Hearing Research最新文献

{"title":"C57BL/6-derived mice and the Cdh23ahl allele – Background matters","authors":"Sherylanne Newton,&nbsp;Carlos Aguilar,&nbsp;Michael R. Bowl","doi":"10.1016/j.heares.2025.109278","DOIUrl":"10.1016/j.heares.2025.109278","url":null,"abstract":"<div><div>C57BL/6-derived mice are the most utilised mice in biomedical research, and yet actually there is no such thing as a generic C57BL/6 mouse. Instead, there are more than 150 C57BL/6-derived sub-strains recognised by the Mouse Genome Informatics (MGI) database, each of which carry sub-strain-specific fixed genetic differences that can potentially lead to phenotypic differences affecting a single, or multiple biological systems. One of the most widely known strain-specific alleles is the <em>Cdh23^ahl</em> allele, a single nucleotide change that predisposes C57BL/6-derived mice to a progressive hearing loss that starts in the high-frequency region. As such, this allele is of particular relevance to auditory researchers. However, a recent study, comparing C57BL/6NTac mice with a co-isogenic strain in which the <em>Cdh23^ahl</em> allele has been ‘repaired’ using genome editing, suggests that the <em>Cdh23^ahl</em> allele may have a broader effect on phenotype expressivity of mouse mutants impacting not just the auditory system, but other organ systems as well. Here, using the <em>Cdh23^ahl</em> allele as an exemplar, we discuss the importance of knowing, understanding and reporting the genetic background of mouse mutants.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"462 ","pages":"Article 109278"},"PeriodicalIF":2.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative MRI, audiovisual speech perception, and mood are associated with cochlear implant outcomes in adults with postlingual deafness","authors":"Anaïs M. Grégoire ,&nbsp;Laurence Dricot ,&nbsp;Caroline Huart ,&nbsp;Monique Decat ,&nbsp;Naïma Deggouj ,&nbsp;Ron Kupers","doi":"10.1016/j.heares.2025.109272","DOIUrl":"10.1016/j.heares.2025.109272","url":null,"abstract":"<div><div>Acquired severe to profound hearing loss is an increasingly challenging problem of our aging population. Cochlear implantation (CI) is the gold standard treatment for this advanced form of sensory deprivation. Despite the overall satisfactory results of CI, a substantial number of patients show unsatisfactory outcomes. This study aims to improve current predictive models of CI outcome by integrating preoperative MRI with behavioral data. We acquired a 3D T1 MRI to measure cortical thickness (CT) and volume using surface-based analysis and parcellation from the Brainnetome atlas. CI success at 6 months post-implant, as measured by audiovisual speech perception, was correlated with preoperative speech and audiovisual perception with hearing aids, and residual hearing, especially at the side of the non-implanted ear. In addition, CI outcome correlated positively with CT of the left superior temporal gyrus and sulcus, left inferior frontal region, and bilateral superior frontal regions. The volume of the left middle frontal gyrus and regions of the parietal lobe, especially at the left side, also correlated with CI outcome. Linear regression models revealed that CI outcome was best predicted by the combination of preoperative measures of audiovisual speech perception, residual hearing, depression and CT. Our results highlight the importance of preserved brain areas implicated in hearing, language, audiovisual integration, and cognitive functions for CI success. Furthermore, brain MRI in conjunction with other predictors can help to identify patients who may need more time to adjust to the CI, allowing a more tailored rehabilitation, and potentially greater efficacy.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109272"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating hearing thresholds in rodents using the parallel auditory brainstem response","authors":"Pawichaya Suphinnapong,&nbsp;Shievanie Sabesan,&nbsp;Nicholas A. Lesica","doi":"10.1016/j.heares.2025.109273","DOIUrl":"10.1016/j.heares.2025.109273","url":null,"abstract":"<div><div>ABR thresholds are traditionally measured for one sound frequency at a time, but a new approach, the parallel ABR (pABR), has recently been developed. The pABR allows thresholds to be measured for multiple frequencies simultaneously and has been shown to be more efficient than the traditional approach for humans. This study explored the applicability of the pABR approach for threshold measurement in gerbils. The basic properties of the estimated ABRs were analyzed and the dependence of the signal-to-noise ratio (SNR) and the reliability of measured thresholds on the number of trials was assessed. For a subset of ears, direct comparisons were made between the pABR and the traditional approach. The results suggest that the pABR approach can be more efficient for rodents than the traditional ABR approach, particularly for threshold estimation. To facilitate its use, software toolboxes in Matlab and Python are provided for the design of the pABR sounds and the analysis of recordings.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109273"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling eye movement-related eardrum oscillations (EMREOs): how saccade direction and tympanometric measurements relate to their amplitude and time course","authors":"Nancy Sotero Silva ,&nbsp;Christoph Kayser ,&nbsp;Felix Bröhl","doi":"10.1016/j.heares.2025.109276","DOIUrl":"10.1016/j.heares.2025.109276","url":null,"abstract":"<div><div>Eye movement-related eardrum oscillations (EMREOs) reflect movements of the tympanic membrane that scale with the magnitude and direction of saccades. EMREOs have been consistently described in humans and non-human primates, yet many questions regarding this phenomenon remain unresolved. Based on bilateral in-ear recordings in human participants we here explore several properties of these EMREOs in order to improve our understanding of this signal's origin and functional significance. Our data support that the EMREO time course is comparable between the left and right ears, and between paradigms guiding saccades by visual and auditory target stimuli. However, the precise amplitude time course differs significantly between ipsi- and contralateral saccades in addition to the previously known phase-inversion described for saccades in opposing directions. Finally, our data suggest that the EMREO amplitude is negatively related to the compliance of the tympanic membrane as established by tympanometry. Collectively, these results support the notion that EMREOs reflect motor-related top-down signals relayed to the ear from yet-to-be-resolved sources, and fuel the speculation that EMREOs may be generated by the middle ear muscles in a differential operation similar to the execution of ipsi- and contralateral saccades.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109276"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain pattern abnormalities in tinnitus with and without hearing loss","authors":"Li Qin ,&nbsp;Qiu Ge ,&nbsp;Chaoqi Shi ,&nbsp;Jiayu Ni ,&nbsp;Zili Yin ,&nbsp;Enli Jin ,&nbsp;Jiaying Wang ,&nbsp;Yu-Feng Zang ,&nbsp;Yuan Li","doi":"10.1016/j.heares.2025.109274","DOIUrl":"10.1016/j.heares.2025.109274","url":null,"abstract":"<div><h3>Objective</h3><div>Subjective tinnitus often coexists with hearing loss, and they share common pathophysiological mechanisms. This comorbidity induces whole-brain gray matter volume (GMV) alterations, manifesting as distributed structural changes in neural networks rather than isolated regional modifications. Multivariate analysis of structural brain patterns is therefore essential to differentiate their underlying mechanisms.</div></div><div><h3>Methods</h3><div>Fifty tinnitus patients and 50 age-/gender-matched controls underwent structural MRI and audiometry. Patients were stratified by hearing level into 22 with hearing loss (T+HL) and 28 without (T-HL). To investigate structural brain patterns specific to tinnitus and hearing loss, Source-Based Morphometry (SBM), a multivariate analytical approach based on Independent Component Analysis (ICA), was applied to identify covarying patterns of GMV. The associations between these structural covariance patterns and clinical characteristics were examined using Spearman's correlation analysis.</div></div><div><h3>Results</h3><div>Our results showed that in T-HL patients, structural abnormalities in the medial prefrontal cortex, precuneus, and auditory cortex were negatively correlated with tinnitus distress. In contrast, in T+HL patients, abnormalities in the insular structural brain pattern were negatively associated with depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Our findings revealed that tinnitus-related structural brain patterns involve regions such as the middle frontal gyrus, supplementary motor area (SMA), and anterior cingulate cortex (ACC), with these changes negatively correlating with tinnitus distress, suggesting adaptive mechanisms in tinnitus perception. Moreover, the structural brain pattern involving the insula, putamen, and superior temporal gyrus appears to be primarily driven by hearing loss. These findings support audiometric-based subgrouping in tinnitus management.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109274"},"PeriodicalIF":2.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle-aged CBA/CaJ mice exhibit auditory dysfunction in background noise","authors":"E. Fabrizio-Stover ,&nbsp;J. Wu ,&nbsp;H. Lang ,&nbsp;K.C. Harris","doi":"10.1016/j.heares.2025.109259","DOIUrl":"10.1016/j.heares.2025.109259","url":null,"abstract":"<div><div>Aging is associated with deficits in auditory functioning. Characterization of auditory deficits that originate in middle-age is crucial for understanding the initial age-related functional impairments and the spatio-temporal progression of age-related auditory pathophysiology. Early age-related deficits in auditory processing are evident in difficult listening conditions, such as background noise, before becoming evident in quiet. To investigate the effect of noise on age-related auditory dysfunction, we collected suprathreshold auditory brainstem responses (ABRs) from young, middle-aged, and aged CBA/CaJ mice in quiet and broad-band background noise. We utilized multiple ABR metrics, including phase locking value (PLV), a measure of neural synchrony correlated to speech-in-noise understanding in humans. Despite no differences in auditory processing in quiet between young and middle-aged mice, middle-aged mice exhibited a distinct auditory phenotype from both young and aged mice in background noise conditions. We found that noise significantly decreased amplitude in middle-aged mice more than in young and aged mice. Noise significantly increased latencies for wave I and V in young mice, but only affected wave V in middle-aged mice and did not affect aged latencies. Noise significantly decreased PLV in middle-aged mice to a greater extent than in young mice, but to a lesser extent in aged mice. These results show that middle-aged mice have a distinct, auditory dysfunction phenotype evident in background noise. Our data show that suprathreshold auditory function in noise can identify early age-related hearing loss and can be used as a sensitive tool for detecting auditory dysfunction in normal hearing animal models.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109259"},"PeriodicalIF":2.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear representation of wideband biosonar sounds and the emergence of neural oscillations","authors":"James A. Simmons ,&nbsp;Darlene R. Ketten ,&nbsp;Andrea Megela Simmons","doi":"10.1016/j.heares.2025.109261","DOIUrl":"10.1016/j.heares.2025.109261","url":null,"abstract":"<div><div>Echolocating big brown bats and bottlenose dolphins broadcast wideband ultrasonic echolocation calls in the baseband to sense their surroundings. Even though these species inhabit different media and emit echolocation calls with different spectra, both show similar perceptual acuity: They determine target range from echo delay, they detect changes in echo delay on a microsecond scale, and they perceive ultrasonic phase. These perceptual performances are too acute to understand on the basis of single neuron responses, and even neural population responses do not reach the required behavioral values. Here we propose two mechanisms that may contribute to temporal hyperacuity in these wideband echolocators. Structural imaging studies show that in both species the cochlea receives input from the middle ear at locations different from that seen in non-echolocating mammals. These unusual patterns of input might produce interference patterns in traveling waves along the basilar membrane, which in turn could facilitate detection of ultrasonic phase by producing low difference frequencies that may form a substrate for further neural processing into perception. The second mechanism is related to oscillations of evoked activity observed in the bat's inferior colliculus, which could create broadcast-echo interference patterns at the neural level. The resulting difference-frequency interference signals would be very sensitive to changes in echo delay and phase. Small changes in ultrasonic sounds thus could lead to much larger changes in neural response timing by magnifying echo time itself.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"462 ","pages":"Article 109261"},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms","authors":"Naomi F. Bramhall ,&nbsp;Brad N. Buran ,&nbsp;Garnett P. McMillan","doi":"10.1016/j.heares.2025.109263","DOIUrl":"10.1016/j.heares.2025.109263","url":null,"abstract":"<div><div>Cochlear synaptopathy, a type of cochlear deafferentation that impacts the synapses between the inner hair cells and the afferent auditory nerve fibers, is predicted to result in speech perception in noise difficulty. However, this has been difficult to confirm due to mixed findings in human studies of the relationship between speech perception in noise and physiological indicators of deafferentation (auditory brainstem response [ABR] wave I amplitude, envelope following response [EFR] magnitude, and middle ear muscle reflex [MEMR] magnitude). One possible explanation for the mixed findings is that some listeners with cochlear deafferentation can increase their cognitive effort to compensate for the degraded speech signal so that their speech-in-noise performance is relatively unaffected, obscuring the relationship between deafferentation and speech-in-noise scores.</div><div>In a population at high risk for noise-induced cochlear deafferentation (military Veterans with normal audiograms), this study evaluated the relationship between physiological indicators of deafferentation (ABR, EFR, and MEMR) and listening effort, as indicated by pupil dilation during a speech-in-noise task.</div><div>Mean reductions in ABR, EFR, and MEMR magnitude were associated with greater task-related pupil dilation, but not with reduced speech-in-noise performance, although only the ABR was statistically significant after accounting for sex and outer hair cell function. This suggests that cochlear deafferentation may result in increased listening effort during speech-in-noise perception, even if performance on the task is not negatively impacted. The observed relationship between EFR magnitude and pupil dilation was non-linear, suggesting that increased listening effort may only occur after a particular threshold level of deafferentation is reached.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109263"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Tinnitus, masked speech perception, and auditory event-related potentials in clinically normal-hearing adults” [Hearing Research 460 (2025) 109239]","authors":"Ning Gao ,&nbsp;Sheng-Yu Tao ,&nbsp;Qian-Jie Fu ,&nbsp;John Galvin ,&nbsp;Sean Lang ,&nbsp;Ya-Feng Yu ,&nbsp;Ji-Sheng Liu ,&nbsp;Duo-Duo Tao","doi":"10.1016/j.heares.2025.109257","DOIUrl":"10.1016/j.heares.2025.109257","url":null,"abstract":"","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109257"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced hearing loss: a real-world pharmacovigilance study using the FDA adverse event reporting system database","authors":"Tingxi Wu ,&nbsp;Zhigang Zhao ,&nbsp;Peng Wang ,&nbsp;Qian Du ,&nbsp;Yanfeng Shi ,&nbsp;Bin Zhu ,&nbsp;Jie Dong ,&nbsp;Dongxuan Li","doi":"10.1016/j.heares.2025.109262","DOIUrl":"10.1016/j.heares.2025.109262","url":null,"abstract":"<div><div>Drug-induced hearing loss (DIHL) is highly prevalent, but a comprehensive picture of ototoxicity associated with drugs are still lacking. In order to comprehensively summarize the hearing safety information of current drugs, we used the real-world data from 2004 to 2023 in the FDA Adverse Event Reporting System (FAERS) database to integrate the reported ototoxicity information of drugs and applied disproportionality analysis to evaluate the hearing impairment risk induced by drugs. A total of 108,435 adverse event (AE) reports of hearing impairment were extracted from the FAERS database, involving 1300 reported culprit-drugs. On the whole, acetylsalicylic acid was the most frequently reported potential ototoxic drug, followed by levothyroxine sodium, adalimumab, omeprazole, and ergocalciferol. Immunosuppressants was the most frequently reported drug class, followed by analgesics, psychoanaleptics, agents acting on the renin-angiotensin system, and antineoplastic agents. In risk signal detection, 432 of 1300 drugs exhibited potential ototoxic risk, in which tafenoquine showed the strongest statistical correlation with hearing impairment, followed by teprotumumab, amyl nitrite, potassium iodide, and paromomycin. Among main drug classes, antibacterials for systemic use was the drug class contained the maximum number of drugs with positive ototoxic risk signals, followed by psychoanaleptics, agents acting on the renin-angiotensin system, antineoplastic agents, and analgesics. In conclusion, our study summarized a comprehensive drug list containing 1300 reported potential ototoxic drugs in the FAERS database and profiled their ototoxicity risk characteristic from the aspect of reporting frequency and risk signal strength, which can provide reference for clinical medical staff to strengthen monitoring and management of DIHL.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"461 ","pages":"Article 109262"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}