Hearing Research最新文献_第7页

Evaluating the role of age on speech-in-noise perception based primarily on temporal envelope information 基于时间包络信息评价年龄对噪声中语音感知的影响

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-07 DOI: 10.1016/j.heares.2025.109236

Jonathan Regev , Andrew J. Oxenham , Helia Relaño-Iborra , Johannes Zaar , Torsten Dau

{"title":"Evaluating the role of age on speech-in-noise perception based primarily on temporal envelope information","authors":"Jonathan Regev , Andrew J. Oxenham , Helia Relaño-Iborra , Johannes Zaar , Torsten Dau","doi":"10.1016/j.heares.2025.109236","DOIUrl":"10.1016/j.heares.2025.109236","url":null,"abstract":"<div><div>Acoustic amplitude modulation (AM) patterns carry important information, particularly in speech. AM masking, influenced by frequency selectivity in the modulation domain, is considered a crucial factor for speech intelligibility in noisy environments. Based on recent evidence suggesting an age-related decline in AM frequency selectivity, this study investigated whether increased AM masking in older listeners is associated with reduced speech intelligibility. Speech reception thresholds (SRTs) were measured using tone-vocoded speech and maskers with no modulation, broadband AM, or narrowband AM at varying modulation frequencies. AM masked thresholds were assessed for a 4-Hz target modulation frequency. The study included young (<em>N</em> = 14, 19–25 years) and older (<em>N</em> = 14, 57–79 years) listeners with normal hearing. It was hypothesized that SRTs would be higher for the older group with modulated maskers and that the age-related increase in SRT would depend on the masker's modulation frequency content. The speech intelligibility results showed that maskers with broadband AM produced higher SRTs than unmodulated maskers. However, SRTs varied little with masker-modulation center frequency across the range tested (2–32 Hz). While older listeners exhibited lower AM frequency selectivity than young listeners, they did not consistently exhibit higher SRTs than their young counterparts across maskers. However, there was a trend for the effect of age to be greater for maskers with broadband AM than for unmodulated maskers. Overall, despite supportive trends, the results do not conclusively demonstrate that older listeners are more susceptible than young listeners to AM masking of speech.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109236"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of visual analogue of speech envelope, formants, and word onsets on word recognition is not pronounced 视觉模拟语音包络、共振峰和单词开始对单词识别的影响不明显

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-07 DOI: 10.1016/j.heares.2025.109237

Kaja Rosa Benz , Anne Hauswald , Nathan Weisz

{"title":"Influence of visual analogue of speech envelope, formants, and word onsets on word recognition is not pronounced","authors":"Kaja Rosa Benz , Anne Hauswald , Nathan Weisz","doi":"10.1016/j.heares.2025.109237","DOIUrl":"10.1016/j.heares.2025.109237","url":null,"abstract":"<div><div>In noisy environments, filtering out the relevant speech signal from the background noise is a major challenge. Visual cues, such as lip movements, can improve speech understanding. This suggests that lip movements carry information about speech features (e.g. speech envelope, formants, word onsets) that can be used to aid speech understanding. Moreover, the isolated visual or tactile presentation of the speech envelope can also aid word recognition. However, the evidence in this area is rather mixed, and formants and word onsets have not been studied in this context.</div><div>This online study investigates the effect of different visually presented speech features (speech envelope, formants, word onsets) during a two-talker audio on word recognition. The speech features were presented as a circle whose size was modulated over time based on the dynamics of three speech features. The circle was either modulated according to the speech features of the target speaker, the distractor speaker or an unrelated control sentence. After each sentence, the participants` word recognition was tested by writing down what they heard. We show that word recognition is not enhanced for any of the visual features relative to the visual control condition.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109237"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells 哺乳动物的TMC1或tmc2对于听觉毛细胞的超燃酶活性是必需的

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-06 DOI: 10.1016/j.heares.2025.109229

Thibault Peineau , Irina Marcovich , Cristobal von Muhlenbrock Rodriguez , Sydney O'Malley , Runjia Cui , Angela Ballesteros , Jeffrey R. Holt

{"title":"Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells","authors":"Thibault Peineau , Irina Marcovich , Cristobal von Muhlenbrock Rodriguez , Sydney O'Malley , Runjia Cui , Angela Ballesteros , Jeffrey R. Holt","doi":"10.1016/j.heares.2025.109229","DOIUrl":"10.1016/j.heares.2025.109229","url":null,"abstract":"<div><div>Sensory transduction in auditory hair cells gates mechanosensitive ion channels, converting sound information into electrical signals (Zheng and Holt, 2021). Previously, we found that Transmembrane channel (TMC) proteins 1 and 2 form the pore of hair cell transduction channels (Pan et al., 2013; 2018). The structure of <em>C. elegans</em> TMC proteins (Jeong et al., 2022; Clark et al., 2024) and predicted mammalian TMC structures (Hahn et al., 2009; Ballesteros et al., 2018; Pan et al., 2018) are reminiscent of TMEM16 proteins, which function as Ca<sup>2+</sup>-activated ion channels and lipid scramblases. Here, we investigated lipid scramblase activity in live auditory hair cells with pharmacologic or genetic disruption of TMC1, extending work reported by Ballesteros and Swartz (2022). We used annexin-V to label phosphatidylserine (PS) localized in the outer leaflet of hair cell stereocilia membranes. PS externalization was triggered by disruption of sensory transduction using the blocker, benzamil, or by genetic mutations that affect TMC1 permeation properties. We found that expression of either TMC1 or TMC2, was essential for PS externalization. <em>Tmc1/Tmc2</em> knockout mice and <em>Tmie</em> mutant mice lacked PS externalization completely. We also determined that expression of exogenous human TMCs (hTMC1 or hTMC2) in <em>Tmc1/Tmc2</em> knockout mice induced PS externalization. Lastly, we demonstrated that expression of a dominant mutation in <em>Tmc1</em> evoked constitutive PS externalization, while a recessive mutation eliminated PS externalization. Our data suggest that disruption of sensory transduction may lead to dysregulation of membrane homeostasis in hair cells and thus may contribute to auditory dysfunction in mice and humans.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109229"},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in auditory function of the desert locust 沙漠蝗听觉功能的性别差异

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-02 DOI: 10.1016/j.heares.2025.109228

Tom T. Austin , Christian L. Thomas , Ben Warren

{"title":"Sex differences in auditory function of the desert locust","authors":"Tom T. Austin , Christian L. Thomas , Ben Warren","doi":"10.1016/j.heares.2025.109228","DOIUrl":"10.1016/j.heares.2025.109228","url":null,"abstract":"<div><div>Age-related auditory decline manifests across the animal kingdom, from humans and mice to zebrafish and insects. Sex differences in auditory decline are established for humans, but there is now evidence in mice and even zebrafish. Here, we found sex differences in auditory decline in an insect, the Desert Locust and investigated its biological basis. We profiled gene expression in a dedicated auditory organ, Müller's organ to understand the genetic underpinning of sex differences and measured sound-evoked transduction currents and electrophysiological properties of auditory neurons to quantify auditory decline. We analysed gene expression in Müller's organ of young locusts where sex differences in auditory function were absent and in older, noise-exposed locusts where sex differences in auditory function were maximal. The auditory organs of both male and females changed expression of 1200 and 931 genes, respectively, as they aged and were exposed to repeated bouts of noise exposure. Only 39 genes were differentially expressed between the sexes for young locusts and 9 for aged and noise exposed auditory organs. In young locusts we found sex-differences in genes for juvenile hormone and proteins involved in egg production and catalysis of steroid hormones. The majority of sex differences in Müller's organ manifested as a function of stress with females upregulating more and downregulating less genes compared to males. We hypothesise that sex differences in auditory decline are due to differences in immune responses and metabolic processes.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109228"},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ankyrins are dispensable for mechanotransduction by cochlear hair cells 锚蛋白对于耳蜗毛细胞的机械传导是必不可少的

IF 2.5 2区医学

Hearing Research Pub Date : 2025-03-01 DOI: 10.1016/j.heares.2025.109224

Hong Zhang, Xufeng Qiu, Jonah Mittelstadt, Ulrich Müller

引用次数: 0

NF2-related schwannomatosis: A view from within the inner ear nf2相关的神经鞘瘤病：内耳观察

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-28 DOI: 10.1016/j.heares.2025.109226

Eleanor D. Brown, Shada Nassar, Daniel J. Jagger

{"title":"NF2-related schwannomatosis: A view from within the inner ear","authors":"Eleanor D. Brown, Shada Nassar, Daniel J. Jagger","doi":"10.1016/j.heares.2025.109226","DOIUrl":"10.1016/j.heares.2025.109226","url":null,"abstract":"<div><div>NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) is an autosomal dominant disorder associated with the growth of bilateral schwannomas on the cochleo-vestibular nerves and meningiomas. NF2-SWN is caused by pathogenic variations in the <em>NF2, moesin-ezrin-radixin-like (MERLIN) tumour suppressor</em> gene. The mostly benign tumours can cause progressive sensorineural hearing loss, tinnitus and balance dysfunction. Outside the inner ear, tumours grow on other intra-cranial nerves, leading to further neurological issues and shortened life-expectancy. Here we re-evaluate some historic cases from our human temporal bone collection, and we review similar instances from the literature to highlight the structural and functional effects of such tumours on the cochlea and vestibular organs. Tumour growth is associated with the remodelling of sensory and ion-transporting epithelia, the loss of afferent neurons and hair cells, and signs of fluid dysregulation. These cases demonstrate the aggressive nature of this disease and the difficulties of surgically excising the bilateral tumours. They also emphasise the need for novel therapies that can slow or prevent tumour growth to preserve sensory function in people living with NF2-SWN.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"460 ","pages":"Article 109226"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the mind's ear: Understanding the science behind auditory processing using illusions 揭开心灵的耳朵：利用幻觉理解听觉处理背后的科学

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-25 DOI: 10.1016/j.heares.2025.109227

Anusha Yasoda-Mohan , Feifan Chen , Sven Vanneste

引用次数: 0

Frequency and level dependence of the middle ear acoustic reflex and its decay measured in wideband absorbance with contralateral narrowband noise elicitors 用对侧窄带噪声激发器测量中耳声反射的频率和水平依赖性及其衰减

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-21 DOI: 10.1016/j.heares.2025.109225

Abbie Baricevich, Danielle Bassett, Sophia Chan, Shayna Lavi, Jonathan Siegel

{"title":"Frequency and level dependence of the middle ear acoustic reflex and its decay measured in wideband absorbance with contralateral narrowband noise elicitors","authors":"Abbie Baricevich, Danielle Bassett, Sophia Chan, Shayna Lavi, Jonathan Siegel","doi":"10.1016/j.heares.2025.109225","DOIUrl":"10.1016/j.heares.2025.109225","url":null,"abstract":"<div><div>The acoustic reflex has potential as a diagnostic tool for identifying individuals with selective damage to cochlear sensory neurons (Bramhall et al., 2022; Feeney et al., 2023; Wojtczak et al., 2017). If damage to neurons is localized, then using broadband stimuli to elicit the reflex, as reported in the studies cited above, may not be most effective in revealing spatially restricted lesions. We have measured changes in absorbance with chirps delivered to one ear and contralateral narrowband noise to elicit the reflex. We aim to characterize the frequency and level dependence of changes in absorbance elicited by noise with different center frequencies as well as the decay of the reflex for prolonged elicitors as a baseline for comparison with similar measurements in individuals suspected of having neural damage. Our hypothesis is that elicitors that preferentially activate the damaged part of the reflex pathway will show the largest deviation from normal. We have identified a novel sensitization of the acoustic reflex following repeated exposure to moderate level elicitors such that absorbance changes more than double, regardless of the level of the elicitor, compared with the minimally stimulated contralateral ear. These changes recover slowly. We are measuring the growth of the reflex vs elicitor level and at constant elicitor level vs center frequency. We are also measuring the rate of reflex decay vs elicitor center frequency. Preliminary findings substantiate the measurement protocols in revealing differences between individuals and ears.</div></div>","PeriodicalId":12881,"journal":{"name":"Hearing Research","volume":"459 ","pages":"Article 109225"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the role of extended high-frequency audibility on temporal envelope processing and spatial release from masking 研究扩展高频可听性在时间包络处理和空间释放中的作用

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-21 DOI: 10.1016/j.heares.2025.109223

Chhayakanta Patro , Nirmal Kumar Srinivasan , Sadie O'Neill , Morgan Barkhouse , Srikanta Kumar Mishra

引用次数: 0

Reply to Manley: Is there more to cochlear tuning than meets the ear? 回复曼利：耳蜗调音是否比耳朵听到的更多？

IF 2.5 2区医学

Hearing Research Pub Date : 2025-02-17 DOI: 10.1016/j.heares.2025.109218

Gavin M. Bidelman

引用次数: 0