Hellenic journal of nuclear medicine最新文献

{"title":"Increased ⁶⁸Ga-FAPI uptake in epithelioid inflammatory myofibroblastic sarcoma.","authors":"Huipan Liu, Yue Chen","doi":"10.1967/s002449912727","DOIUrl":"10.1967/s002449912727","url":null,"abstract":"","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"157-158"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiated thyroid cancer with osteo-granulomatousinflammation: A case report.","authors":"Yan Zhihua, Guo Mingzhen, Cheng Bing, Wu Tong, Li Xiangzhou","doi":"10.1967/s002449912725","DOIUrl":"10.1967/s002449912725","url":null,"abstract":"<p><strong>Objective: </strong>Cryptococcus, a genus of fungi, primarily includes Cryptococcus neoformans and Cryptococcus gattii, both known to cause human infections. Skeletal infections are rare, and there have been no reported cases of bone cryptococcal infection in conjunction with differentiated thyroid carcinoma.</p><p><strong>Subject and methods: </strong>A 56-year-old female presented with a one-month history of \"cough and throat irritation.\" Chest CT revealed scattered small nodules in both lungs,suggestive of metastasis.There was minimal inflammation in both lungs, and scattered lymph nodes were observed in the mediastinum and upper pulmonary hilum.</p><p><strong>Results: </strong>The patient was diagnosed with differentiated thyroid carcinoma complicated by cryptococcal infection. Antifungal treatment with itraconazole 200mg/day was initiated, and after 3 months, clinical symptoms disappeared, with a reduction in lung nodules observed in follow-up chest CT.</p><p><strong>Conclusion: </strong>When diagnosing distant metastasis in differentiated thyroid carcinoma, a comprehensive analysis combining imaging studies and serum thyroid globulin plays a complementary role, as illustrated in this case of differentiated thyroid carcinoma concurrent with cryptococcal infection.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"149-153"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of metabolism and its heterogeneity parameters measured by preoperative ¹⁸ F-FDG PET/CT for mediastinal occult lymph node metastasis in cN0 lung invasive adenocarcinoma.","authors":"Zhi Yang, Ziya Liu, Shilai Zhang, Bingqing Qiu, Hua Chai, Linlin Wei, Ning Li, Zhengzhong He, Yu Luo, Hongjiao Wei, Meishe Gan, Guoyou Xiao","doi":"10.1967/s002449912720","DOIUrl":"10.1967/s002449912720","url":null,"abstract":"<p><strong>Objective: </strong>To explore the potential of intratumoral metabolism and its heterogeneous parameters, as measured by preoperative fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging, to predict mediastinal occult lymph node metastasis in cN0 lung invasive adenocarcinoma.</p><p><strong>Subjects and methods: </strong>Seventy five patients were consecutively enrolled from January 2018 to December 2022. All patients underwent ¹⁸F-FDG PET/CT scans within two weeks before surgery, and had mediastinal lymph node metastasis confirmed by pathologic diagnosis after surgery. Metabolic parameters including the maximum standardized uptake value (SUVmax), mean SUV (SUVmean), maximum average SUV (SUVpeak), tumor metabolic volume (MTV), and metabolic heterogeneity (HF) were measured. The relationship between primary focal metabolism, its heterogeneity parameters, and occult mediastinal lymph node metastasis was analyzed using an independent-sample t-test, analysis of covariance, and Mann-Whitney U test. A multivariate logistic regression model was used to analyze independent risk factors for mediastinal lymph node metastasis, while the receiver operating characteristic (ROC) curve assessed the predictive value of metabolic heterogeneity parameters for mediastinal occult lymph node metastasis.</p><p><strong>Results: </strong>A total of 20 out of 75 patients (26.7%) were pathologically confirmed to have mediastinal lymph node metastasis. Analysis of covariance showed that the SUVmax, SUVmean, SUVpeak and MTV were significantly higher in patients with metastasis than in those without (all P<0.05). The metabolic heterogeneity parameters HF2 and HF3 were significantly higher in patients with mediastinal lymph node metastasis than in those without (P=0.013, 0.001), but not HF1. Multivariate Logistic regression analysis identified that tumor size, SUVmax, SUVpeak, lymph node SUVmax, and HF2 of the primary tumor as independent risk factors for mediastinal lymph node metastasis. Metabolic heterogeneity 3 demonstrated high predictive value for mediastinal occult lymph node metastasis (AUC=0.720, P=0.004).</p><p><strong>Conclusion: </strong>Metabolism and heterogeneity, as measured by preoperative ¹⁸F-FDG PET/CT in lung invasive adenocarcinoma, potentially have clinical value for predicting mediastinal occult lymph node metastasis.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"78-84"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/MR co-imaging in cardiovascular diseases: Current clinical applications and future development.","authors":"Haibo Chen, Guodong Zhang, Jin Lin","doi":"10.1967/s002449912731","DOIUrl":"https://doi.org/10.1967/s002449912731","url":null,"abstract":"<p><strong>Objective: </strong>This paper reviews the current status and future development of positron emission tomography/magnetic resonance (PET/MR) co-imaging technology in the field of cardiovascular diseases.</p><p><strong>Material and methods: </strong>By combining PET and MRI, PET/MR co-imaging provides comprehensive assessment advantages by simultaneously offering functional and anatomical information.</p><p><strong>Results: </strong>Firstly, the basic principles of PET/MR are introduced, and the current state is discussed. Subsequently, a detailed discussion on the application of PET/MR in the diagnosis of cardiovascular diseases, including early detection and comprehensive assessment of conditions like coronary artery disease and myocarditis, is presented. Finally, the challenges and future prospects in PET/MR applications are outlined.</p><p><strong>Conclusion: </strong>Despite facing several technical challenges, PET/MR co-imaging technology is expected to play a crucial role in the early diagnosis, treatment, and research of cardiovascular diseases, paving the way for new directions and possibilities in future medical imaging research.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"27 2","pages":"136-140"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial clinical experience using ⁶⁸Ga-FAPI-46 PET/CT for detecting various cancer types.","authors":"Habibollah Dadgar, Nasim Norouzbeigi, Majid Assadi, Batool Al-Balooshi, Akram Al-Ibraheem, Abdulredha A Esmail, Fahad Marafi, Mohamad Haidar, Haider Muhsin Al-Alawi, Yehia Omar, Sharjeel Usmani, Andrea Cimini, Hossein Arabi, Habib Zaidi","doi":"10.1967/s002449912723","DOIUrl":"10.1967/s002449912723","url":null,"abstract":"<p><strong>Objective: </strong>Numerous studies have shown that gallium-68-labeled fibroblast activation protein inhibitor (⁶⁸Ga-FAPI) positron emission tomography/computed tomography (PET/CT) scans would yield high intra-tumoral tracer uptake and low uptake in normal tissues as background, thus allowing for excellent visualization of lesions in the cancer microenvironment. This study set out to compare the suitability of novel ⁶⁸Ga-FAPI-46 PET versus routine fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET and other few cases of ⁶⁸Ga-DOTATATE/⁶⁸Ga-Pentixafor PET/CT for the assessment of different types of cancer.</p><p><strong>Subjects and methods: </strong>A retrospective analysis of 11 patients (6 males, 5 females; average age: 53 years, range: 10-58 years) with histopathologically confirmed, well-differentiated adenocarcinoma, medullar thyroid cancer (MTC), papillary thyroid carcinoma (PTC), cervical, gastric, glioblastoma multiform (GBM), colon, Ewing's sarcoma, and breast cancer was performed. These patients underwent PET/CT scans using four different radiotracers (9 ¹⁸F-FDG, 11 ⁶⁸Ga- FAPI, 3 ⁶⁸Ga-DOTATATE, and 1 ⁶⁸Ga-Pentixafor). The patients' PET/CT images were visually evaluated for cancer detection, and analyzed semi-quantitatively through image- derived metrics, such as target-to-background ratio (TBR) and maximum standardized uptake value (SUVmax), for recurrence and metastasis.</p><p><strong>Results: </strong>The study of 11 patients revealed that ⁶⁸Ga-FAPI-46 was more effective than other tracers for detecting metastases, with 55 vs. 49 metastases in the lymph nodes, 4 vs. 3 in the liver, and 4 vs. 3 in the bones detected in comparison to ¹⁸F-FDG. No significant differences were observed in ⁶⁸Ga-DOTATATE and ⁶⁸Ga-Pentixafor PET images. In addition, in five patients, the SUVmax and TBR values in ⁶⁸Ga-FAPI-46 PET images were significantly higher than those in ¹⁸F-FDG PET images for lymph nodes and bone metastases. Although the SUVmax in ⁶⁸Ga-FAPI-46 and ¹⁸F-FDG PET images for liver metastases was comparable, ⁶⁸Ga-FAPI- 46 had a significantly higher TBR than ¹⁸F-FDG.</p><p><strong>Conclusion: </strong>Our findings suggest that FAPI PET/CT is not suitable for evaluating GBM and Ewing sarcoma but generally outperforms ¹⁸F-FDG PET/CT in various types of breast cancer, gastrointestinal, gynecological, PTC and MTC. However, larger trials are needed to validate these preliminary findings.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"105-120"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT imaging and curative effect evaluation of multiple muscular tuberculosis.","authors":"Hongzheng Zhang, Sheng Dai","doi":"10.1967/s002449912726","DOIUrl":"10.1967/s002449912726","url":null,"abstract":"<p><p>Tuberculosis continues to be a significant global health concern, impacting various parts of the body aside from the lungs. Muscular tuberculosis (MT), while rare, poses diagnostic hurdles due to its nonspecific imaging features. Presenting a case of a 66-year-old man with multiple MT lesions, we underscore the vital contribution of positron emission tomography/computed tomography (PET/CT) in both diagnosis and treatment assessment. Fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) PET/CT imaging revealed hypermetabolism in bilateral chest and back muscles, facilitating accurate diagnosis and monitoring treatment response. This highlights the pivotal role of ¹⁸F-FDG PET/CT in managing MT, especially in cases with multiple lesions.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"154-156"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of reconstruction algorithms on semi-quantitative measurements in ¹⁸F-FDG PET/CT imaging.","authors":"Filiz Özülker, Gündüzalp Buğrahan Babacan, Safiya Cengiz, Tamer Özülker","doi":"10.1967/s002449912721","DOIUrl":"10.1967/s002449912721","url":null,"abstract":"<p><strong>Objective: </strong>This study was carried out to understand whether Q.Clear and ordered subset expectation maximization (OSEM), reconstruction algorithms used in fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) applications, and parameters such as time of flight (TOF) and point spread function (PSF) cause different results in semi-quantitative measurements.</p><p><strong>Subjects and methods: </strong>Raw PET data of 264 patients who were referred to ¹⁸F-FDG PET/CT imaging with the purpose of evaluation of known or suspicious malignant disease were reconstructed separately with Q.Clear (GE Healthcare), a BPL, an OSEM algorithm, PSF (SharpIR®) and TOF (VUE Point FX®) methods. Each patient's liver, mediastinal blood pool, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and standardized uptake values (SUV) (SUVmax, SUVmean, and SUVpeak) of a total of 264 lesions selected from the patients were performed.</p><p><strong>Results: </strong>β350+ToF yielded higher measurement results than all other variables for all of the lesion SUVmax, lesion SUVmean, L/AP SUVmax, and L/AP SUVmean parameters. OSEM+ToF and OSEM+TOF+PSF algorithms yielded higher mean and median SUVmax values for the reference structures (liver and mediastinum) and for lesions SUVmax and SUVmean values were statistically significantly lower than the β350+ToF method. The method with the lowest mean value for the L/Liver SUVmax variable was OSEM+ToF 4iter16ss (mean=1.76), while the method with the highest mean value was β350+ToF (mean=2.26). β350+ToF was the reconstruction method with the highest ratios for L/AP SUVmax and SUVmean for both lesions below and above 1 cm. β350+ToF algorithm had also statistically significantly higher results for these variables compared to all other parameters in malignant lesions.</p><p><strong>Conclusion: </strong>When comparing ¹⁸F-FDG PET/CT images, the use of different reconstruction algorithms may lead to misleading results, especially in the evaluation of response to treatment of malignancies.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"85-92"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the diagnostic value of CT radiomics models in differentiating GIST and other mesenchymal tumors.","authors":"Bin Du, Zhihui Zhu, Jin Pu, Yaqin Zhao, Shichao Wang","doi":"10.1967/s002449912732","DOIUrl":"https://doi.org/10.1967/s002449912732","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the diagnostic value of computed tomography (CT) radiomics models in differentiating gastrointestinal stromal tumors (GIST) and other mesenchymal tumors.</p><p><strong>Material and methods: </strong>A retrospective analysis of clinical data from 153 patients with pathologically confirmed gastrointestinal mesenchymal tumors treated in our hospital from July 2019 to March 2024 was conducted, including 107 cases of GIST, 18 cases of leiomyoma, and 28 cases of schwannoma. LASSO regression was used for feature selection. Logistic regression and Random Forest (RF) models were established based on selected features using machine learning algorithms, with the dataset divided into training (107 cases) and validation sets (46 cases) at a 7:3 ratio. The diagnostic performance of the models was evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>In the training set, there were significant differences between GIST and non-GIST in terms of enhancement degree, age, maximum diameter, and tumor location distribution (P<0.05). A total of 180 radiomics features were extracted using A.K software. LASSO regression reduced the high-dimensional data to 13 radiomics features. Logistic regression and RF models were established based on these 13 features. The AUC for the Logistic regression model was 0.753 in the training set and 0.582 in the validation set, while the AUC for the RF model was 0.941 in the training set and 0.746 in the validation set. The RF model showed higher diagnostic performance than the Logistic regression model (P<0.05). Decision curve analysis showed that the net benefit of the RF model in differentiating GIST was superior to classifying all patients as either GIST or non-GIST and also superior to the Logistic regression model within a probability threshold range of 20%-90%.</p><p><strong>Conclusion: </strong>The machine learning models based on radiomics features have good diagnostic value in predicting the pathological classification of GIST and other mesenchymal tumors, with the RF model showing superior diagnostic value compared to the Logistic regression model.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"27 2","pages":"141-148"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world applicability of differentiated thyroid cancer guidelines.","authors":"Evanthia Giannoula, Paraskevi Exadaktylou, Christos Melidis, Georgia Koutsouki, Ilias Katsadouros, Agni Tsangaridi, Panos Charalambous, Kyriaki Papadopoulou, Savvas Frangos, Ioannis Iakovou","doi":"10.1967/s002449912730","DOIUrl":"https://doi.org/10.1967/s002449912730","url":null,"abstract":"<p><strong>Objective: </strong>Thyroid cancer (TC) is the most common endocrine malignancy with constantly growing incidence. Radioiodine ablation is a safe and effective method for managing TC. Recently various Guidelines (GL) have been published on whom should be ablated, when and under which circumstances. Our study compares 6 GL with a given patient cohort. Additionally, we evaluated each GL's quality via an independent tool.</p><p><strong>Material and methods: </strong>We compared six Guidelines (GL) for TC ablation on a cohort of 336 patients, implementing GL retrospectively: 2009 and 2016 American Thyroid Association (ATA), European Thyroid Association's (ETA) Consensus Statement, UK's National Institute for Health and Care Excellence (NICE), German position paper from Surgery and Nuclear Medicine (German) and European Association of Nuclear Medicine and Society of Nuclear Medicine and Molecular Image (EANM/SNMMI). Quality assessment was conducted using the Appraisal of Guidelines, Research and Evaluation instrument II (AGREE II).</p><p><strong>Results: </strong>Results showed significant variability among GL. American Thyroid Association 2016, a clear improvement of the ATA 2009, presents a large grey area of \"probable ablation candidates\". European Thyroid Association and NICE agree that only a small portion of our ablated patients would benefit from it and the AGREE II tool shows a lack of applicability, but very good scores elsewhere. German and EANM/SNMMI GL agree that most of our clinical decisions to ablate were correct and their AGREE II scores are the highest in all six domains.</p><p><strong>Conclusion: </strong>Considering that dynamic risk classification plays a major role in determining the most appropriate treatment, it appears that the guidelines should be updated in order to support individualized patient management. However, it is the experience of the individual physician that will determine the final decision.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":"27 2","pages":"121-130"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT image of NK/T cell lymphoma in the sacroiliac joint.","authors":"Liu Xiao, Wei Zhang, Lin Li","doi":"10.1967/s002449912728","DOIUrl":"10.1967/s002449912728","url":null,"abstract":"<p><p>NK/T cell lymphoma in the sacroiliac joint is very rare. We reportfluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) findings of NK/T cell lymphoma in the sacroiliac joint in a 48-year-old man. On ¹⁸F-FDG PET/CT image, it manifested a soft tissue mass with adjacent bone destruction in the sacroiliac joint, which had intense ¹⁸F-FDG uptake. The final pathology supported a diagnosis of NK/T cell lymphoma. Our case added the knowledge of another rare site of NK/T cell lymphoma, which should be regarded as a differential diagnosis for sacroiliac joint mass with intense ¹⁸F-FDG uptake.</p>","PeriodicalId":12871,"journal":{"name":"Hellenic journal of nuclear medicine","volume":" ","pages":"159-160"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}