发布求助
文献互助 智能选刊 最新文献

Growth factors最新文献

筛选
英文 中文
Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke. 当归补血汤治疗缺血性脑卒中的网络药理学和分子对接研究。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2277755
Jinling Zhang, Ruiqing Li, Yang Yu, Weijia Sun, Chengshi Zhang, Haijun Wang
{"title":"Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke.","authors":"Jinling Zhang, Ruiqing Li, Yang Yu, Weijia Sun, Chengshi Zhang, Haijun Wang","doi":"10.1080/08977194.2023.2277755","DOIUrl":"10.1080/08977194.2023.2277755","url":null,"abstract":"<p><p>Danggui blood-supplementing decoction (DBsD) is an herbal preparation treating several diseases including stroke. The present study sought to investigate the potential mechanism of DBsD in ischaemic stroke (IS) using network pharmacology, molecular docking, and cell experiment. Based on the protein-protein (PPI) network analysis, MAPK1 (0.51, 12), KNG1 (0.57, 28), and TNF (0.64, 39) were found with relatively good performance in degree and closeness centrality. The functional enrichment analysis revealed that DBsD contributed to IS-related biological processes, molecule function, and presynaptic/postsynaptic cellular components. Pathway enrichment indicated that DBsD might protect IS by modulating multi-signalling pathways including the sphingolipid signalling pathway. Molecular docking verified the stigmasterol-KNG1, bifendate-TNF, and formononetin-MAPK1 pairs. Cell experiments confirmed the involvement of KNG1 and sphingolipid signalling pathway in hippocampal neuronal cell apoptosis. This study showed that DBsD can protect neuronal cell injury after IS through multiple components, multiple targets, and multiple pathways.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus. 12周高强度间歇训练和中等强度连续训练对2型糖尿病男性FGF21、鸢尾素和肌肉生长抑制素的影响。
IF 1.8 4区 生物学
Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2279163
Simin Riahy
{"title":"The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus.","authors":"Simin Riahy","doi":"10.1080/08977194.2023.2279163","DOIUrl":"10.1080/08977194.2023.2279163","url":null,"abstract":"<p><p>This study investigated the influence of a 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on irisin, fibroblast growth factor 21 (FGF21), and myostatin (MSTN) among men with type 2 diabetes mellitus (T2DM). Forty-five adult men with T2DM were randomly selected and assigned to receive and perform HIIT (4 × 4 min at 85-95% HRmax with three min of active rest at 50-60% HRmax in between) and MICT (walking/running continuously for 47 min at 60-70% HRmax) three sessions per week for 12 weeks, or to act as a non-exercise control (CON) group. The subjects' blood samples were collected at baseline and 48 hours after the last intervention session. Our research revealed that both interventions resulted in similar decreases in FGF21 and MSTN when compared to the CON (<i>p</i> < .01). However, only the HIIT group showed a significant increase in irisin (<i>p</i> < .01) compared to the CON. Further, improvements in insulin resistance, body composition, and VO<sub>2</sub> peak were noted in both intervention groups compared with those of the CON group (<i>p</i> < .01). It seems that while either aerobic exercise strategy could be seen as a therapy for men with T2DM, HIIT had a more advantageous effect on the irisin response.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of transforming growth factor β signaling and therapeutic efficacy. 转化生长因子β信号转导的动态及治疗效果。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-05-25 DOI: 10.1080/08977194.2023.2215335
Siqi Wu, Rodney Brian Luwor, Hong-Jian Zhu
{"title":"Dynamics of transforming growth factor β signaling and therapeutic efficacy.","authors":"Siqi Wu, Rodney Brian Luwor, Hong-Jian Zhu","doi":"10.1080/08977194.2023.2215335","DOIUrl":"10.1080/08977194.2023.2215335","url":null,"abstract":"<p><p>Transforming growth factor β (TGFβ) is a multifunctional cytokine, and its signalling responses are exerted via integrated intracellular pathways and complex regulatory mechanisms. Due to its high potency, TGFβ signalling is tightly controlled under normal circumstances, while its dysregulation in cancer favours metastasis. The recognised potential of TGFβ as a therapeutic target led to emerging development of anti-TGFβ reagents with preclinical success, yet these therapeutics failed to recapitulate their efficacy in experimental settings. In this review, possible reasons for this inconsistency are discussed, addressing the knowledge gap between theoretical and actual behaviours of TGFβ signalling. Previous studies on oncogenic cells have demonstrated the spatiotemporal heterogeneity of TGFβ signalling intensity. Under feedback mechanisms and exosomal ligand recycling, cancer cells may achieve cyclic TGFβ signalling to facilitate dissemination and colonisation. This challenges the current presumption of persistently high TGFβ signalling in cancer, pointing to a new direction of research on TGFβ-targeted therapeutics.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer. 技术进步定义了从正常到原发性和转移性癌症的转移途径信号。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-06-23 DOI: 10.1080/08977194.2023.2227274
Robert G Ramsay, Vicki Whitehall, Michael P Flood
{"title":"Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer.","authors":"Robert G Ramsay,&nbsp;Vicki Whitehall,&nbsp;Michael P Flood","doi":"10.1080/08977194.2023.2227274","DOIUrl":"10.1080/08977194.2023.2227274","url":null,"abstract":"<p><p>Adoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness of chemo-, radio- and immunotherapies can be explored within weeks of deriving these patient-derived tumour avatars informing treatment of these exact patients in a timely manner. Entrenched paths to colorectal cancer (CRC) from the earliest steps of conventional adenoma or serrated lesion formation, and the recognition of further sub-categorisations embodied by consensus-molecular-subtypes (CMS), provide genetic maps allowing a molecular form of pathologic taxonomy. Recent advances in organoid propagation and scRNAseq are reshaping our understanding of CMS and CRC.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs. 添加剂在神经组织工程中的作用综述：生长因子、维生素和药物。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-06-21 DOI: 10.1080/08977194.2023.2226938
Mehrsa Nasiri, Javad Esmaeili, Amir Tebyani, Hojat Basati
{"title":"A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs.","authors":"Mehrsa Nasiri, Javad Esmaeili, Amir Tebyani, Hojat Basati","doi":"10.1080/08977194.2023.2226938","DOIUrl":"10.1080/08977194.2023.2226938","url":null,"abstract":"<p><p>Notably the integration of additives such as growth factors, vitamins, and drugs with scaffolds promoted nerve tissue engineering. This study tried to provide a concise review of all these additives that facilitates nerve regeneration. An attempt was first made to provide information on the main principle of nerve tissue engineering, and then to shed light on the effectiveness of these additives on nerve tissue engineering. Our research has shown that growth factors accelerate cell proliferation and survival, while vitamins play an effective role in cell signalling, differentiation, and tissue growth. They can also act as hormones, antioxidants, and mediators. Drugs also have an excellent and necessary effect on this process by reducing inflammation and immune responses. This review shows that growth factors were more effective than vitamins and drugs in nerve tissue engineering. Nevertheless, vitamins were the most commonly used additive in the production of nerve tissue.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition. 转录因子TP63通过上调KRT17表达，诱导上皮-间质转化，促进甲状腺癌的恶性进展。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-03-15 DOI: 10.1080/08977194.2023.2184656
Fanbo Meng, Liting Dai
{"title":"Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition.","authors":"Fanbo Meng, Liting Dai","doi":"10.1080/08977194.2023.2184656","DOIUrl":"10.1080/08977194.2023.2184656","url":null,"abstract":"<p><p>Thyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspect of transcription factor-target gene interaction. TP63 and KRT17 were both highly expressed in TC tissues and cells. The results of ChIP and dual-luciferase assays confirmed TP63 to bind the KRT17 promoter. Cell function assays revealed that knockdown of TP63 could repress TC cell progression. Furthermore, the rescue assay verified that TP63 could facilitate KRT17 expression to activate the AKT signaling pathway, which in turn stimulated TC cell invasion and migration, and induced EMT. All these results verified that TP63 facilitates TC malignant progression by promoting KRT17 expression and inducing EMT.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9809436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of mesenchymal stem cells conditioned media obtained at different conditioning times: their effect on glial cells in in vitro scratch model. 不同条件下获得的间充质干细胞条件培养基的特性及其对体外划痕模型中胶质细胞的影响。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-02-24 DOI: 10.1080/08977194.2023.2182145
Eva Székiová, Zuzana Michalová, Juraj Blaško, Rastislav Mucha, Lucia Slovinská, Martin Kello, Ivo Vanický
{"title":"Characterisation of mesenchymal stem cells conditioned media obtained at different conditioning times: their effect on glial cells in <i>in vitro</i> scratch model.","authors":"Eva Székiová, Zuzana Michalová, Juraj Blaško, Rastislav Mucha, Lucia Slovinská, Martin Kello, Ivo Vanický","doi":"10.1080/08977194.2023.2182145","DOIUrl":"10.1080/08977194.2023.2182145","url":null,"abstract":"<p><p>In this study, the bone marrow mesenchymal stem cells conditioned media (BMMSC-CM) obtained by conditioning for 24(CM24), 48(CM48) and 72(CM72) hours was characterised. In vitro, the impact of BMMSC-CM on the astrocyte migratory response and oligodendrocyte density was evaluated using the scratch model. The proteomic profiles of individual secretomes were analysed by mass spectrometry and the concentrations of four selected neurotrophins (BDNF, NGF, GDNF and VEGF) were determined by ELISA. Our results revealed an increased number of proteins at CM72, many of which are involved in neuroregenerative processes. ELISA documented a gradual increase in the concentration of two neurotrophins (NGF, VEGF), peaking at CM72. <i>In vitro</i>, the different effect of individual BMMSC-CM on astrocyte migration response and oligodendrocyte density was observed, most pronounced with CM72. The outcomes demonstrate that the prolonged conditioning results in increased release of detectable proteins, neurotrophic factors concentration and stronger effect on reparative processes in neural cell cultures.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10092369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knock-down of IGFBP2 ameliorates lung fibrosis and inflammation in rats with severe pneumonia through STAT3 pathway. IGFBP2的敲除通过STAT3途径改善严重肺炎大鼠的肺纤维化和炎症。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-10-19 DOI: 10.1080/08977194.2023.2259497
Yuyu Wang, Jianjiang Huang, Fang Zhang, Keli Shen, Bin Qiu
{"title":"Knock-down of IGFBP2 ameliorates lung fibrosis and inflammation in rats with severe pneumonia through STAT3 pathway.","authors":"Yuyu Wang,&nbsp;Jianjiang Huang,&nbsp;Fang Zhang,&nbsp;Keli Shen,&nbsp;Bin Qiu","doi":"10.1080/08977194.2023.2259497","DOIUrl":"10.1080/08977194.2023.2259497","url":null,"abstract":"<p><strong>Objective: </strong>To observe the mechanism of IGFBP2 knock-down in improving lung fibrosis and inflammation through STAT3 pathway in rats with severe pneumonia.</p><p><strong>Materials and methods: </strong>First, SP rat model was established. Then rats were divided into the Control group, the SP group, the SP + Lv-vector shRNA group, the SP + Lv-IGFBP2 shRNA group, the SP + Lv-vector group, and the SP + Lv-IGFBP2 group. The mRNA and protein levels of IGFBP2, NOS, CD206 and Arg 1 were detected by RT-qPCR and Western blot. IHC was used to check the positive expression of IGFBP2 and MCP1. A fully automated blood gas analyzer was used to detected PaCO<sub>2</sub>, CO<sub>2</sub> content, PaO2 and SaO2. HE and Masson staining were performed to observe the lung tissue injury and collagen deposition of rats in each group. ELISA assays were used to calculate the levels of inflammatory factors IL-1β, IL-6, TNF-α, IL-4, and IL-10. Flow cytometry was conducted to acquire the ratio of M1-type AMs and M2-type AMs.</p><p><strong>Results: </strong>Compared with the Control group, IGFBP2, iNOS, CD206, and Arg1 mRNA and protein expression levels, IGFBP2 and MCP1 positive expressions, PaCO<sub>2</sub>, p-STAT3/STAT3, p-JAK2/JAK2, IL-1β, IL-6, and TNF-α levels, the number of AMs and neutrophils, the proportion of M1 type AMs and the expressions of α-SMA, Collagen-I, Collagen III, and Fibronectin were significantly increased in SP rats <i>(p</i> < 0.05), while PaCO<sub>2</sub>, CO<sub>2</sub>, and SaO<sub>2</sub>, IL-4 and IL-10 levels, and the proportion of M2 type AMs decreased (<i>p</i> < 0.05). However, the knockdown of IGFBP2 reversed the above index trends.</p><p><strong>Conclusion: </strong>Knock-down of IGFBP2 ameliorated lung injury in SP rats, inhibited inflammation and pulmonary fibrosis, and promoted M2-type transformation of AMs by activating the STAT3 pathway.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41095376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of transforming growth factor-β in airway remodelling in bronchiolitis obliterans. 转化生长因子-β在闭塞性细支气管炎气道重塑中的作用。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-10-01 Epub Date: 2023-07-24 DOI: 10.1080/08977194.2023.2239356
Ziwei Wang
{"title":"Role of transforming growth factor-β in airway remodelling in bronchiolitis obliterans.","authors":"Ziwei Wang","doi":"10.1080/08977194.2023.2239356","DOIUrl":"10.1080/08977194.2023.2239356","url":null,"abstract":"<p><p>Airway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-β (TGF-β) expression is increased in BO during airway remodelling, where it plays an important role in various biological processes by binding to its receptor complex to activate multiple signalling proteins and pathways. This review examines the role of TGF-β in airway remodelling in BO and its potential as a therapeutic target, highlighting the mechanisms of TGF-β activation and signalling, cellular targets of TGF-β actions, and research progress in TGF-β signalling and TGF-β-mediated processes.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis. 膝关节骨性关节炎患者自体富血小板血浆与血小板裂解液的比较评价。
IF 1.8 4区 生物学
Growth factors Pub Date : 2023-08-01 DOI: 10.1080/08977194.2023.2227273
Sareh Hosseini, Mohammad Sadegh Soltani-Zangbar, Majid Zamani, Yoda Yaghoubi, Reza Rikhtegar Ghiasi, Roza Motavalli, Ali Ghassabi, Rahim Iranzad, Amir Mehdizadeh, Seyed Kazem Shakouri, Alireza Pishgahi, Mehdi Yousefi
{"title":"Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis.","authors":"Sareh Hosseini,&nbsp;Mohammad Sadegh Soltani-Zangbar,&nbsp;Majid Zamani,&nbsp;Yoda Yaghoubi,&nbsp;Reza Rikhtegar Ghiasi,&nbsp;Roza Motavalli,&nbsp;Ali Ghassabi,&nbsp;Rahim Iranzad,&nbsp;Amir Mehdizadeh,&nbsp;Seyed Kazem Shakouri,&nbsp;Alireza Pishgahi,&nbsp;Mehdi Yousefi","doi":"10.1080/08977194.2023.2227273","DOIUrl":"https://doi.org/10.1080/08977194.2023.2227273","url":null,"abstract":"<p><p>Autologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured by ELISA. All patients showed significant improvements in pain and function following treatment of KOA with PL and PRP compared to baseline. Moreover, PL's concentration of growth factors was significantly higher than PRP. A significant increase was also observed in all of the aforementioned mediators in both PRP and PL products compared to control. These results can introduce PL as a promising and alternative option for KOA therapy in the future.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9904259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信