发布求助
文献互助 智能选刊 最新文献

Growth factors最新文献

筛选
英文 中文
Association of growth performance and body conformational traits with BMP4 gene variation in Barki lambs Barki羔羊生长性能和身体构象特征与BMP4基因变异的关系
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1662417
A. Ibrahim
{"title":"Association of growth performance and body conformational traits with BMP4 gene variation in Barki lambs","authors":"A. Ibrahim","doi":"10.1080/08977194.2019.1662417","DOIUrl":"https://doi.org/10.1080/08977194.2019.1662417","url":null,"abstract":"Abstract The objective of this study was to test the association of the variation in a 360 bp region in exon 2 of the ovine bone morphogenetic protein 4 (BMP4) gene with growth performance (birth weight, pre-weaning average daily gain, weaning weight, post-weaning average daily gain and marketing weight) and body conformational traits (height at withers, height at hips, body length, heart girth, thigh circumference, body mass index, skeletal muscle index, body index and relative body index) in 242 Barki lambs using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP). Two variants (A and B) and three genotypes (AA, AB and BB) were detected. The BMP4 genotype significantly affected (p < .05 or p < .01) post-weaning daily gain, marketing weight, height at hips, thigh circumference, body mass index and skeletal muscle index. The results provided valuable information indicating selection for the BMP4 genotype might increase growth and muscularity in Barki lambs.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1662417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46859597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Plasma CCN2 is independently related to subsequent need for abdominal aorta aneurysm repair 血浆CCN2与随后腹主动脉动脉瘤修复的需要独立相关
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1662416
J.H. Larsen, L. Rasmussen, J. Lindholt, L. Steffensen
{"title":"Plasma CCN2 is independently related to subsequent need for abdominal aorta aneurysm repair","authors":"J.H. Larsen, L. Rasmussen, J. Lindholt, L. Steffensen","doi":"10.1080/08977194.2019.1662416","DOIUrl":"https://doi.org/10.1080/08977194.2019.1662416","url":null,"abstract":"Abstract The objective of this study was to determine if plasma CCN2 is associated with abdominal aorta aneurysm (AAA), and future need for AAA repair, and further to assess the potential clinical value of CCN2 in predicting disease outcome. CCN2 was quantified in plasma samples obtained from a cohort of 679 men aged 65–74 at initial ultrasound screening for AAA in the Viborg Vascular (VIVA) screening trial. Plasma CCN2 was correlated with need for future surgical repair in the whole study population (HR = 1.457 (1.081–1.962), p = .013) and in the AAA group alone (HR = 1.431 (1.064–1.926), p = .018), yet the predictive value (CCN2 > 0 and <0 of 0.52 and 0.55, respectively) disqualified its use in clinically relevant AAA repair prediction. In conclusion, CCN2 is independently related to subsequent need for AAA repair, but has negligible predictive power for clinical use.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1662416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42960518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lowe syndrome with extremely short stature: growth hormone deficiency may be the pathogeny 身材极矮的洛氏综合征:生长激素缺乏可能是病因
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1669589
C. Dai, Liying Wang, Youli Li, Zhichao Zheng, Jieqi Qian, Chaoban Wang, Zishuo Liu, Xiaoou Shan
{"title":"Lowe syndrome with extremely short stature: growth hormone deficiency may be the pathogeny","authors":"C. Dai, Liying Wang, Youli Li, Zhichao Zheng, Jieqi Qian, Chaoban Wang, Zishuo Liu, Xiaoou Shan","doi":"10.1080/08977194.2019.1669589","DOIUrl":"https://doi.org/10.1080/08977194.2019.1669589","url":null,"abstract":"Abstract Lowe syndrome is an x-linked disorder characterized by congenital cataracts, nervous system abnormalities and renal tubular dysfunction. With the rising number of reported cases, more patients are found to suffer from endocrine abnormalities. Hereby, three Chinese patients with typical symptoms and extremely short stature were described. The OCRL gene was analyzed. A combination of blood biochemistry and radiological examinations were performed. Growth hormone provocation test was taken in one patient. Nucleotide sequence analysis revealed a de novo novel hemizygous mutation (c.2290_2291delinsCT) in exon 21 in an adolescent boy. As indicated by the growth hormone provocation test, the boy had growth hormone deficiency. The other two patients were brothers with extremely short stature, and manifested the same hemizygous mutation (c.2581G > A) in exon 23. It was speculated that the mutation of OCRL gene could lead to deficiency of growth hormone, for which an early growth hormone intervention may be beneficial.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1669589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46799793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dose optimisation of PTEN inhibitor, bpV (HOpic), and SCF for the in-vitro activation of sheep primordial follicles PTEN抑制剂bpV（HOpic）和SCF体外激活绵羊原始卵泡的剂量优化
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1680661
S. Adib, M. R. Valojerdi, M. Alikhani
{"title":"Dose optimisation of PTEN inhibitor, bpV (HOpic), and SCF for the in-vitro activation of sheep primordial follicles","authors":"S. Adib, M. R. Valojerdi, M. Alikhani","doi":"10.1080/08977194.2019.1680661","DOIUrl":"https://doi.org/10.1080/08977194.2019.1680661","url":null,"abstract":"Abstract The in-vitro development of primordial follicles is critical for improving mammalian fertility and wildlife conservation. This study aimed to optimise the effective doses of bpV (HOpic) and stem cell factor (SCF) for the in-vitro activation of sheep primordial follicles. To do this, sheep ovarian cortex was treated with bpV (1.5, 15, and 150 μM) and SCF (50 and 100 ng/ml). Follicular count indicated that 15 μM bpV and 100 ng/ml SCF significantly increased normal primary follicles compared to other groups (p < 0.05). Also, a significant downregulation of P53 and PTEN, as well as the increased expression of PI3K was observed. The in-vitro maturation was more pronounced when the fragmented tissues were co-treated with selected doses of bpV and SCF. In conclusion, the combination of 15 μM bpV and 100 ng/ml SCF was the most effective treatment strategy for the activation and survival of primordial follicles in sheep ovarian fragments.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1680661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43793491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Recombinant protein CCN5/WISP2 promotes islet cell proliferation and survival in vitro 重组蛋白CCN5/WISP2促进胰岛细胞体外增殖和存活
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1652400
Nancy Kaddour, Di Zhang, Zu-hua Gao, Jun-li Liu
{"title":"Recombinant protein CCN5/WISP2 promotes islet cell proliferation and survival in vitro","authors":"Nancy Kaddour, Di Zhang, Zu-hua Gao, Jun-li Liu","doi":"10.1080/08977194.2019.1652400","DOIUrl":"https://doi.org/10.1080/08977194.2019.1652400","url":null,"abstract":"Abstract Pancreatic ß cell proliferation, survival and function are key elements that need to be considered in developing novel antidiabetic therapies. We recently identified CCN5/WISP2 to have potential growth promoting properties when overexpressed in ß cells; however, further investigations are needed to validate those properties. In this study, we demonstrated that exogenous treatment of insulinoma cells and primary islets with recombinant CCN5 (rh-CCN5) protein enhanced the proliferative capacity which was correlated with activation of cell-cycle regulators CDK4 and cyclin D1. Furthermore, pre-incubation of these cells with rh-CCN5 enhanced their survival rate after being exposed to harsh treatments such as streptozotocin and high concentrations of glucose and free fatty acids. CCN5 as well caused an upregulation in the expression of key genes associated with ß cell identity and function such as GLUT-2 and GCK. Finally, CCN5 activated FAK and downstream ERK kinases which are known to stimulate cell proliferation and survival. Hence, our results validate the growth promoting activities of rh-CCN5 in ß cells and open the door for further investigations in vivo.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1652400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46017962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Growth factor signaling pathways in vascular development and disease. 血管发育和疾病中的生长因子信号通路。
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-04-01 Epub Date: 2019-07-08 DOI: 10.1080/08977194.2019.1635591
Zoe L Grant, Leigh Coultas
{"title":"Growth factor signaling pathways in vascular development and disease.","authors":"Zoe L Grant,&nbsp;Leigh Coultas","doi":"10.1080/08977194.2019.1635591","DOIUrl":"https://doi.org/10.1080/08977194.2019.1635591","url":null,"abstract":"<p><p>Angiogenic blood vessel growth is essential to ensure organs receive adequate blood supply to support normal organ function and homeostasis. Angiogenesis involves a complex series of cellular events through which new vessels grow out from existing vasculature. Growth factor signaling, layered over a range of other signaling inputs, orchestrates this process. The response of endothelial cells (ECs) to growth factor signals must be carefully controlled through feedback mechanisms to prevent excessive vessel growth, remodeling or destabilization. In this article, we summarize recent findings describing how ECs respond to growth factor signals during blood vessel development and homeostasis and how perturbation of these responses can lead to disease.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1635591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37400838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Emerging roles for Interleukin-11 in disease. 白细胞介素-11在疾病中的新作用。
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-04-01 Epub Date: 2019-06-04 DOI: 10.1080/08977194.2019.1620227
Paul M Nguyen, Suad M Abdirahman, Tracy L Putoczki
{"title":"Emerging roles for Interleukin-11 in disease.","authors":"Paul M Nguyen,&nbsp;Suad M Abdirahman,&nbsp;Tracy L Putoczki","doi":"10.1080/08977194.2019.1620227","DOIUrl":"https://doi.org/10.1080/08977194.2019.1620227","url":null,"abstract":"<p><p>Interleukin (IL)-11 belongs to the IL-6 family of cytokines, discovered over 30 years ago. While early studies focused on the ability of IL-11 to stimulate megakaryocytopoiesis, the importance of this cytokine to inflammatory disease and cancers is only just beginning to be uncovered. This review outlines recent advances in our understanding of IL-11 biology, and highlights the development of novel therapeutics with the potential for clinical targeting of signaling by this cytokine in multiple diseases.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1620227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37301371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Bone morphogenetic protein signaling in breast cancer progression. 乳腺癌进展中的骨形态发生蛋白信号。
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-04-01 Epub Date: 2019-07-05 DOI: 10.1080/08977194.2019.1626378
Lap Hing Chi, Allan D Burrows, Robin L Anderson
{"title":"Bone morphogenetic protein signaling in breast cancer progression.","authors":"Lap Hing Chi,&nbsp;Allan D Burrows,&nbsp;Robin L Anderson","doi":"10.1080/08977194.2019.1626378","DOIUrl":"https://doi.org/10.1080/08977194.2019.1626378","url":null,"abstract":"<p><p>Breast cancer is the most prevalent type of cancer amongst women worldwide. The mortality rate for patients with early-stage breast cancer has been decreasing, however, the 5-year survival rate for patients with metastatic disease remains poor, currently at 27%. Here, we have reviewed the current understanding of the role of bone morphogenetic protein (BMP) signaling in breast cancer progression, and have highlighted the discordant results that are reported in different studies. We propose that some of these contradictory outcomes may result from signaling through either the canonical or non-canonical pathways in different cell lines and tumors, or from different tumor-stromal interactions that occur <i>in vivo</i>.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1626378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37389398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Hepatocyte growth factor levels in livers and serum at Kasai-portoenterostomy are not predictive of clinical outcome in infants with biliary atresia. kasai门肠造口术患者肝脏和血清中的肝细胞生长因子水平不能预测胆道闭锁婴儿的临床结果。
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-04-01 Epub Date: 2019-06-11 DOI: 10.1080/08977194.2019.1626379
Omid Madadi-Sanjani, Joachim F Kuebler, Stephanie Dippel, Anna Gigina, Christine S Falk, Gertrud Vieten, Claus Petersen, Christian Klemann
{"title":"Hepatocyte growth factor levels in livers and serum at Kasai-portoenterostomy are not predictive of clinical outcome in infants with biliary atresia.","authors":"Omid Madadi-Sanjani,&nbsp;Joachim F Kuebler,&nbsp;Stephanie Dippel,&nbsp;Anna Gigina,&nbsp;Christine S Falk,&nbsp;Gertrud Vieten,&nbsp;Claus Petersen,&nbsp;Christian Klemann","doi":"10.1080/08977194.2019.1626379","DOIUrl":"https://doi.org/10.1080/08977194.2019.1626379","url":null,"abstract":"<p><p>Biliary atresia (BA) is characterized by progressive destruction of the biliary system leading to liver fibrosis and deterioration of liver function. Serum hepatocyte growth factor (HGF) has been shown to be increased in cirrhotic diseases including BA. The aim of this study was to investigate the prognostic value of HGF levels in sera and liver tissue for the further disease course. A total of 49 serum and liver samples from infants with BA were acquired during Kasai-portoenterostomy (KPE) and analyzed by multiplex immunoassay including HGF, as marker of liver regeneration, and Interleukin 6 (IL-6) as a marker of inflammation. Both mediators showed no correlation with the outcome defined as favorable (survival with native liver (SNL)) or, in contrast, rapid deterioration of liver function requiring transplantation. Our data suggest that the degree of liver regeneration indicated by high levels of HGF within the liver is a dismissible factor in the post-KPE disease course.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1626379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37057550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Structure, function and disease relevance of Wnt inhibitory factor 1, a secreted protein controlling the Wnt and hedgehog pathways. Wnt抑制因子1(一种控制Wnt和hedgehog通路的分泌蛋白)的结构、功能和疾病相关性
IF 1.8 4区 生物学
Growth factors Pub Date : 2019-04-01 Epub Date: 2019-06-18 DOI: 10.1080/08977194.2019.1626380
Krisztina Kerekes, László Bányai, Mária Trexler, László Patthy
{"title":"Structure, function and disease relevance of Wnt inhibitory factor 1, a secreted protein controlling the Wnt and hedgehog pathways.","authors":"Krisztina Kerekes,&nbsp;László Bányai,&nbsp;Mária Trexler,&nbsp;László Patthy","doi":"10.1080/08977194.2019.1626380","DOIUrl":"https://doi.org/10.1080/08977194.2019.1626380","url":null,"abstract":"<p><p>Wnts and Hedgehogs (Hh) are large, lipid-modified extracellular morphogens that play key roles in embryonic development and stem cell proliferation of Metazoa. Both morphogens signal through heptahelical Frizzled-type receptors of the G-Protein Coupled Receptor family and there are several other similarities that suggest a common evolutionary origin of the Hh and Wnt pathways. There is evidence that the secreted protein, Wnt inhibitory factor 1 (WIF1) modulates the activity of both Wnts and Hhs and may thus contribute to the intertwining of these pathways. In this article, we review the structure, evolution, molecular interactions and functions of WIF1 with major emphasis on its role in carcinogenesis.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1626380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37337593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信