Hearing restoration through hair cell regeneration: A review of recent advancements and current limitations

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research Pub Date : 2025-03-22 DOI:10.1016/j.heares.2025.109256

Melissa M. McGovern , Brandon C. Cox

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引用次数: 0

Abstract

Hearing loss is extremely common, yet limited treatment options are available to restore hearing, and those that are available provide incomplete recovery of hearing detection. For patients who are born with normal hearing, the most common cause of hearing loss is the loss of the sensory hair cells located in the cochlea of the inner ear. Non-mammals, including birds, fish, and amphibians, naturally regenerate new hair cells after damage and this natural process results in functional recovery. While some limited hair cell regeneration also occurs in the immature cochlea of mice, the mature mammalian cochlea does not naturally produce replacement hair cells, and thus hearing loss is permanent. Since the late 1980s, researchers have been investigating mechanisms to convert supporting cells, the cells that remain once hair cells have been killed, into new replacement hair cells. Here we review the current status of hair cell regeneration in the adult cochlea, highlighting recent achievements, as well as challenges that have yet to be resolved.

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通过毛细胞再生恢复听力：回顾最近的进展和当前的局限性

听力损失是非常普遍的，然而，用于恢复听力的治疗方案有限，而那些可用的治疗方案提供了听力检测的不完全恢复。对于天生听力正常的患者来说，听力损失最常见的原因是位于内耳耳蜗的感觉毛细胞的损失。非哺乳动物，包括鸟类、鱼类和两栖动物，在受损后会自然地再生新的毛细胞，这一自然过程会导致功能恢复。虽然一些有限的毛细胞再生也发生在小鼠的未成熟耳蜗中，但成熟的哺乳动物耳蜗不会自然产生替代毛细胞，因此听力损失是永久性的。自20世纪80年代末以来，研究人员一直在研究将支持细胞（毛细胞被杀死后留下的细胞）转化为新的替代毛细胞的机制。在这里，我们回顾了成人耳蜗毛细胞再生的现状，突出了最近的成就，以及尚未解决的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hearing Research 医学-耳鼻喉科学

CiteScore

5.30

自引率

14.30%

发文量

163

审稿时长

75 days

期刊介绍： The aim of the journal is to provide a forum for papers concerned with basic peripheral and central auditory mechanisms. Emphasis is on experimental and clinical studies, but theoretical and methodological papers will also be considered. The journal publishes original research papers, review and mini- review articles, rapid communications, method/protocol and perspective articles. Papers submitted should deal with auditory anatomy, physiology, psychophysics, imaging, modeling and behavioural studies in animals and humans, as well as hearing aids and cochlear implants. Papers dealing with the vestibular system are also considered for publication. Papers on comparative aspects of hearing and on effects of drugs and environmental contaminants on hearing function will also be considered. Clinical papers will be accepted when they contribute to the understanding of normal and pathological hearing functions.