Quantitative assessment of volume-based metabolic parameters in early-stage invasive ductal breast cancer: Impact of different standardized uptake value thresholds on prognostic factors - A comprehensive analysis.

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2024-09-01 Epub Date: 2024-12-09 DOI:10.1967/s002449912758

Mustafa Erol, Hasan Önner, Meryem I E Karanis, Ahmet E Şen

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引用次数: 0

Abstract

Objective: This study compares volume-based metabolic parameters in early-stage invasive ductal breast cancer using different standardized uptake value (SUV) thresholds and examines their association with immunohistochemical factors.

Subjects and methods: A retrospective analysis included 135 patients with early-stage invasive ductal breast cancer who underwent preoperative fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) scans. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were derived using absolute SUV threshold methods and fixed % maximum tumor SUV threshold methods. Associations with immunohistochemical factors were explored, and receiver operating characteristic curves were generated.

Results: Metabolic tumor volume 2.5 and TLG 2.5 showed stronger correlations with maximum tumor SUV values. Metabolic tumor volume 2.0 and TLG 2.0 had superior area under the curve (AUC) values in predicting estrogen and progesterone receptor negativity. Metabolic tumor volume 2.0 and TLG 2.0 were superior in distinguishing low and high-grade tumors.

Conclusion: Absolute SUV threshold methods with a threshold of 2.0 are recommended for calculating volume-based metabolic parameters due to their strong correlation with immunohistochemical factors in invasive ductal breast cancer.

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早期浸润性导管性乳腺癌中基于体积的代谢参数的定量评估：不同标准化摄取值阈值对预后因素的影响——一项综合分析

目的：本研究采用不同的标准化摄取值（SUV）阈值比较早期浸润性导管性乳腺癌的体积代谢参数，并探讨其与免疫组织化学因子的关系。研究对象和方法：回顾性分析135例术前接受氟-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）的早期浸润性导管乳腺癌患者。采用绝对SUV阈值法和固定%最大肿瘤SUV阈值法计算肿瘤代谢体积（MTV）和总病灶糖酵解（TLG）。探讨了与免疫组织化学因子的关系，并生成了受试者工作特征曲线。结果：代谢肿瘤体积2.5和TLG 2.5与肿瘤最大SUV值有较强的相关性。代谢性肿瘤体积2.0和TLG 2.0在预测雌激素和孕激素受体阴性方面具有较好的曲线下面积（AUC）值。代谢肿瘤体积2.0和TLG 2.0在区分低级别和高级别肿瘤方面具有优势。结论：浸润性导管性乳腺癌中基于体积的代谢参数与免疫组织化学因子相关性强，推荐阈值为2.0的绝对SUV阈值法计算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.