Growth factors最新文献

Plasma levels and diagnostic utility of VEGF, MMP-9 and TIMP-2 in the diagnosis of psoriasis forms. 血管内皮生长因子、MMP-9 和 TIMP-2 的血浆水平及其在诊断银屑病中的作用。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-11-23 DOI: 10.1080/08977194.2024.2430205

Imen Chihaoui, Arbia Abbes, Wiem Zidi, Nesrine Fourti, Dalenda El Euch, Amel Mebazaa, Moncef Feki, Mourad Mokni, Sameh Hadj Taieb, Monia Allal-Elasmi

{"title":"Plasma levels and diagnostic utility of VEGF, MMP-9 and TIMP-2 in the diagnosis of psoriasis forms.","authors":"Imen Chihaoui, Arbia Abbes, Wiem Zidi, Nesrine Fourti, Dalenda El Euch, Amel Mebazaa, Moncef Feki, Mourad Mokni, Sameh Hadj Taieb, Monia Allal-Elasmi","doi":"10.1080/08977194.2024.2430205","DOIUrl":"https://doi.org/10.1080/08977194.2024.2430205","url":null,"abstract":"Psoriasis pathogenisis remain unknown despite the fact that it is considered as the most common autoimmune skin disease. We raised the hypothesis whether the selected biomarkers in this study provide actual evidence of psoriasis presence and severity. We aim in a first level to study serum level of pro-angiogenic marker VEGF variation and its correlation with MMP-9 and its specific inhibitor TIMP-2 in psoriatic patients serum. The study included 115 psoriatic patients and 51 controls. The biological parameters were measured by ELISA methods. Logistic regression analysis showed that VEGF, MMP-9, and inflammation Z-score are associated with psoriasis. ROC analysis showed that VEGF has low discriminant power for PsVG, However TIMP-2 and inflammation Z-scorewell discriminate this variant of psoriasis. The combined analysis of VEGF-TIMP-2 resulted in a significant increase in discriminant power for PsVG. Increase inflammatory phase may be reflecting the tissue destruction byMMP-9, emphasizing the deleterious expanse and the architectural changes of the skin which are more severe in PsP.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease. 瘦素和胰岛素样生长因子-1 在调节先天性紫绀型心脏病患儿生长中的作用。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-11-23 DOI: 10.1080/08977194.2024.2432941

Ashraf A Elsharkawy, Amany K El-Hawary, Gehan A AlSawah, Hadil M AboElenin, Mohammad H Awad

{"title":"Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease.","authors":"Ashraf A Elsharkawy, Amany K El-Hawary, Gehan A AlSawah, Hadil M AboElenin, Mohammad H Awad","doi":"10.1080/08977194.2024.2432941","DOIUrl":"https://doi.org/10.1080/08977194.2024.2432941","url":null,"abstract":"Background: Congenital cyanotic heart disease (CHD) in children is associated with several complications, amongst these complications is growth retardation which is believed to be multifactorial.Objectives: The objective of this study is to find out the role of leptin and Insulin-Like Growth Factor-1 (IGF-1) in the growth of paediatric patients with cyanotic CHD of different anatomical defects.Design/methods: This is a cross-sectional study involving thirty-nine children known to suffer from congenital cyanotic heart disease followed by the cardiology outpatient department, and forty-seven matched controls. Serum leptin and IGF-1 were evaluated in all the enrolled subjects besides anthropometric measurement and assessment of average oxygen saturation.Results: The patients' group showed statistically significant lower height, weight, Body mass index (BMI), leptin levels, and IGF-1. In addition, the patient group had a significant positive correlation between serum leptin and BMI, as well as a positive correlation of IGF-1 with average oxygen saturation.Conclusion: Children suffering from congenital cyanotic heart disease have a higher probability of developing poor growth. Serum leptin and IGF-1 are lower in affected children with congenital cyanotic cardiac defects suggesting that they may play a role in their poor growth.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet-rich plasma promotes wound repair in diabetic foot ulcer mice via the VEGFA/VEGFR2/ERK pathway. 富血小板血浆通过 VEGFA/VEGFR2/ERK 通路促进糖尿病足溃疡小鼠的伤口修复。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-11-14 DOI: 10.1080/08977194.2024.2422014

Weiqiang Wei, Di Xu, Fan Hu, Tenglong Jiang, Hong Liu

{"title":"Platelet-rich plasma promotes wound repair in diabetic foot ulcer mice via the VEGFA/VEGFR2/ERK pathway.","authors":"Weiqiang Wei, Di Xu, Fan Hu, Tenglong Jiang, Hong Liu","doi":"10.1080/08977194.2024.2422014","DOIUrl":"10.1080/08977194.2024.2422014","url":null,"abstract":"Diabetic foot ulcers (DFUs) are a severe microvascular complication. Platelet-rich plasma (PRP) pitches in DFU treatment. This study explored the mechanism of PRP facilitating wound repair in DFU mice via vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 (VEGFR2)/extracellular signal-regulated kinase (ERK) pathway. The DFU mouse model was established, with wound skin injected with PRP, followed by the detections of wound area, histopathological changes, and CD31-positive cells. IL-6/TNF-α/VEGFA/VEGFR2/p-VEGFR2/(ERK1/2)/(p-ERK1/2) levels in wound tissue homogenates were assessed. VEGFA-VEGFR2 interaction was evaluated. PRP-treated DFU mice were simultaneously treated with fruquintinib/PD98059. PRP reduced wound area, IL-6 and TNF-α levels, elevated epidermal dermal thickness, CD31-positive cell number, and aligned tissue structure, which were mitigated by fruquintinib/PD98059. PRP promoted VEGFR2 phosphorylation. PRP and fruquintinib/PD98059 abated p-VEGFR2/VEGFR2 or p-ERK1/2/ERK1/2 levels in DFU mice. PRP activated the ERK pathway through VEGFA/VEGFR2. Collectively, PRP promoted VEGFR2 phosphorylation and activated the ERK pathway, thereby facilitating wound repair in DFU mice.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The codon optimised gene produces an active human basic fibroblastic growth factor in rice cell suspension culture. 经过密码子优化的基因能在水稻细胞悬浮培养中产生活性人碱性成纤维细胞生长因子。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-11-01 DOI: 10.1080/08977194.2024.2423747

Meysam Bastami, Ramin Hosseini

引用次数: 0

PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells. PDGF诱导的内化可促进间充质细胞中PDGFRβ的蛋白水解。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-10-10 DOI: 10.1080/08977194.2024.2413623

Marie Rubin Sander, Agni Karolina Tsiatsiou, Kehuan Wang, Natalia Papadopoulos, Charlotte Rorsman, Frida Olsson, Johan Heldin, Ola Söderberg, Carl-Henrik Heldin, Johan Lennartsson

{"title":"PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells.","authors":"Marie Rubin Sander, Agni Karolina Tsiatsiou, Kehuan Wang, Natalia Papadopoulos, Charlotte Rorsman, Frida Olsson, Johan Heldin, Ola Söderberg, Carl-Henrik Heldin, Johan Lennartsson","doi":"10.1080/08977194.2024.2413623","DOIUrl":"https://doi.org/10.1080/08977194.2024.2413623","url":null,"abstract":"Platelet-derived growth factor (PDGF)-induced signalling via PDGF receptor β (PDGFRβ) leads to activation of downstream signalling pathways which regulate multiple cellular responses. It is unclear how PDGFRβ is degraded; both lysosomal and proteasomal degradation have been suggested. In this study, we have characterised the proteolytic cleavage of ligand-activated PDGFRβ, which results in two fragments: a larger fragment containing the extracellular domain, the transmembrane segment, and a part of the intracellular juxtamembrane region with a molecular mass of ∼130 kDa, and an intracellular ∼70 kDa fragment released into the cytoplasm. The proteolytic processing did not take place without internalisation of PDGFRβ. In addition, chelation of intracellular Ca2+ inhibited proteolytic processing. Inhibition of the proteasome affected signal transduction by increasing the phosphorylation of PDGFRβ, PLCγ, and STAT3 while reducing it on Erk1/2 and not affecting Akt. The proteolytic cleavage was observed in fibroblasts or cells that had undergone epithelial-mesenchymal transition.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-14"},"PeriodicalIF":1.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-Glutamine mitigates bile acid-induced inhibition of growth factor activity in rat hepatocyte cultures. L-谷氨酰胺可减轻胆汁酸对大鼠肝细胞生长因子活性的抑制。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-09-25 DOI: 10.1080/08977194.2024.2407566

Wafa'a Alqabandi, Gursev S Dhaunsi

{"title":"L-Glutamine mitigates bile acid-induced inhibition of growth factor activity in rat hepatocyte cultures.","authors":"Wafa'a Alqabandi, Gursev S Dhaunsi","doi":"10.1080/08977194.2024.2407566","DOIUrl":"10.1080/08977194.2024.2407566","url":null,"abstract":"Bile acid-induced hepatotoxicity is inevitable in Cholestasis pathogenesis and L-Glutamine (L-Gln) has been reported to prevent total parenteral nutrition (TPN)-induced cholestasis in premature neonates. While mechanisms remain unknown, we hypothesize that bile acids impair growth factor (GF) function in hepatocytes which L-glutamine prevents through NAPDH oxidase (NOX) modulation. Glycochenodeoxycholic acid (GCDC, 0-100 µM) when added to primary hepatocyte cultures significantly (p < 0.01) decreased the FBS-induced BrdU incorporation, however inhibition of Fibroblast Growth factor (FGF)- or Hepatocyte growth factor (HGF)-induced DNA synthesis was more pronounced (p < 0.001). L-Gln markedly attenuated GCDC-mediated inhibition of DNA synthesis in both FBS and GF-treated cells. GCDC significantly increased the NADPH oxidase activity and NOX-1 protein expression that were markedly reduced by L-Gln and protein kinase c (PKC) inhibitor, LY-333531. Apocynin (APCN) and diphenyliodonium (DPI) significantly blocked the GCDC-mediated inhibition of GF-induced DNA synthesis. This study demonstrates that bile acid-induced hepatotoxicity involves dysfunction of certain growth factors via protein kinase c (PKC)- mediated NOX modulation which can be corrected, at least partly, by L-glutamine.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"120-127"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tibial transverse transport combined with platelet-rich plasma sustained-release microspheres activates the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in diabetic foot ulcer. 胫骨横向运输结合富血小板血浆缓释微球可激活 VEGFA/VEGFR2 通路，促进糖尿病足溃疡的微循环重建。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-09-27 DOI: 10.1080/08977194.2024.2407318

Weiqiang Wei, Tenglong Jiang, Fan Hu, Hong Liu

{"title":"Tibial transverse transport combined with platelet-rich plasma sustained-release microspheres activates the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in diabetic foot ulcer.","authors":"Weiqiang Wei, Tenglong Jiang, Fan Hu, Hong Liu","doi":"10.1080/08977194.2024.2407318","DOIUrl":"10.1080/08977194.2024.2407318","url":null,"abstract":"This study proposes to investigate the therapeutic efficacy and mechanism of combining tibial transverse transport (TTT) with platelet-rich plasma (PRP) for diabetic foot ulcer (DFU). The diabetic rabbit model was constructed with Streptozotocin, which was intervened with TTT and PRP. PRP injection combined with TTT significantly promoted vascularisation and enhanced CD31, VEGFA, and VEGFR2 expressions compared to traditional TTT. However, the VEGFR2 inhibitor suppressed these phenomena. In the in vitro injury model, PRP reversed the diminished human umbilical vein endothelial cells (HUVECs) function and vascularisation caused by high-glucose damage. Additionally, PRP reduced inflammation and oxidative stress (approximately 47% ROS level) and enhanced VEGFA and VEGFR2 expression in HUVECs. However, the knockdown of VEGFR2 reversed the effect of PRP. In conclusion, TTT combined with intraosseous flap injection of PRP sustained-release microspheres activated the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in DFU. These findings may provide new potential therapeutic strategies for DFU.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"128-144"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes. VEGF-B 与 2 型糖尿病患者的糖尿病周围神经病变有关。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-07-12 DOI: 10.1080/08977194.2024.2377553

Ruonan Zhou, Yingying Xue, Ziwei Zhu, Pingyuan Xu, Lixuan Shen, Ziwei Wang, Yingying Xiang, Yue Cao, Xizhong Yu, Wenbin Shang

引用次数: 0

Statement of Retraction: Elevated Neurotrophin and Neurotrophin Receptor Expression in Spontaneously Hypertensive Rat Lungs. 撤回声明：自发性高血压大鼠肺中神经营养素和神经营养素受体表达的升高。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-08-16 DOI: 10.1080/08977194.2024.2392373

引用次数: 0

Expression of Concern. 表达关切。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-08-28 DOI: 10.1080/08977194.2024.2392344

引用次数: 0