Hellenic journal of nuclear medicine最新文献

{"title":"Salivary scintigraphy as a pre-treatment diagnostic tool to predict gland dysfunction following ¹³¹I therapy.","authors":"Hui Zhu, Wei Shen, Yuan Zhu, Zhao Liu, Zhiyong Li, Xiancun Hou, Yuetao Wang","doi":"10.1967/s002449912801","DOIUrl":"10.1967/s002449912801","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether pre-treatment salivary gland scintigraphy (SGS) with technetium-99m pertechnetate (^99mTcO₄^-) can predict the risk of moderate to severe salivary gland dysfunction and xerostomia in differentiated thyroid cancer (DTC) patients following their first radioiodine-131 (¹³¹I) therapy.</p><p><strong>Subjects and methods: </strong>We retrospectively enrolled 149 DTC patients (107 females, 42 males; mean age 46.6±12.7 years) who underwent total thyroidectomy between October 2022 and March 2024. All subjects received pre-treatment SGS to measure the uptake index (UI) and excretion fraction (EF) of bilateral parotid and submandibular glands. Patients then underwent ¹³¹I therapy (1.85-5.55GBq) and repeat SGS 6-12 months later under identical conditions. Xerostomia severity was assessed using the xerostomia inventory (XI) score, categorizing patients into no/mild (XI 11-23) versus moderate-extreme xerostomia (XI 24-55).</p><p><strong>Results: </strong>Post-therapy, all glands exhibited significant declines in UI (parotid and submandibular glands, P<0.001) and EF (P≤0.004). There was no significant correlation between administered ¹³¹I dose and percentage changes in UI (ΔUI%) or EF (ΔEF). However, higher ¹³¹I doses were associated with increased rates of moderate-severe xerostomia (P=0.015) and higher mean XI scores (P=0.008). Receiver operating characteristic (ROC) analysis demonstrated that pre-treatment UI reliably predicted moderate to severe functional decline (ΔUI% >20%) with areas under the curve (AUC) of 0.866 for the right parotid, 0.793 for the left parotid, 0.769 for the right submandibular, and 0.816 for the left submandibular glands (all P<0.001). Additionally, ΔUI% in both submandibular glands differed significantly between patients with no/mild and moderate-extreme xerostomia (right: P=0.004; left: P=0.012).</p><p><strong>Conclusion: </strong>Pretreatment ^99mTcO₄^- SGS uptake index is a dependable predictor of moderate to severe salivary gland dysfunction and xerostomia following ¹³¹I therapy in DTC patients, enabling early identification of individuals at high risk and guiding tailored preventive strategies.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"96-114"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of splenic scintigraphy in the diagnosis of thoracic nodules.","authors":"Hamdi Afşin, Emine Afsin, Billur Çalışkan","doi":"10.1967/s002449912808","DOIUrl":"10.1967/s002449912808","url":null,"abstract":"<p><p>Thoracic splenosis is the presence of acquired ectopic splenic tissue within the thoracic cavity, typically following thoracoabdominal trauma or surgery. It is mostly asymptomatic and detected incidentally on radiography or tomography. A 64-year-old man was admitted with exertional dyspnea without any other respiratory complaints. The patient had a history of diabetes mellitus and hypertension and had undergone bilateral lung surgery and splenectomy due to a traffic accident 30 years ago. Thoracic computed tomograph (CT) revealed an 11x7mm nodular lesion in the posterobasal lower lobe of the left lung, multiple millimetric nodular lesions in the pleura corresponding to the left lung operation site, a focal defect in the right diaphragm, and liver herniation in this area. The diagnosis of \"thoracic splenosis\" was made by splenic scintigraphy.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"173-175"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"⁶⁸Ga-FAPI PET/CT for diagnosing multifocal head-neck and liver paragangliomas.","authors":"Jing Zhou, Longlan Chen, Ruyan Liu, Yigang Zhao","doi":"10.1967/s002449912810","DOIUrl":"10.1967/s002449912810","url":null,"abstract":"<p><p>This report presents a case of a 51-year-old woman who was admitted to our hospital with incomplete closure of the left eyelid and a crooked right corner of the mouth. She was diagnosed with multifocal head-neck and liver paragangliomas that were confirmed by pathological tests and gallium-68-fibroblast activation protein inhibitor (⁶⁸Ga-FAPI) positron emission tomography/computed tomography (PET/CT) imaging. The findings of this case suggest that ⁶⁸Ga-FAPI PET/CT may be a potential diagnostic tool for paragangliomas.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"181-182"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-head comparison of ¹⁸F-FDG versus ¹⁸F-FAPI-74 PET in radioactive-iodine refractory differentiated thyroid cancer patients.","authors":"Panayiotis Hadjitheodorou, Wolfgang Roll, Emmanouil Alevroudis, Kyriaki Kyrou, Giorgos Adamou, Andreas Fesas, Mohammad Reza Pourkhessalian, Charalambia Kalogirou, Ioannis Tsechelidis, Alexis Vrachimis","doi":"10.1967/s002449912780","DOIUrl":"10.1967/s002449912780","url":null,"abstract":"<p><strong>Objective: </strong>Fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) was reported to outperform fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET/CT in thyroid cancer in heterogenous patient collectives. This interim analysis of a prospective study aims to determine whether ¹⁸F-FAPI-74 is superior to ¹⁸F-FDG PET/CT in the distinct subgroup of radioactive-iodine (RAI)-refractory differentiated thyroid cancer (DTC).</p><p><strong>Subjects and methods: </strong>Ten patients with recurrent DTC, detected by elevated thyroglobulin, negative RAI-scan after thyroidectomy and RAI-therapy were prospectively included. All patients underwent ¹⁸F-FAPI-74 and ¹⁸F-FDG PET/CT. The diagnostic performances were compared on a per-patient and per-lesion basis.</p><p><strong>Results: </strong>Fluorine-18-FAPI-74 PET/CT missed tumour recurrence in one patient. Fluorine-18-FDG PET/CT revealed more metastases in three patients. No management change following ¹⁸F-FAPI-74 PET/CT was documented. On a per-lesion analysis, the quantitative uptake values were significantly higher for ¹⁸F-FDG than ¹⁸F-FAPI-74 in all metastases (¹⁸F-FDG: median tumor to background ratio-TBRmax: 3.05 (1.02-9.55), ¹⁸F-FAPI-74: median TBRmax: 1.09 (0.38-5.09); P<0.001) (¹⁸F-FDG: median TBRmean: 1.71 (0.65-11.53), ¹⁸F-FAPI-74: median TBRmean: 0.64 (0.24-3.20). The detection rate was significantly higher for ¹⁸F-FDG (29/71) compared to ¹⁸F-FAPI-74 PET/CT (13/71, P<0.001).</p><p><strong>Conclusion: </strong>Fluorine-18-FDG-PET/CT outperforms ¹⁸F-FAPI-74 PET/CT in RAI-refractory DTC in this prospective analysis.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"2-7"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of bone metastases of pancreatic cancer with ¹⁷⁷Lu-DOTA-IBA.","authors":"Liyi Liu, Yueqi Zhao, Huajun Liu, Chunyin Zhang","doi":"10.1967/s002449912792","DOIUrl":"10.1967/s002449912792","url":null,"abstract":"","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"83-84"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applied research on the diagnostic value of ¹⁸F-FDG PET/CT in different subtypes mantle cell lymphoma.","authors":"Antonio Rosario Pisani, Dino Rubini, Corinna Altini, Nicola Lucarelli, Angela Gaudiano, Cristina Ferrari, Giuseppe Rubini","doi":"10.1967/s002449912785","DOIUrl":"10.1967/s002449912785","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the diagnostic value of fluorine-18-fluoro-deoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application in distinguishing between the classic and aggressive variants of MCL.</p><p><strong>Subjects and methods: </strong>Retrospective analysis was performed on the ¹⁸F-FDG PET/CT imaging, clinical, and pathological data of 134 newly diagnosed MCL patients confirmed by pathology.</p><p><strong>Results: </strong>Among the 134 patients, 97.8% had increased ¹⁸F-FDG uptake in lymph nodes, and 88.8% had increased ¹⁸F-FDG uptake in extranodal tissues or organs. In the diagnosis of bone marrow infiltration in MCL patients, ¹⁸F-FDG PET/CT has demonstrated a high specificity rate of 86.4% and a limited sensitivity rate of 43.9%. Fluorine-18-FDG PET/CT performs well in diagnosing gastric and intestinal infiltration, with high accuracies of 85.0% and 91.7% respectively. The receiver operating characteristic (ROC) curve analysis revealed that a diagnostic threshold of maximum standardized uptake value (SUVmax) at 10.4 effectively distinguished between the classic and aggressive variants of MCL, achieving a sensitivity of 68.0%, a specificity of 80.7%, and an accuracy of 79.1%, with an area under the curve (AUC) value of 0.771.</p><p><strong>Conclusion: </strong>Fluorine-18-FDG PET/CT has a high positive detection rate in both intra-nodal and extra-nodal lesions of MCL at initial diagnosis. It exhibits high specificity and positive predictive value (PPV) in diagnosing bone marrow infiltration and possesses strong comprehensive diagnostic capabilities in gastrointestinal infiltration. Furthermore, the SUVmax can be used to distinguish between the classic and aggressive variants of MCL, and it is significantly positively correlated with the Ki-67 index, providing valuable clinical reference.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"36-43"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of multiparametric prostate MRI and ⁶⁸Ga-PSMA PET/MRI with radical prostatectomy specimens in prostate cancer staging.","authors":"Engin Derekoylu, Kadir Can Sahin, Goktug Kalender, Mustafa Ozkaya, Iclal Gurses, Fatih Kantarcı, Haluk Burcak Sayman, Ahmet Erozenci","doi":"10.1967/s002449912783","DOIUrl":"10.1967/s002449912783","url":null,"abstract":"<p><strong>Objective: </strong>Because of low mortality rates and high treatment-related adverse effects in patients diagnosed early, active surveillance, focused treatments, and watchful waiting are currently advocated, emphasizing the importance of proper prostate cancer (Pca) staging using imaging techniques. We aimed to comparatively investigate the success rates of multiparametric prostate magnetic resonance imaging (MRI) and prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/MRI in predicting tumoral regions, seminal vesicle invasion, and extraprostatic extension.</p><p><strong>Subjects and methods: </strong>Twenty six patients with a biopsy diagnosis of prostate cancer who underwent radical prostatectomy between January 2021 and September 2022 were included in the study. Preoperative evaluation was conducted through a combination of multi-parametric (Mp)MR and PSMA PET/MRI. Findings such as tumoral regions, seminal vesicle invasion, and extra-prostatic extension in prostatectomy specimens were compared with the MpMRI and PSMA PET/MRI images.</p><p><strong>Results: </strong>Prostate cancer was present in 103 foci of a total of 156 segments. In the context of identifying the aforementioned foci, the sensitivity of MpMRI was determined to be 74.8%, coupled with a specificity of 94.3%. Similarly, the sensitivity of PSMA PET/MRI was established at 70.9%, accompanied by a specificity rate of 90.6%. In the prediction of extraprostatic extension, MpMRI exhibited a sensitivity of 33.33% alongside a specificity of 78.57%. In contrast, PSMA PET/MRI displayed a sensitivity of 25% but achieved a higher specificity of 100%. Concerning the prediction of seminal vesicle invasion, MpMRI demonstrated a sensitivity of 40% and a specificity of 95.24%. Conversely, PSMA PET/MRI yielded a sensitivity of 60%, which was slightly superior to MpMRI's sensitivity with a close specificity rate of 95.24%.</p><p><strong>Conclusion: </strong>MRI and PSMA PET/MRI are reliable methods for the local staging of prostate cancer and the prediction of tumor localization. No statistically significant advantage of either method was discerned in the course of our study.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"20-27"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT image of invasive hemangioma in the lumbar vertebra.","authors":"Yuhao Li, Ruxin Luo, Futao Cui, Lin Li","doi":"10.1967/s002449912791","DOIUrl":"10.1967/s002449912791","url":null,"abstract":"<p><p>In the usual scenario, vertebral hemangiomas do not demonstrate heightened uptake above background on fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) scans. Here we presented a case of a positive ¹⁸F-FDG PET/CT result indicating invasive vertebral hemangioma at the L2 vertebra, with atypical CT imaging features of heterogeneous increased density and multiple patchy density shadows. Our case underscores an additional uncommon aspect of invasive vertebral hemangioma imaging, warranting consideration in the differential diagnosis when encountering analogous findings on ¹⁸F-FDG PET/CT.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"81-82"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerosing liposarcoma with rib involvement detected by CT and ^99mTc-MDP bone scintigraphy: A case report and review of the literature.","authors":"Hongzheng Zhang, Hongqin Zhao, Sheng Dai","doi":"10.1967/s002449912789","DOIUrl":"10.1967/s002449912789","url":null,"abstract":"<p><p>A 70-year-old male patient who presented with persistent upper abdominal pain was found to have a rare case of sclerosing liposarcoma with rib involvement. Despite the absence of significant weight loss or a history of infectious disease, elevated inflammatory markers suggested an underlying inflammatory or neoplastic process. Diagnostic imaging by computed tomography (CT) and single photon emission computed tomography (SPECT) played a critical role in identifying a soft tissue mass causing osteolytic damage to the left 9^th rib. The rapid enlargement of the lesion and the specific imaging characteristics challenged conventional detection methods. Biopsy confirmed the diagnosis of low-grade sclerosing liposarcoma. This case highlights the range of abilities of current imaging modalities in detecting certain forms of liposarcoma and emphasizes the need for a comprehensive diagnostic approach that integrates clinical findings, radiology, and pathology to accurately diagnose and manage such complex cases.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"75-78"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental finding of transthyretin myocardial amyloidosis in a patient with neurological symptoms and unexplained skeletal pain on bone scintigraphy using ^99mTc-DPD: A case report.","authors":"Milos Stevic, Filip Velickovic, Tamara Andjelkovic, Nina Topic","doi":"10.1967/s002449912788","DOIUrl":"10.1967/s002449912788","url":null,"abstract":"<p><p>Hereditary transthyretin amyloidosis (hATTR) is considered a rare disease. This is precisely why there are cases of undiagnosed transthyretin amyloidosis, in patients present with restrictive cardiomyopathy, with or without neurological or other symptoms. There are cases of incidental detection of hATTR in patients with cardiac or neurological symptoms using whole-body scintigraphy with diphosphonates. In this paper, we present the accidental detection of hATTR in a 65-year-old patient with neurological and cardiac symptoms, who was referred for skeletal scintigraphy with skeletally avid radiopharmaceuticals due to skeletal pain of unknown origin. Significantly increased uptake of radiopharmaceuticals in the myocardium was observed, corresponding to a Perugini score of 3, with semi-quantification of the heart/contralateral lung fixation ratio (H/CL) of 2.6 in the second hour after radiopharmaceutical application. Ultrasound of the heart was in favor of concentric cardiomyopathy. Due to the high suspicion of hATTR, a genetic test was performed, which showed a pathological mutation of the gene for transthyretin. Hereditary hTTR is probably a more common disease than reported in the literature. Using hATTR detection algorithms and raising awareness of the possible existence of this disease, timely diagnosis using scintigraphy with bone avid radiopharmaceuticals and appropriate therapy can help patients and their close relatives.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"71-74"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}