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GDF15 promotes corneal neovascularization and RB cell progression via AKT/ERK signal pathway. GDF15通过AKT/ERK信号通路促进角膜新生血管和RB细胞进展。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-10-01 Epub Date: 2025-01-07 DOI: 10.1080/08977194.2024.2432948
Haijian Zheng, Wen Zheng, Shiliang Cheng, Chunguang Li, Guanglan Liu, Miao Yu, Meng Li, Xinfeng Liu, Fangfang Li, Yanluan Wan, Ling Wang
{"title":"GDF15 promotes corneal neovascularization and RB cell progression via AKT/ERK signal pathway.","authors":"Haijian Zheng, Wen Zheng, Shiliang Cheng, Chunguang Li, Guanglan Liu, Miao Yu, Meng Li, Xinfeng Liu, Fangfang Li, Yanluan Wan, Ling Wang","doi":"10.1080/08977194.2024.2432948","DOIUrl":"10.1080/08977194.2024.2432948","url":null,"abstract":"<p><p>In this study, we aim to explore the involvement of growth differentiation factor 15 (GDF15) in both corneal neovascularization (CNV) and retinoblastoma (RB) progression. Cell migration and proliferation were assessed through Scratch assays and CCK-8 assays. Apoptosis was quantified using flow cytometry. In vitro angiogenesis was evaluated through a tube formation assay. RT-PCR and western blot analyses were employed to assess the angiogenesis-related factors. Results demonstrated that RhGDF15 has a promotional effect on the migration of RB cells. Conversely, si-GDF15 demonstrated an opposite effect. RhGDF15 exhibited an enhancement the tube formation, the levels of HIF-1α and SDF, as well as cell migration. Conversely, si-GDF15 demonstrated an opposite effect. The levels of factors were elevated by rhGDF15 in both HREC and RB cell lines. In conclusion, the downregulation of GDF15 has the potential to inhibit corneal angiogenesis and impede the migration of RB cells. These effects may be dependent on the AKT/ERK pathway.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"205-215"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells. PDGF诱导的内化可促进间充质细胞中PDGFRβ的蛋白水解。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-10-01 Epub Date: 2024-10-10 DOI: 10.1080/08977194.2024.2413623
Marie Rubin Sander, Agni Karolina Tsiatsiou, Kehuan Wang, Natalia Papadopoulos, Charlotte Rorsman, Frida Olsson, Johan Heldin, Ola Söderberg, Carl-Henrik Heldin, Johan Lennartsson
{"title":"PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells.","authors":"Marie Rubin Sander, Agni Karolina Tsiatsiou, Kehuan Wang, Natalia Papadopoulos, Charlotte Rorsman, Frida Olsson, Johan Heldin, Ola Söderberg, Carl-Henrik Heldin, Johan Lennartsson","doi":"10.1080/08977194.2024.2413623","DOIUrl":"10.1080/08977194.2024.2413623","url":null,"abstract":"<p><p>Platelet-derived growth factor (PDGF)-induced signalling via PDGF receptor β (PDGFRβ) leads to activation of downstream signalling pathways which regulate multiple cellular responses. It is unclear how PDGFRβ is degraded; both lysosomal and proteasomal degradation have been suggested. In this study, we have characterised the proteolytic cleavage of ligand-activated PDGFRβ, which results in two fragments: a larger fragment containing the extracellular domain, the transmembrane segment, and a part of the intracellular juxtamembrane region with a molecular mass of ∼130 kDa, and an intracellular ∼70 kDa fragment released into the cytoplasm. The proteolytic processing did not take place without internalisation of PDGFRβ. In addition, chelation of intracellular Ca<sup>2+</sup> inhibited proteolytic processing. Inhibition of the proteasome affected signal transduction by increasing the phosphorylation of PDGFRβ, PLCγ, and STAT3 while reducing it on Erk1/2 and not affecting Akt. The proteolytic cleavage was observed in fibroblasts or cells that had undergone epithelial-mesenchymal transition.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"147-160"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease. 瘦素和胰岛素样生长因子-1 在调节先天性紫绀型心脏病患儿生长中的作用。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-10-01 Epub Date: 2024-11-23 DOI: 10.1080/08977194.2024.2432941
Ashraf A Elsharkawy, Amany K El-Hawary, Gehan A AlSawah, Hadil M AboElenin, Mohammad H Awad
{"title":"Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease.","authors":"Ashraf A Elsharkawy, Amany K El-Hawary, Gehan A AlSawah, Hadil M AboElenin, Mohammad H Awad","doi":"10.1080/08977194.2024.2432941","DOIUrl":"10.1080/08977194.2024.2432941","url":null,"abstract":"<p><strong>Background: </strong>Congenital cyanotic heart disease (CHD) in children is associated with several complications, amongst these complications is growth retardation which is believed to be multifactorial.</p><p><strong>Objectives: </strong>The objective of this study is to find out the role of leptin and Insulin-Like Growth Factor-1 (IGF-1) in the growth of paediatric patients with cyanotic CHD of different anatomical defects.</p><p><strong>Design/methods: </strong>This is a cross-sectional study involving thirty-nine children known to suffer from congenital cyanotic heart disease followed by the cardiology outpatient department, and forty-seven matched controls. Serum leptin and IGF-1 were evaluated in all the enrolled subjects besides anthropometric measurement and assessment of average oxygen saturation.</p><p><strong>Results: </strong>The patients' group showed statistically significant lower height, weight, Body mass index (BMI), leptin levels, and IGF-1. In addition, the patient group had a significant positive correlation between serum leptin and BMI, as well as a positive correlation of IGF-1 with average oxygen saturation.</p><p><strong>Conclusion: </strong>Children suffering from congenital cyanotic heart disease have a higher probability of developing poor growth. Serum leptin and IGF-1 are lower in affected children with congenital cyanotic cardiac defects suggesting that they may play a role in their poor growth.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"198-204"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The codon optimised gene produces an active human basic fibroblastic growth factor in rice cell suspension culture. 经过密码子优化的基因能在水稻细胞悬浮培养中产生活性人碱性成纤维细胞生长因子。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-10-01 Epub Date: 2024-11-01 DOI: 10.1080/08977194.2024.2423747
Meysam Bastami, Ramin Hosseini
{"title":"The codon optimised gene produces an active human basic fibroblastic growth factor in rice cell suspension culture.","authors":"Meysam Bastami, Ramin Hosseini","doi":"10.1080/08977194.2024.2423747","DOIUrl":"10.1080/08977194.2024.2423747","url":null,"abstract":"<p><p>The coding sequence of human basic fibroblast growth factor (hbFGF) was optimised for expression in rice. An expression cassette was constructed by fusing the PCR-amplified <i>RAmy3D</i> promoter, along with its 5'UTR, 3'UTR, and terminator sequences, to the codon-optimised hbFGF sequence. This cassette was inserted into the pCAMBIA1304 shuttle vector, which also contained the RAmy3D signal peptide. <i>Agrobacterium tumefaciens</i> strain LBA 4404 was used to transform rice callus. Among the transformed lines, the callus expressing the highest level of bFGF (38.1 mg/kg fresh weight) was identified via ELISA and selected for establishing a cell suspension culture. Expression and secretion of the recombinant bFGF into the culture medium were observed three days after incubating the transgenic rice cells in sucrose-free medium. The presence of recombinant bFGF was confirmed through Western blot and SDS-PAGE analyses. Furthermore, the rice-derived bFGF effectively stimulated the proliferation of NIH/3T3 cells, demonstrating a comparable biological activity to that of commercial bFGF.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"171-187"},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-Glutamine mitigates bile acid-induced inhibition of growth factor activity in rat hepatocyte cultures. L-谷氨酰胺可减轻胆汁酸对大鼠肝细胞生长因子活性的抑制。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-01 Epub Date: 2024-09-25 DOI: 10.1080/08977194.2024.2407566
Wafa'a Alqabandi, Gursev S Dhaunsi
{"title":"L-Glutamine mitigates bile acid-induced inhibition of growth factor activity in rat hepatocyte cultures.","authors":"Wafa'a Alqabandi, Gursev S Dhaunsi","doi":"10.1080/08977194.2024.2407566","DOIUrl":"10.1080/08977194.2024.2407566","url":null,"abstract":"<p><p>Bile acid-induced hepatotoxicity is inevitable in Cholestasis pathogenesis and L-Glutamine (L-Gln) has been reported to prevent total parenteral nutrition (TPN)-induced cholestasis in premature neonates. While mechanisms remain unknown, we hypothesize that bile acids impair growth factor (GF) function in hepatocytes which L-glutamine prevents through NAPDH oxidase (NOX) modulation. Glycochenodeoxycholic acid (GCDC, 0-100 µM) when added to primary hepatocyte cultures significantly (p < 0.01) decreased the FBS-induced BrdU incorporation, however inhibition of Fibroblast Growth factor (FGF)- or Hepatocyte growth factor (HGF)-induced DNA synthesis was more pronounced (p < 0.001). L-Gln markedly attenuated GCDC-mediated inhibition of DNA synthesis in both FBS and GF-treated cells. GCDC significantly increased the NADPH oxidase activity and NOX-1 protein expression that were markedly reduced by L-Gln and protein kinase c (PKC) inhibitor, LY-333531. Apocynin (APCN) and diphenyliodonium (DPI) significantly blocked the GCDC-mediated inhibition of GF-induced DNA synthesis. This study demonstrates that bile acid-induced hepatotoxicity involves dysfunction of certain growth factors via protein kinase c (PKC)- mediated NOX modulation which can be corrected, at least partly, by L-glutamine.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"120-127"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tibial transverse transport combined with platelet-rich plasma sustained-release microspheres activates the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in diabetic foot ulcer. 胫骨横向运输结合富血小板血浆缓释微球可激活 VEGFA/VEGFR2 通路，促进糖尿病足溃疡的微循环重建。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-01 Epub Date: 2024-09-27 DOI: 10.1080/08977194.2024.2407318
Weiqiang Wei, Tenglong Jiang, Fan Hu, Hong Liu
{"title":"Tibial transverse transport combined with platelet-rich plasma sustained-release microspheres activates the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in diabetic foot ulcer.","authors":"Weiqiang Wei, Tenglong Jiang, Fan Hu, Hong Liu","doi":"10.1080/08977194.2024.2407318","DOIUrl":"10.1080/08977194.2024.2407318","url":null,"abstract":"<p><p>This study proposes to investigate the therapeutic efficacy and mechanism of combining tibial transverse transport (TTT) with platelet-rich plasma (PRP) for diabetic foot ulcer (DFU). The diabetic rabbit model was constructed with Streptozotocin, which was intervened with TTT and PRP. PRP injection combined with TTT significantly promoted vascularisation and enhanced CD31, VEGFA, and VEGFR2 expressions compared to traditional TTT. However, the VEGFR2 inhibitor suppressed these phenomena. In the <i>in vitro</i> injury model, PRP reversed the diminished human umbilical vein endothelial cells (HUVECs) function and vascularisation caused by high-glucose damage. Additionally, PRP reduced inflammation and oxidative stress (approximately 47% ROS level) and enhanced VEGFA and VEGFR2 expression in HUVECs. However, the knockdown of VEGFR2 reversed the effect of PRP. In conclusion, TTT combined with intraosseous flap injection of PRP sustained-release microspheres activated the VEGFA/VEGFR2 pathway to promote microcirculatory reconstruction in DFU. These findings may provide new potential therapeutic strategies for DFU.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"128-144"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes. VEGF-B 与 2 型糖尿病患者的糖尿病周围神经病变有关。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-01 Epub Date: 2024-07-12 DOI: 10.1080/08977194.2024.2377553
Ruonan Zhou, Yingying Xue, Ziwei Zhu, Pingyuan Xu, Lixuan Shen, Ziwei Wang, Yingying Xiang, Yue Cao, Xizhong Yu, Wenbin Shang
{"title":"VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes.","authors":"Ruonan Zhou, Yingying Xue, Ziwei Zhu, Pingyuan Xu, Lixuan Shen, Ziwei Wang, Yingying Xiang, Yue Cao, Xizhong Yu, Wenbin Shang","doi":"10.1080/08977194.2024.2377553","DOIUrl":"10.1080/08977194.2024.2377553","url":null,"abstract":"<p><p><b>Aims:</b> This study aims to explore the potential role of vascular endothelial growth factor-B (VEGF-B) in the pathogenesis of diabetic peripheral neuropathy (DPN). The expression of VEGFRs were reanalysed by using gene arrays of peripheral nerve samples from mouse models of DPN retrieved from the GEO database. 213 T2D patients as well as 31 healthy individuals were recruited. The serum VEGF-B was detected and its relationship with DPN was analysed. The elevated VEGFR1 was the only change of VEGFR gene expression in the peripheral nerve from mouse models of DPN. The level of serum VEGF-B in T2D patients with DPN was higher than that in T2D patients without DPN and healthy people. Analysis of correlation and binary logistic regression confirmed that the increased serum VEGF-B level was an independent risk factor of DPN in T2D patients. VEGF-B-VEGFR1 signaling pathway may be involved in the development of DPN.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"101-110"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141599106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: Elevated Neurotrophin and Neurotrophin Receptor Expression in Spontaneously Hypertensive Rat Lungs. 撤回声明：自发性高血压大鼠肺中神经营养素和神经营养素受体表达的升高。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-01 Epub Date: 2024-08-16 DOI: 10.1080/08977194.2024.2392373
{"title":"Statement of Retraction: Elevated Neurotrophin and Neurotrophin Receptor Expression in Spontaneously Hypertensive Rat Lungs.","authors":"","doi":"10.1080/08977194.2024.2392373","DOIUrl":"10.1080/08977194.2024.2392373","url":null,"abstract":"","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"146"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Concern. 表达关切。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-01 Epub Date: 2024-08-28 DOI: 10.1080/08977194.2024.2392344
{"title":"Expression of Concern.","authors":"","doi":"10.1080/08977194.2024.2392344","DOIUrl":"10.1080/08977194.2024.2392344","url":null,"abstract":"","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"145"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men. 为期 8 周的联合阻力运动训练和隔日热量限制对肥胖男性可溶性表皮生长因子受体（sEGFR）和腺苷的比较效应。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1080/08977194.2024.2378889
Yousif Hikmat, Alireza Safarzade, Hamid Alizadeh
{"title":"Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men.","authors":"Yousif Hikmat, Alireza Safarzade, Hamid Alizadeh","doi":"10.1080/08977194.2024.2378889","DOIUrl":"10.1080/08977194.2024.2378889","url":null,"abstract":"<p><p>This study investigated the combined effects of resistance exercise training (RET) and alternate-day calorie restriction (ADCR) on body composition, insulin resistance (IR), insulin resistance-related biomarkers (adipokine adipsin and hepatokine soluble EFGR), and weight loss in obese men. The findings revealed that RET + ADCR induced the greatest reductions in body weight, body fat percentage, and waist-to-hip ratio (WHR) compared to RET and ADCR alone (<i>p</i> < 0.05). Additionally, RET + ADCR resulted in the most significant improvements in IR, as measured by HOMA-IR, and in circulating levels of adipsin and soluble EFGR (<i>p</i> < 0.05). These findings suggest that combining RET and ADCR may be a more effective strategy for improving metabolic health, including body composition, IR, and metabolic tissues' functions, in obese men than either intervention alone.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"111-119"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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