Hearing Research最新文献_第4页

Sex differences in auditory function of the desert locust 沙漠蝗听觉功能的性别差异

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-02 DOI: 10.1016/j.heares.2025.109228

Tom T. Austin , Christian L. Thomas , Ben Warren

{"title":"Sex differences in auditory function of the desert locust","authors":"Tom T. Austin , Christian L. Thomas , Ben Warren","doi":"10.1016/j.heares.2025.109228","DOIUrl":"10.1016/j.heares.2025.109228","url":null,"abstract":"<div><div>Age-related auditory decline manifests across the animal kingdom, from humans and mice to zebrafish and insects. Sex differences in auditory decline are established for humans, but there is now evidence in mice and even zebrafish. Here, we found sex differences in auditory decline in an insect, the Desert Locust and investigated its biological basis. We profiled gene expression in a dedicated auditory organ, Müller's organ to understand the genetic underpinning of sex differences and measured sound-evoked transduction currents and electrophysiological properties of auditory neurons to quantify auditory decline. We analysed gene expression in Müller's organ of young locusts where sex differences in auditory function were absent and in older, noise-exposed locusts where sex differences in auditory function were maximal. The auditory organs of both male and females changed expression of 1200 and 931 genes, respectively, as they aged and were exposed to repeated bouts of noise exposure. Only 39 genes were differentially expressed between the sexes for young locusts and 9 for aged and noise exposed auditory organs. In young locusts we found sex-differences in genes for juvenile hormone and proteins involved in egg production and catalysis of steroid hormones. The majority of sex differences in Müller's organ manifested as a function of stress with females upregulating more and downregulating less genes compared to males. We hypothesise that sex differences in auditory decline are due to differences in immune responses and metabolic processes.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109228"},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ankyrins are dispensable for mechanotransduction by cochlear hair cells 锚蛋白对于耳蜗毛细胞的机械传导是必不可少的

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-01 DOI: 10.1016/j.heares.2025.109224

Hong Zhang, Xufeng Qiu, Jonah Mittelstadt, Ulrich Müller

引用次数: 0

NF2-related schwannomatosis: A view from within the inner ear nf2相关的神经鞘瘤病：内耳观察

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-28 DOI: 10.1016/j.heares.2025.109226

Eleanor D. Brown, Shada Nassar, Daniel J. Jagger

{"title":"NF2-related schwannomatosis: A view from within the inner ear","authors":"Eleanor D. Brown, Shada Nassar, Daniel J. Jagger","doi":"10.1016/j.heares.2025.109226","DOIUrl":"10.1016/j.heares.2025.109226","url":null,"abstract":"<div><div>NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) is an autosomal dominant disorder associated with the growth of bilateral schwannomas on the cochleo-vestibular nerves and meningiomas. NF2-SWN is caused by pathogenic variations in the <em>NF2, moesin-ezrin-radixin-like (MERLIN) tumour suppressor</em> gene. The mostly benign tumours can cause progressive sensorineural hearing loss, tinnitus and balance dysfunction. Outside the inner ear, tumours grow on other intra-cranial nerves, leading to further neurological issues and shortened life-expectancy. Here we re-evaluate some historic cases from our human temporal bone collection, and we review similar instances from the literature to highlight the structural and functional effects of such tumours on the cochlea and vestibular organs. Tumour growth is associated with the remodelling of sensory and ion-transporting epithelia, the loss of afferent neurons and hair cells, and signs of fluid dysregulation. These cases demonstrate the aggressive nature of this disease and the difficulties of surgically excising the bilateral tumours. They also emphasise the need for novel therapies that can slow or prevent tumour growth to preserve sensory function in people living with NF2-SWN.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109226"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the mind's ear: Understanding the science behind auditory processing using illusions 揭开心灵的耳朵：利用幻觉理解听觉处理背后的科学

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-25 DOI: 10.1016/j.heares.2025.109227

Anusha Yasoda-Mohan , Feifan Chen , Sven Vanneste

引用次数: 0

Frequency and level dependence of the middle ear acoustic reflex and its decay measured in wideband absorbance with contralateral narrowband noise elicitors 用对侧窄带噪声激发器测量中耳声反射的频率和水平依赖性及其衰减

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-21 DOI: 10.1016/j.heares.2025.109225

Abbie Baricevich, Danielle Bassett, Sophia Chan, Shayna Lavi, Jonathan Siegel

{"title":"Frequency and level dependence of the middle ear acoustic reflex and its decay measured in wideband absorbance with contralateral narrowband noise elicitors","authors":"Abbie Baricevich, Danielle Bassett, Sophia Chan, Shayna Lavi, Jonathan Siegel","doi":"10.1016/j.heares.2025.109225","DOIUrl":"10.1016/j.heares.2025.109225","url":null,"abstract":"<div><div>The acoustic reflex has potential as a diagnostic tool for identifying individuals with selective damage to cochlear sensory neurons (Bramhall et al., 2022; Feeney et al., 2023; Wojtczak et al., 2017). If damage to neurons is localized, then using broadband stimuli to elicit the reflex, as reported in the studies cited above, may not be most effective in revealing spatially restricted lesions. We have measured changes in absorbance with chirps delivered to one ear and contralateral narrowband noise to elicit the reflex. We aim to characterize the frequency and level dependence of changes in absorbance elicited by noise with different center frequencies as well as the decay of the reflex for prolonged elicitors as a baseline for comparison with similar measurements in individuals suspected of having neural damage. Our hypothesis is that elicitors that preferentially activate the damaged part of the reflex pathway will show the largest deviation from normal. We have identified a novel sensitization of the acoustic reflex following repeated exposure to moderate level elicitors such that absorbance changes more than double, regardless of the level of the elicitor, compared with the minimally stimulated contralateral ear. These changes recover slowly. We are measuring the growth of the reflex vs elicitor level and at constant elicitor level vs center frequency. We are also measuring the rate of reflex decay vs elicitor center frequency. Preliminary findings substantiate the measurement protocols in revealing differences between individuals and ears.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"459 ","pages":"Article 109225"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the role of extended high-frequency audibility on temporal envelope processing and spatial release from masking 研究扩展高频可听性在时间包络处理和空间释放中的作用

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-21 DOI: 10.1016/j.heares.2025.109223

Chhayakanta Patro , Nirmal Kumar Srinivasan , Sadie O'Neill , Morgan Barkhouse , Srikanta Kumar Mishra

引用次数: 0

Reply to Manley: Is there more to cochlear tuning than meets the ear? 回复曼利：耳蜗调音是否比耳朵听到的更多？

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-17 DOI: 10.1016/j.heares.2025.109218

Gavin M. Bidelman

引用次数: 0

Thyroid hormone signaling is essential for the maturation and survival of cochlear root cells in mice 甲状腺激素信号对小鼠耳蜗根细胞的成熟和存活至关重要

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-15 DOI: 10.1016/j.heares.2025.109222

XianHua Ma , Fei Jiang , Chunchun Wei , Shuang Han , Yuqing Zhang , Lianhua Sun , Jiaxi Qu , Hao Ying , Yuxia Chen , Jie Tang , David Z. He , Weiping J. Zhang , Zhifang Xie

{"title":"Thyroid hormone signaling is essential for the maturation and survival of cochlear root cells in mice","authors":"XianHua Ma , Fei Jiang , Chunchun Wei , Shuang Han , Yuqing Zhang , Lianhua Sun , Jiaxi Qu , Hao Ying , Yuxia Chen , Jie Tang , David Z. He , Weiping J. Zhang , Zhifang Xie","doi":"10.1016/j.heares.2025.109222","DOIUrl":"10.1016/j.heares.2025.109222","url":null,"abstract":"<div><div>Thyroid hormone and its receptors (TRs) are crucial for late-stage cochlear development and the maintenance of endocochlear potential (EP), yet the mechanisms underlying EP reduction in their absence remain unclear. Cochlear outer sulcus root cells undergo significant morphological changes during late-stage development and are thought to play a role in maintaining endolymph homeostasis and EP. Nevertheless, it remains unknown whether thyroid hormone and TRs are essential for root cell differentiation and function. Here, we demonstrate that thyroid hormone or TRs are indispensable for postnatal root cell development and survival in the mouse cochlea. Thyroid hormone deficiency markedly delays root cell differentiation. Otocyst-selective deletion of both <em>Thra</em> and <em>Thrb</em>, but not <em>Thrb</em> alone, leads to a similar impairment, accompanied by early degeneration of root cells, with the stria vascularis unaffected. Furthermore, conditional double knockout of TRs results in a 22 % reduction in mean EP magnitude at 4 months, less severe than the effects observed in global TRs knockout models. Transcriptome analysis reveals that thyroid hormone deficiency downregulates a significant portion of root cell-enriched genes. These findings underscore the redundant roles of TRα and TRβ in promoting the late-stage differentiation and survival of root cells. Additionally, they suggest that the expression of TRs in cochlear epithelium is crucial for maintaining an optimal EP magnitude, while TRs expressed in areas outside cochlear epithelium, particularly in spiral ligament fibrocytes, may also significantly contribute to EP maintenance. This study advances our understanding of thyroid hormone in cochlear outer sulcus development and EP maintenance.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"459 ","pages":"Article 109222"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mutation in Tmem135 causes progressive sensorineural hearing loss Tmem135基因突变导致进行性感音神经性听力损失

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-14 DOI: 10.1016/j.heares.2025.109221

Mi-Jung Kim , Shion Simms , Ghazaleh Behnammanesh , Wei-Wen Chen , Yohei Honkura , Jun Suzuki , Hyo-Jin Park , Marcus Milani , Yukio Katori , Jonathan E Bird , Akihiro Ikeda , Shinichi Someya

{"title":"A mutation in Tmem135 causes progressive sensorineural hearing loss","authors":"Mi-Jung Kim , Shion Simms , Ghazaleh Behnammanesh , Wei-Wen Chen , Yohei Honkura , Jun Suzuki , Hyo-Jin Park , Marcus Milani , Yukio Katori , Jonathan E Bird , Akihiro Ikeda , Shinichi Someya","doi":"10.1016/j.heares.2025.109221","DOIUrl":"10.1016/j.heares.2025.109221","url":null,"abstract":"<div><div>Transmembrane protein 135 (TMEM135) is a highly conserved 52 kDa protein with five predicted transmembrane domains that colocalizes with mitochondria and peroxisomes. Previous studies have shown that TMEM135 is involved in mitochondrial dynamics, thermogenesis, and lipid metabolism across multiple tissues and species; however, its role in the inner ear and auditory system remains unknown. We investigated the function of TMEM135 in hearing using wild-type (WT) and <em>Tmem135</em><sup>FUN025/FUN025</sup> (<em>FUN025</em>) mutant mice on a CBA/CaJ background, a normal-hearing mouse strain. Although <em>FUN025</em> mice displayed normal auditory brainstem response (ABR) thresholds at 1 month, we observed significantly elevated ABR thresholds at 8, 16, and 64 kHz by 3 months, which progressed to profound hearing loss by 12 months. Consistent with our auditory testing results, 13-month-old <em>FUN025</em> mice exhibited a severe loss of outer hair cells and more modest changes in inner hair cell survival, spiral ganglion neuron density, and stria vascularis integrity in the cochlea. Our results using BaseScope RNA in situ hybridization indicate that TMEM135 is expressed in the inner hair cells, outer hair cells, supporting cells, and stria vascularis. Using Volocity software and Costes colocalization analysis, we found that TMEM135 closely colocalizes with mitochondria in hair cells. Together, these results demonstrate that the <em>FUN025</em> mutation in <em>Tmem135</em> causes progressive sensorineural hearing loss, and suggest that TMEM135 is crucial for maintaining key cochlear cell types and normal sensory function in the aging cochlea.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"459 ","pages":"Article 109221"},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Music to my ears 悦耳的音乐

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-14 DOI: 10.1016/j.heares.2025.109219

Geoffrey A. Manley

引用次数: 0