Hearing Research最新文献

{"title":"NADH against noise-induced hearing loss: Evidence from models of \"temporary\" and \"permanent\" deafness","authors":"Ziyi Chen ,&nbsp;Tao Shi ,&nbsp;Jin Li ,&nbsp;Danyang Li ,&nbsp;Yi Luo ,&nbsp;Yuhan Chen ,&nbsp;Xiaolong Zhang ,&nbsp;Hongyang Wang ,&nbsp;Qiuju Wang","doi":"10.1016/j.heares.2025.109431","DOIUrl":"10.1016/j.heares.2025.109431","url":null,"abstract":"<div><div>Exposure to different types of noise for varying durations can lead to damage in different parts of the auditory pathway, such as synapse and hair cell loss, resulting in temporary or permanent threshold shifts. Noise-induced hearing loss (NIHL) involves intricate mechanisms in its pathogenesis, with oxidative stress and glutamate excitotoxicity considered important factors. Currently, there is a lack of effective drugs for NIHL. This study exhibited noise-induced hidden hearing loss (NIHHL) and noise-induced permanent hearing loss in CBA/CaJ mouse models and found that pre-administration of NADH via intraperitoneal injection effectively mitigated noise-induced damage in both models. NIHHL mice exhibited threshold recovery at 14 days post-exposure but mild sustained synapse loss. NIHL mice developed persistent threshold elevation with irreversible ribbon synapse and outer hair cells (OHC) damage. NADH pretreatment mitigated temporary threshold shifts in the NIHHL model, while in the NIHL model, it reduced threshold elevation, attenuated synapse and OHC loss, and preserved stereocilia bundle integrity. Furthermore, pretreatment with NADH significantly reduced cochlear Ca²⁺ levels and delayed the time to peak Ca²⁺ concentration in NIHL mice. Concurrently, upregulated mGluR expression and dynamic changes in P-PKC levels were observed, with P-PKC exhibiting a trend consistent with Ca²⁺ fluctuations. Additionally, cochlear ROS levels decreased, while NRF2 was rapidly upregulated and underwent nuclear translocation in OHCs, accompanied by enhanced mRNA expression of its downstream antioxidant factors. These results indicated that the mitigation of hearing loss by NADH pretreatment in NIHL mice may involve both the mGluR-PKC<img>Ca²⁺ and NRF2 pathways.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109431"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OSBPL2 deficiency impaired cochlear blood-labyrinth barrier via activation of NF-κB signaling pathway","authors":"Qian Yang ,&nbsp;Tianqi Li ,&nbsp;Yajie Lu ,&nbsp;Tianming Wang ,&nbsp;Zhibin Chen ,&nbsp;Guangqian Xing ,&nbsp;Qinjun Wei ,&nbsp;Xin Cao ,&nbsp;Jun Yao","doi":"10.1016/j.heares.2025.109432","DOIUrl":"10.1016/j.heares.2025.109432","url":null,"abstract":"<div><div><em>OSBPL2</em> was one of the causal genes responsible for autosomal dominant non-syndromic hearing loss (DFNA) and the pathogenic mechanism of <em>OSBPL2</em> mutations remain elusive. OSBPL2 was detected to be highly expressed in stria vascularis (SV) of mouse cochleae, in which the blood-labyrinth barrier (BLB) was located as an essential component of cochlear spiral duct. The present study explored a potential pathologic mechanism of OSBPL2 deficiency underlying the structural and functional impact on BLB. <em>Osbpl2</em>-knockout (KO) mice were used to characterize SV permeability, which was measured using FITC-dextran injection. <em>OSBPL2</em>-deficient human umbilical vein endothelial cells (HUVECs) were used to evaluate the endothelial permeability <em>in vitro</em>. Tight junctions (TJs) in SV and HUVECs were characterized using immunofluorescent staining. The results showed that significant SV leakage was detected in cochleae of 10-month-old <em>Osbpl2</em>-KO mice, which was consistent with the increased endothelial permeability in OSBPL2<em>-</em>deficient HUVECs. It was also noted that OSBPL2 deficiency led to TJs disruption and induced inflammation-mediated apoptosis via the activation of NF-κB signaling. This study revealed the potential pathogenic mechanism of OSBPL2 deficiency in SV lesion, which helped to elucidate the underlying pathogenesis of <em>OSBPL2</em> mutations in DFNA.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109432"},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrophy of the auditory cortex in Alzheimer’s disease","authors":"Ana Sousa Menezes ,&nbsp;Ana Coelho ,&nbsp;Rafaela Morais-Ribeiro ,&nbsp;Tiago Gil Oliveira ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.heares.2025.109430","DOIUrl":"10.1016/j.heares.2025.109430","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the auditory cortex (AC) in patients with Alzheimer’s Disease (AD) and to assess the effect of ageing using Magnetic Resonance Imaging.</div></div><div><h3>Design</h3><div>Multicenter, cross-sectional study. Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed, including 200 patients with AD, 200 elderly controls, and 200 individuals with Mild Cognitive Impairment (MCI). Volumes of the Heschl's gyrus, Planum Temporale and Planum Polare-corresponding to the primary, secondary and association AC, respectively- were obtained using Freesurfer. Regional volumes were normalized to intracranial volume and compared between groups, considering age and sex.</div></div><div><h3>Results</h3><div>Patients with AD showed significantly lower AC volumes compared with individuals with MCI and elderly controls. In addition, AC volumes declined with increasing age, though this reduction was less pronounced in the left Planum Temporale and left Heschl’s gyrus of AD patients. In multivariate analysis, both age and AD diagnosis were independent negative predictors, with the effect of AD being more pronounced, even after adjusting for age.</div></div><div><h3>Conclusions</h3><div>The AC is significantly affected in AD. Furthermore, AC volumes decline with ageing across all regions, although the reduction is less evident in the secondary AC and left primary AC of AD patients. Patients with MCI showed relative preservation of the primary AC and left secondary AC compared with AD patients.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109430"},"PeriodicalIF":2.5,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loudness discomfort levels at extended high frequencies in young adults: A potential marker of hyperacusis","authors":"Charlotte Bigras ,&nbsp;Victoria Duda ,&nbsp;Sylvie Hébert","doi":"10.1016/j.heares.2025.109425","DOIUrl":"10.1016/j.heares.2025.109425","url":null,"abstract":"<div><div>Loudness discomfort levels (LDLs) are typically measured only at standard frequencies (0.25–8 kHz), which may limit their diagnostic utility in assessing loudness disorders such as hyperacusis. The aim of this study was to (1) establish normative LDL for extended high frequencies (EHFs, 9–16 kHz) in a <em>non-hyperacusis</em> population, (2) examine associations with participant audiological and demographic characteristics, and (3) explore EHFs LDLs in a small group of self-reported <em>hyperacusis</em> participants. We recruited 103 participants (52 female, 50 male, 1 non-binary) with a mean age of 27.5 years, divided into a <em>non-hyperacusis</em> group (<em>n</em> = 94) and a <em>hyperacusis</em> group (<em>n</em> = 9). Pure tone hearing thresholds (HTs) were measured from 0.25 to 16 kHz and LDLs were assessed at 0.5, 4, 9, 11.2, 12.5, 14 and 16 kHz. In <em>non-hyperacusis</em> participants, average EHF LDLs were of 74 dB HL (SD = 9.1–16.8; range = 10–100). LDLs showed small to medium negative correlations with the Hyperacusis Questionnaire (HQ), the Noise Sensitivity Scale (NSS) and the depression subscale of the Hospital Anxiety and Depression Scale, but no significant correlations with age or anxiety. <em>Hyperacusis</em> participants had significantly worse EHF average HTs, lower LDLs and reduced dynamic ranges across frequency ranges. This study provides the first report of LDLs for EHF in a large cohort and is a valuable reference for audiologists. These findings suggest that EHF measures could improve the diagnosis of loudness related disorders such as hyperacusis, supporting early identification and tailored interventions. Further research is needed to fully assess the clinical value of EHF LDL assessments.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109425"},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentence recall and neurophysiological effects of the “2-Sentence Problem” under time compression in younger and older listeners","authors":"Victoria C. Sinfield ,&nbsp;Sandy Snyder ,&nbsp;Yunjie Tong ,&nbsp;Maureen J. Shader","doi":"10.1016/j.heares.2025.109427","DOIUrl":"10.1016/j.heares.2025.109427","url":null,"abstract":"<div><div>Understanding how auditory cognitive load impacts speech recognition is critical for improving communication strategies across the lifespan. This study investigated the effects of two auditory cognitive load factors – sentence count (one vs two sentences) and speech rate (natural vs time-compressed) – on delayed sentence recall in younger and older listeners with normal and near-normal hearing. Forty participants (20 younger, <em>M</em> = 21.15 ± 1.18 years; 20 older, <em>M</em> = 64.50 ± 6.19 years) completed a sentence-recall task under four conditions combining sentence count and speech rate. Neural and physiological responses were recorded using systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). Participants also provided subjective workload ratings (NASA-TLX) and completed assessments of working memory and temporal processing speed. Results showed that increased sentence count and faster speech rate significantly reduced recall accuracy, with older adults being more negatively affected, particularly under time compression. Higher working memory capacity was associated with better performance on two-sentence conditions, and better temporal processing speed supported time-compressed sentence recall in older listeners. Younger adults demonstrated strong premotor cortex activation during listening, while older adults had weak premotor cortex activation isolated to the higher-load conditions, consistent with possible compensatory strategies and reduced neural efficiency. Galvanic skin response suggested blunted reactivity in older adults under increased load. Subjective workload ratings reflected greater perceived effort in older adults, particularly during time-compressed conditions. These findings highlight age-related differences in cognitive and neurophysiological responses to auditory load and emphasize the importance of multimodal approaches for understanding effortful listening.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109427"},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted fundamental frequency encoding in sensorineural hearing loss revealed by the frequency-following response","authors":"Laura Jacxsens ,&nbsp;Lana Biot ,&nbsp;Tinne Vandenbroeke ,&nbsp;Emilie Cardon ,&nbsp;Vincent Van Rompaey ,&nbsp;Willem De Hertogh ,&nbsp;Carles Escera ,&nbsp;Marc J.W. Lammers","doi":"10.1016/j.heares.2025.109426","DOIUrl":"10.1016/j.heares.2025.109426","url":null,"abstract":"<div><h3>Objectives</h3><div>The frequency-following response (FFR) is a scalp-recorded auditory evoked potential that reflects subcortical and cortical encoding of speech through neural phase-locking to its spectro-temporal features. Previous research on the influence of sensorineural hearing loss (SNHL) on the FFR has been inconsistent, with a tendency towards smaller spectral amplitudes at the fundamental frequency (F₀), however often limited by small samples, use of short stimuli that prevent proper phase locking, and poor control for audibility.</div></div><div><h3>Methods</h3><div>Seventy adults (18–65 years) with normal hearing or various degrees of SNHL were included. Pure-tone audiometry (PTA) and speech-in-noise tests were performed. FFRs were recorded using the 217 ms /dao/ stimulus presented monaurally in three randomized blocks of 1000 trials each. Stimuli were calibrated to 60 dB above the mean PTA threshold (at 0.5, 1, and 2 kHz) or adjusted to maximum comfortable loudness level.</div></div><div><h3>Results</h3><div>Significant correlations were found between the PTA and both the F₀ response amplitude and the signal-to-noise ratio (SNR) at F₀ for the /o/ section of the stimulus (<em>r</em> = -0.341 and <em>r</em> = -0.438, respectively; <em>p</em> &lt; 0.001). Stimulus-to-response cross-correlation, pitch error, and pitch strength for both /a/ and /o/ segments were also significantly associated with PTA. Most speech-in-noise tests correlated significantly with the SNR at F₀ for the /o/ segment.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that SNHL disrupts subcortical encoding of the fundamental frequency, particularly in the /o/ vowel segment. These results highlight the potential of the FFR as an objective marker of auditory processing deficits associated with SNHL.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109426"},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional characteristics of speech perception decline in healthy aging based on resting-state EEG-fNIRS","authors":"Liu Yang ,&nbsp;Songjian Wang ,&nbsp;Jian Wang ,&nbsp;Shuo Wang ,&nbsp;Yu Gu","doi":"10.1016/j.heares.2025.109415","DOIUrl":"10.1016/j.heares.2025.109415","url":null,"abstract":"<div><div>Older adults frequently struggle with speech perception in noisy environments, a challenge influenced by age-related changes in brain function. Resting-state brain activity has emerged as a crucial area of research for understanding alterations in functional connectivity associated with aging. We herein used a multimodal approach, integrating electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), to examine how aging affects the resting-state auditory network. Additionally, we assessed speech perception across three age groups—youth group (YG), middle-aged group (MG), and older group (OG)—under varying signal-to-noise ratio (SNR) conditions: speech in quiet (SIQ), moderate noise (SNR = 5 dB), and high noise (SNR = −5 dB). The results indicate that aging is linked to heightened functional connectivity in key brain regions responsible for speech processing and cognitive control, including the dorsolateral prefrontal cortex, Broca’s area, Wernicke’s area, and both the primary auditory cortex and auditory association cortices. However, despite this heightened connectivity, critical network properties—such as small-worldness, local efficiency, and nodal efficiency—show a decline, particularly in speech-related regions such as the left superior temporal gyrus. EEG microstate analysis further highlights a shift in brain dynamics with aging, demonstrating a transition from microstate C to microstate D. This shift suggests a compensatory reliance on executive functions, likely reflecting an adaptive mechanism to counteract age-related declines in auditory processing efficiency. Notably, higher small-worldness and local efficiency correlate with better speech recognition in noisy environments, while specific microstate features are associated with improved speech perception performance. These findings indicate that aging alters brain network dynamics, leading to compensatory neural adaptations that support auditory processing. By integrating EEG and fNIRS, this study provides a comprehensive analysis of the neural mechanisms underlying age-related changes in speech perception and cognitive control. The results underscore the importance of functional connectivity and network efficiency in maintaining speech comprehension in older adults, provide exploratory evidence on neural features underlying age-related auditory decline, which may inform future intervention research.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109415"},"PeriodicalIF":2.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Automatic Classifier AutoSense Sky OS for pediatric cochlear implant users using a virtual classroom environment","authors":"Maartje M.E. Hendrikse,&nbsp;André Goedegebure,&nbsp;Kars R. Tjepkema,&nbsp;Jantien L. Vroegop","doi":"10.1016/j.heares.2025.109414","DOIUrl":"10.1016/j.heares.2025.109414","url":null,"abstract":"<div><div>This study evaluated whether AutoSense Sky OS, an automatic classifier used in pediatric Advanced Bionics cochlear implants (CIs), improves speech intelligibility from the front without significantly impairing spatial awareness (i.e., sound detection and identification from all directions), with the main focus on the classroom situation. A double-blind crossover study was conducted with 12 pediatric CI users aged 7–16 years. Participants tested two settings: one with AutoSense Sky OS activated and the other with an omnidirectional microphone mode. Speech intelligibility from the front and spatial awareness were assessed in a virtual classroom environment using a Virtual Reality headset and a 12-loudspeaker array. Participants also rated the performance of each setting during a take-home period. A technical evaluation revealed that AutoSense Sky OS activated its directional microphone mode in the virtual classroom, significantly improving speech intelligibility from the front during the listening test, while causing a statistically significant but small reduction in spatial awareness. While not all participants reported noticeable differences between settings in daily life, 8 out of 12 children preferred “AutoSense on”. Conversely, some participants preferred “AutoSense off” due to poorer localization and speech intelligibility from behind with “AutoSense on”. In conclusion, the automatic classifier provided improved speech understanding in noisy conditions such as a classroom, at the cost of a slightly reduced spatial awareness. The preference for AutoSense Sky OS among CI children and their parents appears to be a matter of individual trade-offs between improved speech intelligibility in noisy conditions and reduced spatial awareness.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109414"},"PeriodicalIF":2.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory analysis of the tinnitus magnitude equation (TMe). An adaptation level theory based measure of tinnitus therapy outcome","authors":"Grant D Searchfield ,&nbsp;Dunja Vajsakovic","doi":"10.1016/j.heares.2025.109413","DOIUrl":"10.1016/j.heares.2025.109413","url":null,"abstract":"<div><h3>Background</h3><div>In this study we undertook an exploratory analysis of a new method for quantifying change in perceived intensity of tinnitus: the tinnitus magnitude equation (TMe). The TMe is based on Adaptation Level Theory (ALT) and is the difference between the product of Tinnitus Function Index (TFI) questions asking tinnitus loudness, awareness, and annoyance (intrusiveness scale) before and after therapy.</div></div><div><h3>Methods</h3><div>This is a secondary analysis of anonymized data. In part 1. Two sets of 3 questions (<em>n</em> = 126) were compared for internal consistency and content validity. A triplet of questions from the Tinnitus Sample Case History Questionnaire (TSCHQ) and a triplet from the TFI that were candidate measures for calculating the adaptation level (AL) to tinnitus and magnitude were compared. In part 2. Change in AL, the magnitude of treatment effect, was compared to the change in TFI total score (<em>n</em> = 155).</div></div><div><h3>Results</h3><div>The 2 sets of questions from the TSCHQ and TFI were broadly equivalent, but the TFI triplet items had higher internal consistency. Moderate convergent validity was found between the TMe and TFI. Interim criteria for responsiveness were determined relative to anchor and distribution-based measures that characterize magnitude from a small change or greater (41% of participants) to a very large change (15% of participants).</div></div><div><h3>Conclusion</h3><div>The TMe is a novel approach to the assessment of tinnitus that could address the need for a robust measure of tinnitus perception. Further evaluation and validation of the measure is needed.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109413"},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The functioning of otolith organs in individuals with type-II diabetes mellitus","authors":"Prawin Kumar ,&nbsp;Niraj Kumar Singh ,&nbsp;Rajesh Kumar Raveendran ,&nbsp;Kumari Apeksha ,&nbsp;Vipin Ghosh ,&nbsp;M. Bhanukumar","doi":"10.1016/j.heares.2025.109412","DOIUrl":"10.1016/j.heares.2025.109412","url":null,"abstract":"<div><h3><strong>Aim</strong></h3><div>Diabetes mellitus (DM), a systemic disease, is a major public health concern. It is possible that micro and macrovascular changes in the inner ear due to DM could affect both auditory and vestibular functioning. However, there is a lack of conclusive evidence for vestibular impairment in individuals with DM. The current study investigated the effects of Type 2 diabetes mellitus (T2DM) on the functioning of the vestibular system and its duration dependency. <strong><em>Methods:</em></strong> Eighty individuals in the age range of 40-70 years (40 with T2DM and 40 age-matched healthy controls) underwent cervical vestibular evoked myogenic potential (cVEMP) and ocular vestibular evoked myogenic potential (oVEMP) in response to 500 Hz tone-burst. They also underwent behavioral tests of posture and equilibrium. <strong><em>Results:</em></strong> Response rates and peak-to-peak amplitude of cVEMP and oVEMP were significantly lower in T2DM than in the healthy controls (p&lt;0.05). Additionally, the asymmetry ratio on cVEMP was significantly higher in T2DM than in the control group (p&lt;0.05). There was no significant correlation between the duration of T2DM, the abnormality in vestibular tests, and abnormalities in the behavioral tests for the posture and equilibrium (<em>p</em>&gt;0.05). <strong><em>Conclusions:</em></strong> A relatively higher proportion of individuals with T2DM show otolith dysfunction than non-diabetic individuals.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109412"},"PeriodicalIF":2.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}