Growth factors最新文献

Effects of aging in combination with high-fat or ketogenic diet on skeletal muscle hypertrophy after functional overloading in C57BL/6J mice. 衰老联合高脂或生酮饮食对C57BL/6J小鼠功能超负荷后骨骼肌肥大的影响

IF 1.9 4区生物学

Growth factors Pub Date : 2026-07-19 DOI: 10.1080/08977194.2026.2704554

Mantas Dirmontas, Petras Minderis, Aivaras Ratkevicius

引用次数: 0

Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study. 可溶性EGFR、Fas和Fas配体在不孕妇女盆腔疼痛严重程度中的作用及其与子宫内膜异位症的关系：一项病例对照研究

IF 1.9 4区生物学

Growth factors Pub Date : 2026-05-01 Epub Date: 2026-04-08 DOI: 10.1080/08977194.2026.2656185

Fadhil Ahsan, Nanda Yuli Rahmawati, Fidyah Nanda Alditia, Alfin Firasy Mufid, Ashon Sa'adi, Sri Ratna Dwiningsih, M Y Ardianta Widyanugraha, Arif Tunjungseto, Budi Santoso

{"title":"Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study.","authors":"Fadhil Ahsan, Nanda Yuli Rahmawati, Fidyah Nanda Alditia, Alfin Firasy Mufid, Ashon Sa'adi, Sri Ratna Dwiningsih, M Y Ardianta Widyanugraha, Arif Tunjungseto, Budi Santoso","doi":"10.1080/08977194.2026.2656185","DOIUrl":"10.1080/08977194.2026.2656185","url":null,"abstract":"Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women undergoing diagnostic laparoscopy and assessed serum and peritoneal levels of sEGFR, sFas, and sFasL using ELISA. Pain intensity was evaluated via the Visual Analog Scale (VAS). Peritoneal sFasL concentrations were significantly higher in infertile women with pelvic pain (p = 0.012) and correlated with VAS scores (r = 0.261, p = 0.014). Serum and peritoneal sFasL levels were significantly elevated in endometriosis patients with pelvic pain compared to controls (p = 0.003, p = 0.002, respectively). Peritoneal sFasL levels were also associated with dysmenorrhea and dyspareunia. ROC analysis demonstrated that serum sFasL differentiated endometriosis from controls (AUC = 0.797, p < 0.001). These findings suggest that sFasL may serve as a potential noninvasive biomarker for endometriosis. Further research should investigate its regulatory role in endometriosis-related pain.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"125-137"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BMP7 peripheral sequence evolution correlates with mammalian cloacal septation. BMP7外周序列进化与哺乳动物泄殖腔分隔相关。

IF 1.9 4区生物学

Growth factors Pub Date : 2026-05-01 Epub Date: 2026-07-09 DOI: 10.1080/08977194.2026.2696513

Aditi Kaloni, Meghal Vaishnani, Mansi Popat, Swayamprabha Samantaray, Shrinal Vasa, Anupama Modi, Bhavin Parekh

{"title":"BMP7 peripheral sequence evolution correlates with mammalian cloacal septation.","authors":"Aditi Kaloni, Meghal Vaishnani, Mansi Popat, Swayamprabha Samantaray, Shrinal Vasa, Anupama Modi, Bhavin Parekh","doi":"10.1080/08977194.2026.2696513","DOIUrl":"10.1080/08977194.2026.2696513","url":null,"abstract":"Vertebrate evolution from a single multipurpose cloaca to separate urogenital and anal openings remains a central molecular question with relevance to reproductive diversification and anorectal malformations. We investigated BMP7, a critical regulator of cloacal formation, across 37 vertebrates from cartilaginous fish to mammals using phylogenetics, sequence alignment, physicochemical assessment, domain analysis, motif analysis and molecular docking. The BMP7 core TGF-beta domain was highly conserved (>90% identity), whereas peripheral regions showed significant habitat-associated divergence (p < 0.01), including shifts in isoelectric point between aquatic and terrestrial vertebrates (pI 6.22-6.97 to 6.98-8.98) and altered stability indices. A key finding was that placental mammals, in which cloacal septation produces distinct anorectal and urogenital outlets, showed lineage-specific amino-acid changes, including Pro111Ala, linked to predicted BMP7-FOXA1 regulatory refinement. MEME analysis identified mammal-bird GWQDWI conservation and amphibian-reptile RACGCH divergence, supporting peripheral BMP7 adaptation during cloacal evolution.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"138-149"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ErbB receptor stimulation is required for mouse Colon adenoma organoids to form crypts. 小鼠结肠腺瘤类器官形成隐窝需要ErbB受体刺激。

IF 1.9 4区生物学

Growth factors Pub Date : 2026-05-01 Epub Date: 2026-03-31 DOI: 10.1080/08977194.2026.2649730

Chin Wee Tan, Ruiyan Zhu, Serena R Kane, Michelle Au, Xiaoyu Zhang, Yumiko Hirokawa, Maree C Faux, Antony W Burgess

引用次数: 0

The role of ERK signaling pathway in pituitary adenomas: from molecular mechanisms to targeted therapy. ERK信号通路在垂体腺瘤中的作用：从分子机制到靶向治疗。

IF 1.9 4区生物学

Growth factors Pub Date : 2026-05-01 Epub Date: 2026-05-28 DOI: 10.1080/08977194.2026.2671736

Jingwei Ye, Yuan Wen, Jingyang Zhan, Khaing Wut Yi Hla, Tong Li, Zhiyu Xiao, Xianghan Shu

{"title":"The role of ERK signaling pathway in pituitary adenomas: from molecular mechanisms to targeted therapy.","authors":"Jingwei Ye, Yuan Wen, Jingyang Zhan, Khaing Wut Yi Hla, Tong Li, Zhiyu Xiao, Xianghan Shu","doi":"10.1080/08977194.2026.2671736","DOIUrl":"10.1080/08977194.2026.2671736","url":null,"abstract":"ERK, a core member of the MAPK family, operates through the classical Ras/Raf/MEK/ERK signaling cascade. Abnormal activation of this pathway is closely associated with malignant tumor progression and represents a critical target in anticancer drug development. In this article, we systematically describe the regulatory network of the ERK pathway, including negative feedback mechanisms, cross-pathway interactions, non-coding RNAs, and epigenetic regulation, with a particular focus on ERK's dual role-promoting both cell proliferation and apoptosis-in pituitary adenomas compared to other tumors. Additionally, we explore emerging ERK-targeted therapies and their associated resistance mechanisms. Despite substantial research on ERK, further investigation into its underlying mechanisms is warranted. We propose the construction of computational modeling approaches to analyze these complex regulatory relationships and to develop precise combination therapies aimed at overcoming resistance. Such strategies could enable personalized treatment and offer more effective solutions for managing pituitary tumors and other malignancies.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"77-93"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the epidermal growth factor in the pathogenesis of schizophrenia. Clinical and diagnostic value. 表皮生长因子在精神分裂症发病机制中的作用。临床和诊断价值。

IF 1.9 4区生物学

Growth factors Pub Date : 2026-05-01 Epub Date: 2026-07-02 DOI: 10.1080/08977194.2026.2695623

Daria Piskareva, Yana Zorkina, Alisa Andryushenko, Georgy Kostyuk

引用次数: 0

Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R. IGF1R临床显著变体（M1054I）的功能特征-参与定义IGF1R变构口袋中小分子结合的关键残基。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2025-12-26 DOI: 10.1080/08977194.2025.2606677

Farheen Showket, Aubaidah Akhtar, Sabra Parveen, Neetu Badesra, Mir Owais Ayaz, Md Mehedi Hossain, Mohmmad Saleem Dar, Razak Hussain, Pankaj Keshari, Riyaz A Mir, Mohd Jamal Dar

{"title":"Functional characterization of a clinically significant variant of IGF1R (M1054I) - a critical residue involved in defining the binding of small molecules in the allosteric pocket of IGF1R.","authors":"Farheen Showket, Aubaidah Akhtar, Sabra Parveen, Neetu Badesra, Mir Owais Ayaz, Md Mehedi Hossain, Mohmmad Saleem Dar, Razak Hussain, Pankaj Keshari, Riyaz A Mir, Mohd Jamal Dar","doi":"10.1080/08977194.2025.2606677","DOIUrl":"10.1080/08977194.2025.2606677","url":null,"abstract":"IGF1R, a receptor tyrosine kinase, is crucial for cell growth, proliferation, and differentiation. Overexpression of IGF1R is linked to cancer and resistance to therapies, making it a target for drug development. Previously, we identified an allosteric binding pocket in IGF1R, which could be exploited for the development of IGF1R specific small molecule inhibitors. A recent study linked M1054I variant to growth defects and microcephaly. In this study, we functionally characterized M1054I to assess its effects on kinase activity, downstream signaling, and receptor structure. Replacing methionine with isoleucine at position 1054 leads to complete loss of kinase activity. Consequently, activation of downstream signaling molecules is significantly reduced in cells carrying the M1054I mutation. Structural analysis reveals that the mutation causes conformational changes in key conserved regions, particularly in the activation loop, compromising IGF1R's structural integrity and function. Additionally, the roles of residues Y987 and K1033 in regulating IGF1R functions were examined.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"42-52"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers. 肥大性心肌病的细胞外基质生物标志物和转化生长因子-β：生物标志物之间的相互作用。

IF 1.9 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2026-02-06 DOI: 10.1080/08977194.2026.2626057

Nesrine Fourti, Manel Ben Halima, Wiem Zidi, Mohamed Sami Mourali, Haifa Sanhaji, Monia Allal-Elasmi

{"title":"Extracellular matrix biomarkers and transforming growth factor-β in hypertrophic cardiomyopathy: interaction between biomarkers.","authors":"Nesrine Fourti, Manel Ben Halima, Wiem Zidi, Mohamed Sami Mourali, Haifa Sanhaji, Monia Allal-Elasmi","doi":"10.1080/08977194.2026.2626057","DOIUrl":"10.1080/08977194.2026.2626057","url":null,"abstract":"Significant dysregulation of matrix metalloproteinase (MMPs), their tissue inhibitors (TIMPs) and profibrotic cytokines have been reported in hypertrophic cardiomyopathy (HCM) and associated with adverse cardiac remodeling. We aim to investigate the relationship among MMPs, TIMPs, transforming growth factor-β (TGF-β) and amino terminal propeptide of type III procollagen (PIIINP) in HCM patients, and to explore their associations with clinical outcomes. We recruited 46 HCM patients and 49 controls, and measured biomarkers levels using ELISA. Receiver operating characteristic (ROC) analysis revealed the highest diagnostic sensitivity for MMP-2 (93.3%) and specificity for TGF-β (90%). Significant correlations were found between biomarkers and clinical parameters, including interactions between TGF-β and left ventricular mass, MMP-2 and intraventricular septum, PIIINP and maximal wall thickness. We suggest that TGF-β, with the highest specificity and MMP-2, with high sensitivity, may offer significant potential for identifying patients with HCM and serve as useful biomarkers for this disease.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"53-63"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chorioallantoic membrane assay demonstrating pro-angiogenic properties of BRAF inhibitor: a tool to treat chronic wounds. 绒毛膜尿囊膜试验显示BRAF抑制剂的促血管生成特性：治疗慢性伤口的工具。

IF 1.9 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1080/08977194.2026.2632046

Sonali Karhana, Yasmin Sultana, Nilanjan Saha, Nidhi, Mohd Ashif Khan

引用次数: 0

Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review. 生长因子负载壳聚糖支架作为生物活性仿生多功能平台在牙周组织工程中的研究进展。

IF 1.7 4区生物学

Growth factors Pub Date : 2026-02-01 Epub Date: 2025-12-29 DOI: 10.1080/08977194.2025.2606675

Mohammed Alkandari, Meshari Alkandari, Gamal Abdel Nasser Atia, Eman Abd El-Halim, Mohamed Mohamady Ghobashy, Hany K Shalaby, Dinesh Rokaya, Tarek Foda, Khaled Hendy, Danishuddin, Md Azizul Haque

{"title":"Growth factors loaded chitosan scaffolds as bioactive biomimetic multifunctional platforms in periodontal tissue engineering: a review.","authors":"Mohammed Alkandari, Meshari Alkandari, Gamal Abdel Nasser Atia, Eman Abd El-Halim, Mohamed Mohamady Ghobashy, Hany K Shalaby, Dinesh Rokaya, Tarek Foda, Khaled Hendy, Danishuddin, Md Azizul Haque","doi":"10.1080/08977194.2025.2606675","DOIUrl":"10.1080/08977194.2025.2606675","url":null,"abstract":"Periodontitis causes severe tissue loss, making predictable regeneration a major challenge. Growth factor-loaded chitosan scaffolds offer a promising, multifunctional approach to enhance tissue regeneration. This review explores their design, optimization, and therapeutic potential, focusing on delivery methods, release kinetics, and biocompatibility. Studies show these scaffolds improve local delivery, sustain growth factor release, and reduce cytotoxicity while offering reinforcement and encouraging cell adhesion. Optimized release kinetics ensure a favorable prognosis, reducing the necessity for recurrent administration. Growth factor-loaded chitosan scaffolds create a biomimetic environment that supports periodontal healing, representing an innovative strategy for advancing periodontal therapy. Further research on scaffold design, growth factor combinations, and long-term outcomes is essential to refine this approach for more effective, predictable regeneration.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"1-41"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145855426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0