Hellenic journal of nuclear medicine最新文献

{"title":"Abnormal cortical amyloid deposition in ¹⁸F-Florbetapir PET/CT: General paresis of the insane mimicking early-onset Alzheimer's disease.","authors":"Yinting Hu, Xiaolin Sun, Shuhua Ren, Xiaoyue Tan, Lei Jiang","doi":"10.1967/s002449912790","DOIUrl":"10.1967/s002449912790","url":null,"abstract":"<p><p>General paresis (GP) is a type of neurosyphilis characterized by progressive memory impairment and mental disorders. It exhibits clinical, neuroimaging, and pathological similarities to Alzheimer's disease (AD). Here, we report a 37-year-old man with memory impairment and emotional disorders, who was clinically diagnosed with neurosyphilis, specifically GP. The fluorine-18 (¹⁸F)-Florbetapir positron emission tomography/computed tomography (PET/CT) of the patient showed mild diffuse amyloid deposition in both the cerebral and cerebellar cortex. Moreover, hypermetabolism in the left hippocampal region was revealed on ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET/CT. The patient's cerebrospinal fluid (CSF) test and genotyping results further excluded coexistent genetic AD. This case highlights the significance of considering neurosyphilis as a possible differential diagnosis in dementia patients with atypical positive amyloid PET findings. The mechanisms underlying aberrant amyloid deposition in neurosyphilis require further investigation.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"79-80"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of Philips Ingenuity TF PET/CT scanner imaging agent FAP in evaluating renal fibrosis.","authors":"Xueqin Zhao, Wei Fu","doi":"10.1967/s002449912784","DOIUrl":"10.1967/s002449912784","url":null,"abstract":"<p><strong>Objective: </strong>Chronic kidney disease (CKD) progression is accelerated by renal fibrosis, which causes abnormal extracellular matrix (ECM) accumulation. Non-invasive precision in measuring renal fibrosis is now possible with the help of advanced imaging techniques like magnetic resonance imaging (MRI) and ultrasound elastography. Fluorine-18-fibroblast activation protein (¹⁸F-FAP) is a promising Philips ingenuity TF positron emission tomography/computed tomography (PET/CT) scanner imaging target in activated fibroblasts associated with fibrotic disorders. Real-time quantification with FAP-targeted imaging improves kidney fibrosis diagnosis and guides anti-fibrotic therapies. The aim of this study is to develop reliable diagnostic and treatment techniques for renal fibrosis, Philips ingenuity TF PET/CT scanner imaging with FAP is useful.</p><p><strong>Materials and methods: </strong>Positron emission tomography data from 100 patients in our hospital (October 2022-September 2023) was analyzed to see if renal radiotracer uptake correlated with CKD progression. Fluorine-18-FAPI-04 synthesis and Philips ingenuity TF PET/CT scanner imaging were standard. One person determined CKD stage and glomerular filtration rate (GFR) after imaging processing. Imaged renal radiotracer distribution using maximum standardized uptake value (SUVmax) and mean SUV (SUVmean). The study sought to improve renal radiotracer dispersion estimation for CKD assessment.</p><p><strong>Results: </strong>The study reveals a complex relationship between GFR and radiotracer uptake in kidneys. At lower GFR, substantial uptake is seen, but a GFR of 15mL/min/1.73m² shows a drop to zero. Higher GFR generally correlate with increased uptake, peaking at GFR of 75 and 90mL/min/1.73m². Yet, at GFR of 115 and 120mL/min/1.73m², there is a reduction in radiotracer uptake, suggesting a nuanced association with renal function. Varied kidney SUVmax and SUVmean were significant for ¹⁸F-FAPI C (P<0.001), while baseline SUV readings were not significant. Fluorine-18-L-dihydroxyphenylalanine (¹⁸F-DOPA) and gallium-68 (⁶⁸Ga) ¹⁸F-prostate specific membrane antigen (PSMA) had significant kidney SUVmax values (P=0.05). Results suggest diverse absorption patterns for different radiotracers in kidneys and tissues.</p><p><strong>Conclusion: </strong>Fluorine-18-FAPI is a promising noninvasive approach for evaluating and quantifying CKD grades. Its excellent CKD severity correlation and renal insights make it a transformative diagnostic tool.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"28-35"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D quantitative values of osteoradionecrosis of the jaw derived from ¹⁸F-FDG PET/CT and bone SPECT/CT studies.","authors":"Kazuhiro Kitajima, Masayuki Fujiwara, Tomonori Terada, Kazuma Noguchi, Hiromitsu Kishimoto, Koichiro Yamakado","doi":"10.1967/s002449912781","DOIUrl":"10.1967/s002449912781","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical utility of the 3D quantitative values derived from fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) and bone single-photon computed tomography-computed tomography (SPECT/CT) for the diagnosis of osteoradionecrosis (ORN) of the jaw.</p><p><strong>Subjects and methods: </strong>Thirty four patients with head and neck cancer who had a history of radiotherapy and clinically diagnosed as ORN and who undertaken ¹⁸F-FDG PET/CT (n=23) or quantitative bone SPECT/CT (n=11) were enrolled. Standardized uptake values (SUV), including maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean), as well as metabolic lesion volume (MLV), representing total volume above threshold, and total lesion uptake (TLU), calculated as MLVxSUVmean were determined.</p><p><strong>Results: </strong>In ¹⁸F-FDG PET/CT results, mean values (range) of SUVmax, SUVpeak, SUVmean, MLV, and TLU of 24 lesions were 6.72±2.62 (3.67~14.36), 5.25±2.05 (2.46~10.88), 3.77±1.33 (1.74~7.69), 11.49±9.61 (1.54~43.14), and 49.07±59.26 (4.44~271.05), respectively. In quantitative bone SPECT/CT results, mean values (range) of SUVmax, SUVpeak, SUVmean, MLV, and TLU of 16 lesions were 5.26±0.89 (3.71~7.07), 4.62±0.78 (3.09~6.02), 3.44±0.46 (2.68~4.32), 14.45±9.93 (1.48~33.32), and 49.72±35.51 (4.60~127.86), respectively.</p><p><strong>Conclusion: </strong>As objective and reliable indicators, 3D quantitative values (SUV and volume) derived from ¹⁸F-FDG PET/CT and quantitative bone SPECT/CT results are useful for evaluation of the disease activity of ORN of the jaw.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"8-13"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ¹⁸F-FDG uptake patterns in liver, spleen, and bone marrow: Implications for inflammatory and infectious conditions.","authors":"Şadiye Altun Tuzcu, Erdal Çetinkaya, Fatih GÇzel, İlbey Erkin Çetin, Ümit Mete, Eşref Argın, Bekir Taşdemir","doi":"10.1967/s002449912752","DOIUrl":"10.1967/s002449912752","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the relationship between fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) uptake in the liver, spleen, and bone marrow and inflammatory markers such as c-reactive protein (CRP), albumin, and erythrocyte sedimentation rate (ESR) in patients undergoing positron emission tomography/computed tomography (PET/CT) imaging for cancer diagnosis.</p><p><strong>Subjects and methods: </strong>This retrospective cross-sectional study included a total of 708 patients with a diagnosis of malignancy. Fluorine-18-FDG PET/CT images acquired between January 2021 and December 2022. Exclusion criteria comprised prior chemotherapy, radiotherapy, hematological malignancies, or liver/spleen tumors. Statistical analysis included correlation analysis, univariate, and multivariate regression analysis.</p><p><strong>Results: </strong>C-reactive protein levels demonstrated a significant positive correlation with ¹⁸F-FDG uptake in the spleen (r=0.104, P=0.006) and bone marrow (r=0.112, P=0.003). Albumin showed a negative correlation with liver ¹⁸F-FDG uptake (r=-0.220, P<0.001). Regression analysis revealed ESR's impact on spleen-to-liver (P=0.023) and bone marrow-to-liver (P=0.012) ¹⁸F-FDG uptake.</p><p><strong>Conclusion: </strong>This study demonstrates the association between inflammatory markers and ¹⁸F-FDG uptake in liver, spleen and bone marrow. C-reactive protein and ESR showing significant correlations with spleen and bone marrow ¹⁸F-FDG uptake, and albumin correlated with liver ¹⁸F-FDG uptake negatively. Erythrocyte sedimentation rate had significant impact on spleen and bone marrow ¹⁸F-FDG uptakes. These findings suggest the potential of ¹⁸F-FDG PET/CT in diagnosing inflammatory conditions, warranting further investigation into its clinical implications.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"181-187"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI potential in PET/CT cancer imaging.","authors":"Georgia Panagiota Vazoura, Dimitrios Filos, Evanthia Giannoula, Ioannis Iakovou, Ioanna Chouvarda","doi":"10.1967/s002449912756","DOIUrl":"10.1967/s002449912756","url":null,"abstract":"<p><p>Positron emission tomography/computed tomography (PET/CT) is a hybrid medical imaging technique that combines PET and CT to provide detailed images of the body's anatomical structures and metabolic activity. It is frequently used for oncology and other medical diagnoses. This overview aims to examine how artificial intelligence (AI) has been used in PET/CT, based on recent state-of-art. There are a number of clinical questions in Nuclear Medicine, and AI could provide answers, having the capability to enhance various aspects of medical imaging. The overview focuses on how machine learning (ML) and deep learning (DL), enhance tumor segmentation, classification, diagnosis, disease-free survival prediction and treatment response prediction in oncology. The analysis showed that the application of AI provides reliable results, especially in the fields of classification and diagnosis. In addition, radiomics is a novel research field enabling quantitative analysis of medical images through feature extraction, utilized for AI model implementation. Despite these advances, addressing issues such as dataset size, standardization, and ethical concerns are essential for broad clinical integration of AI in PET/CT oncology imaging.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"212-221"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the diagnostic effect of ¹⁸F-FDG PET/CT in IIM patients and its relationship with disease severity.","authors":"Binbin Wang, Lu Liu, Na Wang, Yuqian Chen, Yanpeng Sun","doi":"10.1967/s002449912755","DOIUrl":"10.1967/s002449912755","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the diagnostic effect of fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with idiopathic inflammatory myopathies (IIM) and its relationship with disease severity.</p><p><strong>Subjects and methods: </strong>A retrospective analysis was conducted on the clinical and imaging data of 31 IIM patients treated in our hospital from April 2020 to April 2024, who were included in the lesion group. Additionally, 30 patients without muscle disease during the same period were selected as the control group. The maximum standardized uptake value (SUVmax) of the proximal limb girdle muscles was measured in both groups and compared. A receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of SUVmax for IIM using ¹⁸F-FDG PET/CT. Spearman rank correlation was used to analyze the relationship between muscle SUVmax in IIM patients and relevant laboratory indicators, including creatine kinase (CK), creatine kinase-MB (CK-MB), C-reactive protein (CRP), serum ferritin (SF), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT).</p><p><strong>Results: </strong>The SUVmax level of the lesion group (2.94±0.58) was significantly higher than that of the control group (1.17±0.23) (t=15.568, P<0.05). A receiver operating characteristic curve analysis indicated that the optimal cut-off value of SUVmax for distinguishing the lesion group from the control group was 2.16g/mL, with a diagnostic sensitivity of 100%, specificity of 91.8%, and an area under the curve (AUC) of 0.952. Correlation analysis showed a positive correlation between SUVmax and CK (r=0.659), CK-MB (r=0.523), AST (r=0.458), and LDH (r=0.437) (P<0.05), but no significant correlation with CRP (r=0.219), SF (r=0.348), or ALT (r=0.237).</p><p><strong>Conclusion: </strong>Fluorine-18-FDG PET/CT demonstrates an ideal diagnostic effect for IIM patients, and its semi-quantitative parameter, SUVmax, holds good auxiliary diagnostic value for IIM. It can reflect the activity and severity of the disease to a certain extent.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"206-211"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental renal cell carcinoma detected on ⁶⁸Ga-Pentixafor PET/MR.","authors":"Wei Zhang, Liu Xiao, Wenjie Zhang, Lin Li","doi":"10.1967/s002449912761","DOIUrl":"10.1967/s002449912761","url":null,"abstract":"<p><p>The value of gallium-68 (⁶⁸Ga)-Pentixafor positron emission tomography/magnetic resonance (PET/MR) image in renal carcinoma is unknown. Herein, we reported ⁶⁸Ga-Pentixafor PET/MR findings in a 47-year-old man with accidental renal carcinoma. Gallium-68-Pentixafor PET/MR showed a small nodule in the left kidney with iso-signal on T1WI and low signal on T2WI. This lesion had intense ⁶⁸Ga-Pentixafor uptake with a maximum standardized uptake value (SUVmax) of 7.05. This case suggested the potential of ⁶⁸Ga-Pentixafor PET/MR in the image evaluation of renal carcinoma.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"251-252"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostics, Theragnostics, or Iama-gnostics?","authors":"Spyros Retsas","doi":"10.1967/s002449912762","DOIUrl":"10.1967/s002449912762","url":null,"abstract":"<p><p>Many reputable medical journals, including The Lancet and the BMJ, have adopted the term \"Theranostics\". Under the alternative term \"Theragnostics\", PubMed currently registers 1207 articles. Both terms encountered by the reader for the first time are puzzling and largely meaningless, if not confusing. According to Idée et al. (2013), the concept of \"Theranostics\" was coined in 1998 in the USA by John Funkhouser, to describe a material that allows the combined diagnosis, treatment and follow up of a disease. Presumably the word was invented by truncating therapeutics to thera and diagnostics to nostics joining the two into Theranostics. But in Greek \"thera\" relates to hunting of wild beasts, the chase. Metaphorically, it may also mean \"the eager pursuit of anything\". Although chasing cancer by any means remains a justifiable and desirable pursuit, Theranostics does not exactly reflect the meaning intended by the originator. Iama (in Greek, ̓íαμα or ̓íημα) also refers to therapy but more importantly and specifically also, to means of therapy. May I, therefore, propose that a more meaningful term encompassing both therapy and diagnosis served by the same material, could be iama-gnostics? Considering the Anglo-Saxon compulsion for precise terminology and for laconic exactitude, could iama-gnostics find its place in the medical literature?</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"253"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of PET/CT scan in addressing autoinflammatory diseases; A case report of a young man presenting with fever, splenomegaly and exanthem.","authors":"Eleni V Geladari, Nikoletta K Pianou, Nikolaos A Angelis, Anna G Skourou, Anastasia G Roumpaki, Ioannis K Landrou, Kyriaki A Papahristodoulou, Stouras K Argirios, Leonidas D Marinos, Stylianos V Benakis, Phoivi E Rondogianni, Vasileios A Sevastianos","doi":"10.1967/s002449912759","DOIUrl":"10.1967/s002449912759","url":null,"abstract":"<p><strong>Objective: </strong>Adult-onset Still's disease (AOSD) is an uncommon autoinflammatory syndrome characterized by quotidian fever, arthritis, evanescent exanthem and splenomegaly. Lymphadenopathy is present in about a half of patients; it is usually symmetrical with the cervical area being most commonly involved. When constitutional symptoms are present, an extensive work-up should be performed in order to exclude hematological malignancies, such as lymphoma.</p><p><strong>Subjects and methods: </strong>A 38-year-old male is presented due to fatigue and high-grade fever that first appeared a month ago. He did also refer night sweats, arthralgias and an evanescent erythema on the trunk and anterior thigh area. Serology testing for bacteria and viruses as well as autoimmune rheumatic diseases was requested. Whole body computed tomography (CT) scan was ordered and displayed a marginal lymph node in the right hilum and smaller ones in the axillary region. Positron emission tomography/CT (PET/CT) with fluorine-18-fluoro-deoxy-glucose (¹⁸F-FDG) showed hypermetabolic lymph nodes, with the right upper internal jugular lymph node being the most dominant, as well as diffusely increased ¹⁸F-FDG uptake by bone marrow and spleen, posing in the differential diagnosis a neoplastic disease of the hematopoietic tissues.</p><p><strong>Results: </strong>Further laboratory testing showed high ferritin levels. It was decided to procced with biopsy of the aforementioned hypermetabolic internal jugular lymph node and bone marrow. Histopathological examination did show hyperreactivity and no malignant cells neither in the lymph node nor in the bone marrow.</p><p><strong>Conclusion: </strong>Adult-onset Still's disease is a rare disorder and it is a diagnosis of exclusion. High-grade fever along with arthralgias, splenomegaly, high serum ferritin levels and the presence of exanthem should pose high in the differential the AOSD. In this case, PET/CT guided the anatomical location for lymph node biopsy in order to differentiate AOSD from lymphoma. The dissociated increased ¹⁸F-FDG uptake from the cervical and axillary lymph nodes is characteristic of AOSD.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"243-246"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease management of malignant struma ovarii.","authors":"Yanli Ning, Cen Lou, Zhongke Huang","doi":"10.1967/s002449912760","DOIUrl":"10.1967/s002449912760","url":null,"abstract":"<p><strong>Objective: </strong>Ovarian goiter that meets the diagnostic criteria for malignant thyroid tumors or has invasive distant metastasis is called malignant struma ovarii (MSO). The incidence of MSO is very low. The level of serum thyroglobulin (Tg) is helpful to differentiate MSO with highly differentiated pathological type from other ovarian malignancies. But its therapeutic method is currently debated. Herein, we present a case of 54 years old woman, who was admitted to hospital due to frequent abdominal pain for 9 months and with normal serum Tg. Postoperative pathological examination revealed highly differentiated follicular thyroid carcinoma of bilateral ovarian origin, which penetrated bilateral ovarian cortex, involved the serosal surface of left fallopian tube and disseminated to sigmoid mesentery, small intestinal mesentery and pelvic cavity. The disseminated lesions were considered to originate from right ovary. After the total thyroidectomy, iodine-131(¹³¹I) treatment was performed with a dose of 150mCi. The ¹³¹I whole-body scintigraphy (WBS) 2 days after treatment showed residual thyroid tissue in the neck and implantation metastasis in mesentery. After 1-year regular follow-up, no significant abnormalities were found in tumor indicators, Tg, thyroid function, neck ultrasound and abdominopelvic enhanced computed tomography (CT). This MSO case with normal Tg and multiple implantation metastasis aimed to discuss its clinical management especially for Tg and ¹³¹I and to improve its prognosis.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"247-250"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}