits in auditory functioning. Characterization of auditory deficits that originate in middle-age is crucial for understanding the initial age-related functional impairments and the spatio-temporal progression of age-related auditory pathophysiology. Early age-related deficits in auditory processing are evident in difficult listening conditions, such as background noise, before becoming evident in quiet. To investigate the effect of noise on age-related auditory dysfunction, we collected suprathreshold auditory brainstem responses (ABRs) from young, middle-aged, and aged CBA/CaJ mice in quiet and broad-band background noise. We utilized multiple ABR metrics, including phase locking value (PLV), a measure of neural synchrony correlated to speech-in-noise understanding in humans. Despite no differences in auditory processing in quiet between young and middle-aged mice, middle-aged mice exhibited a distinct auditory phenotype from both young and aged mice in background noise conditions. We found that noise significantly decreased amplitude in middle-aged mice more than in young and aged mice. Noise significantly increased latencies for wave I and V in young mice, but only affected wave V in middle-aged mice and did not affect aged latencies. Noise significantly decreased PLV in middle-aged mice to a greater extent than in young mice, but to a lesser extent in aged mice. These results show that middle-aged mice have a distinct, auditory dysfunction phenotype evident in background noise. Our data show that suprathreshold auditory function in noise can identify early age-related hearing loss and can be used as a sensitive tool for detecting auditory dysfunction in normal hearing animal models.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109259"},"PeriodicalIF":2.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear representation of wideband biosonar sounds and the emergence of neural oscillations","authors":"James A. Simmons ,&nbsp;Darlene R. Ketten ,&nbsp;Andrea Megela Simmons","doi":"10.1016/j.heares.2025.109261","DOIUrl":"10.1016/j.heares.2025.109261","url":null,"abstract":"<div><div>Echolocating big brown bats and bottlenose dolphins broadcast wideband ultrasonic echolocation calls in the baseband to sense their surroundings. Even though these species inhabit different media and emit echolocation calls with different spectra, both show similar perceptual acuity: They determine target range from echo delay, they detect changes in echo delay on a microsecond scale, and they perceive ultrasonic phase. These perceptual performances are too acute to understand on the basis of single neuron responses, and even neural population responses do not reach the required behavioral values. Here we propose two mechanisms that may contribute to temporal hyperacuity in these wideband echolocators. Structural imaging studies show that in both species the cochlea receives input from the middle ear at locations different from that seen in non-echolocating mammals. These unusual patterns of input might produce interference patterns in traveling waves along the basilar membrane, which in turn could facilitate detection of ultrasonic phase by producing low difference frequencies that may form a substrate for further neural processing into perception. The second mechanism is related to oscillations of evoked activity observed in the bat's inferior colliculus, which could create broadcast-echo interference patterns at the neural level. The resulting difference-frequency interference signals would be very sensitive to changes in echo delay and phase. Small changes in ultrasonic sounds thus could lead to much larger changes in neural response timing by magnifying echo time itself.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"462 ","pages":"Article 109261"},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms","authors":"Naomi F. Bramhall ,&nbsp;Brad N. Buran ,&nbsp;Garnett P. McMillan","doi":"10.1016/j.heares.2025.109263","DOIUrl":"10.1016/j.heares.2025.109263","url":null,"abstract":"<div><div>Cochlear synaptopathy, a type of cochlear deafferentation that impacts the synapses between the inner hair cells and the afferent auditory nerve fibers, is predicted to result in speech perception in noise difficulty. However, this has been difficult to confirm due to mixed findings in human studies of the relationship between speech perception in noise and physiological indicators of deafferentation (auditory brainstem response [ABR] wave I amplitude, envelope following response [EFR] magnitude, and middle ear muscle reflex [MEMR] magnitude). One possible explanation for the mixed findings is that some listeners with cochlear deafferentation can increase their cognitive effort to compensate for the degraded speech signal so that their speech-in-noise performance is relatively unaffected, obscuring the relationship between deafferentation and speech-in-noise scores.</div><div>In a population at high risk for noise-induced cochlear deafferentation (military Veterans with normal audiograms), this study evaluated the relationship between physiological indicators of deafferentation (ABR, EFR, and MEMR) and listening effort, as indicated by pupil dilation during a speech-in-noise task.</div><div>Mean reductions in ABR, EFR, and MEMR magnitude were associated with greater task-related pupil dilation, but not with reduced speech-in-noise performance, although only the ABR was statistically significant after accounting for sex and outer hair cell function. This suggests that cochlear deafferentation may result in increased listening effort during speech-in-noise perception, even if performance on the task is not negatively impacted. The observed relationship between EFR magnitude and pupil dilation was non-linear, suggesting that increased listening effort may only occur after a particular threshold level of deafferentation is reached.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109263"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Tinnitus, masked speech perception, and auditory event-related potentials in clinically normal-hearing adults” [Hearing Research 460 (2025) 109239]","authors":"Ning Gao ,&nbsp;Sheng-Yu Tao ,&nbsp;Qian-Jie Fu ,&nbsp;John Galvin ,&nbsp;Sean Lang ,&nbsp;Ya-Feng Yu ,&nbsp;Ji-Sheng Liu ,&nbsp;Duo-Duo Tao","doi":"10.1016/j.heares.2025.109257","DOIUrl":"10.1016/j.heares.2025.109257","url":null,"abstract":"","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109257"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced hearing loss: a real-world pharmacovigilance study using the FDA adverse event reporting system database","authors":"Tingxi Wu ,&nbsp;Zhigang Zhao ,&nbsp;Peng Wang ,&nbsp;Qian Du ,&nbsp;Yanfeng Shi ,&nbsp;Bin Zhu ,&nbsp;Jie Dong ,&nbsp;Dongxuan Li","doi":"10.1016/j.heares.2025.109262","DOIUrl":"10.1016/j.heares.2025.109262","url":null,"abstract":"<div><div>Drug-induced hearing loss (DIHL) is highly prevalent, but a comprehensive picture of ototoxicity associated with drugs are still lacking. In order to comprehensively summarize the hearing safety information of current drugs, we used the real-world data from 2004 to 2023 in the FDA Adverse Event Reporting System (FAERS) database to integrate the reported ototoxicity information of drugs and applied disproportionality analysis to evaluate the hearing impairment risk induced by drugs. A total of 108,435 adverse event (AE) reports of hearing impairment were extracted from the FAERS database, involving 1300 reported culprit-drugs. On the whole, acetylsalicylic acid was the most frequently reported potential ototoxic drug, followed by levothyroxine sodium, adalimumab, omeprazole, and ergocalciferol. Immunosuppressants was the most frequently reported drug class, followed by analgesics, psychoanaleptics, agents acting on the renin-angiotensin system, and antineoplastic agents. In risk signal detection, 432 of 1300 drugs exhibited potential ototoxic risk, in which tafenoquine showed the strongest statistical correlation with hearing impairment, followed by teprotumumab, amyl nitrite, potassium iodide, and paromomycin. Among main drug classes, antibacterials for systemic use was the drug class contained the maximum number of drugs with positive ototoxic risk signals, followed by psychoanaleptics, agents acting on the renin-angiotensin system, antineoplastic agents, and analgesics. In conclusion, our study summarized a comprehensive drug list containing 1300 reported potential ototoxic drugs in the FAERS database and profiled their ototoxicity risk characteristic from the aspect of reporting frequency and risk signal strength, which can provide reference for clinical medical staff to strengthen monitoring and management of DIHL.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109262"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based prediction of hearing loss: Findings of the US NHANES from 2003 to 2018","authors":"Yi Mi,&nbsp;Pin Sun","doi":"10.1016/j.heares.2025.109252","DOIUrl":"10.1016/j.heares.2025.109252","url":null,"abstract":"<div><div>The prevalence of hearing loss (HL) has emerged as an escalating public health concern globally. The objective of this study was to leverage data from the National Health and Nutritional Examination Survey (NHANES) to develop an interpretable predictive machine learning (ML) model for HL.</div><div>In accordance with the established inclusion and exclusion criteria, a total of 2814 participants were randomly assigned to one of two distinct groups for the training and validation of the predictive models. We identified the most significant variables using Recursive Feature Elimination and constructed a HL prediction model through various ML models. The generalization ability of the models was evaluated via 10-fold cross-validation. Eight different models were utilized to develop the optimal prediction model for HL. Subsequently, three interpretable methods, Feature importance analysis, Generalized linear model (GLM) and Restricted cubic spline (RCS) were integrated into a pipeline and embedded in ML for model interpretation.</div><div>In this study, the Random Forest (RF) exhibited superior performance across all evaluation metrics after balancing the data using the Synthetic Minority Oversampling Technique (SMOTE), particularly excelling in AUC, PR-AUC and F1 score. Feature importance analysis uncovered significant correlations between HL and top 10 features, including age, blood lead (Pb) level, urine thallium (Tl) level, BMI, total energy, urine antimon (Sb) level, vitamin E intake, urine cobalt (Co) level, calcium intake and urine cesium (Cs) level. Moreover, both univariate and multivariate GLMs identified blood Pb [OR (95 % CI):1.169 (1.037,1.311)] and vitamin E intake [OR (95 % CI):0.776 (0.641,0.928)] as the main features associated with HL. The RCS analysis further revealed that increased blood Pb level and decreased vitamin E intake correspond to a proportional rise in the anticipated risk of HL after adjusted by confounders.</div><div>Our ML models identify key factors that, if validated by future studies, will have important implications for hearing conservation. Furthermore, these ML-based point-of-care prediction models will help overcome barriers to hearing healthcare and enable the efficient allocation of resources by accurately identifying individuals who are in dire need of hearing assessment.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109252"},"PeriodicalIF":2.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABRpresto: An algorithm for automatic thresholding of the Auditory Brainstem Response using resampled cross-correlation across subaverages","authors":"Luke A. Shaheen ,&nbsp;Brad N. Buran ,&nbsp;Kirupa Suthakar ,&nbsp;Seth D. Koehler ,&nbsp;Yoojin Chung","doi":"10.1016/j.heares.2025.109258","DOIUrl":"10.1016/j.heares.2025.109258","url":null,"abstract":"<div><div>The Auditory Brainstem Response (ABR) is an essential diagnostic indicator of overall health of cochlea, auditory brainstem and midbrain, used extensively in both basic research and clinical studies. A key quantification of the ABR is threshold, the lowest sound level that elicits a response. Because the morphology of ABR waveforms shift with stimulus level and the overall signal-to-noise ratio is low, threshold estimation is not straightforward. Although several algorithmic approaches have been proposed, the current standard practice remains the visual evaluation of ABR waveforms as a function of stimulus level.</div><div>We developed an algorithm based on the cross-correlation of two independent averages of responses to the same stimulus. For each stimulus level, the individual responses to each tone-pip are randomly split into two groups. The median waveform for each group is calculated, and then the normalized cross-correlation between these median waveforms is obtained. This process is repeated 500 times to obtain a resampled cross-correlation distribution. For each frequency, the mean values of these distributions are computed for each level and fit with a sigmoid or a power law function to estimate the threshold.</div><div>Algorithmic thresholds demonstrated robust and accurate performance, achieving 92% accuracy within ±10 dB of human-rated thresholds on a large pool of mouse data. This performance was better than that of several published algorithms on the same dataset. This algorithm has now fully replaced the manual estimation of ABR thresholds for our preclinical studies, thereby saving significant time and enhancing objectivity in the process.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"462 ","pages":"Article 109258"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implantation with a dexamethasone-eluting electrode array: First-in-human safety and performance results","authors":"Nils Prenzler ,&nbsp;Rolf Salcher ,&nbsp;Andreas Büchner ,&nbsp;Athanasia Warnecke ,&nbsp;Daniel Kley ,&nbsp;Cornelia Batsoulis ,&nbsp;Sarah Vormelcher ,&nbsp;Maria Mitterberger-Vogt ,&nbsp;Stefano Morettini ,&nbsp;Soeren Schilp ,&nbsp;Ingeborg Hochmair ,&nbsp;Thomas Lenarz","doi":"10.1016/j.heares.2025.109255","DOIUrl":"10.1016/j.heares.2025.109255","url":null,"abstract":"<div><div>Cochlear implantation is the standard of care for individuals with severe-to-profound sensorineural hearing loss. However, implantation itself can degrade residual hearing, for example due to insertional trauma and subsequent inflammatory processes. One potential method to mitigate this loss of residual hearing is through the local and sustained delivery of anti-inflammatory drugs released from the electrode array. To this end, a dexamethasone eluting electrode array (FLEX28 DEX) was developed by MED-EL.</div><div>Here we present the results from a first-in-human feasibility study of the CIDEXEL system (the Mi1200 SYNCHRONY cochlear implant combined with the FLEX28 DEX array). A single-arm, exploratory, open-label, prospective, longitudinal, and monocentric study design with sequential block enrolment was used. Nine participants were implanted with the CIDEXEL and were followed up to 9 months post first fitting. The primary aim was to evaluate the safety of the device. The secondary aims were to assess: 1) electrode impedance levels; 2) hearing preservation rates; 3) speech perception outcomes; and 4) subjective feedback from the surgeons regarding their experience with the device during the operation.</div><div>There were no device- or procedure-related serious adverse events. Low and stable impedance levels were observed across all electrode sites (basal, medial and apical). In the majority of participants, good preservation of residual hearing (≤15 dB hearing loss) was achieved. The participants showed speech perception test results which were comparable to those with a non-eluting FLEX28 array. Surgeons reported that the CIDEXEL had similar handling and insertion properties to a conventional electrode array.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109255"},"PeriodicalIF":2.5,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing restoration through hair cell regeneration: A review of recent advancements and current limitations","authors":"Melissa M. McGovern ,&nbsp;Brandon C. Cox","doi":"10.1016/j.heares.2025.109256","DOIUrl":"10.1016/j.heares.2025.109256","url":null,"abstract":"<div><div>Hearing loss is extremely common, yet limited treatment options are available to restore hearing, and those that are available provide incomplete recovery of hearing detection. For patients who are born with normal hearing, the most common cause of hearing loss is the loss of the sensory hair cells located in the cochlea of the inner ear. Non-mammals, including birds, fish, and amphibians, naturally regenerate new hair cells after damage and this natural process results in functional recovery. While some limited hair cell regeneration also occurs in the immature cochlea of mice, the mature mammalian cochlea does not naturally produce replacement hair cells, and thus hearing loss is permanent. Since the late 1980s, researchers have been investigating mechanisms to convert supporting cells, the cells that remain once hair cells have been killed, into new replacement hair cells. Here we review the current status of hair cell regeneration in the adult cochlea, highlighting recent achievements, as well as challenges that have yet to be resolved.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109256"},"PeriodicalIF":2.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}