Hearing Research最新文献

筛选
英文 中文
Ethacrynic acid regulates gentamicin ototoxicity via the blood-labyrinth barrier 乙酸通过血迷宫屏障调节庆大霉素耳毒性
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-15 DOI: 10.1016/j.heares.2025.109405
Liling Li, Jingqian Tan, Dan Chen, Jia Luo, Peng Li
{"title":"Ethacrynic acid regulates gentamicin ototoxicity via the blood-labyrinth barrier","authors":"Liling Li,&nbsp;Jingqian Tan,&nbsp;Dan Chen,&nbsp;Jia Luo,&nbsp;Peng Li","doi":"10.1016/j.heares.2025.109405","DOIUrl":"10.1016/j.heares.2025.109405","url":null,"abstract":"<div><div>Gentamicin (GM), a widely used aminoglycoside antibiotic, has its clinical utility significantly limited by ototoxicity, which may be further exacerbated by co-administered drugs. This study systematically investigated the ototoxic mechanisms of GM combined with ethacrynic acid (EA) and the protective effects of N-acetylcysteine (NAC) using C57BL/6 J mice. Results revealed dose-dependent GM-induced ototoxicity. Intravenous administration caused more severe damage than intraperitoneal injection. Co-administration of EA synergistically potentiated GM toxicity. This exacerbated cochlear hair cell loss, auditory nerve fiber degeneration, and spiral ganglion neuron damage. Additionally, it induced systemic hepatorenal toxicity, manifested by increased macrophage activation and suppressed cell proliferation. EA disrupted inner ear homeostasis via a dual mechanism: impairing blood-labyrinth barrier integrity and triggering compensatory pericyte-mediated repair. NAC intervention significantly attenuated the combined toxicity. The pretreatment group showed the highest hair cell survival rate. Notably, EA facilitated NAC entry into the cochlea, enhancing its protective efficacy. Delayed EA administration (6 h post-GM) reduced hair cell damage by 50%. Furthermore, NAC ameliorated damage to neural fibers and synapses. This study shows that EA modulates GM ototoxicity by disrupting BLB equilibrium. The time-dependent nature of NAC intervention offers a strategy to prevent drug-induced hearing loss. These findings provide critical insights for optimizing clinical regimens involving aminoglycosides and loop diuretics.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109405"},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensorimotor contingencies in congenital hearing loss: The critical first nine months 先天性听力损失的感觉运动意外:关键的前9个月
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-13 DOI: 10.1016/j.heares.2025.109401
Andrej Kral , Liat Kishon-Rabin , Gerard M. O’Donoghue , Rachel R. Romeo
{"title":"Sensorimotor contingencies in congenital hearing loss: The critical first nine months","authors":"Andrej Kral ,&nbsp;Liat Kishon-Rabin ,&nbsp;Gerard M. O’Donoghue ,&nbsp;Rachel R. Romeo","doi":"10.1016/j.heares.2025.109401","DOIUrl":"10.1016/j.heares.2025.109401","url":null,"abstract":"<div><div>In the recent two decades it became possible to compensate severe-to-profound hearing loss using cochlear implants (CIs). The data from implanted children demonstrate that hearing and language acquisition is well-possible within an early critical period of 3 years, however, the earlier the access to sound is provided, the better outcomes can be expected. While the clinical priority is providing deaf and hard of hearing children with access to spoken language through hearing aids and CIs as early as possible, for most deaf children this access is currently in the second or third year of life. We review the findings on neural development during the first year of life, including language development, multimodal interactions between sensory and motor systems, as well as brain connectivity. Some irreversible consequences of early auditory deprivation within the first year are exacerbated when the auditory system is not developed in synchrony with the other sensory and motor systems, incorporating hearing into other sensory and motor representation. The key role of the motor system (sensorimotor contingencies) in development of sensory representations is discussed. We propose that the first year includes critical developmental steps that should be exploited to provide the framework for optimal functional connectivity of language and cognitive networks.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109401"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging and the effect of background rhythm on selective listening in multiple-source environments 年龄和背景节奏对多源环境下选择性听力的影响
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-13 DOI: 10.1016/j.heares.2025.109389
Dylan V. Pearson , Yi Shen , J. Devin McAuley , Gary R. Kidd
{"title":"Aging and the effect of background rhythm on selective listening in multiple-source environments","authors":"Dylan V. Pearson ,&nbsp;Yi Shen ,&nbsp;J. Devin McAuley ,&nbsp;Gary R. Kidd","doi":"10.1016/j.heares.2025.109389","DOIUrl":"10.1016/j.heares.2025.109389","url":null,"abstract":"<div><div>In multi-source environments, rhythmic regularities in both to-be-attended signals (targets), as well as to-be-ignored signals (backgrounds) have been found to influence selective listening across a variety of stimuli and listening conditions. Specifically, regular rhythmic structures facilitate recognition of target signals, and background signals with regular rhythmic structures are more effective maskers than irregular backgrounds. The current study focused on the background rhythm effect and assessed to what degree it depends on the perceptual similarity between the target and background signals, and its dependence on listener age. A novel synthetic-vowel identification paradigm was used, in which young and older listeners were presented with an isochronous (regular) target sequence interleaved with background sequences that were either isochronous or anisochronous (irregular). When the background sequences consisted of a repeating vowel-like stimulus that was easily distinguished from the target vowel sequence, listeners were not sensitive to the rhythmic regularity of the background sequences. However, when the background consisted of vowels that only differed from the target vowels in fundamental frequency, regular backgrounds led to lower vowel identification rates than irregular backgrounds. These findings mirror those obtained with natural speech stimuli. The replication and extension of the background rhythm effect with the current paradigm demonstrates that the background rhythm effect is not attributable to differences in energetic masking (there was no target/background overlap in the current study) and is not restricted to continuous speech stimuli. Further, the background rhythm effect was reduced in older listeners, suggesting that sensitivity to background rhythm in multi-source environments may decrease with age.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"467 ","pages":"Article 109389"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive testing to diagnose the underlying auditory pathology of hearing impairment 无创测试诊断听力障碍的潜在听觉病理
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-10 DOI: 10.1016/j.heares.2025.109391
Neil J Ingham, Karen P Steel
{"title":"Non-invasive testing to diagnose the underlying auditory pathology of hearing impairment","authors":"Neil J Ingham,&nbsp;Karen P Steel","doi":"10.1016/j.heares.2025.109391","DOIUrl":"10.1016/j.heares.2025.109391","url":null,"abstract":"<div><div>Of the three major classifications of inner ear pathology, sensory, neural and metabolic, it is relatively easy to distinguish a sensory pathology from a neural or inner hair cell pathology using current clinical tools. Deficiencies in both distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) suggest a sensory pathology involving outer hair cells. Normal DPOAEs with deficiencies in ABRs suggest a neural pathology, involving inner hair cells, auditory nerve synapses or neural deficiencies. However, there are currently no non-invasive methods to distinguish a metabolic pathology from sensory or neural pathologies that may be suitable for translation into a clinical setting. Here, mutant mouse lines with defined sites-of-lesion in the inner ear are used to evaluate a method published by Mills (2006) to differentiate these main classes of inner ear pathology. ABR and DPOAE thresholds were recorded from mutant mice and littermate controls. Plotting normalised DPOAE thresholds against ABR thresholds resulted in a continuum of responses from normal to severe threshold elevations for both the ABR and DPOAE recordings. These responses did not fall neatly in the different pathology zones suggested by Mills, or into elliptical clusters suggested by the recordings made in exemplar mutant lines in the current study. Examination of extended parameters, such as response amplitude, did not provide any further differentiation between mice carrying different pathologies. We conclude that measurement of ABR and DPOAE thresholds and response amplitudes does not provide sufficient information to stratify metabolic inner ear pathology from either sensory or neural pathologies.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109391"},"PeriodicalIF":2.5,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk cancellation for users of bilateral bone-conduction hearing aids 双侧骨传导助听器使用者的串音消除
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-09 DOI: 10.1016/j.heares.2025.109390
Ryan D. Barnsley, John F. Culling
{"title":"Crosstalk cancellation for users of bilateral bone-conduction hearing aids","authors":"Ryan D. Barnsley,&nbsp;John F. Culling","doi":"10.1016/j.heares.2025.109390","DOIUrl":"10.1016/j.heares.2025.109390","url":null,"abstract":"<div><div>A bone-conduction hearing aid delivers sound to both cochleae by vibrating the skull. Consequently, bilateral fitting results in poor stereo separation. Here, we demonstrate improved stereo separation using crosstalk cancellation in unimpaired listeners using two bone vibrators and in two patients with bilateral bone-conduction hearing aids. The crosstalk filters were calibrated using a psychophysical sound-lateralisation method and the benefit of crosstalk cancellation was assessed using masked thresholds when noise was presented to one side and a tone to the other. Improvements in masked threshold of ∼10 dB were demonstrated bilaterally in unimpaired listeners using digital filters typical of a clinical device. Improvements were also demonstrated bilaterally in one patient, albeit with a strong asymmetry, and unilaterally in another. Without recalibration of the filters, the patients’ improvements decreased gradually over successive experimental sessions. We conclude that crosstalk cancellation can be successfully implemented for bilaterally implanted users of bone-conduction hearing aids but may require periodic recalibration.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109390"},"PeriodicalIF":2.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early hearing deprivation by silicon earplugs does not alter electrophysiological development of mouse dorsal cochlear nucleus fusiform neurons 早期硅耳塞剥夺听力对小鼠耳蜗背核梭状神经元的电生理发育无影响
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-08 DOI: 10.1016/j.heares.2025.109388
Alan Eidi Sasaki , Nikollas Moreira Benites , Beatriz Rodrigues , Ricardo Amaral Juliano Jr , Natalia Boaretto , Mario Henrique Duarte de Oliveira , Ricardo Mauricio Leão
{"title":"Early hearing deprivation by silicon earplugs does not alter electrophysiological development of mouse dorsal cochlear nucleus fusiform neurons","authors":"Alan Eidi Sasaki ,&nbsp;Nikollas Moreira Benites ,&nbsp;Beatriz Rodrigues ,&nbsp;Ricardo Amaral Juliano Jr ,&nbsp;Natalia Boaretto ,&nbsp;Mario Henrique Duarte de Oliveira ,&nbsp;Ricardo Mauricio Leão","doi":"10.1016/j.heares.2025.109388","DOIUrl":"10.1016/j.heares.2025.109388","url":null,"abstract":"<div><div>Rodent auditory brainstem neurons undergo substantial electrophysiological maturation during the postnatal period, spanning both pre- and post-hearing phases. These developmental adaptations support high-frequency, temporally precise neurotransmission and action potential firing. In the dorsal cochlear nucleus (DCN), fusiform neurons exhibit marked postnatal changes after the onset of hearing (postnatal day 14, P14), including refined action potential firing and the emergence of spontaneous activity. However, whether these changes are driven by acoustic input following ear canal opening remains unclear. To address this, we used a model of early hearing deprivation (EHD) in mice by inserting silicon earplugs at P14, elevating auditory thresholds by 30–40 dB, and assessed fusiform neuron electrophysiology 5–7 days later. Contrary to our hypothesis, neurons from EHD mice displayed properties similar to those of sham-treated animals. In contrast, both groups differed significantly from untreated controls, suggesting a potential influence of isoflurane anesthesia. Our findings indicate that the maturation of DCN fusiform neurons occurs independently of normal acoustic stimulation, suggesting that an intrinsic developmental program might be more relevant than experience-driven refinement.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109388"},"PeriodicalIF":2.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways MiRNA-634通过调节AK4和AKT/mTOR信号通路促进HEI-OC1细胞凋亡
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-07 DOI: 10.1016/j.heares.2025.109386
Yida Wang , Yongzhi Liu
{"title":"MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways","authors":"Yida Wang ,&nbsp;Yongzhi Liu","doi":"10.1016/j.heares.2025.109386","DOIUrl":"10.1016/j.heares.2025.109386","url":null,"abstract":"<div><div>Presbycusis, or age-related hearing loss (ARHL), is a complex condition characterized by the progressive accumulation of hearing loss associated with aging. Age-related deafness is caused by inner ear hair cell damage and loss. Previously, we extracted exosomal miRNA from peripheral blood samples of elderly deaf individuals to corroborate the differentially high expression of miR-634. This work examines how miR-634 regulates HEI-OC1 cell death via the downstream target gene AK4 and the AKT/mTOR signaling pathway. KEGG and GO enrichment studies identified miR-634′s downstream target gene AK4, followed by a dual luciferase reporter test to evaluate binding. HEI-OC1 cells underwent transfection utilizing miR-634 mimics and vectors for the overexpression and knockdown of AK4. qRT-PCR quantified miRNA, flow double staining detected apoptosis, immunoblotting measured protein, and a fluorescent probe measured ROS. Transfection of HEI-OC1 cells with miR-634 mimics enhanced Caspase-7, Caspase-3, and Bax protein expression, decreased Bcl-2 protein expression, and significantly raised ROS levels. Apoptosis and ROS levels decreased in the AK4-OE group, but Bcl-2 protein and downstream-associated proteins p-AKT and p-mTOR increased. AK4-ShRNA and miRNA-OE showed different changes from AK4-OE. In HEI-OC1 cells, overexpression of AK4 inhibited apoptosis. In contrast, overexpression of miR-634 mimics and AK4 knockdown accelerated apoptosis. miR-634 may facilitate the apoptosis of HEI-OC1 cells by down-regulating AK4 and its downstream associated proteins, p-AKT and p-mTOR. miR-634 and AK4 may serve as targets that induce functional alterations and ultimately lead to the death of inner ear hair cells in individuals with presbycusis.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109386"},"PeriodicalIF":2.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha-dystroglycan receptor signaling likely influences basement membrane laminin α2 mediated pathology in the stria vascularis of Alport mice α -三磷酸腺苷受体信号可能影响Alport小鼠血管纹基底膜层粘连蛋白α2介导的病理
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-05 DOI: 10.1016/j.heares.2025.109383
Daniel T. Meehan, Julia Brockhouse, Katherine Connell, Jacob Madison, Michael Anne Gratton, Dominic Cosgrove
{"title":"Alpha-dystroglycan receptor signaling likely influences basement membrane laminin α2 mediated pathology in the stria vascularis of Alport mice","authors":"Daniel T. Meehan,&nbsp;Julia Brockhouse,&nbsp;Katherine Connell,&nbsp;Jacob Madison,&nbsp;Michael Anne Gratton,&nbsp;Dominic Cosgrove","doi":"10.1016/j.heares.2025.109383","DOIUrl":"10.1016/j.heares.2025.109383","url":null,"abstract":"<div><div>We previously demonstrated that endothelin A receptor (ET<sub>A</sub>R) signaling plays a major role in regulating strial pathology in the COL4A3 knockout mouse model for Alport syndrome. Blocking the receptor prevented accumulation of extracellular matrix (ECM) in the strial capillary basement membranes (SCBMs) including laminin α2. Herein, we explored whether α-dystroglycan receptors for laminin α2 are present on cultured strial pericytes, marginal cells, and intermediate cells, as well as in intact stria vascularis. We performed comparative analysis of gene expression in isolated glomeruli and stria vascularis from wild type and Alport mice using RNA-seq. We examined the effects of endothelin treatment of pericytes on cytoskeletal dynamics and CDC42 activation using immunofluorescence, and on cell signaling using phosphoantibody microarrays. mRNA encoding α-dystroglycan receptors are present in strial cell lines as well as RNA from micro dissected stria vascularis. These same receptors were found adjacent to the capillary basement membranes on strial endothelial cells, marginal cells, intermediate cells, and pericytes in vivo by immunofluorescence. RNA-seq analysis of RNA from wild type and Alport glomeruli and stria vascularis revealed similar regulation of genes implicated in the pathogenesis of both organs. Treatment of pericytes with endothelin-1 (ET-1) resulted in changes in cell signaling consistent with observed reduction of filamentous to globular actin ratios and cell adhesion. Therefore, the induction of laminin α2 likely contributes to strial pathology in Alport syndrome via signaling through α-dystroglycan receptors. ET-1 activation of ET<sub>A</sub>Rs directly contributes to altered cell signaling in strial pericytes, resulting in changes in actin cytoskeletal dynamics.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109383"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of transcranial ultrasound on auditory brainstem responses and neuronal activation in the cochlear nucleus 经颅超声对听觉脑干反应及耳蜗核神经元活化的影响
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-05 DOI: 10.1016/j.heares.2025.109379
Shang-Yi Hsueh , Ying-Chang Lu , Jormay Lim , Ya-Cherng Chu , Pei-Hsuan Lin , Yen-Hui Chan , Yu-Wei Wu , Chen-Chi Wu , Jaw-Lin Wang
{"title":"The impact of transcranial ultrasound on auditory brainstem responses and neuronal activation in the cochlear nucleus","authors":"Shang-Yi Hsueh ,&nbsp;Ying-Chang Lu ,&nbsp;Jormay Lim ,&nbsp;Ya-Cherng Chu ,&nbsp;Pei-Hsuan Lin ,&nbsp;Yen-Hui Chan ,&nbsp;Yu-Wei Wu ,&nbsp;Chen-Chi Wu ,&nbsp;Jaw-Lin Wang","doi":"10.1016/j.heares.2025.109379","DOIUrl":"10.1016/j.heares.2025.109379","url":null,"abstract":"<div><h3>Objectives</h3><div>Transcranial ultrasound stimulation (TUS) is a non-invasive technique with therapeutic potential for neurodegenerative diseases. Given its increasing therapeutic relevance, it is essential to identify any unintended consequences, especially on vulnerable systems such as the auditory pathway. Specifically, the precise impact of TUS on auditory responses and neural activation patterns within the central auditory system remains unclear. We hypothesized that TUS could indirectly modulate central auditory processing, even at frequencies outside the direct hearing range, leading to observable changes in auditory brainstem responses (ABRs) and neuronal activity in the cochlear nucleus.</div></div><div><h3>Design</h3><div>We analyzed periodic ABR recordings before and after 1 MHz ultrasound stimulation in mice. To investigate the immediate and long-term engram effects of ultrasound stimulation in the cochlear nucleus, we used c-Fos TRAP2 mice. All mice received a 12 kHz pure tone stimulation to establish the tonal signature in the cochlear nucleus. We administered ultrasound stimulation transcranially over the entire brain, covering the region including the cochlear nucleus, either immediately prior to the first tone presentation (ultrasound preconditioning group) or 30 minutes prior to sacrifice (acute ultrasound group) to analyze the long-term and immediate responses to ultrasound stimulation, respectively. A sham control group received only the 12 kHz tone stimulation.</div></div><div><h3>Results</h3><div>Ultrasound stimulation induced latency shifts in ABR recordings. The effect of ultrasound on latency was more pronounced at regions of the auditory pathway farther from the inner ear. A significant increase in immediate neural activation was observed in the acute ultrasound group, while a trend toward an increase in long-term engram effect was seen in the ultrasound preconditioning group. A broader band pattern of neural activation was consistently identified in the cochlear nucleus following TUS. These results suggest that TUS can affect neural activation in the cochlear nucleus, manifesting as ABR latency shifts.</div></div><div><h3>Conclusions</h3><div>This study provides evidence that ultrasound stimulation can induce latency shifts in ABR recordings and alter neuronal activation patterns in the cochlear nucleus, indicating a modulatory effect of ultrasound on the auditory pathway. The observed activation of neurons along the auditory pathway by ultrasound may offer therapeutic opportunities to improve auditory transduction in patients with central auditory pathway dysfunction, such as auditory neuropathy.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109379"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial introduction: A collection of papers presented at the Symposium on ‘‘The roots of auditory neuroscience in Spain: A tribute to Prof. Miguel A. Merchán’’ 编辑简介:在“西班牙听觉神经科学的根源:向Miguel A. Merchán教授致敬”研讨会上发表的论文集。
IF 2.5 2区 医学
Hearing Research Pub Date : 2025-08-05 DOI: 10.1016/j.heares.2025.109381
Manuel S. Malmierca , Stephen G. Lomber , Eckhard Friauf
{"title":"Editorial introduction: A collection of papers presented at the Symposium on ‘‘The roots of auditory neuroscience in Spain: A tribute to Prof. Miguel A. Merchán’’","authors":"Manuel S. Malmierca ,&nbsp;Stephen G. Lomber ,&nbsp;Eckhard Friauf","doi":"10.1016/j.heares.2025.109381","DOIUrl":"10.1016/j.heares.2025.109381","url":null,"abstract":"","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109381"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信