3D quantitative values of osteoradionecrosis of the jaw derived from ¹⁸F-FDG PET/CT and bone SPECT/CT studies.

IF 1 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2025-01-01 Epub Date: 2025-04-07 DOI:10.1967/s002449912781

Kazuhiro Kitajima, Masayuki Fujiwara, Tomonori Terada, Kazuma Noguchi, Hiromitsu Kishimoto, Koichiro Yamakado

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引用次数: 0

Abstract

Objective: To investigate the clinical utility of the 3D quantitative values derived from fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) and bone single-photon computed tomography-computed tomography (SPECT/CT) for the diagnosis of osteoradionecrosis (ORN) of the jaw.

Subjects and methods: Thirty four patients with head and neck cancer who had a history of radiotherapy and clinically diagnosed as ORN and who undertaken ¹⁸F-FDG PET/CT (n=23) or quantitative bone SPECT/CT (n=11) were enrolled. Standardized uptake values (SUV), including maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean), as well as metabolic lesion volume (MLV), representing total volume above threshold, and total lesion uptake (TLU), calculated as MLVxSUVmean were determined.

Results: In ¹⁸F-FDG PET/CT results, mean values (range) of SUVmax, SUVpeak, SUVmean, MLV, and TLU of 24 lesions were 6.72±2.62 (3.67~14.36), 5.25±2.05 (2.46~10.88), 3.77±1.33 (1.74~7.69), 11.49±9.61 (1.54~43.14), and 49.07±59.26 (4.44~271.05), respectively. In quantitative bone SPECT/CT results, mean values (range) of SUVmax, SUVpeak, SUVmean, MLV, and TLU of 16 lesions were 5.26±0.89 (3.71~7.07), 4.62±0.78 (3.09~6.02), 3.44±0.46 (2.68~4.32), 14.45±9.93 (1.48~33.32), and 49.72±35.51 (4.60~127.86), respectively.

Conclusion: As objective and reliable indicators, 3D quantitative values (SUV and volume) derived from ¹⁸F-FDG PET/CT and quantitative bone SPECT/CT results are useful for evaluation of the disease activity of ORN of the jaw.

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来自18F-FDG PET/CT和骨SPECT/CT研究的颌骨骨放射性坏死的三维定量值。

目的：探讨氟-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）和骨单光子计算机断层扫描/计算机断层扫描（SPECT/CT）三维定量值在颌骨放射性骨坏死（ORN）诊断中的临床应用价值。研究对象和方法：34例有放疗史且临床诊断为恶性肿瘤的头颈癌患者接受了18F-FDG PET/CT检查（n=23）或骨定量SPECT/CT检查（n=11）。确定标准化摄取值（SUV），包括最大SUV （SUVmax）、峰值SUV （SUVpeak）和平均SUV (SUVmean)，以及代表阈值以上总量的代谢病变体积（MLV）和以MLVxSUVmean计算的总病变摄取（TLU）。结果：在18F-FDG PET/CT结果中，24个病灶的SUVmax、SUVpeak、SUVmean、MLV、TLU平均值（范围）分别为6.72±2.62（3.67~14.36）、5.25±2.05（2.46~10.88）、3.77±1.33（1.74~7.69）、11.49±9.61（1.54~43.14）、49.07±59.26（4.44~271.05）。16个病灶的SUVmax、SUVpeak、SUVmean、MLV、TLU平均值（范围）分别为5.26±0.89（3.71~7.07）、4.62±0.78（3.09~6.02）、3.44±0.46（2.68~4.32）、14.45±9.93（1.48~33.32）、49.72±35.51（4.60~127.86）。结论：18F-FDG PET/CT和骨SPECT/CT定量结果的三维定量值（SUV和体积）作为客观可靠的指标，可用于评估颌骨ORN的疾病活动性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.