Hearing Research最新文献

{"title":"The inner ear of the Port Jackson shark, Heterodontus portusjacksoni: morphometric analysis using bioimaging and phalloidin staining","authors":"H. Robins ,&nbsp;L. Chapuis ,&nbsp;C.C. Kerr ,&nbsp;T. Dutka ,&nbsp;J. Donald ,&nbsp;S.P. Collin","doi":"10.1016/j.heares.2025.109368","DOIUrl":"10.1016/j.heares.2025.109368","url":null,"abstract":"<div><div>The inner ear plays a crucial role in detecting sound and maintaining balance in elasmobranchs, yet its morphology and function remain poorly understudied compared to teleosts. This study provides the first detailed morphometric analysis of the inner ear in the Port Jackson shark <em>Heterodontus portusjacksoni</em> using micro-computed tomography (µCT), fine dissection, and phalloidin labelling of macular hair cells. Measurements of key structures, including the saccule, lagena, utricle, and semicircular canals, are obtained from individuals across different life stages. Hair cell density and orientation are quantified using phalloidin staining and confocal microscopy to assess potential auditory and vestibular specialisations. The macula neglecta, a structure associated with directional hearing in elasmobranchs but not previously identified in this species, is present but relatively small, with low hair cell density, consistent with the benthic lifestyle of <em>H. portusjacksoni</em>. The findings suggest that this species relies more on substrate-borne vibrations and spatial stability than on acute directional hearing, aligning with its ecology in wave-exposed, rocky reef habitats. These findings contribute to the understanding of sensory adaptations in elasmobranchs and highlight the need for further research on the impacts of anthropogenic sound on elasmobranch auditory systems.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109368"},"PeriodicalIF":2.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural tracking of continuous speech in adverse acoustic conditions among healthy adults with normal hearing and hearing loss: A systematic review","authors":"David Ratelle ,&nbsp;Pascale Tremblay","doi":"10.1016/j.heares.2025.109367","DOIUrl":"10.1016/j.heares.2025.109367","url":null,"abstract":"<div><div>The study of neural speech tracking (NST) has gained increasing attention in the field of auditory neuroscience in recent years. However, its contribution to speech perception in noise (SPiN), especially regarding aging and hearing loss, has yet to be fully explored. This systematic review examined NST in adults with and without hearing loss, focusing on its modulation by age, hearing impairment, and adverse acoustic conditions, as well as its relationship with behavioral SPiN performance. A systematic literature search identified studies using electroencephalography (EEG) or magnetoencephalography (MEG) to investigate NST in continuous speech processing under adverse acoustic conditions. Studies included participants with and without hearing loss, excluding those with neurological disorders. Various NST methods, including forward and backward modeling, coherence, and cross-correlation, were examined. Fifty-four studies met the inclusion criteria. Most studies focused on young adults, with fewer studies including older adults or individuals with hearing loss. Findings suggest that older adults exhibit increased NST compared to younger adults, potentially reflecting compensatory mechanisms for auditory processing declines. Similarly, hearing impairment was generally associated with enhanced NST, likely due to altered neural encoding and increased reliance on cognitive resources. The impact of adverse acoustic conditions, as reflected by the signal-to-noise ratio (SNR), on NST was predominantly negative, with NST decreasing as noise levels increased. However, some studies suggested a non-linear relationship, with NST peaking at intermediate SNRs. Furthermore, most studies reported a positive correlation between NST and SPiN performance, typically observed across individuals or conditions within homogeneous groups or pooled samples. While stronger tracking was generally associated with better behavioral outcomes, this relationship does not imply that higher NST always corresponds to better performance across different populations. Age and hearing loss appear to modulate NST, likely through both neural compensation and auditory processing adaptations. The complex effects of SNR on NST highlight the need for additional research to better understand its underlying mechanisms. Future studies should delve deeper into the interplay between aging, cognition, and auditory deficits in shaping NST, offering a more comprehensive understanding of speech processing in challenging acoustic environments.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109367"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mouse model of acute vestibular dysfunction via semicircular canal injection of absolute ethanol","authors":"Pei Zhou ,&nbsp;Jing Wang ,&nbsp;Yuwei Zhang ,&nbsp;Xinrui Xu ,&nbsp;Chengwei Liu ,&nbsp;Ru Zhang ,&nbsp;Yiming Shen ,&nbsp;Feitian Li ,&nbsp;Weimin Qu ,&nbsp;Zhili Huang ,&nbsp;Chunfu Dai","doi":"10.1016/j.heares.2025.109366","DOIUrl":"10.1016/j.heares.2025.109366","url":null,"abstract":"<div><h3>Objective</h3><div>Various vestibular pathology models have been developed to elucidate the underlying mechanisms of vestibular diseases; however, there is a notable absence of minimally invasive mouse model of vestibular dysfunction. In this study, we established a novel model and conducted a comprehensive evaluation of vestibular function alongside various behavioral assessments.</div></div><div><h3>Methods</h3><div>We developed a surgical procedure involving canalostomy followed by injection of absolute ethanol into the semicircular canal of mice. Histological analysis and auditory brainstem response (ABR) testing were conducted to confirm vestibular and cochlear damage. Vestibular dysfunction was assessed using a syndrome scoring system, the horizontal angular vestibulo-ocular reflex (hVOR) test, and the rotarod test. Additionally, home-cage behavior was recorded to evaluate spontaneous behavioral changes.</div></div><div><h3>Results</h3><div>The surgical procedure resulted in significant, irreversible damage to the vestibulocochlear structures at the pre-ganglionic level. The model exhibited severe vestibular symptoms, including acute weight loss, postural deviation, reduced locomotor ability, and impaired hVOR function. Static vestibular compensation was observed within 14 days post-surgery, whereas dynamic compensation progressed more gradually. Home-cage behavior monitoring revealed increased walking and turning activity, accompanied by a reduction in other dynamic and exploratory behaviors (sniffing, rearing, and hanging) compared to sham controls. In contrast, basic behaviors related to survival (sleeping, drinking, eating, and grooming) were largely preserved.</div></div><div><h3>Conclusion</h3><div>In this study, we successfully established a novel mouse model of acute vestibular dysfunction via semicircular canal injection of absolute ethanol. This model is minimally invasive, reproducible, and exhibits consistent behavioral phenotypes, making it a valuable tool for studying peripheral vestibular disorders and their compensatory mechanisms.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"466 ","pages":"Article 109366"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causal relationship between circulating inflammatory proteins and tinnitus: Insights from a Mendelian Randomization study","authors":"Shichun He ,&nbsp;Meiqi Wei ,&nbsp;Deyu Meng ,&nbsp;Zongnan Lv ,&nbsp;Guang Yang ,&nbsp;Ziheng Wang","doi":"10.1016/j.heares.2025.109300","DOIUrl":"10.1016/j.heares.2025.109300","url":null,"abstract":"<div><div>Tinnitus, a condition characterized by the perception of ringing in the ears, significantly impacts quality of life, yet its underlying biological mechanisms remain poorly understood. Emerging evidence suggests a role for inflammation in tinnitus pathophysiology. This study employs a bidirectional two-sample Mendelian Randomization (MR) approach to investigate the causal relationship between circulating inflammatory proteins and tinnitus. Genetic data from large-scale pQTL and GWAS datasets were analyzed to identify potential causal links. The results reveal that elevated levels of CCL19, CXCL11, and TNFSF12 are positively associated with tinnitus risk, while CD40L and IL-10 exhibit protective effects. Reverse MR analysis suggests that tinnitus may weakly influence levels of Cystatin D, IL-18, and MCP-1, though these associations require further validation. These findings provide novel insights into the inflammatory pathways involved in tinnitus, paving the way for targeted therapeutic strategies and future research into anti-inflammatory interventions.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109300"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of intracochlear electrical fields with spread of excitation and voltage matrix in cochlear implant users and their link to speech perception","authors":"Pascal Nachtigäller ,&nbsp;Tobias Weissgerber ,&nbsp;Uwe Baumann ,&nbsp;Tobias Rader","doi":"10.1016/j.heares.2025.109357","DOIUrl":"10.1016/j.heares.2025.109357","url":null,"abstract":"<div><h3>Background</h3><div>Objective measures and their relation to listening performance are of interest in the study of cochlear implants (CIs). Both spread of excitation (SoE) and the voltage matrix (VM) are objective descriptors of electric field spread. VM is easier to measure and therefore preferable to SoE. The aim of the study was comparing both measurements postoperatively and investigating their relation to listening performance.</div></div><div><h3>Methods</h3><div>Postoperative SoE and VM data for 10 out of 17 CI-users were normalized to their maximum amplitude before comparison. A previously published SoE-width-based analysis method (Rader et al., 2023) was adapted and applied to the VM data. The ECAP separation index (from Hughes, 2008), comparing SoE data of two neighboring electrodes, was also adapted to the VM data of 17 CI-users and correlated with speech perception.</div></div><div><h3>Results</h3><div>Recorded SoE and VM data correlated strongly in most CI-users. The normalized SoE and VM data showed good alignment. Some deviations were observable: an average RMS-difference of 0.159 normalized amplitude was found between SoE and VM data. Asymmetric width measures extracted from exponential fitting differed significantly between SoE and VM data. No correlation between width measures and speech perception could be found. The VM separation index correlated with speech perception.</div></div><div><h3>Conclusions</h3><div>SoE and VM are closely related measurements, however they are not identical. The neural information in SoE can’t be ignored and VM can’t replace SoE. The VM separation index appeared to be a promising approach for predicting listening performance. Nevertheless, further research is required to corroborate this finding.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109357"},"PeriodicalIF":2.5,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPA1 deficiency affects cochlear potentials days after noise exposure","authors":"Samantha A. Radomski,&nbsp;D․ Susana Llanes-Coronel,&nbsp;Ava M. Kruse,&nbsp;A․ Catalina Vélez-Ortega","doi":"10.1016/j.heares.2025.109358","DOIUrl":"10.1016/j.heares.2025.109358","url":null,"abstract":"<div><div>TRPA1 channels are master sensors of tissue damage. We recently showed that, after acoustic trauma, TRPA1 activation in cochlear supporting cells regulates hearing sensitivity and is a component of the temporary threshold shift. In the neonate organ of Corti, TRPA1 activation in the Hensen’s cells leads to prolonged calcium responses that propagate across the organ of Corti and cause long-lasting tissue displacements. In the adult cochlea, such tissue shape changes would be expected to affect the geometry and/or stiffness of the cochlear partition and, consequently, cochlear amplification. However, we still lack direct evidence of TRPA1-mediated changes to cochlear mechanics in adult mice. Here, we extracted remote cochlear microphonic (rCM) and summating potential (SP) data from auditory brainstem responses (ABRs) to evaluate noise-induced changes to these cochlear potentials that depend on TRPA1 signaling. Our results show significant differences in SP amplitudes of click-evoked ABRs between <em>Trpa1^–/–</em> mice and wild-type littermates. However, five days after noise exposure, the SP differences were no longer observed likely due to an overall reduction in rCM amplitudes in the <em>Trpa1^–/–</em> mice which was not seen in wild-type littermates. In addition, mice exhibited a direct current (DC) shift in the rCM elicited by an 8 kHz tone burst as the sound intensity increased, which was delayed in <em>Trpa1^–/–</em> mice. Our results indicate that TRPA1 signaling after loud sound stimulation triggers changes in the cochlear transducer, but the specific mechanisms underlying these changes and whether they minimize noise-induced tissue damage remain to be elucidated.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109358"},"PeriodicalIF":2.5,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low level of expression of known deafness genes Kcne1, Kcnj10 or Col4a3 is sufficient to maintain hearing in mice","authors":"Darcey A Kirwin,&nbsp;Nina Treder,&nbsp;Elisa Martelletti,&nbsp;Daniel R Pentland,&nbsp;Rechal Kumar,&nbsp;Neil J Ingham,&nbsp;Karen P Steel","doi":"10.1016/j.heares.2025.109356","DOIUrl":"10.1016/j.heares.2025.109356","url":null,"abstract":"<div><div><em>Kcne1, Kcnj10</em> and <em>Col4a3</em> are all expressed in the stria vascularis where they serve critical roles in generating the endocochlear potential. Mutations in any of these three genes are linked to human deafness syndromes for which there are currently no treatments. Here, the hearing ability of three mouse lines carrying mutant alleles in these genes (<em>Kcne1^tm1a, Kcnj10^tm1a</em> and <em>Col4a3^tm1a</em>) was investigated to assess whether they would develop an auditory phenotype similar to that of human patients. Surprisingly, all three mutant mice had normal hearing, at least up to 6 months of age, assessed by auditory brainstem response thresholds and waveforms and endocochlear potentials. Marginal cell arrangement in the stria vascularis was normal in <em>Col4a3^tm1a/tm1a</em> mice at 8 weeks of age but showed evidence of early cellular disorganisation in <em>Kcnj10^tm1a/tm1a</em> and <em>Kcne1^tm1a/tm1a</em> mice. We found that the <em>Kcne1^tm1a, Kcnj10^tm1a</em> and <em>Col4a3^tm1a</em> mutations led to incomplete knockdown of transcript, to 25 % of normal values in each case, indicating these are hypomorphic alleles. These results suggest that partial restoration of <em>KCNE1, KCNJ10</em> and <em>COL4A3</em> expression in patients affected by mutations in these genes may be sufficient to preserve auditory function.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109356"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of stimulus level on speech masking by multitalker noise in a cochlear model","authors":"Václav Vencovský ,&nbsp;Zbyněk Bureš","doi":"10.1016/j.heares.2025.109343","DOIUrl":"10.1016/j.heares.2025.109343","url":null,"abstract":"<div><div>Previous research shows that intelligibility of speech in noise (SIN) with a constant speech-to-noise ratio (SNR) changes in dependence on overall stimulus level. It has been hypothesized that these changes were associated with nonlinear responses of the cochlear basilar membrane, however, the exact role of auditory periphery in this behavior is not clear. We explore this phenomenon using a nonlinear cochlear model with adjustable gain to examine how multi-talker (babble) noise affects the speech signal at the output of the auditory periphery. The amount of distortion at various intensities caused by babble noise is calculated by correlating the model responses to speech alone and to SIN with a constant speech-to-noise ratio of −5 dB. The model shows that both 5% quantile and the mean value of the cross-correlation coefficient increase with stimulus level from 30 to 60–70 dB SPL and then decline for levels between 70 dB and 90 dB SPL, indicating that babble noise represents a less effective masker at intermediate intensities and its influence is strongest at both low and high levels. In addition, reduction of the gain of the cochlear amplifier decreases the cross-correlation, leading to worsened SIN intelligibility. Altogether, while not ruling out possible central contributions, our results offer a plausible peripheral mechanism suggesting that the level dependence of SIN intelligibility has its origins already in peripheral processing and that cochlear amplification plays an important role in this process.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109343"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing function and ossicular deformities and fractures in the oim mouse model of brittle bone disease","authors":"Maialen Ugarteburu ,&nbsp;Aliah F. Shaheen ,&nbsp;Christoph Rau ,&nbsp;Luis Cardoso ,&nbsp;Claus-Peter Richter ,&nbsp;Alessandra Carriero","doi":"10.1016/j.heares.2025.109351","DOIUrl":"10.1016/j.heares.2025.109351","url":null,"abstract":"<div><div>Hearing loss is a prevalent symptom of osteogenesis imperfecta (OI), a group of collagen type I-related skeletal disorders, commonly known as <em>brittle bone disease</em>. Clinical manifestation of hearing loss in OI often presents with stapes footplate fixation and hypodense foci in the otic capsule. However, the etiology and evolution of OI-hearing loss and its relation to bone abnormalities are still unknown. This study investigates the onset, severity, and progression of hearing loss in the homozygous <em>oim</em> mouse model of severe OI Type III, which is reported to exhibit hearing loss at 11-12 weeks of age (Chen et al., 2007), using auditory brainstem responses up to 26 weeks of age. We further examine the presence of deformities, microcracks, and fractures of the ossicular chain using synchrotron microtomography. Our results demonstrate that <em>oim/oim</em> mice have normal hearing, regardless of i) their parental lineage, ii) their husbandry in isolation or with other animals, iii) their mastication with powder or chow food, and iv) their anesthesia with single or multiple ketamine injections. Bone abnormalities like excessive formations, fusions, and fractures, were observed in up to 33 % of wild-type and up to 43 % of <em>oim/oim</em> mice in each group. Among these, joint and bone-tendon abnormalities were twice as frequent in the <em>oim/oim</em> mice compared to the wild-type mice. Notably, these abnormalities did not impact the hearing response in mice. Whether such bone abnormalities occur and alter auditory function in humans with OI remains uncertain.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109351"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate presbycusis boosts audio-visual integration, but not lip-reading","authors":"Tanguy Delmas ,&nbsp;Mathieu Pham Van Cang ,&nbsp;Grégory Gerenton ,&nbsp;Jérôme Lefeuvre ,&nbsp;Keith B. Doelling ,&nbsp;Luc H. Arnal ,&nbsp;Diane S. Lazard","doi":"10.1016/j.heares.2025.109355","DOIUrl":"10.1016/j.heares.2025.109355","url":null,"abstract":"<div><div>In audiological practice, speech comprehension is typically assessed in the auditory modality alone (speech in quiet or noise). However, in real-life communication when the auditory input is degraded - due to noise or hearing loss (HL) - individuals rely on ancillary signals to enhance speech perception. Audio-visual (AV) integration is particularly effective in improving speech perception in noisy environments, yet the influence of HL and aging on this ability remains underexplored.</div><div>This study aims to disentangle the effects of HL and age on visual aspects of speech processing, both unimodally (lip-reading) and bimodally (AV integration). In sixty-five participants aged 50 and older, with hearing abilities ranging from normal to moderate HL (from 4 to 63 dB HL), we tested speech comprehension in challenging auditory, visual (lip-reading) and AV conditions using an adaptive procedure. AV gain (AV performance minus Auditory-alone performance) served as a measure of audio-visual integration.</div><div>Using multiple linear regressions and causal inference to account for the relative impact and potential interactions between HL and age, our results show that mild to moderate HL does not improve unimodal visual processing but does improve AV gain. In contrast, aging negatively impacts visual speech processing but does not directly affect AV gain.</div><div>These findings suggest that mild to moderate HL enhances the integration of visual and auditory speech cues to improve AV performance without affecting the efficacy of the visual information processing itself, while age-related decline in visual speech processing does not appear to effect overall AV integration. We propose that this reflects a form of central plasticity, in which moderate HL drives adaptive changes at high-order multimodal levels, counterbalancing age-related sensory decline in visual speech processing to maintain AV speech integration. Future research should explore how this plasticity evolves with more severe HL.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"465 ","pages":"Article 109355"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}