Middle-aged CBA/CaJ mice exhibit auditory dysfunction in background noise

Abstract

Aging is associated with deficits in auditory functioning. Characterization of auditory deficits that originate in middle-age is crucial for understanding the initial age-related functional impairments and the spatio-temporal progression of age-related auditory pathophysiology. Early age-related deficits in auditory processing are evident in difficult listening conditions, such as background noise, before becoming evident in quiet. To investigate the effect of noise on age-related auditory dysfunction, we collected suprathreshold auditory brainstem responses (ABRs) from young, middle-aged, and aged CBA/CaJ mice in quiet and broad-band background noise. We utilized multiple ABR metrics, including phase locking value (PLV), a measure of neural synchrony correlated to speech-in-noise understanding in humans. Despite no differences in auditory processing in quiet between young and middle-aged mice, middle-aged mice exhibited a distinct auditory phenotype from both young and aged mice in background noise conditions. We found that noise significantly decreased amplitude in middle-aged mice more than in young and aged mice. Noise significantly increased latencies for wave I and V in young mice, but only affected wave V in middle-aged mice and did not affect aged latencies. Noise significantly decreased PLV in middle-aged mice to a greater extent than in young mice, but to a lesser extent in aged mice. These results show that middle-aged mice have a distinct, auditory dysfunction phenotype evident in background noise. Our data show that suprathreshold auditory function in noise can identify early age-related hearing loss and can be used as a sensitive tool for detecting auditory dysfunction in normal hearing animal models.