Hellenic journal of nuclear medicine最新文献

{"title":"¹⁸F-FDG PET radiomics for predicting progression-free survival in locally advanced cervical squamous cell carcinoma.","authors":"Dinghua Pang, Shilai Zhang, Hong Yang, Kaili Liang, Ziya Liu, Zhi Yang, Chang Yan, Hongjiao Wei, Hai Liao, Guoyou Xiao","doi":"10.1967/s002449912906","DOIUrl":"10.1967/s002449912906","url":null,"abstract":"<p><strong>Objective: </strong>To develop a fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) radiomics-based nomogram model for predicting progression-free survival (PFS) in locally advanced cervical squamous cell carcinoma (LACSC) patients undergoing concurrent chemoradiotherapy (CCRT).</p><p><strong>Subjects and methods: </strong>A retrospective study included 241 LACSC patients treated with CCRT, divided into training (n=168) and validation (n=73) sets. Lesion segmentation, radiomics feature extraction and screening were performed on ¹⁸F-FDG PET images of each patient, and radiomics scores (Rad-scores) were calculated.Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors and create a combined model and nomogram. Predictive performance was assessed using time-dependent receiver operating characteristic (ROC) curves, area under the curve (AUC), and consistency index (C-index). Calibration curves evaluated nomogram accuracy, and decision curve analysis (DCA) assessed nomogram clinical applicability.</p><p><strong>Results: </strong>The Rad-score calculated from five optimal radiomics features and FIGO stage were independent predictors of PFS in LACSC patients.The C-index values for the FIGO stage, Rad-score, and combined model were 0.586, 0.692, and 0.727 in the training set, and 0.612, 0.668, and 0.698 in the validation set, respectively. The combined model showed excellent predictive ability for PFS at 12, 18, and 24 months, with training set AUCs of 0.805, 0.738, and 0.719, and validation set AUCs of 0.670, 0.744, and 0.741, respectively. The calibration curves confirmed a good agreement between predicted and actual progression probabilities, with DCA revealing significant clinical net benefits.</p><p><strong>Conclusion: </strong>The ¹⁸F-FDG PET radiomics-based nomogram effectively predicted PFS in LACSC patients and could support individualized treatment decisions and accurate prognostic evaluations.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"232-245"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration and practice of undergraduate teachingre form of Nuclear Medicine guided by OBE concept under the background of New Medicine.","authors":"Ning Li, Hai Liao, Meishe Gan, Hua Chai, Bingqing Qiu, Guangxing Liao, Hongjiao Wei, Jianyun Fang, Guoyou Xiao, Zhi Yang","doi":"10.1967/s002449912900","DOIUrl":"10.1967/s002449912900","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the relationship between fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) and ultrasound breast imaging reporting and data system (BI-RADS) classification, and to evaluate the diagnostic value of their combined application in breast diseases.</p><p><strong>Subjects and methods: </strong>A retrospective analysis was conducted on the ¹⁸F-FDG PET/CT images and ultrasound BI-RADS classification data of 110 patients with suspected breast cancer treated at our hospital from July 2020 to May 2022. Pearson correlation analysis was used to assess the relationship between the maximum standardized uptake value (SUVmax) and BI-RADS classification. Using pathology or long-term follow-up results as the \"gold standard,\" the diagnostic value of ¹⁸F-FDG PET/CT, ultrasound BI-RADS classification, and their combined application in breast diseases was analyzed.</p><p><strong>Results: </strong>Based on the \"gold standard\" of pathology or long-term follow-up, of the 110 patients with suspected breast cancer, 49 were benign, and 61 were malignant. The SUVmax levels of malignant lesions were significantly higher than those of benign lesions (P<0.05). Pearson correlation analysis indicated a low correlation between SUVmax and ultrasound BI-RADS classification (r=0.458, P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of the combined application of SUVmax and ultrasound BI-RADS classification was higher than that of either method alone, both for breast tumors and for patients classified as BI-RADS category 3 to 4.</p><p><strong>Conclusion: </strong>The correlation between SUVmax and ultrasound BI-RADS classification is low (r=0.458), indicating that these two methods assess different biological aspects of breast tumors. However, the combined use of SUVmax and BI-RADS classification significantly enhances diagnostic accuracy, particularly for patients with BI-RADS 3 to 4 lesions. Although this combination improves diagnostic efficacy, ¹⁸F-FDG PET/CT should not be used as a primary screening tool but rather as a complementary method in specific clinical scenarios where imaging findings are inconclusive or suspicion of malignancy is high.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"190-195"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of myocardial blood flow SPECT imagingwith ²⁰¹Tl with guidelines.","authors":"Tomoyasu Sakuma, Yoshiyuki Takahashi, Ryosuke Miki, Hodaka Nakagiri, Takahiro Minamoto, Kazuhiro Kitajima, Koichiro Yamakado","doi":"10.1967/s002449912903","DOIUrl":"10.1967/s002449912903","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we compared myocardial blood flow single photon emission computed tomography (SPECT) using technetium-99m (^99mTc) and thalium-201 (²⁰¹Tl) preparations.</p><p><strong>Materials and methods: </strong>An the EMIT phantom was used to confirm that the ^99mTc formulation met the criteria of the \"myocardial blood flow SPECT standardization guidelines\", and ²⁰¹Tl formulation was imaging performed under the same conditions.</p><p><strong>Results: </strong>In the physical evaluation, no significant differences were found in differential homogeneity and % counts. However, in the evaluation using the RH-2 phantom, increasing the ²⁰¹Tl concentration from 2% to 4% decreased the difference from the ^99mTc preparation in the bull's eye display.</p><p><strong>Conclusion: </strong>The lack of differences in physical and visual evaluations despite different collection energies and doses may be because the number of gates and matrix size remained constant. These results suggest that imaging conditions that meet the criteria for ^99mTc formulations can be applied to ²⁰¹Tl formulations.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"212-217"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET based intratumoral and peritumoral explainable radiomics for predicting cervical cancer prognosis: A multi-center retrospective study.","authors":"Ruihe Lai, Dandan Sheng, Yuzhi Geng, Chongyang Ding, Tingting Tang, Zhengyang Zhou","doi":"10.1967/s002449912907","DOIUrl":"10.1967/s002449912907","url":null,"abstract":"<p><strong>Objective: </strong>Prognosis evaluation in cervical cancer is crucial for treatment decisions. This study aims to develop and validate a combined model using positron emission tomography (PET)-derived intratumoral and peritumoral radiomic parameters to predict cervical cancer prognosis based on the Shapley additive explanations (SHAP) method.</p><p><strong>Subjects and methods: </strong>A retrospective cohort of 114 patients with cervical cancer from two institutions was used, with one institution's data designated for training and the other for testing. Semi-automatic segmentation of fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET images was performed to delineate the primary intratumoral and peritumoral regions, defined by expanding the tumor boundary by 2mm, 4mm, 6mm, and 8mm. Radiomic features were extracted from each region. Six machine learning algorithms were employed to construct intratumoral and peritumoral radiomic models, with the optimal model selected based on performance evaluated through receiver operating characteristic (ROC) and calibration curves. Area under the curve (AUC) values were compared using the DeLong test. The SHAP method was used to identify the key features influencing prognosis.</p><p><strong>Results: </strong>Among the intratumoral and peritumoral radiomic models, the Gradient Boosting Machine (GBM) algorithm showed superior performance. The 4mm peritumoral model exhibited the best performance among the four peritumoral models, with a testing AUC of 0.762 (95% CI: 0.582-0.944). The integrated model combining the intratumoral and 4mm peritumoral regions emerged as the optimal radiomic model for predicting cervical cancer prognosis, achieving the highest AUC of 0.954 (95% CI: 0.882-1.000) in the testing set. At the patient level, SHAP force plots provided valuable insights into the combined model's predictive ability for prognosis.</p><p><strong>Conclusion: </strong>The integrated radiomic model, particularly for the 4mm peritumoral region, was validated as the optimal approach for predicting overall survival in cervical cancer. The application of the SHAP method enhanced interpretability, allowing for the identification of key features influencing prognosis and offering transparent insights for guiding personalized treatment strategies.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"246-255"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of serum vitamin D levels in patients with diabetic polyneuropathy using radioimmunoassay method.","authors":"Anastasia Pistola, Evangelos Karathanos, Theocharis Konstantinidis, Dimitrios Papazoglou, Christina Tsigalou, Athanasios Zissimopoulos","doi":"10.1967/s002449912800","DOIUrl":"10.1967/s002449912800","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic polyneuropathy (DPN) is a common and disabling complication of type 2 diabetes mellitus (T2DM). Vitamin D deficiency has been implicated as a potential modifiable risk factor. This study aimed to investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and DPN using the radioimmunoassay (RIA) method.</p><p><strong>Subjects and methods: </strong>One hundred twenty T2DM patients (80 with DPN and 40 without neuropathy) have been enrolled, while 40 healthy volunteers served as group control. Neuropathy diagnosis was based on clinical assessment (through Michigan neuropathy screening instrument (MNSI) - both questionnaire and examination) and nerve conduction studies. Serum 25(OH)D levels were quantified using RIA.</p><p><strong>Results: </strong>Vitamin D levels were significantly lower in DPN patients (mean 13.2ng/mL) compared to diabetic (18.3ng/mL) and healthy controls (31.2ng/mL, P<0.001). Vitamin D deficiency (<10ng/mL) was found in 72.5% of DPN patients. Apart from severe neuropathy, other factors (age, body mass index -BMI- and HbA1c) have all been mildly inversely correlated to Vitamin D levels.</p><p><strong>Conclusion: </strong>Vitamin D deficiency is significantly associated with the presence and severity of DPN. These findings support the clinical value of assessing and potentially improving vitamin D status in diabetic patients, particularly in those with severe neuropathy.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"90-95"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of radiation on living beings.","authors":"Andreas Otte","doi":"10.1967/s002449912805","DOIUrl":"10.1967/s002449912805","url":null,"abstract":"<p><p>This overview covers the effects of radiation on living organisms, including risks and legal requirements. It defines basic radiation terms, such as ionization, activity, energy dose, or equivalent dose, and explains direct and indirect radiation effects. It also lists foods that should be avoided after a reactor accident, including the topic of iodine prophylaxis.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"145-148"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of PET/CT uptake in the salivary glands in T1N0M0-T2N0M0 glottic cancer.","authors":"Yukinori Okada, Tatsuhiko Zama, Tomohiro Itonaga, Ryuji Mikami, Mtsuru Okubo, Shinji Sugahara, Shiho Wada, Masumi Kawaguchi, Tsubasa Kawamoto, Masanori Ishida, Motoki Nakai, Koichiro Abe, Mana Yoshimura, Takashi Kodama, Masahiko Kurooka, Kazuhiro Saito","doi":"10.1967/s002449912812","DOIUrl":"https://doi.org/10.1967/s002449912812","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify factors influencing salivary gland uptake in fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT).</p><p><strong>Subjects and methods: </strong>We retrospectively reviewed patients aged 20-95 years diagnosed with T1N0M0 or T2N0M0 glottic carcinoma between July 2019 and March 2025, who underwent PET/CT for initial staging and radiotherapy planning. Maximum standardized uptake value (SUVmax) and total lesion glycolysis (TLG) were measured and compared based on gender, smoking history, hypertension, diabetes mellitus, dyslipidemia, stage, and primary tumor site.</p><p><strong>Results: </strong>A total of 61 patients were included (mean age, 68.3±12.4 years; 57 male, 4 female). The cohort included 41 patients with T1N0M0 and 20 with T2N0M0 disease. Hypertension status was negative in 32, positive in 28, and unknown in 1; diabetes status was negative in 54, positive in 6, and unknown in 1; dyslipidemia status was negative in 51, positive in 9, and unknown in 1. Smoking history was negative in 7, positive in 53, and unknown in 1. Primary tumor accumulation was observed in 44 patients, while 17 showed no uptake at the primary site. The mean SUVmax of the right submandibular gland was 3.16±0.70 on the left, it was 3.05±0.76. In the right gland, median SUVmax was significantly higher in patients without hypertension 3.350 than in those with hypertension 2.725; P<0.01). In the left gland, median SUVmax was significantly higher in patients without hypertension 3.18 than in those with hypertension 2.56; P<0.01.</p><p><strong>Conclusion: </strong>In T1N0M0-T2N0M0 glottic carcinoma, ¹⁸F-FDG uptake in the submandibular glands is reduced in patients with hypertension.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"28 2","pages":"137-144"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric signet ring cell carcinoma with ureteral metastasis as the first manifestation detected by ⁶⁸Ga-FAPI PET/CT.","authors":"Yuhong Liu, Jia Deng, Yue Chen, Huipan Liu, Jianwen Zhang","doi":"10.1967/s002449912811","DOIUrl":"10.1967/s002449912811","url":null,"abstract":"<p><p></p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"183-184"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of ²²⁵Ac-PSMA RLT targeted therapy for metastatic castration-resistant prostate cancer: A systematic review and meta-analysis.","authors":"Huajun Liu, Ma Jiao, Junzheng Wang, Chunyin Zhang","doi":"10.1967/s002449912806","DOIUrl":"10.1967/s002449912806","url":null,"abstract":"<p><strong>Objective: </strong>Using radiolabeled prostate-specific membrane antigen (PSMA) ligands for the treatment of metastatic prostate cancer is a promising therapeutic approach. This systematic review and meta-analysis aims to assess the efficacy and safety of actinium-225 (²²⁵Ac)-PSMA radioligand therapy (RLT) for prostate cancer.</p><p><strong>Materials and methods: </strong>The systematic review and meta-analysis adheres to the preferred reporting items for systematic reviews and meta-analyses (PRISMA). Searches were conducted in databases including PubMed, Web of Science, Medline, CNKI, and VIP, for studies related to ²²⁵Ac-PSMA RLT for prostate cancer from inception until April 2024. The primary endpoint was the therapeutic effect as measured by post-treatment biochemical response evaluation criteria, while secondary endpoints included evaluating overall survival (OS), progression-free survival (PFS), molecular responses.</p><p><strong>Results: </strong>A total of 17 studies involving 1042 patients were included. The pooled proportion of patients with PSA reduction was 85% (95% confidence interval [CI]: 80%-91%), and the pooled rate of PSA reduction >50% was 66% (95% CI: 58%-75%). The combined values for OS and PFS were 13.79 months (95% CI: 11.11-16.48 months) and 9.67 months (95% CI: 6.99-12.35 months), respectively. The molecular response rate was 71% (95% CI: 56-87%). The most common side effect of ²²⁵Ac-PSMA RLT was xerostomia, accounting for 63.5%. Anemia, leukopenia, thrombocytopenia, and renal toxicity were observed in 54.3%, 30.4%, 31.8%, 32.0%, respectively.</p><p><strong>Conclusion: </strong>Actinium-225 -PSMA RLT is an effective and safe treatment for metastatic castration-resistant prostate cancer (mCRPC) patients, with a low incidence of treatment-related adverse reactions. Additionally, a history of lutetium-177 (¹⁷⁷Lu) treatment may have an impact on PSA reduction in mCRPC patients.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"149-167"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the diagnostic value of ¹⁸F-FDG PET/CT imaging and integrated PET/MR imaging in pediatric tumors.","authors":"Xuemei Sun, Jiahe Gu","doi":"10.1967/s002449912804","DOIUrl":"10.1967/s002449912804","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and compare the diagnostic value of fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging and integrated PET/magnetic resonance imaging (MR) in pediatric tumors.</p><p><strong>Subjects and methods: </strong>A retrospective analysis was conducted on the clinical data of 61 pediatric patients with malignant tumors admitted to our hospital from September 2022 to December 2023. All patients underwent pathological examinations as well as ¹⁸F-FDG PET/CT and integrated PET/MR imaging. The pathological diagnosis results were used as the gold standard. Pearson correlation analysis, Bland-Altman analysis, and t-tests were used to compare the maximum standardized uptake value (SUVmax), signal-to-noise ratio (SNR), and target-to-background ratio (T/B) between the two methods. Chi-square tests were employed to compare the diagnostic efficacy differences of each index.</p><p><strong>Results: </strong>Among the 61 pediatric malignant tumor patients, a total of 417 lesions were detected, of which 363 lesions showed high uptake on both PET/MR and PET/CT. Among the remaining 54 PET-negative lesions, 9 were CT-positive but MR-negative, including 6 in the lungs and 3 in the vertebrae, while 12 lesions were MR-positive but CT-negative, including 5 in the liver, 4 in the brain, and 3 in the breasts. No statistically significant difference was found in the PET positivity rate or diagnostic results between the two devices (P<0.05). Bland-Altman analysis showed that the background uptake of PET/MR images was lower than that of PET/CT, and the SNR was higher (P<0.05); the SUVmax of the lesions on PET/MR was higher than that on PET/CT (P<0.05); the T/B value of PET/MR images was higher than that of PET/CT (P<0.05). In terms of correlation, the SUVmax, SNR, and T/B values between PET/MR and PET/CT were positively correlated (r=0.919, 0.507, 0.698, P<0.05).</p><p><strong>Conclusion: </strong>In the diagnosis of pediatric malignant tumors, PET/MR and PET/CT have relatively consistent lesion detection rates. PET/MR images have a higher SNR and better resolution, making them more advantageous than PET/CT for evaluating lesions in the liver, brain, and other soft tissue organs, thus warranting clinical application.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"131-136"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}