Growth factors最新文献

Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study. 可溶性EGFR、Fas和Fas配体在不孕妇女盆腔疼痛严重程度中的作用及其与子宫内膜异位症的关系：一项病例对照研究

IF 1.7 4区生物学

Growth factors Pub Date : 2026-04-08 DOI: 10.1080/08977194.2026.2656185

Fadhil Ahsan, Nanda Yuli Rahmawati, Fidyah Nanda Alditia, Alfin Firasy Mufid, Ashon Sa'adi, Sri Ratna Dwiningsih, M Y Ardianta Widyanugraha, Arif Tunjungseto, Budi Santoso

{"title":"Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study.","authors":"Fadhil Ahsan, Nanda Yuli Rahmawati, Fidyah Nanda Alditia, Alfin Firasy Mufid, Ashon Sa'adi, Sri Ratna Dwiningsih, M Y Ardianta Widyanugraha, Arif Tunjungseto, Budi Santoso","doi":"10.1080/08977194.2026.2656185","DOIUrl":"https://doi.org/10.1080/08977194.2026.2656185","url":null,"abstract":"Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women undergoing diagnostic laparoscopy and assessed serum and peritoneal levels of sEGFR, sFas, and sFasL using ELISA. Pain intensity was evaluated via the Visual Analog Scale (VAS). Peritoneal sFasL concentrations were significantly higher in infertile women with pelvic pain (p = 0.012) and correlated with VAS scores (r = 0.261, p = 0.014). Serum and peritoneal sFasL levels were significantly elevated in endometriosis patients with pelvic pain compared to controls (p = 0.003, p = 0.002, respectively). Peritoneal sFasL levels were also associated with dysmenorrhea and dyspareunia. ROC analysis demonstrated that serum sFasL differentiated endometriosis from controls (AUC = 0.797, p < 0.001). These findings suggest that sFasL may serve as a potential noninvasive biomarker for endometriosis. Further research should investigate its regulatory role in endometriosis-related pain.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ErbB receptor stimulation is required for mouse Colon adenoma organoids to form crypts. 小鼠结肠腺瘤类器官形成隐窝需要ErbB受体刺激。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-03-31 DOI: 10.1080/08977194.2026.2649730

Chin Wee Tan, Ruiyan Zhu, Serena R Kane, Michelle Au, Xiaoyu Zhang, Yumiko Hirokawa, Maree C Faux, Antony W Burgess

引用次数: 0

Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R. IGF1R临床显著变体（M1054I）的功能特征-参与定义IGF1R变构口袋中小分子结合的关键残基。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2025-12-26 DOI: 10.1080/08977194.2025.2606677

Farheen Showket, Aubaidah Akhtar, Sabra Parveen, Neetu Badesra, Mir Owais Ayaz, Md Mehedi Hossain, Mohmmad Saleem Dar, Razak Hussain, Pankaj Keshari, Riyaz A Mir, Mohd Jamal Dar

{"title":"Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R.","authors":"Farheen Showket, Aubaidah Akhtar, Sabra Parveen, Neetu Badesra, Mir Owais Ayaz, Md Mehedi Hossain, Mohmmad Saleem Dar, Razak Hussain, Pankaj Keshari, Riyaz A Mir, Mohd Jamal Dar","doi":"10.1080/08977194.2025.2606677","DOIUrl":"10.1080/08977194.2025.2606677","url":null,"abstract":"IGF1R, a receptor tyrosine kinase, is crucial for cell growth, proliferation, and differentiation. Overexpression of IGF1R is linked to cancer and resistance to therapies, making it a target for drug development. Previously, we identified an allosteric binding pocket in IGF1R, which could be exploited for the development of IGF1R specific small molecule inhibitors. A recent study linked M1054I variant to growth defects and microcephaly. In this study, we functionally characterized M1054I to assess its effects on kinase activity, downstream signaling, and receptor structure. Replacing methionine with isoleucine at position 1054 leads to complete loss of kinase activity. Consequently, activation of downstream signaling molecules is significantly reduced in cells carrying the M1054I mutation. Structural analysis reveals that the mutation causes conformational changes in key conserved regions, particularly in the activation loop, compromising IGF1R's structural integrity and function. Additionally, the roles of residues Y987 and K1033 in regulating IGF1R functions were examined.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"42-52"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers. 肥大性心肌病的细胞外基质生物标志物和转化生长因子-β：生物标志物之间的相互作用。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2026-02-06 DOI: 10.1080/08977194.2026.2626057

Nesrine Fourti, Manel Ben Halima, Wiem Zidi, Mohamed Sami Mourali, Haifa Sanhaji, Monia Allal-Elasmi

{"title":"Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers.","authors":"Nesrine Fourti, Manel Ben Halima, Wiem Zidi, Mohamed Sami Mourali, Haifa Sanhaji, Monia Allal-Elasmi","doi":"10.1080/08977194.2026.2626057","DOIUrl":"10.1080/08977194.2026.2626057","url":null,"abstract":"Significant dysregulation of matrix metalloproteinase (MMPs), their tissue inhibitors (TIMPs) and profibrotic cytokines have been reported in hypertrophic cardiomyopathy (HCM) and associated with adverse cardiac remodeling. We aim to investigate the relationship among MMPs, TIMPs, transforming growth factor-β (TGF-β) and amino terminal propeptide of type III procollagen (PIIINP) in HCM patients, and to explore their associations with clinical outcomes. We recruited 46 HCM patients and 49 controls, and measured biomarkers levels using ELISA. Receiver operating characteristic (ROC) analysis revealed the highest diagnostic sensitivity for MMP-2 (93.3%) and specificity for TGF-β (90%). Significant correlations were found between biomarkers and clinical parameters, including interactions between TGF-β and left ventricular mass, MMP-2 and intraventricular septum, PIIINP and maximal wall thickness. We suggest that TGF-β, with the highest specificity and MMP-2, with high sensitivity, may offer significant potential for identifying patients with HCM and serve as useful biomarkers for this disease.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"53-63"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chorioallantoic membrane assay demonstrating pro-angiogenic properties of BRAF inhibitor: a tool to treat chronic wounds. 绒毛膜尿囊膜试验显示BRAF抑制剂的促血管生成特性：治疗慢性伤口的工具。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1080/08977194.2026.2632046

Sonali Karhana, Yasmin Sultana, Nilanjan Saha, Nidhi, Mohd Ashif Khan

引用次数: 0

Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review. 生长因子负载壳聚糖支架作为生物活性仿生多功能平台在牙周组织工程中的研究进展。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2025-12-29 DOI: 10.1080/08977194.2025.2606675

Mohammed Alkandari, Meshari Alkandari, Gamal Abdel Nasser Atia, Eman Abd El-Halim, Mohamed Mohamady Ghobashy, Hany K Shalaby, Dinesh Rokaya, Tarek Foda, Khaled Hendy, Danishuddin, Md Azizul Haque

{"title":"Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review.","authors":"Mohammed Alkandari, Meshari Alkandari, Gamal Abdel Nasser Atia, Eman Abd El-Halim, Mohamed Mohamady Ghobashy, Hany K Shalaby, Dinesh Rokaya, Tarek Foda, Khaled Hendy, Danishuddin, Md Azizul Haque","doi":"10.1080/08977194.2025.2606675","DOIUrl":"10.1080/08977194.2025.2606675","url":null,"abstract":"Periodontitis causes severe tissue loss, making predictable regeneration a major challenge. Growth factor-loaded chitosan scaffolds offer a promising, multifunctional approach to enhance tissue regeneration. This review explores their design, optimization, and therapeutic potential, focusing on delivery methods, release kinetics, and biocompatibility. Studies show these scaffolds improve local delivery, sustain growth factor release, and reduce cytotoxicity while offering reinforcement and encouraging cell adhesion. Optimized release kinetics ensure a favorable prognosis, reducing the necessity for recurrent administration. Growth factor-loaded chitosan scaffolds create a biomimetic environment that supports periodontal healing, representing an innovative strategy for advancing periodontal therapy. Further research on scaffold design, growth factor combinations, and long-term outcomes is essential to refine this approach for more effective, predictable regeneration.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-41"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145855426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA methyltransferase 1-mediated methylation of midkine regulate myocardial ischemia-reperfusion injury via the Notch2/Hes1 axis. DNA甲基转移酶1介导的midkine甲基化通过Notch2/Hes1轴调控心肌缺血再灌注损伤。

IF 1.7 4区生物学

Growth factors Pub Date : 2025-10-01 Epub Date: 2025-12-04 DOI: 10.1080/08977194.2025.2595011

Wei Liu, Yuqin Wang, Jiayuan Wu, Caihong He, Zhengwei Zhou

{"title":"DNA methyltransferase 1-mediated methylation of midkine regulate myocardial ischemia-reperfusion injury via the Notch2/Hes1 axis.","authors":"Wei Liu, Yuqin Wang, Jiayuan Wu, Caihong He, Zhengwei Zhou","doi":"10.1080/08977194.2025.2595011","DOIUrl":"10.1080/08977194.2025.2595011","url":null,"abstract":"myocardial ischemia-reperfusion injury (MI/RI) threatens people's lives. Midkine (MDK) has a protective effect against MI/RI. DNA methyltransferase 1 (DNMT1) is closely associated with MI/RI. Mouse cardiomyocytes were isolated to establish a model of myocardial ischemia-reperfusion. Subsequently, the viability, apoptosis, and inflammatory factors of the cardiomyocytes treated under different conditions were measured. Western blotting was employed to examine the expression of related proteins. Chromatin immunoprecipitation (CHIP) and dual-luciferase reporter gene assays were conducted to verify the relationships among the DNMT1, MDK, and Notch2/Hes1 signaling pathways. The expression of MDK was reduced in the MI/RI cell model, while Notch2/Hes1 was activated. Overexpression of MDK mitigated the injury associated with MI/RI. Methylation modification of DNMT1 downregulated MDK, thereby mediating the Notch2/Hes1 pathway. The methylation modification of DNMT1 on MDK regulated the progression of MI/RI. The methylation modification of MDK by DNMT1 likely downregulates the Notch2/Hes1 pathway, thereby influencing MI/RI.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"203-215"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mendelian randomization analyses explore the causal relationship between fibroblast growth factor receptors and hypertrophic scar. 孟德尔随机化分析探讨了成纤维细胞生长因子受体与增生性瘢痕之间的因果关系。

IF 1.7 4区生物学

Growth factors Pub Date : 2025-10-01 Epub Date: 2025-11-30 DOI: 10.1080/08977194.2025.2595010

Hong-Fang Ma, Jun Shen

引用次数: 0

Growth hormone induces GATA3 gene expression via STAT5B. 生长激素通过STAT5B诱导GATA3基因表达。

IF 1.7 4区生物学

Growth factors Pub Date : 2025-08-01 Epub Date: 2025-11-24 DOI: 10.1080/08977194.2025.2584804

Mana Mitsutani, Hiromi Hano, Mei Yokoyama, Midori Matsushita, Tomomi Fujikawa, Tetsuya Tagami, Kenji Moriyama

引用次数: 0

VEGF ameliorates acute kidney injury by suppressing ferroptosis through activation of the ERK1/2-NRF2 pathway. VEGF通过激活ERK1/2-NRF2通路抑制铁下垂，改善急性肾损伤。

IF 1.7 4区生物学

Growth factors Pub Date : 2025-08-01 Epub Date: 2025-07-22 DOI: 10.1080/08977194.2025.2533773

Xiangtian Liu, Yuqi Song, Weikun Tian, Liping Ye, Dongxiao Li, Meifeng Li, Xinghan Tian, Xiaoli Li

引用次数: 0