Hellenic journal of nuclear medicine最新文献

{"title":"Head-to-head comparison of ¹⁸F-FDG versus ¹⁸F-FAPI-74 PET in radioactive-iodine refractory differentiated thyroid cancer patients.","authors":"Panayiotis Hadjitheodorou, Wolfgang Roll, Emmanouil Alevroudis, Kyriaki Kyrou, Giorgos Adamou, Andreas Fesas, Mohammad Reza Pourkhessalian, Charalambia Kalogirou, Ioannis Tsechelidis, Alexis Vrachimis","doi":"10.1967/s002449912780","DOIUrl":"https://doi.org/10.1967/s002449912780","url":null,"abstract":"<p><strong>Objective: </strong>Fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) was reported to outperform fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET/CT in thyroid cancer in heterogenous patient collectives. This interim analysis of a prospective study aims to determine whether ¹⁸F-FAPI-74 is superior to ¹⁸F-FDG PET/CT in the distinct subgroup of radioactive-iodine (RAI)-refractory differentiated thyroid cancer (DTC).</p><p><strong>Subjects and methods: </strong>Ten patients with recurrent DTC, detected by elevated thyroglobulin, negative RAI-scan after thyroidectomy and RAI-therapy were prospectively included. All patients underwent ¹⁸F-FAPI-74 and ¹⁸F-FDG PET/CT. The diagnostic performances were compared on a per-patient and per-lesion basis.</p><p><strong>Results: </strong>Fluorine-18-FAPI-74 PET/CT missed tumour recurrence in one patient. Fluorine-18-FDG PET/CT revealed more metastases in three patients. No management change following ¹⁸F-FAPI-74 PET/CT was documented. On a per-lesion analysis, the quantitative uptake values were significantly higher for ¹⁸F-FDG than ¹⁸F-FAPI-74 in all metastases (¹⁸F-FDG: median tumor to background ratio-TBRmax: 3.05 (1.02-9.55), ¹⁸F-FAPI-74: median TBRmax: 1.09 (0.38-5.09); P<0.001) (¹⁸F-FDG: median TBRmean: 1.71 (0.65-11.53), ¹⁸F-FAPI-74: median TBRmean: 0.64 (0.24-3.20). The detection rate was significantly higher for ¹⁸F-FDG (29/71) compared to ¹⁸F-FAPI-74 PET/CT (13/71, P<0.001).</p><p><strong>Conclusion: </strong>Fluorine-18-FDG-PET/CT outperforms ¹⁸F-FAPI-74 PET/CT in RAI-refractory DTC in this prospective analysis.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applied research on the diagnostic value of ¹⁸F-FDG PET/CT in different subtypes mantle cell lymphoma.","authors":"Yixuan Ren, Jiamin Chen, Chao Wang, Xiaozhu Lin, Shu Cheng, Xufeng Jiang, Dongxu Chen","doi":"10.1967/s002449912785","DOIUrl":"https://doi.org/10.1967/s002449912785","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the diagnostic value of fluorine-18-fluoro-deoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application in distinguishing between the classic and aggressive variants of MCL.</p><p><strong>Subjects and methods: </strong>Retrospective analysis was performed on the ¹⁸F-FDG PET/CT imaging, clinical, and pathological data of 134 newly diagnosed MCL patients confirmed by pathology.</p><p><strong>Results: </strong>Among the 134 patients, 97.8% had increased ¹⁸F-FDG uptake in lymph nodes, and 88.8% had increased ¹⁸F-FDG uptake in extranodal tissues or organs. In the diagnosis of bone marrow infiltration in MCL patients, ¹⁸F-FDG PET/CT has demonstrated a high specificity rate of 86.4% and a limited sensitivity rate of 43.9%. Fluorine-18-FDG PET/CT performs well in diagnosing gastric and intestinal infiltration, with high accuracies of 85.0% and 91.7% respectively. The receiver operating characteristic (ROC) curve analysis revealed that a diagnostic threshold of maximum standardized uptake value (SUVmax) at 10.4 effectively distinguished between the classic and aggressive variants of MCL, achieving a sensitivity of 68.0%, a specificity of 80.7%, and an accuracy of 79.1%, with an area under the curve (AUC) value of 0.771.</p><p><strong>Conclusion: </strong>Fluorine-18-FDG PET/CT has a high positive detection rate in both intra-nodal and extra-nodal lesions of MCL at initial diagnosis. It exhibits high specificity and positive predictive value (PPV) in diagnosing bone marrow infiltration and possesses strong comprehensive diagnostic capabilities in gastrointestinal infiltration. Furthermore, the SUVmax can be used to distinguish between the classic and aggressive variants of MCL, and it is significantly positively correlated with the Ki-67 index, providing valuable clinical reference.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸Treatment of bone metastases of pancreatic cancer with ¹⁷⁷Lu-DOTA-IBA.","authors":"Liyi Liu, Yueqi Zhao, Huajun Liu, Chunyin Zhang","doi":"10.1967/s002449912792","DOIUrl":"https://doi.org/10.1967/s002449912792","url":null,"abstract":"","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT image of invasive hemangioma in the lumbar vertebra.","authors":"Yuhao Li, Ruxin Luo, Futao Cui, Lin Li","doi":"10.1967/s002449912791","DOIUrl":"https://doi.org/10.1967/s002449912791","url":null,"abstract":"<p><p>In the usual scenario, vertebral hemangiomas do not demonstrate heightened uptake above background on fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) scans. Here we presented a case of a positive ¹⁸F-FDG PET/CT result indicating invasive vertebral hemangioma at the L2 vertebra, with atypical CT imaging features of heterogeneous increased density and multiple patchy density shadows. Our case underscores an additional uncommon aspect of invasive vertebral hemangioma imaging, warranting consideration in the differential diagnosis when encountering analogous findings on ¹⁸F-FDG PET/CT.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of multiparametric prostate MRI and ⁶⁸Ga-PSMA PET/MRI with radical prostatectomy specimens in prostate cancer staging.","authors":"Engin Derekoylu, Kadir Can Sahin, Goktug Kalender, Mustafa Ozkaya, Iclal Gurses, Fatih Kantarcı, Haluk Burcak Sayman, Ahmet Erozenci","doi":"10.1967/s002449912783","DOIUrl":"https://doi.org/10.1967/s002449912783","url":null,"abstract":"<p><strong>Objective: </strong>Because of low mortality rates and high treatment-related adverse effects in patients diagnosed early, active surveillance, focused treatments, and watchful waiting are currently advocated, emphasizing the importance of proper prostate cancer (Pca) staging using imaging techniques. We aimed to comparatively investigate the success rates of multiparametric prostate magnetic resonance imaging (MRI) and prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/MRI in predicting tumoral regions, seminal vesicle invasion, and extraprostatic extension.</p><p><strong>Subjects and methods: </strong>Twenty six patients with a biopsy diagnosis of prostate cancer who underwent radical prostatectomy between January 2021 and September 2022 were included in the study. Preoperative evaluation was conducted through a combination of multi-parametric (Mp)MR and PSMA PET/MRI. Findings such as tumoral regions, seminal vesicle invasion, and extra-prostatic extension in prostatectomy specimens were compared with the MpMRI and PSMA PET/MRI images.</p><p><strong>Results: </strong>Prostate cancer was present in 103 foci of a total of 156 segments. In the context of identifying the aforementioned foci, the sensitivity of MpMRI was determined to be 74.8%, coupled with a specificity of 94.3%. Similarly, the sensitivity of PSMA PET/MRI was established at 70.9%, accompanied by a specificity rate of 90.6%. In the prediction of extraprostatic extension, MpMRI exhibited a sensitivity of 33.33% alongside a specificity of 78.57%. In contrast, PSMA PET/MRI displayed a sensitivity of 25% but achieved a higher specificity of 100%. Concerning the prediction of seminal vesicle invasion, MpMRI demonstrated a sensitivity of 40% and a specificity of 95.24%. Conversely, PSMA PET/MRI yielded a sensitivity of 60%, which was slightly superior to MpMRI's sensitivity with a close specificity rate of 95.24%.</p><p><strong>Conclusion: </strong>MRI and PSMA PET/MRI are reliable methods for the local staging of prostate cancer and the prediction of tumor localization. No statistically significant advantage of either method was discerned in the course of our study.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of ¹⁸F-FDG and ⁶⁸Ga-FAPI in head and neck cancers: A systematic review and meta-analysis.","authors":"Jiao Ma, Jiayu Zhang, Ting Zhao, Jia Deng, Chunyin Zhang","doi":"10.1967/s002449912786","DOIUrl":"https://doi.org/10.1967/s002449912786","url":null,"abstract":"<p><strong>Objective: </strong>Gallium-68-labeled fibroblast activating protein inhibitor (⁶⁸Ga-FAPI) has been developed for positron emission tomography (PET) and proved to be a promising imaging agent. It has shown good diagnostic performance in the diagnosis of various solid tumors, including head and neck cancers (HNC). This study conducted a meta-analysis on the diagnostic performance of fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) and ⁶⁸Ga-FAPI in HNC, summarized the clinical evidence of ⁶⁸Ga-FAPI for HNC, and compared the diagnostic sensitivity of the two imaging agents in the primary and metastatic lesions of HNC.</p><p><strong>Materials and methods: </strong>PubMed/ Medline, Embase and Cochrane Library databases were searched from built to 31 January 2023. Studies on patients with HNC underwent paired ¹⁸F-FDG and ⁶⁸Ga-FAPI were included. Literature screening, full text review and data extraction were performed by 2 investigators. The risk of bias was examined with the QUADAS-2 tool. Meta-analysis of diagnostic test sensitivity was performed by a random-effect model and displayed by a forest plot.</p><p><strong>Results: </strong>A total of 507 studies were comprehensively retrieved, and 11 studies, 297 patients were selected for the systematic review and 9 studies for meta-analysis. Two hundred and nine patients selected for initial staging and 88 patients for recurrence. Pooled sensitivity at initial stage was conducted. Based on primary lesions, the sensitivity were ¹⁸F-FDG 0.95 (0.81-0.99) vs ⁶⁸Ga-FAPI 0.99 (0.90-1.00). For lymph node metastases, based on patients, the sensitivity were ¹⁸F-FDG 0.99 (0.77-1.00) vs ⁶⁸Ga-FAPI 0.92 (0.68-0.98); For distant metastases, based on patients, the sensitivity were ¹⁸F-FDG 0.82 (0.03-1.00) vs ⁶⁸Ga-FAPI 0.92 (0.59-0.99).</p><p><strong>Conclusion: </strong>Gallium-68-FAPI has great potential in the diagnosis of HNC and has similar diagnostic value with ¹⁸F-FDG. While there is much overlap in the performance (as measured by sensitivity) of these two agents but a trend may favor ⁶⁸Ga-FAPI over ¹⁸F-FDG for detection of primary tumor and distant metastases. Therefore, in the diagnosis and evaluation of head and neck cancers, the combination of ⁶⁸Ga-FAPI and ¹⁸F-FDG can be considered according to the individual situation.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental finding of transthyretin myocardial amyloidosis in a patient with neurological symptoms and unexplained skeletal pain on bone scintigraphy using ^99mTc-DPD: A case report.","authors":"Milos Stevic, Filip Velickovic, Tamara Andjelkovic, Nina Topic","doi":"10.1967/s002449912788","DOIUrl":"https://doi.org/10.1967/s002449912788","url":null,"abstract":"<p><p>Hereditary transthyretin amyloidosis (hATTR) is considered a rare disease. This is precisely why there are cases of undiagnosed transthyretin amyloidosis, in patients present with restrictive cardiomyopathy, with or without neurological or other symptoms. There are cases of incidental detection of hATTR in patients with cardiac or neurological symptoms using whole-body scintigraphy with diphosphonates. In this paper, we present the accidental detection of hATTR in a 65-year-old patient with neurological and cardiac symptoms, who was referred for skeletal scintigraphy with skeletally avid radiopharmaceuticals due to skeletal pain of unknown origin. Significantly increased uptake of radiopharmaceuticals in the myocardium was observed, corresponding to a Perugini score of 3, with semi-quantification of the heart/contralateral lung fixation ratio (H/CL) of 2.6 in the second hour after radiopharmaceutical application. Ultrasound of the heart was in favor of concentric cardiomyopathy. Due to the high suspicion of hATTR, a genetic test was performed, which showed a pathological mutation of the gene for transthyretin. Hereditary hTTR is probably a more common disease than reported in the literature. Using hATTR detection algorithms and raising awareness of the possible existence of this disease, timely diagnosis using scintigraphy with bone avid radiopharmaceuticals and appropriate therapy can help patients and their close relatives.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerosing liposarcoma with rib involvement detected by CT and ^99mTc-MDP bone scintigraphy: A case report and review of the literature.","authors":"Hongzheng Zhang, Hongqin Zhao, Sheng Dai","doi":"10.1967/s002449912789","DOIUrl":"https://doi.org/10.1967/s002449912789","url":null,"abstract":"<p><p>A 70-year-old male patient who presented with persistent upper abdominal pain was found to have a rare case of sclerosing liposarcoma with rib involvement. Despite the absence of significant weight loss or a history of infectious disease, elevated inflammatory markers suggested an underlying inflammatory or neoplastic process. Diagnostic imaging by computed tomography (CT) and single photon emission computed tomography (SPECT) played a critical role in identifying a soft tissue mass causing osteolytic damage to the left 9^th rib. The rapid enlargement of the lesion and the specific imaging characteristics challenged conventional detection methods. Biopsy confirmed the diagnosis of low-grade sclerosing liposarcoma. This case highlights the range of abilities of current imaging modalities in detecting certain forms of liposarcoma and emphasizes the need for a comprehensive diagnostic approach that integrates clinical findings, radiology, and pathology to accurately diagnose and manage such complex cases.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiopharmaceutical properties of hydroxyapatite smaller than 50nm produced from eggshell and labeled with ^99mTc and its biodistribution in rabbits.","authors":"Aziz Gültekin, Ayşe Uğur, Mine Sulak, Samiye Demirezen, Doğangün Yüksel","doi":"10.1967/s002449912787","DOIUrl":"https://doi.org/10.1967/s002449912787","url":null,"abstract":"<p><strong>Objective: </strong>Radiolabeling of nanoparticles has potential benefits for personalized treatments and theranostic applications, which have been on the agenda in recent years. Hydroxyapatite nanoparticles (HANP), which have a great similarity to bone tissue, stand out as a biocompatible nanoparticle. The different biodistribution properties of hydroxyapatite molecules in different nanosizes may create new opportunities for their use, especially in bone imaging and in the treatment of bone tumors. This study aims to investigate the labeling of hydroxyapatite molecules smaller than 50 nanometers obtained from eggshells with technetium-99m (^99mTc) and the in vivo distribution of this molecule in rabbits.</p><p><strong>Materials and methods: </strong>Characterization of nanohydroxyapatite particles obtained from eggshells was performed using scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and X-ray diffraction (XRD). Radiolabeling of HANP smaller than 50nm with ^99mTc radionuclide, stability of the labeled product, and biodistribution profile in rabbits were investigated.</p><p><strong>Results: </strong>The radiochemical purity of the ^99mTc-HANP was obtained as 96%. The in vitro stability of ^99mTc labeled HANP was examined for up to 12 hours and showed excellent in vitro stability for the first 4 hours in saline. Technetium-99m-HANP remained stable in vivo during the 6-hour imaging period. In quantitative analysis, ^99mTc-HANP showed accumulation in bone tissue in the second hour.</p><p><strong>Conclusion: </strong>Technetium-99m-HANP nanoradiopharmaceuticals with sizes less than 50 nanometers (20-31nm) showed high uptake in bone tissue in rabbits. Therefore, HANP can be developed as imaging radiopharmaceuticals in bone tissue and bone cancers.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of ¹⁸F-FDG PET/CT in risk assessment of Medication-related osteonecrosis of jaw.","authors":"Kazuhiro Kitajima, Kazuma Noguchi, Kuniyasu Moridera, Kyohei Yoshikawa, Kazuki Takaoka, Hiromitsu Kishimoto, Yukihisa Tamaki, Koichiro Yamakado","doi":"10.1967/s002449912782","DOIUrl":"https://doi.org/10.1967/s002449912782","url":null,"abstract":"<p><strong>Objective: </strong>The clinical utility of quantitative fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) for classification of medication-related osteonecrosis of the jaw (MRONJ) was determined.</p><p><strong>Subjects and methods: </strong>Seventy-one lesions in 59 patients clinically diagnosed as MRONJ, based on American Association of Oral and Maxillofacial Surgeons (AAOMS) diagnostic criteria by Japanese Society of Oral Surgery specialists and who received ¹⁸F-FDG PET/CT examinations, were enrolled. For analysis, standard uptake values (SUV), including maximum (SUVmax), peak (SUVpeak), and mean (SUVmean) were evaluated, and also metabolic lesion volume (MLV) for total volume above the threshold, and total lesion glycolysis (TLG), calculated as MLVxSUVmean. To compare quantitative values between clinical stages, one-way repeated measures analysis of variance and subsequent post-hoc analysis were used.</p><p><strong>Results: </strong>The mean SUVmax values for AAOMS stage 1 (n=13), 2 (n=43), and 3 (n=15) patients were 3.68±0.83, 6.15±1.32, and 9.92±1.63, respectively, while MLV values were 6.51±5.53, 8.76±9.74, and 13.92±13.89, respectively, and TLG values were 16.84±17.23, 31.36±35.25, and 66.27±58.51, respectively. Maximum SUV and TLG showed significant differences between clinical stages (P<0.0001 and P=0.0029, respectively). With stage increase, MLV showed a mild increasing tendency, though the difference between stages was not significant (P=0.13), while SUVmax value differences between individual stages were significant in subsequent post-hoc analysis (P<0.0001). Furthermore, post-hoc analysis indicated that the stage 3 TLG value was significantly greater than that of stage 1 and 2 (P<0.01 and P<0.05, respectively).</p><p><strong>Conclusion: </strong>For MRONJ patients, SUVmax and TLG derived from quantitative ¹⁸F-FDG PET/CT results are reliable objective indicators useful for disease activity evaluation and staging.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}