Growth factors最新文献_第2页

Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease. 瘦素和胰岛素样生长因子-1 在调节先天性紫绀型心脏病患儿生长中的作用。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-10-01 Epub Date: 2024-11-23 DOI: 10.1080/08977194.2024.2432941

Ashraf A Elsharkawy, Amany K El-Hawary, Gehan A AlSawah, Hadil M AboElenin, Mohammad H Awad

{"title":"Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease.","authors":"Ashraf A Elsharkawy, Amany K El-Hawary, Gehan A AlSawah, Hadil M AboElenin, Mohammad H Awad","doi":"10.1080/08977194.2024.2432941","DOIUrl":"10.1080/08977194.2024.2432941","url":null,"abstract":"Background: Congenital cyanotic heart disease (CHD) in children is associated with several complications, amongst these complications is growth retardation which is believed to be multifactorial.Objectives: The objective of this study is to find out the role of leptin and Insulin-Like Growth Factor-1 (IGF-1) in the growth of paediatric patients with cyanotic CHD of different anatomical defects.Design/methods: This is a cross-sectional study involving thirty-nine children known to suffer from congenital cyanotic heart disease followed by the cardiology outpatient department, and forty-seven matched controls. Serum leptin and IGF-1 were evaluated in all the enrolled subjects besides anthropometric measurement and assessment of average oxygen saturation.Results: The patients' group showed statistically significant lower height, weight, Body mass index (BMI), leptin levels, and IGF-1. In addition, the patient group had a significant positive correlation between serum leptin and BMI, as well as a positive correlation of IGF-1 with average oxygen saturation.Conclusion: Children suffering from congenital cyanotic heart disease have a higher probability of developing poor growth. Serum leptin and IGF-1 are lower in affected children with congenital cyanotic cardiac defects suggesting that they may play a role in their poor growth.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"198-204"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The codon optimised gene produces an active human basic fibroblastic growth factor in rice cell suspension culture. 经过密码子优化的基因能在水稻细胞悬浮培养中产生活性人碱性成纤维细胞生长因子。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-10-01 Epub Date: 2024-11-01 DOI: 10.1080/08977194.2024.2423747

Meysam Bastami, Ramin Hosseini

引用次数: 0

L-Glutamine mitigates bile acid-induced inhibition of growth factor activity in rat hepatocyte cultures. L-谷氨酰胺可减轻胆汁酸对大鼠肝细胞生长因子活性的抑制。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-09-25 DOI: 10.1080/08977194.2024.2407566

Wafa'a Alqabandi, Gursev S Dhaunsi

{"title":"L-Glutamine mitigates bile acid-induced inhibition of growth factor activity in rat hepatocyte cultures.","authors":"Wafa'a Alqabandi, Gursev S Dhaunsi","doi":"10.1080/08977194.2024.2407566","DOIUrl":"10.1080/08977194.2024.2407566","url":null,"abstract":"Bile acid-induced hepatotoxicity is inevitable in Cholestasis pathogenesis and L-Glutamine (L-Gln) has been reported to prevent total parenteral nutrition (TPN)-induced cholestasis in premature neonates. While mechanisms remain unknown, we hypothesize that bile acids impair growth factor (GF) function in hepatocytes which L-glutamine prevents through NAPDH oxidase (NOX) modulation. Glycochenodeoxycholic acid (GCDC, 0-100 µM) when added to primary hepatocyte cultures significantly (p < 0.01) decreased the FBS-induced BrdU incorporation, however inhibition of Fibroblast Growth factor (FGF)- or Hepatocyte growth factor (HGF)-induced DNA synthesis was more pronounced (p < 0.001). L-Gln markedly attenuated GCDC-mediated inhibition of DNA synthesis in both FBS and GF-treated cells. GCDC significantly increased the NADPH oxidase activity and NOX-1 protein expression that were markedly reduced by L-Gln and protein kinase c (PKC) inhibitor, LY-333531. Apocynin (APCN) and diphenyliodonium (DPI) significantly blocked the GCDC-mediated inhibition of GF-induced DNA synthesis. This study demonstrates that bile acid-induced hepatotoxicity involves dysfunction of certain growth factors via protein kinase c (PKC)- mediated NOX modulation which can be corrected, at least partly, by L-glutamine.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"120-127"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tibial transverse transport combined with platelet-rich plasma sustained-release microspheres activates the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in diabetic foot ulcer. 胫骨横向运输结合富血小板血浆缓释微球可激活 VEGFA/VEGFR2 通路，促进糖尿病足溃疡的微循环重建。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-09-27 DOI: 10.1080/08977194.2024.2407318

Weiqiang Wei, Tenglong Jiang, Fan Hu, Hong Liu

{"title":"Tibial transverse transport combined with platelet-rich plasma sustained-release microspheres activates the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in diabetic foot ulcer.","authors":"Weiqiang Wei, Tenglong Jiang, Fan Hu, Hong Liu","doi":"10.1080/08977194.2024.2407318","DOIUrl":"10.1080/08977194.2024.2407318","url":null,"abstract":"This study proposes to investigate the therapeutic efficacy and mechanism of combining tibial transverse transport (TTT) with platelet-rich plasma (PRP) for diabetic foot ulcer (DFU). The diabetic rabbit model was constructed with Streptozotocin, which was intervened with TTT and PRP. PRP injection combined with TTT significantly promoted vascularisation and enhanced CD31, VEGFA, and VEGFR2 expressions compared to traditional TTT. However, the VEGFR2 inhibitor suppressed these phenomena. In the in vitro injury model, PRP reversed the diminished human umbilical vein endothelial cells (HUVECs) function and vascularisation caused by high-glucose damage. Additionally, PRP reduced inflammation and oxidative stress (approximately 47% ROS level) and enhanced VEGFA and VEGFR2 expression in HUVECs. However, the knockdown of VEGFR2 reversed the effect of PRP. In conclusion, TTT combined with intraosseous flap injection of PRP sustained-release microspheres activated the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in DFU. These findings may provide new potential therapeutic strategies for DFU.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"128-144"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes. VEGF-B 与 2 型糖尿病患者的糖尿病周围神经病变有关。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-07-12 DOI: 10.1080/08977194.2024.2377553

Ruonan Zhou, Yingying Xue, Ziwei Zhu, Pingyuan Xu, Lixuan Shen, Ziwei Wang, Yingying Xiang, Yue Cao, Xizhong Yu, Wenbin Shang

引用次数: 0

Statement of Retraction: Elevated Neurotrophin and Neurotrophin Receptor Expression in Spontaneously Hypertensive Rat Lungs. 撤回声明：自发性高血压大鼠肺中神经营养素和神经营养素受体表达的升高。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-08-16 DOI: 10.1080/08977194.2024.2392373

引用次数: 0

Expression of Concern. 表达关切。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-08-28 DOI: 10.1080/08977194.2024.2392344

引用次数: 0

Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men. 为期 8 周的联合阻力运动训练和隔日热量限制对肥胖男性可溶性表皮生长因子受体（sEGFR）和腺苷的比较效应。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1080/08977194.2024.2378889

Yousif Hikmat, Alireza Safarzade, Hamid Alizadeh

引用次数: 0

Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. 基底样乳腺癌细胞产生的白细胞介素-3与预后不良有关。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-05-01 Epub Date: 2024-02-01 DOI: 10.1080/08977194.2023.2297693

Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder

{"title":"Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis.","authors":"Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder","doi":"10.1080/08977194.2023.2297693","DOIUrl":"10.1080/08977194.2023.2297693","url":null,"abstract":"Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. \"Basal-like\" breast cancers predominantly lack the receptors for estrogen and progesterone (ER/PR), lack amplification of human epidermal growth factor receptor 2 (HER2) but account for 10-15% of all breast cancers, are largely insensitive to targeted treatment and represent a disproportionate number of metastatic cases and deaths. Analysis of interleukin (IL)-3 and the IL-3 receptor subunits (IL-3RA + CSF2RB) reveals elevated expression in predominantly the basal-like group. Further analysis suggests that IL-3 itself, but not the IL-3 receptor subunits, associates with poor patient outcome. Histology on patient-derived xenografts supports the notion that breast cancer cells are a significant source of IL-3 that may promote disease progression. Taken together, these observations suggest that IL-3 may be a useful marker in solid tumors, particularly triple negative breast cancer, and warrants further investigation into its contribution to disease pathogenesis.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"49-61"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GALNT6, GALNT14, and Gal-3 in association with GDF-15 promotes drug resistance and stemness of breast cancer via β-catenin axis. GALNT6、GALNT14和Gal-3与GDF-15通过β-catenin轴促进乳腺癌的耐药性和干性。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-05-01 Epub Date: 2024-06-18 DOI: 10.1080/08977194.2024.2368907

Ashita Gadwal, Purvi Purohit, Manoj Khokhar, Jeewan Ram Vishnoi, Puneet Pareek, Ramkaran Choudhary, Poonam Elhence, Mithu Banerjee, Praveen Sharma

{"title":"GALNT6, GALNT14, and Gal-3 in association with GDF-15 promotes drug resistance and stemness of breast cancer via β-catenin axis.","authors":"Ashita Gadwal, Purvi Purohit, Manoj Khokhar, Jeewan Ram Vishnoi, Puneet Pareek, Ramkaran Choudhary, Poonam Elhence, Mithu Banerjee, Praveen Sharma","doi":"10.1080/08977194.2024.2368907","DOIUrl":"10.1080/08977194.2024.2368907","url":null,"abstract":"N-acetylgalactosaminyltransferases (GALNTs) are a polypeptide responsible for aberrant glycosylation in breast cancer (BC), but the mechanism is unclear. In this study, expression levels of GALNT6, GALNT14, and Gal-3 were assessed in BC, and their association with GDF-15, β-catenin, stemness (SOX2 and OCT4), and drug resistance marker (ABCC5) was evaluated. Gene expression of GALNT6, GALNT14, Gal-3, GDF-15, OCT4, SOX2, ABCC5, and β-catenin in tumor and adjacent non-tumor tissues (n = 30) was determined. The same was compared with GEO-microarray datasets. A significant increase in the expression of candidate genes was observed in BC tumor compared to adjacent non-tumor tissue; and in pre-therapeutic patients compared to post-therapeutic. GALNT6, GALNT14, Gal-3, and GDF-15 showed positive association with β-catenin, SOX2, OCT4, and ABCC5 and were significantly associated with poor Overall Survival. Our findings were also validated via in silico analysis. Our study suggests that GALNT6, GALNT14, and Gal-3 in association with GDF-15 promote stemness and intrinsic drug resistance in BC, possibly by β-catenin signaling pathway.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"84-100"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0