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Expression of Concern. 表达关切。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-28 DOI: 10.1080/08977194.2024.2392344
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引用次数: 0
Statement of Retraction: Elevated Neurotrophin and Neurotrophin Receptor Expression in Spontaneously Hypertensive Rat Lungs. 撤回声明：自发性高血压大鼠肺中神经营养素和神经营养素受体表达的升高。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-16 DOI: 10.1080/08977194.2024.2392373
{"title":"Statement of Retraction: Elevated Neurotrophin and Neurotrophin Receptor Expression in Spontaneously Hypertensive Rat Lungs.","authors":"","doi":"10.1080/08977194.2024.2392373","DOIUrl":"https://doi.org/10.1080/08977194.2024.2392373","url":null,"abstract":"","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men. 为期 8 周的联合阻力运动训练和隔日热量限制对肥胖男性可溶性表皮生长因子受体（sEGFR）和腺苷的比较效应。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-07-15 DOI: 10.1080/08977194.2024.2378889
Yousif Hikmat, Alireza Safarzade, Hamid Alizadeh
{"title":"Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men.","authors":"Yousif Hikmat, Alireza Safarzade, Hamid Alizadeh","doi":"10.1080/08977194.2024.2378889","DOIUrl":"https://doi.org/10.1080/08977194.2024.2378889","url":null,"abstract":"<p><p>This study investigated the combined effects of resistance exercise training (RET) and alternate-day calorie restriction (ADCR) on body composition, insulin resistance (IR), insulin resistance-related biomarkers (adipokine adipsin and hepatokine soluble EFGR), and weight loss in obese men. The findings revealed that RET + ADCR induced the greatest reductions in body weight, body fat percentage, and waist-to-hip ratio (WHR) compared to RET and ADCR alone (<i>p</i> < 0.05). Additionally, RET + ADCR resulted in the most significant improvements in IR, as measured by HOMA-IR, and in circulating levels of adipsin and soluble EFGR (<i>p</i> < 0.05). These findings suggest that combining RET and ADCR may be a more effective strategy for improving metabolic health, including body composition, IR, and metabolic tissues' functions, in obese men than either intervention alone.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes. VEGF-B 与 2 型糖尿病患者的糖尿病周围神经病变有关。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-07-12 DOI: 10.1080/08977194.2024.2377553
Ruonan Zhou, Yingying Xue, Ziwei Zhu, Pingyuan Xu, Lixuan Shen, Ziwei Wang, Yingying Xiang, Yue Cao, Xizhong Yu, Wenbin Shang
{"title":"VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes.","authors":"Ruonan Zhou, Yingying Xue, Ziwei Zhu, Pingyuan Xu, Lixuan Shen, Ziwei Wang, Yingying Xiang, Yue Cao, Xizhong Yu, Wenbin Shang","doi":"10.1080/08977194.2024.2377553","DOIUrl":"https://doi.org/10.1080/08977194.2024.2377553","url":null,"abstract":"<p><p><b>Aims:</b> This study aims to explore the potential role of vascular endothelial growth factor-B (VEGF-B) in the pathogenesis of diabetic peripheral neuropathy (DPN). The expression of VEGFRs were reanalysed by using gene arrays of peripheral nerve samples from mouse models of DPN retrieved from the GEO database. 213 T2D patients as well as 31 healthy individuals were recruited. The serum VEGF-B was detected and its relationship with DPN was analysed. The elevated VEGFR1 was the only change of VEGFR gene expression in the peripheral nerve from mouse models of DPN. The level of serum VEGF-B in T2D patients with DPN was higher than that in T2D patients without DPN and healthy people. Analysis of correlation and binary logistic regression confirmed that the increased serum VEGF-B level was an independent risk factor of DPN in T2D patients. VEGF-B-VEGFR1 signaling pathway may be involved in the development of DPN.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141599106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. 基底样乳腺癌细胞产生的白细胞介素-3与预后不良有关。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-05-01 Epub Date: 2024-02-01 DOI: 10.1080/08977194.2023.2297693
Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder
{"title":"Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis.","authors":"Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder","doi":"10.1080/08977194.2023.2297693","DOIUrl":"10.1080/08977194.2023.2297693","url":null,"abstract":"<p><p>Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. \"Basal-like\" breast cancers predominantly lack the receptors for estrogen and progesterone (ER/PR), lack amplification of human epidermal growth factor receptor 2 (HER2) but account for 10-15% of all breast cancers, are largely insensitive to targeted treatment and represent a disproportionate number of metastatic cases and deaths. Analysis of interleukin (IL)-3 and the IL-3 receptor subunits (<i>IL-3RA + CSF2RB</i>) reveals elevated expression in predominantly the basal-like group. Further analysis suggests that IL-3 itself, but not the IL-3 receptor subunits, associates with poor patient outcome. Histology on patient-derived xenografts supports the notion that breast cancer cells are a significant source of IL-3 that may promote disease progression. Taken together, these observations suggest that IL-3 may be a useful marker in solid tumors, particularly triple negative breast cancer, and warrants further investigation into its contribution to disease pathogenesis.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GALNT6, GALNT14, and Gal-3 in association with GDF-15 promotes drug resistance and stemness of breast cancer via β-catenin axis. GALNT6、GALNT14和Gal-3与GDF-15通过β-catenin轴促进乳腺癌的耐药性和干性。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-05-01 Epub Date: 2024-06-18 DOI: 10.1080/08977194.2024.2368907
Ashita Gadwal, Purvi Purohit, Manoj Khokhar, Jeewan Ram Vishnoi, Puneet Pareek, Ramkaran Choudhary, Poonam Elhence, Mithu Banerjee, Praveen Sharma
{"title":"GALNT6, GALNT14, and Gal-3 in association with GDF-15 promotes drug resistance and stemness of breast cancer <i>via</i> β-catenin axis.","authors":"Ashita Gadwal, Purvi Purohit, Manoj Khokhar, Jeewan Ram Vishnoi, Puneet Pareek, Ramkaran Choudhary, Poonam Elhence, Mithu Banerjee, Praveen Sharma","doi":"10.1080/08977194.2024.2368907","DOIUrl":"10.1080/08977194.2024.2368907","url":null,"abstract":"<p><p>N-acetylgalactosaminyltransferases (GALNTs) are a polypeptide responsible for aberrant glycosylation in breast cancer (BC), but the mechanism is unclear. In this study, expression levels of GALNT6, GALNT14, and Gal-3 were assessed in BC, and their association with GDF-15, β-catenin, stemness (SOX2 and OCT4), and drug resistance marker (ABCC5) was evaluated. Gene expression of GALNT6, GALNT14, Gal-3, GDF-15, OCT4, SOX2, ABCC5, and β-catenin in tumor and adjacent non-tumor tissues (<i>n</i> = 30) was determined. The same was compared with GEO-microarray datasets. A significant increase in the expression of candidate genes was observed in BC tumor compared to adjacent non-tumor tissue; and in pre-therapeutic patients compared to post-therapeutic. GALNT6, GALNT14, Gal-3, and GDF-15 showed positive association with β-catenin, SOX2, OCT4, and ABCC5 and were significantly associated with poor Overall Survival. Our findings were also validated <i>via in silico</i> analysis. Our study suggests that GALNT6, GALNT14, and Gal-3 in association with GDF-15 promote stemness and intrinsic drug resistance in BC, possibly by β-catenin signaling pathway.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLA2G2D fosters angiogenesis in non-small cell lung cancer through aerobic glycolysis. PLA2G2D通过有氧糖酵解促进非小细胞肺癌的血管生成
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-05-01 Epub Date: 2024-01-01 DOI: 10.1080/08977194.2023.2297702
Huaizhong Zhang, Keng Chen, Yongqing Zhou, Zhuo Cao, Cunlai Xu, Lin Zhou, Gongzhi Wu, Congxiong Peng, Songqing Lai, Xuhui Wu
{"title":"PLA2G2D fosters angiogenesis in non-small cell lung cancer through aerobic glycolysis.","authors":"Huaizhong Zhang, Keng Chen, Yongqing Zhou, Zhuo Cao, Cunlai Xu, Lin Zhou, Gongzhi Wu, Congxiong Peng, Songqing Lai, Xuhui Wu","doi":"10.1080/08977194.2023.2297702","DOIUrl":"10.1080/08977194.2023.2297702","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) stands prominent among the prevailing and formidable oncological entities. The immune and metabolic-related molecule Phospholipase A2, group IID (PLA2G2D) exerts promotional effects on tumor progression. However, its involvement in cancer angiogenesis remains elusive. Therefore, this investigation delved into the functional significance of PLA2G2D concerning angiogenesis in NSCLC. This study analyzed the expression and enriched pathways of PLA2G2D in NSCLC tissues through bioinformatics analysis, and measured the expression of PLA2G2D in NSCLC cells using qRT-PCR and western blot (WB). Subsequently, the viability and angiogenic potential of NSCLC cells were assessed employing CCK-8 and angiogenesis assays, respectively. The expression profile of angiogenic factors was analyzed through WB. Finally, the expression of glycolysis pathway-related genes, extracellular acidification rate and oxygen consumption rate, and the levels of pyruvate, lactate, citrate, and malate were analyzed in NSCLC cells using qRT-PCR, Seahorse XF 96, and related kits. Bioinformatics analysis revealed the upregulation of PLA2G2D in NSCLC tissues and its association with VEGF and glycolysis signaling pathways. Molecular and cellular experiments demonstrated that upregulated PLA2G2D promoted the viability, angiogenic ability, and glycolysis pathway of NSCLC cells. Rescue assays revealed that the effects of high expression of PLA2G2D on the viability, angiogenic ability, and glycolysis of NSCLC cells were weakened after the addition of the glycolysis inhibitor 2-DG. In summary, PLA2G2D plays a key role in NSCLC angiogenesis through aerobic glycolysis, displaying great potential as a target for anti-angiogenesis therapy.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer 被确定为血清中新型生物标记物的 FOXN2 通过与分割缺陷 6 同源物 alpha 的相互作用调节转化生长因子-β 信号通路，从而促进胃癌的发病机制
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-03-04 DOI: 10.1080/08977194.2023.2297700
Liang Li, XueFeng Sun, Mei Zhang, BangShuo Zhang, Yi Yang, Sheng Wang
{"title":"FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer","authors":"Liang Li, XueFeng Sun, Mei Zhang, BangShuo Zhang, Yi Yang, Sheng Wang","doi":"10.1080/08977194.2023.2297700","DOIUrl":"https://doi.org/10.1080/08977194.2023.2297700","url":null,"abstract":"Dysregulated expression of Forkhead Box N2 (FOXN2) has been detected in various cancer types. However, the underlying mechanisms by which FOXN2 contributes to the onset and progression of gastric c...","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140073436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study. 评价注射富血小板纤维蛋白(i-PRF)对大鼠伤口愈合和生长因子释放的影响:一项裂口研究。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2289375
Aysan Lektemur Alpan, Gizem Torumtay Cin, Alper Kızıldağ, Necati Zavrak, Özlem Özmen, Şevki Arslan, Doğukan Mutlu
{"title":"Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study.","authors":"Aysan Lektemur Alpan, Gizem Torumtay Cin, Alper Kızıldağ, Necati Zavrak, Özlem Özmen, Şevki Arslan, Doğukan Mutlu","doi":"10.1080/08977194.2023.2289375","DOIUrl":"10.1080/08977194.2023.2289375","url":null,"abstract":"<p><p>This experimental study aimed to evaluate the effects of injectable platelet-rich fibrin (i-PRF) on mucosal healing and the release of growth factors in rats. 40 rats were used; i-PRF was administered in the right buccal area while saline was injected in the left. Cytokeratin, FGF, PDGF, TGF, and VEGF expressions were determined with immunohistochemistry. Gene expressions of EGF, TGF-β, and VEGF were analysed. Epithelialization started on the 3rd day, and connective tissue maturation was more prominent in the i-PRF-applied group. Also, the releases of VEGF, EGF, TGF-β, PDGF, and FGF were higher in the i-PRF group during the 14 days. Gene expression analysis showed that changes in TGF-β at 14 days after i-PRF injection and VEGF after 21 days were statistically significant. The results of this study suggested that autologous i-PRF application enhanced the healing of oral mucosal wounds by increasing the release of growth factors for 21 days.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibroblast growth factor 23 and its role in bone diseases. 成纤维细胞生长因子23及其在骨疾病中的作用。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2274579
Andrija Jurina, Dino Kasumović, Valentina Delimar, Tajana Filipec Kanižaj, Mladen Japjec, Tomislav Dujmović, Marijana Vučić Lovrenčić, Mario Starešinić
{"title":"Fibroblast growth factor 23 and its role in bone diseases.","authors":"Andrija Jurina, Dino Kasumović, Valentina Delimar, Tajana Filipec Kanižaj, Mladen Japjec, Tomislav Dujmović, Marijana Vučić Lovrenčić, Mario Starešinić","doi":"10.1080/08977194.2023.2274579","DOIUrl":"10.1080/08977194.2023.2274579","url":null,"abstract":"<p><p>Fibroblast growth factor 23 (FGF23) has been casually linked to numerous hypophosphatemic bone diseases, however connection with bone loss or fragility fractures is still a matter of debate. The purpose of this review is to explore and summarise the known actions of FGF23 in various pathological bone conditions. Besides implication in bone mineralisation, elevated FGF23 showed a pathological effecton bone remodelling, primarily by inhibiting osteoblast function. Unlike the weak association with bone mineral density, high values of FGF23 have been connected with fragility fracture prevalence. This review shows that its effects on bone are concomitantly present on multiple levels, affecting both qualitative and quantitative part of bone strength, eventually leading to impaired bone strength and increased tendency of fractures. Recognising FGF23 as a risk factor for the development of bone diseases and correcting its levels could lead to the reduction of morbidity and mortality in specific groups of patients.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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