Hearing Research最新文献

{"title":"Alterations in functional connectivity related to prognosis in unilateral sudden sensorineural hearing loss","authors":"Jin Sun ,&nbsp;Baohong Wen ,&nbsp;Zijun Liu ,&nbsp;Yulin Zhang ,&nbsp;Le Wang ,&nbsp;Yong Zhang ,&nbsp;Jingliang Cheng","doi":"10.1016/j.heares.2025.109322","DOIUrl":"10.1016/j.heares.2025.109322","url":null,"abstract":"<div><h3>Objectives</h3><div>Sudden Sensorineural Hearing Loss (SSNHL) is a critical otological emergency characterized by a rapid decline in hearing, primarily affecting one ear. The exact cause of SSNHL remains unclear, which complicates both diagnosis and treatment. This study aimed to explore changes in functional connectivity (FC) related to prognosis in patients with unilateral SSNHL, thereby enhancing our understanding of the potential neural correlates associated with clinical outcomes.</div></div><div><h3>Materials and Methods</h3><div>The study involved 111 patients diagnosed with unilateral SSNHL, who underwent audiological evaluations and functional magnetic resonance imaging (fMRI) scans, focusing on changes in FC related to their prognosis.</div></div><div><h3>Results</h3><div>Significant differences were found between the effective (<em>n</em> = 72) and ineffective (<em>n</em> = 39) treatment groups regarding the duration from onset to treatment and the presence of dizziness. Compared with effective group, the cohort with a poor prognosis demonstrated a significant increase in FC between the bilateral superior temporal gyrus (STG) and the left hippocampus, right supramarginal gyrus (SMG), left middle frontal gyrus (MFG), and right precuneus.</div></div><div><h3>Conclusion</h3><div>The research highlights the significance of investigating the alterations in FC observed in patients experiencing SSNHL. These findings suggest a potential association between altered FC and patient outcomes, which could contribute to future studies on the neural mechanisms underlying SSNHL.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109322"},"PeriodicalIF":2.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No association between idiopathic hidden hearing loss and behavioral adaptation to noise in humans","authors":"Sónia L. Coelho de Sousa ,&nbsp;Miriam I. Marrufo Pérez ,&nbsp;Peter T. Johannesen ,&nbsp;Marcelo Gómez Álvarez ,&nbsp;Enrique A. Lopez-Poveda","doi":"10.1016/j.heares.2025.109321","DOIUrl":"10.1016/j.heares.2025.109321","url":null,"abstract":"<div><div>Adaptation to noise refers to the improvement in word-in-noise recognition as words are delayed a few hundred milliseconds in the noise. This adaptation is thought to reflect adjustments of the dynamic range of auditory neurons to the most frequent noise level. Evidence from a mouse model suggests that hidden hearing loss (HHL), a diminished auditory nerve response without a hearing loss, selectively impairs neural dynamic range adaptation to loud sound environments. The aim of the present study was to investigate whether HHL is associated with poor behavioral adaptation to loud noise in speech recognition.</div><div>For 89 people (aged 19–86 years) with clinically normal hearing, we measured speech reception thresholds (SRTs; signal-to-noise ratios at 50 % recognition) for disyllabic words in stationary, speech-shaped noise. SRTs were measured for words delayed 50 and 800 ms in the noise and for noise levels of 55 and 78 dB SPL. Adaptation was calculated as the SRT improvement in the long-delay relative to the short-delay condition. Because adaptation is greater for vocoded than for natural words, words were processed through a tone vocoder. The response of the auditory nerve was assessed using the amplitude of the auditory brainstem response (ABR) wave I and the rate of growth (slope) of the wave I amplitude with increasing stimulus level.</div><div>Adaptation occurred at the two noise levels but was greater for the louder noise than for the softer noise (2.3 dB vs 1.3 dB, respectively). This happened because SRTs were worse for the louder noise in the short but not in the long delay condition. The large variability in ABR wave I amplitude (0.10 to 0.54 μV) and slope (-0.004 to 0.023 μV/dB) suggested that the sample included participants with varying degrees of HHL of uncertain etiology (idiopathic). However, adaptation was not correlated with the wave I amplitude or slope, even after accounting for the potential confounding effect of elevated hearing thresholds in an extended frequency range.</div><div>Findings suggest that adaptation to noise in speech recognition is greater at higher noise levels but provide no evidence that idiopathic HHL leads to reduced adaptation to noise in humans.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109321"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and treatment of noise-induced hearing loss and cochlear synapse degeneration by potassium channel blockers in vivo","authors":"Hong-Bo Zhao ,&nbsp;Li-Man Liu ,&nbsp;Xiaoling Lu ,&nbsp;Auraemil T Quinonez ,&nbsp;Rafael A Roberts ,&nbsp;Tian-Ying Zhai ,&nbsp;Chun Liang","doi":"10.1016/j.heares.2025.109319","DOIUrl":"10.1016/j.heares.2025.109319","url":null,"abstract":"<div><div>Noise can induce hearing loss. In particular, noise can induce cochlear synapse degeneration leading to hidden hearing loss, which is the most common type of hearing disorders in the clinic. Currently, there is no pharmacological treatment, especially no post-exposure (i.e., therapeutic) treatment available in the clinic. Here, we report that systemic administration of K⁺ channel blockers by intraperitoneal injection before or after noise exposure significantly ameliorated noise-induced hearing loss (NIHL) and cochlear synapse degeneration. After systemic administration of a general K⁺-channel blocker tetraethylammonium (TEA) before or after noise exposure, the noise-induced threshold elevation of auditory brainstem responses (ABRs) and reduction of suprathreshold responses were significantly attenuated. The impairment on the active cochlear mechanics measured by distortion product otoacoustic emission (DPOAE) was also reduced. The therapeutic effect was further improved as the post-exposure administration time extended. BK channel is a predominant K⁺ channel in the inner hair cell. We further found that post-exposure administration of a BK channel blocker GAL-021 could ameliorate NIHL and improved the hearing behavioral responses examined by acoustic startle response (ASR). Finally, both TEA and GAL-021 significantly reduced noise-induced ribbon synapse degeneration. These findings demonstrate a promise of systemic administration of K⁺ channel blockers to treat synapse degeneration and NIHL after noise exposure, which currently is urgently required in the clinic.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109319"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sound degradation type differentially affects neural indicators of cognitive workload and speech tracking","authors":"Nathan Gagné ,&nbsp;Keelin M. Greenlaw ,&nbsp;Emily B.J. Coffey","doi":"10.1016/j.heares.2025.109303","DOIUrl":"10.1016/j.heares.2025.109303","url":null,"abstract":"<div><div>Hearing-in-noise (HIN) is a challenging task that is essential to human functioning in social, vocational, and educational contexts. Successful speech perception in noisy settings is thought to rely in part on the brain's ability to enhance neural representations of attended speech. In everyday HIN situations, important features of speech (i.e., pitch, rhythm) may be degraded in addition to being embedded in noise. The impact of these differences in sound quality on experiences of workload and neural representations of speech will be important for informing our knowledge on the cognitive demands imposed by every-day difficult listening situations. We investigated HIN perception in 20 healthy adults using continuous speech that was either clean, spectrally degraded, or temporally degraded. Each sound condition was presented both with and without pink noise. Participants engaged in a selective listening task, in which a short-story was presented with varying sound quality, while EEG data were recorded. Neural correlates of cognitive workload were obtained using power levels of two frequency bands sensitive to task difficulty manipulations: alpha (8 – 12 Hz) and theta (4 – 8 Hz). Acoustic and linguistic features (speech envelope, word onsets, word surprisal) were decoded to reveal the degree to which speech was successfully encoded. Overall, alpha-theta power increased significantly when noise was added across sound conditions, while prediction accuracy of speech tracking decreased, suggesting that more effort was required to listen, and that the speech was not as successfully encoded. The temporal degradation also resulted in greater EEG power, possibly as a function of a compensatory mechanism to restore the important temporal information required for speech comprehension. Our findings suggest that measures related to cognitive workload and successful speech encoding are differentially affected by noise and sound degradations, which may help to inform future interventions that aim to mitigate these every-day challenges.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109303"},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory sensitivity in the great evening bat (Ia io): Insights from auditory brainstem response","authors":"Zhiqiang Wang ,&nbsp;Lixin Gong ,&nbsp;Huan Wu ,&nbsp;Jiang Feng ,&nbsp;Tinglei Jiang","doi":"10.1016/j.heares.2025.109310","DOIUrl":"10.1016/j.heares.2025.109310","url":null,"abstract":"<div><div>The great evening bat (<em>Ia io</em>), a large frequency-modulating (FM) bat species in the Vespertilionidae family, may exhibit unique auditory adaptations that support its bird-predatory behavior. In this study, we employed auditory brainstem response (ABR) measurements to evaluate the auditory sensitivity of five adult male <em>I. io</em> across a 2 to 80 kHz frequency range. The results showed the most sensitive auditory threshold appears at 24–28 kHz (range 24 to 32 kHz for individual bats), aligning with the species’ peak frequency of echolocation calls, enhancing large prey detection and localization. ABRs identify five distinct wave peaks (P1–P5) at high sound pressure levels, with the largest amplitude peak observed for P4. Furthermore, <em>I. io</em> has lower auditory thresholds across higher frequencies than most other FM bats. These findings suggest <em>I. io</em> has a broad auditory range that may facilitate adaptive flexibility in varied ecological settings.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109310"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of relative cochlear motions using high resolution optical coherence microscopy","authors":"Scott Page ,&nbsp;Roozbeh Ghaffari ,&nbsp;Dennis M. Freeman","doi":"10.1016/j.heares.2025.109311","DOIUrl":"10.1016/j.heares.2025.109311","url":null,"abstract":"<div><div>Despite enormous progress in understanding the electro-mechanical properties of outer hair cells and the molecular basis of these properties, less is known about the relative motion of the organ of Corti and accessory structures that shape cochlear responses to acoustic stimulation. Here, we characterize absolute and relative motions of apical regions of the excised gerbil cochleae using a custom Doppler optical coherence microscopy (DOCM) system. Responses to sinusoidal stimuli show nanometer-scale motions of the tectorial membrane (TM), organ of Corti structures (e.g. outer hair cells, pillar cells), and basilar membrane in the apical turn of the cochlea. Motion-magnified analysis reveals rotations about the inner pillar cells at nearly constant phase, whereas TM motion lags that of the underlying cells by as much as 0.1 radians. Our DOCM results demonstrate a new technique capable of concurrent high resolution anatomical imaging and nanometer-scale motion analysis of cellular and acellular structures in response to stapes stimulation, enabling investigations of relative cochlear motions and feedback mechanisms.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109311"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of audiometric parameters throughout the lifespan. I: Auditory data","authors":"Dora Čapková ,&nbsp;Zbyněk Bureš ,&nbsp;Jakub Fuksa ,&nbsp;Václav Vencovský ,&nbsp;Veronika Svobodová ,&nbsp;Diana Tóthová ,&nbsp;Michaela Vojtová ,&nbsp;Sangyun Cha ,&nbsp;Martin Chovanec ,&nbsp;Josef Syka ,&nbsp;Oliver Profant","doi":"10.1016/j.heares.2025.109308","DOIUrl":"10.1016/j.heares.2025.109308","url":null,"abstract":"<div><div>Age-related hearing loss (presbycusis) is a nonsyndromic sensorineural condition that affects the inner ear, auditory pathway, and related cortical regions to varying degrees, typically beginning around age 65. However, hearing can start to deteriorate as early as age 18 and can be negatively influenced by several external factors throughout the lifespan. Depending on the location and severity of the pathology, different aspects of hearing may be affected, resulting in various phenotypes of hearing loss.</div><div>The aim of this study is to determine average data for a complex battery of auditory tests for different age groups along life span.</div><div>Two hundred ninety (116 males and 174 females) volunteers between 18 and 87 years of age were enrolled in this study. All volunteers underwent meticulous auditory examination on our custom made audiometric device that consisted of following tests: pure tone audiometry (PTA) in quiet and noise (PTAN), high frequency hearing thresholds (PTAhf), detection of short tones (STD), sensitivity to interaural time delay (ITD), sensitivity to amplitude (AMT) and frequency modulation (FMT), gap in noise detection threshold (GDT), identification of frequency (FPT) and duration patterns (DPT), speech audiometry in babble noise (SIN), and gated (interrupted) speech audiometry (GS).</div><div>The data are presented as group means and standard deviations in six 10-year age categories (from 20 to 80) and also as regression fits along with the corresponding prediction bands. All reported results show a significant effect of aging on examined auditory parameters; however, the effect of aging differs. In following tests, the dependence is continuous and starts relatively early in life: PTA, PTAhf, STD, AMT, GDT, FPT; whereas in following tests the effect of aging becomes apparent only after the age of 60: PTAN, ITD, FMT, DPT, SIN, GS. Altogether, the results demonstrate clear, yet diverse effects of aging on various aspects of auditory processing and provide a baseline for future experimental and clinical investigations.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109308"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of audiometric parameters throughout the lifespan. II: Relationships between parameters","authors":"Zbyněk Bureš ,&nbsp;Jan Voráček ,&nbsp;Dora Čapková ,&nbsp;Jakub Fuksa ,&nbsp;Václav Vencovský ,&nbsp;Veronika Svobodová ,&nbsp;Diana Tóthová ,&nbsp;Michaela Vojtová ,&nbsp;Sangyun Cha ,&nbsp;Josef Syka ,&nbsp;Oliver Profant","doi":"10.1016/j.heares.2025.109309","DOIUrl":"10.1016/j.heares.2025.109309","url":null,"abstract":"<div><div>Aging is associated with a complex deterioration of hearing functions, which spans from the periphery to central auditory structures. To characterize this process, we measured a wide set of auditory parameters in 290 healthy volunteers aged from 18 to 87 years. In our companion paper, we investigate the age-related progression of individual auditory parameters with the objective of determining average parameters in age decades. The current paper focuses on evaluation of relationships between the variables, which may also change depending on the age and hearing status. We present three types of analyses: 1) clustering of variables, 2) predictions of speech comprehension ability based on the elementary auditory parameters, and 3) mutual correlations between the variables. The analyses are performed in several selected subgroups of subjects, such as those having excellent hearing threshold, or those belonging to a certain age group. The results support the hypothesis that individual auditory functions are interrelated and may be clustered into more general characteristics such as “hearing sensitivity” or “temporal processing”. However, grouping of auditory variables is by no means universal and the relationships between variables markedly differ in different subject subgroups. In addition, predictions of speech comprehension ability indicate that speech understanding relies on different mechanisms depending on age and hearing status. We conclude that relationships among auditory functions develop during aging and gradually progress to larger interdependence; eventual classification of phenotypes of hearing abilities must thus consider age of the subject.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109309"},"PeriodicalIF":2.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical temporal mismatch compensation in bimodal cochlear implant users: Selective attention decoding and pupillometry study","authors":"Hanna Dolhopiatenko,&nbsp;Waldo Nogueira","doi":"10.1016/j.heares.2025.109306","DOIUrl":"10.1016/j.heares.2025.109306","url":null,"abstract":"<div><div>Bimodal cochlear implant (CI) users combine electrical stimulation from a CI in one ear with acoustic stimulation through either normal hearing or a hearing aid in the opposite ear. While this bimodal stimulation typically improves speech perception, the degree of improvement varies significantly and can sometimes result in interference effects. This variability is associated with the integration of electric and acoustic signals, which can be influenced by several factors, including temporal mismatch between the two sides.</div><div>In previous work, we utilized cortical auditory evoked potentials (CAEPs) to estimate the temporal mismatch between the CI stimulation (CIS) side and the acoustic stimulation (AS) side, based on differences in N1 latencies when listening with the CIS alone and the AS alone. Building on this approach, the present study estimates individual temporal mismatch at cortical level through N1 latency of CAEPs and investigates the impact of compensating for this mismatch on speech perception.</div><div>Behavioral and objective measures of speech perception were conducted in bimodal CI users under three bimodal listening conditions: clinical setting, a setting with compensated temporal mismatch between electric and acoustic stimulation and a setting with a large temporal mismatch of 50 ms between electric and acoustic stimulation. The behavioral measure consisted of a speech understanding test. Objective measures included pupillometry, electroencephalography (EEG) based on cortical auditory evoked potentials (CAEPs), EEG based on selective attention decoding including analysis of parietal alpha power.</div><div>No significant effect of listening condition on behavioral speech understanding performance was observed, even for the condition with a large temporal mismatch of 50 ms. Similarly, pupillometry did not reveal a significant difference across listening conditions, although it was found to be related to behavioral speech understanding. N1P2 amplitude of CAEPs was greatest under the condition with compensated temporal mismatch. The phase-locking value of CAEPs, the temporal response function related to selective attention decoding, and parietal alpha power all showed a significant improvement when applying temporal mismatch compensation, compared to the condition with a substantial 50 ms temporal mismatch. However, these metrics did not exhibit significant effects when compared to the standard clinical setting condition.</div><div>These findings emphasize that neural metrics are more sensitive than behavioral measures in detecting interaural mismatch effects. A significant enhancement of CAEPs N1P2 amplitude compared to clinical setting was observed. Other neural metrics showed a limited improvement with compensated listening condition, suggesting insufficient compensation solely in temporal domain.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"464 ","pages":"Article 109306"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chirp sensitivity and vowel coding in the inferior colliculus","authors":"Paul W. Mitchell ,&nbsp;Laurel H. Carney","doi":"10.1016/j.heares.2025.109307","DOIUrl":"10.1016/j.heares.2025.109307","url":null,"abstract":"<div><div>The inferior colliculus (IC) is an important brain region to understand neural encoding of complex sounds due to its diverse sound-feature sensitivities, including features that are affected by peripheral nonlinearities. Recent physiological studies in rabbit IC demonstrate that IC neurons are sensitive to chirp direction and velocity. Fast spectrotemporal changes, known as chirps, are contained within pitch-periods of natural vowels. Here, we use a combination of physiological and modeling strategies to assess the impact of chirp-sensitivity on vowel coding. Neural responses to vowel stimuli were recorded and vowel-token identification was evaluated based on average-rate and spike-timing metrics. Response timing was found to result in higher identification accuracy than rate. Additionally, rate bias towards low-velocity chirps, independent of chirp direction, was shown to correlate with higher vowel-identification accuracy based on timing. Also, direction bias in response to chirps of high velocity was shown to correlate with vowel-identification accuracy based on both rate and timing. Responses to natural-vowel tokens of individual neurons were simulated using an IC model with controllable chirp sensitivity. Responses of upward-biased, downward-biased, and non-selective model neurons were generated. Manipulating chirp sensitivity influenced response profiles across natural vowel tokens and vowel discrimination based on model-neuron responses. More work is needed to match all features of model responses to those of physiological recordings.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"463 ","pages":"Article 109307"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}