Growth factors最新文献_第7页

Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells. 半乳糖凝集素-1对人单核细胞源性树突状细胞免疫调节特性的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-12-01 Epub Date: 2021-07-05 DOI: 10.1080/08977194.2021.1947267

Tanja Džopalić, Miloš Kostić, Milena Kostić, Goran Marjanović, Jelena Guzina, Vladimir Jurišić, Biljana Božić Nedeljković

{"title":"Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells.","authors":"Tanja Džopalić, Miloš Kostić, Milena Kostić, Goran Marjanović, Jelena Guzina, Vladimir Jurišić, Biljana Božić Nedeljković","doi":"10.1080/08977194.2021.1947267","DOIUrl":"https://doi.org/10.1080/08977194.2021.1947267","url":null,"abstract":"Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs in-vitro. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4+T cells. Gal-1 reduced the expression of CD80 and CD86 molecules on MoDCs compared to untreated MoDCs. Gal-1 at concentrations of 1 and 6 μg/mL significantly reduced IL-12 production, while the concentration of 3 μg/mL led to its significant increase. Gal-1 in all concentrations induced a significant increase in the production of IL-10. Treatment of MoDCs with 3 and 6 μg/mL of Gal-1 stimulated the production of IL-2 and IFN-γ in the co-culture with CD4+T lymphocytes. This study demonstrated a dual immunomodulatory effect of Gal-1 on MoDCs in terms of immune stimulation and immune suppression, depending on the applied concentration.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1947267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39151611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2. 重组人成纤维细胞生长因子2治疗三度烧伤小鼠。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-12-01 Epub Date: 2021-08-20 DOI: 10.1080/08977194.2021.1967342

Thu-Minh Tran-Nguyen, Khanh-Thien Le, Le-Giang Thi Nguyen, Thanh-Loan Thi Tran, Phuong-Cac Hoang-Thai, Thuoc Linh Tran, Sik-Loo Tan, Hieu Tran-Van

{"title":"Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2.","authors":"Thu-Minh Tran-Nguyen, Khanh-Thien Le, Le-Giang Thi Nguyen, Thanh-Loan Thi Tran, Phuong-Cac Hoang-Thai, Thuoc Linh Tran, Sik-Loo Tan, Hieu Tran-Van","doi":"10.1080/08977194.2021.1967342","DOIUrl":"https://doi.org/10.1080/08977194.2021.1967342","url":null,"abstract":"Fibroblast growth factor 2 (FGF-2) is a multifunctional protein that has major roles in wound healing, tissue repair, and regeneration. This therapeutic protein is widely used for burn treatment because it can stimulate cell proliferation and differentiation, angiogenesis, and extracellular matrix remodeling. In this study, we developed a simple method using a controlled heated brass rod to create a homogenous third-degree burn murine model and evaluated the treatment using recombinant human FGF-2 (rhFGF-2). The results indicated that the wound area was 0.83 ± 0.05 cm2 and wound depth was 573.42 ± 147.82 μm. Mice treated with rhFGF-2 showed higher rates of wound closure, granulation tissue formation, angiogenesis, and re-epithelialization than that of phosphate-buffered saline (PBS)-treated group. In conclusion, our lab-made rhFGF-2 could be a potentially therapeutic protein for burn treatment as well as a bioequivalent drug for other commercial applications using FGF-2.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39329436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Exploring the role of oxidative stress, fatty acids and neurotrophins in gestational diabetes mellitus. 探讨氧化应激、脂肪酸和神经营养因子在妊娠期糖尿病中的作用。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-11 DOI: 10.1080/08977194.2021.1895143

Anjali Jadhav, Amrita Khaire, Sadhana Joshi

引用次数: 6

Attenuating influenza a virus infection by heparin binding EGF-like growth factor. 肝素结合egf样生长因子减毒甲型流感病毒感染。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-15 DOI: 10.1080/08977194.2021.1895144

K M Lai, B H Goh, W L Lee

引用次数: 4

Effects of platelet-rich plasma on the pancreatic islet survival and function, islet transplantation outcome and pancreatic pdx₁ and insulin gene expression in streptozotocin-induced diabetic rats. 富血小板血浆对链脲佐菌素诱导的糖尿病大鼠胰岛存活和功能、胰岛移植结局及胰腺pdx1和胰岛素基因表达的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-02-11 DOI: 10.1080/08977194.2021.1881502

Marzieh Nemati, Narges Karbalaei, Pooneh Mokarram, Farzaneh Dehghani

{"title":"Effects of platelet-rich plasma on the pancreatic islet survival and function, islet transplantation outcome and pancreatic pdx1 and insulin gene expression in streptozotocin-induced diabetic rats.","authors":"Marzieh Nemati, Narges Karbalaei, Pooneh Mokarram, Farzaneh Dehghani","doi":"10.1080/08977194.2021.1881502","DOIUrl":"https://doi.org/10.1080/08977194.2021.1881502","url":null,"abstract":"Platelet-rich plasma (PRP) is a therapeutic option in different fields based on its growth factors. We investigated influence of PRP on islet survival, function, transplantation outcomes, and pancreatic genes expression in diabetic rats. In vitro: pancreatic isolated islets were incubated with/without PRP then viability, insulin secretion, and content were assessed. In vivo: Series 1 were designed to determine whether islet treatment with PRP improves transplantation outcome in diabetic rats by evaluating plasma glucose and insulin concentrations and oxidative parameters. Series 2, effects of PRP subcutaneous injection were evaluated on pancreatic genes expression and glucose tolerance test in diabetic rats. PRP enhanced viability and secretary function of islet. Reduced glucose and malondialdehyde levels as well as increased insulin levels, superoxide dismutase activity, and expressions of pdx1 and insulin were observed in diabetic rats. PRP treatment has positive effects on islet viability, function, transplantation outcome, and pancreatic genes expression in diabetic rats.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1881502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25355874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer. 转移性结直肠癌患者表皮生长因子受体配体水平的预后和预测能力的免疫组织化学评估。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-27 DOI: 10.1080/08977194.2021.1878166

Siavash Foroughi, Ryan A Hutchinson, Hui-Li Wong, Michael Christie, Ahida Batrouney, Rachel Wong, Margaret Lee, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs

{"title":"Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer.","authors":"Siavash Foroughi, Ryan A Hutchinson, Hui-Li Wong, Michael Christie, Ahida Batrouney, Rachel Wong, Margaret Lee, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs","doi":"10.1080/08977194.2021.1878166","DOIUrl":"https://doi.org/10.1080/08977194.2021.1878166","url":null,"abstract":"For patients with metastatic colorectal cancer (mCRC), epidermal growth factor receptor (EGFR) inhibitors are limited to patients with RAS wild-type tumours. Not all patients will benefit from treatment and better predictive biomarkers are needed. Here we investigated the prognostic and predictive impact of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG). Expression levels were assessed by immunohistochemistry on 99 KRAS wild-type tumours. AREG and EREG positivity was seen in 49% and 50% of cases, respectively. No difference in expression was observed by primary tumour side. There was no significant difference in OS by AREG or EREG expression. In the subset of patients who received an EGFR inhibitor, EREG positivity was associated with longer OS (median 34.0 vs. 27.0 months, p = 0.033), driven by a difference in patients with a left-sided primary (HR 0.37, p = 0.015). Our study supports further investigation into EREG as a predictive biomarker in mCRC.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1878166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25523180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet rich plasma efficiently substitutes the beneficial effects of serum during in vitro oocyte maturation and helps maintain the mitochondrial activity of maturing oocytes. 富血小板血浆有效地替代血清在卵母细胞体外成熟过程中的有益作用，并有助于维持成熟卵母细胞的线粒体活性。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-19 DOI: 10.1080/08977194.2021.1900168

F Moulavi, R T Akram, S Khorshid Sokhangouy, S M Hosseini

{"title":"Platelet rich plasma efficiently substitutes the beneficial effects of serum during in vitro oocyte maturation and helps maintain the mitochondrial activity of maturing oocytes.","authors":"F Moulavi, R T Akram, S Khorshid Sokhangouy, S M Hosseini","doi":"10.1080/08977194.2021.1900168","DOIUrl":"https://doi.org/10.1080/08977194.2021.1900168","url":null,"abstract":"Platelets contain most of the potent mitogenic factors present in serum and follicular fluid and intraovarian injection of autologous platelet rich plasma (PRP) was shown to improve ovarian function and development of preantral follicles. This study evaluated the effect of PRP on caprine oocyte maturation in vitro and subsequent fertilization and embryonic development. Cumulus oocyte complexes were cultured in a maturation medium supplemented with (1) fetal bovine serum (FBS, control), (2) PRP, extracted from healthy female goats, (3) polyvinyl alcohol (PVA), and (4) PVA plus PRP (PVA-PRP). The degree of cumulus expansion was scored, and denuded oocytes were used for assessment of nuclear maturation, mitochondrial activity, lipid content, redox status, yield and quality of in vitro embryo development, and cryosurvival of the resulting blastocysts. PRP supported the same beneficial effects of FBS on cumulus expansion, nuclear maturation, in vitro developmental competence of oocytes, and survival of vitrified-warmed blastocysts. Moreover, PRP protected oocytes from undesirable effects FBS exerted on the mitochondrial activity and intracytoplasmic lipid content of maturing oocyte. Although PVA could support the same beneficial effects of neither FBS nor PRP on oocyte maturation, its combined addition with PRP improved the yield and quality of oocyte maturation at rates closely similar to PRP. PRP efficiently substitutes beneficial effects of serum during in vitro oocyte maturation and helps maintain the mitochondrial activity of maturing oocytes.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1900168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25495880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Application of bioinformatics and molecular dynamics simulation approaches for identification of fibroblast growth factor 10 analogues with potentially improved thermostability. 应用生物信息学和分子动力学模拟方法鉴定具有潜在改善热稳定性的成纤维细胞生长因子10类似物。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 DOI: 10.1080/08977194.2021.1881501

Ali Akbar Alizadeh, Behzad Jafari, Siavoush Dastmalchi

{"title":"Application of bioinformatics and molecular dynamics simulation approaches for identification of fibroblast growth factor 10 analogues with potentially improved thermostability.","authors":"Ali Akbar Alizadeh, Behzad Jafari, Siavoush Dastmalchi","doi":"10.1080/08977194.2021.1881501","DOIUrl":"https://doi.org/10.1080/08977194.2021.1881501","url":null,"abstract":"Fibroblast growth factor 10 functions as a paracrine mesenchymal molecule to initiate signalling pathways regarding to cellular development and health. However, the low thermal stability restricts it's functionality in the human body and the shelf-life of FGF10-based formulations. The current study aimed to employ rational design and bioinformatics approaches to identify some point mutations which may improve the thermal stability of FGF10. Bioinformatics analyses resulted in N105D, C106F, K144R, K153M and I156R as the potential stability conferring mutations. The identified mutants were subjected to MD simulation indicating that all mutations are both structurally and energetically favoured. Finally, the effects of the identified mutations on receptor binding of FGF10 were predicted and the results showed that K144R and K153M mutations may increase the binding affinity relative to the wild type. The findings of the current study propose potentially improved FGF10 analogues for further experimental investigations.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1881501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39009210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative review of brain-derived neurotrophic factor (BDNF) on cognitive performance in Alzheimer's disease. 脑源性神经营养因子(BDNF)对阿尔茨海默病认知表现的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-01-11 DOI: 10.1080/08977194.2020.1864347

Noor Azila Ismail, Mohammad Farris Iman Leong Abdullah, Rohayu Hami, Hazwani Ahmad Yusof

引用次数: 9

Interactions between thymic endothelial cells and thymocytes are influenced by growth hormone. 胸腺内皮细胞和胸腺细胞之间的相互作用受生长激素的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-05-24 DOI: 10.1080/08977194.2021.1924699

Marvin Paulo Lins, Iana Mayane Mendes Nicácio Viana, Salete Smaniotto, Maria Danielma Dos Santos Reis

{"title":"Interactions between thymic endothelial cells and thymocytes are influenced by growth hormone.","authors":"Marvin Paulo Lins, Iana Mayane Mendes Nicácio Viana, Salete Smaniotto, Maria Danielma Dos Santos Reis","doi":"10.1080/08977194.2021.1924699","DOIUrl":"https://doi.org/10.1080/08977194.2021.1924699","url":null,"abstract":"Growth hormone (GH), in addition to its classic actions on growth and metabolism in the body, exerts pleiotropic effects on the immune system, particularly on the thymus. The aim of this study was to evaluate the influence of GH on the interactions between mature thymocytes and the thymic endothelium involved in the migratory process. To this end, fresh thymocytes (C57BL/6 mice) and the thymic endothelial cell line (tEnd.1) were used. In the cell adhesion assay, the GH-treated thymocytes adhered more to tEnd.1 cells. Additionally, there was an improvement in the deposition of fibronectin by tEnd.1 cells when co-cultured with GH-pre-treated thymocytes. Furthermore, GH induced thymocyte F-actin polymerization. In the transendothelial migration assay, a large number of GH-treated thymocytes, mainly the CD4-CD8+ subset, migrated towards the endothelium under the stimulus of insulin-like growth factor 1. In conclusion, we demonstrated the positive actions of GH in thymocyte/thymic endothelium interactions, including transendothelial migration.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1924699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38930839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3