Hellenic journal of nuclear medicine最新文献

{"title":"Genetic predisposition in gynecologic cancers: From knowledge to clinical management.","authors":"Maria Satra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Genetic predisposition contributes significantly to the development of specific gynecologic cancers, particularly ovarian and endometrial malignancies. Germline pathogenic variants in BRCA1 and BRCA2 genes account for a considerable proportion of hereditary ovarian cancer cases, while mismatch repair gene alterations underlie Lynch syndrome, strongly associated with endometrial cancer. Current international guidelines recommend universal genetic testing for all patients with ovarian cancer and systematic screening for mismatch repair deficiency in endometrial tumors. These molecular alterations directly impact therapeutic decisions, including the use of poly (ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors, while enabling preventive strategies through cascade testing in relatives. The integration of genetic data with nuclear medicine imaging enhances disease characterization and treatment monitoring. Multidisciplinary collaboration is essential for the effective implementation of precision medicine in gynecologic oncology.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"81-83"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide receptor radionuclide therapy with ¹⁷⁷Lu-DOTATATE: A retrospective evaluation of the experience at the Department of Nuclear Medicine at Theageneio Cancer Hospital.","authors":"Ioannis Kitsatis","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this retrospective study was to evaluate the clinical characteristics, treatment response and toxicity profile of patients treated withpeptide receptor radionuclidetherapy (PRRT) using ¹⁷⁷Lu-DOTATATE at the Department of Nuclear Medicine at Theageneio Cancer Hospital.</p><p><strong>Materials and methods: </strong>Forty-nine patients with advanced somatostatin receptor-positive neuroendocrine tumors (NETs) and related neoplasms underwent treatment with ¹⁷⁷Lu-DOTATATE between January 2022 and January 2026. Demographic, clinical, imaging and therapeutic data were retrospectively analyzed. Response assessment was performed according to RECIST 1.1 criteria. Toxicity evaluation included hematologic, renal and hepatic adverse effects.</p><p><strong>Results: </strong>Pancreatic and small intestine NETs represented the most common primarytumors. Liver, lymph node and bone metastases were the predominant metastaticsites. Disease control was achieved in 81.3% of patients, with partial response observed in 27.1% and stable disease in 54.2% of patients, and most individuals completed the planned four treatment cycles. Hematologic toxicity was recorded in a minority of eight cases, while severe renal or hepatic toxicity remained uncommon.</p><p><strong>Conclusion: </strong>PRRT with ¹⁷⁷Lu-DOTATATE appears to be an effective and generally well-tolerated therapeutic option in patients with advanced NETs, providing high disease control rates with acceptable toxicity.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"118-129"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models for predicting microvascular invasion in hepatocellular carcinoma with three-dimensional whole-lesion ¹⁸F-FDG PET radiomics.","authors":"Hong Yang, Dinghua Pang, Shilai Zhang, Zhi Yang, Meishe Gan, Linlin Wei, Ning Li, Hongjiao Wei, Guoyou Xiao, Hai Liao","doi":"10.1967/s002449912942","DOIUrl":"10.1967/s002449912942","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the performance of machine learning models based on preoperative three-dimensional whole-lesion radiomics features for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC).</p><p><strong>Subjects and methods: </strong>This retrospective study included 106 individuals who underwent preoperative fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) and were pathologically diagnosed with HCC at Guangxi Medical University Cancer Hospital between January 2018 and December 2023. Individuals were randomly assigned to training (n=74) and validation (n=32) sets. A total of 2,016 radiomic features were extracted from three-dimensional whole-lesion PET images. Least absolute shrinkage and selection operator regression combined with recursive feature elimination identified the optimal feature subset. Logistic regression (LR), Light Gradient Boosting Machine (LightGBM), and multilayer perceptron (MLP) models were developed. Model performance in the validation set was evaluated using precision, area under the receiver operating characteristic curve (AUC), and F1-score.</p><p><strong>Results: </strong>Six key radiomic features were selected. In the validation set, the LR model achieved an AUC of 0.703, precision of 0.750, and F1-score of 0.765; the LightGBM model achieved an AUC of 0.654, precision of 0.688, and F1-score of 0.687; and the MLP model achieved an AUC of 0.629, precision of 0.625, and F1-score of 0.625.</p><p><strong>Conclusion: </strong>The LR model demonstrates the best overall performance and shows promise for noninvasive preoperative MVI assessment.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"16-25"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant primary hepatic osteosarcoma: A rare case report and review of the literature.","authors":"Haoliang Zhu, Hangzhe Sun, Tianyun Zhang, Yu Chen, Siqi Wang","doi":"10.1967/s002449912946","DOIUrl":"10.1967/s002449912946","url":null,"abstract":"<p><strong>Objective: </strong>Primary hepatic extraskeletal osteosarcoma (PHOS) is an extremely rare and aggressive malignant tumor originating in the liver with no primary skeletal lesion. Less than 1% of all extraskeletal osteosarcomas occur in the liver, often presenting as a large abdominal mass with poor prognosis.</p><p><strong>Case presentation: </strong>We report a rare case of a 64-year-old man diagnosed with a giant PHOS (163×128×160mm) accompanied by pulmonary and lymph node metastases. Multimodal imaging magnetic resonance imaging (MRI), computed tomography (CT), bone scintigraphy, positron emission tomography (PET)/CT demonstrated a heterogeneous hepatic mass with extensive calcifications, rim enhancement, restricted diffusion, and elevated fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) uptake. Histopathological analysis confirmed the diagnosis, showing atypical mesenchymal cells producing osteoid matrix with strong special AT-rich sequence-binding protein 2 (SATB2) positivity and negative epithelial markers.</p><p><strong>Discussion: </strong>Imaging characteristics and immunohistochemical profiling were crucial in differentiating PHOS from hepatocellular carcinoma and metastatic osteosarcoma. The case supports the metaplasia theory of PHOS pathogenesis and highlights its radiologic-pathologic correlation, especially the \"cloud-like\" enhancement on imaging corresponding to unmineralized osteoid and vascular proliferation.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic challenge and clinical significance of PHOS. Comprehensive imaging and pathological evaluation are essential for accurate diagnosis. Due to its rarity and aggressiveness, PHOS requires individualized management strategies, typically involving surgery and adjuvant therapies despite limited evidence-based guidelines.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"42-47"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/CT in Staging, Response Assessment, and Restaging of Lung Cancer: Emerging Advances in Molecular Imaging and Their Clinical Implications.","authors":"N Kapsoritakis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Text in Greek.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"135-139"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/CT in Lymphomas: Current clinical applications and future directions.","authors":"Anna Paschali, Despoina Iakovoglou, Theodoros Kalathas, Vasiliki Chatzipvlidou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>¹⁸F-FDG PET/CT imaging has transformed the way lymphoma patients are managed, playing a pivotal role in diagnosis, staging, prognostication, and treatment response evaluation. PET/CT guided treatment is a reality in HL, having spared patients from unnecessary toxicities while maximizing responses. Advancements in imaging technology and methodologies, along with the development of artificial intelligence, are expected to revolutionize the evaluation of complex imaging data, enhancing the diagnostic and predictive power of PET in lymphoma.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"62-69"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioembolization (Selective Internal Radiation Therapy-SIRT). Changes in clinical practice, points of our experience.","authors":"T Spyridonidis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radioembolization (SIRT) was initially introduced in the early 21^st century as a whole-liver, primarily palliative treatment, for hepatocellular carcinoma (HCC) and liver metastatic colorectal cancer (mCRC). Over time, its application expanded to include other primary and secondary liver tumors. Clinical experience and emerging studies have demonstrated a clear relationship between higher tumor-absorbed radiation doses and improved tumor response. Such dose escalation can be achieved through advanced, more precise, and synchronous dosimetric approaches (personalized dosimetry), or in selected cases, through targeted treatments such as segmentectomy or lobectomy. These strategies have been associated with improved survival outcomes and, in certain cases, have enabled a shift toward curative treatment intent.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"87-91"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double myocardial bridge causing acute myocardial infarction in a premenopausal woman.","authors":"Varvara Valotassiou, Vasilios Dimopoulos, George Angelidis, Emmanouil Panagiotidis, Dimitrios Psimadas, John Skoularigis, Panagiotis Georgoulias","doi":"10.1967/s002449912945","DOIUrl":"10.1967/s002449912945","url":null,"abstract":"<p><p>Myocardial bridging is a congenital abnormality which is characterized by an intramuscular course of a segment of the coronary artery. The presence of myocardial bridging influences coronary vasculature due to mechanical compression and systolic milking. The symptoms and complications of myocardial bridging depend on the number and depth of the tunneled artery segments, the grade of systolic narrowing and the heart rate, and include myocardial ischemia, coronary spasm or acute coronary syndrome. Dual myocardial bridges are rare. We present a case of an acute myocardial infarction in a premenopausal woman due to double myocardial bridging which was identified on coronary angiography. Myocardial perfusion single photon emission tomography (SPECT) was performed for the evaluation of infarct size and residual ischemia.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"39-41"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative review of contemporary guidelines for differentiated thyroid cancer management.","authors":"Panos Charalambous, Socratis Gourgiotis, Evanthia Giannoula","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical practice guidelines are indispensable tools for evidence-based decision-making, yet they are not inherently free of subjectivity and cannot replace clinical expertise or critical judgment. This is particularly relevant in differentiated thyroid cancer, where disease heterogeneity, overdiagnosis of low-risk tumors, and variability among available recommendations often complicate management, especially in relation to postoperative radioiodine administration. This review critically appraises contemporary guideline documents relevant to differentiated thyroid cancer, with emphasis on their evidence base, practical applicability, and implications for nuclear medicine practice. Major European recommendations from ESMO, ETA, and SNMMI/EANM were compared with the 2025 American Thyroid Association guidelines, focusing on risk stratification, radioiodine use, molecular testing, surveillance, and multidisciplinary implementation. Real-world applicability was also considered in light of published comparative analyses. Across the reviewed documents, a clear trend toward individualized, risk-adapted management was observed. Routine radioiodine ablation is increasingly discouraged in low-risk disease, while selective use is recommended in intermediate-risk patients and retained in high-risk settings. Dynamic reassessment, structured follow-up with ultrasound and thyroglobulin monitoring, and incorporation of molecular markers are now integral components of modern management frameworks. However, differences in terminology, structure, and implementation persist between European and American guidance. Overall, contemporary guidelines support a precision medicine approach to differentiated thyroid cancer while underscoring the need for contextual interpretation and critical appraisal. European recommendations offer a practical framework for everyday clinical use, whereas ATA 2025 contributes methodological refinement through dynamic reassessment. The findings highlight the importance of combining evidence-based recommendations with physician judgment to optimize individualized patient care.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"29 Suppl ","pages":"99-108"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the impact of reconstruction algorithms on Deauville scoring in digital PET/CT.","authors":"Jiayi Chen","doi":"10.1967/s002449912951","DOIUrl":"10.1967/s002449912951","url":null,"abstract":"","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"58"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}