Growth factors最新文献_第2页

Comparative effects of 8-week combined resistance exercise training and alternate-day calorie restriction on soluble epidermal growth factor receptor (sEGFR) and adipsin in obese men. 为期 8 周的联合阻力运动训练和隔日热量限制对肥胖男性可溶性表皮生长因子受体（sEGFR）和腺苷的比较效应。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1080/08977194.2024.2378889

Yousif Hikmat, Alireza Safarzade, Hamid Alizadeh

引用次数: 0

Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. 基底样乳腺癌细胞产生的白细胞介素-3与预后不良有关。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-05-01 Epub Date: 2024-02-01 DOI: 10.1080/08977194.2023.2297693

Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder

{"title":"Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis.","authors":"Emma J Thompson, Samantha Escarbe, Denis Tvorogov, Gelareh Farshid, Philip A Gregory, Yeesim Khew-Goodall, Stephen Madden, Wendy V Ingman, Geoffrey J Lindeman, Elgene Lim, Angel F Lopez, Claudine S Bonder","doi":"10.1080/08977194.2023.2297693","DOIUrl":"10.1080/08977194.2023.2297693","url":null,"abstract":"Breast cancer represents a collection of pathologies with different molecular subtypes, histopathology, risk factors, clinical behavior, and responses to treatment. \"Basal-like\" breast cancers predominantly lack the receptors for estrogen and progesterone (ER/PR), lack amplification of human epidermal growth factor receptor 2 (HER2) but account for 10-15% of all breast cancers, are largely insensitive to targeted treatment and represent a disproportionate number of metastatic cases and deaths. Analysis of interleukin (IL)-3 and the IL-3 receptor subunits (IL-3RA + CSF2RB) reveals elevated expression in predominantly the basal-like group. Further analysis suggests that IL-3 itself, but not the IL-3 receptor subunits, associates with poor patient outcome. Histology on patient-derived xenografts supports the notion that breast cancer cells are a significant source of IL-3 that may promote disease progression. Taken together, these observations suggest that IL-3 may be a useful marker in solid tumors, particularly triple negative breast cancer, and warrants further investigation into its contribution to disease pathogenesis.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"49-61"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GALNT6, GALNT14, and Gal-3 in association with GDF-15 promotes drug resistance and stemness of breast cancer via β-catenin axis. GALNT6、GALNT14和Gal-3与GDF-15通过β-catenin轴促进乳腺癌的耐药性和干性。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-05-01 Epub Date: 2024-06-18 DOI: 10.1080/08977194.2024.2368907

Ashita Gadwal, Purvi Purohit, Manoj Khokhar, Jeewan Ram Vishnoi, Puneet Pareek, Ramkaran Choudhary, Poonam Elhence, Mithu Banerjee, Praveen Sharma

{"title":"GALNT6, GALNT14, and Gal-3 in association with GDF-15 promotes drug resistance and stemness of breast cancer via β-catenin axis.","authors":"Ashita Gadwal, Purvi Purohit, Manoj Khokhar, Jeewan Ram Vishnoi, Puneet Pareek, Ramkaran Choudhary, Poonam Elhence, Mithu Banerjee, Praveen Sharma","doi":"10.1080/08977194.2024.2368907","DOIUrl":"10.1080/08977194.2024.2368907","url":null,"abstract":"N-acetylgalactosaminyltransferases (GALNTs) are a polypeptide responsible for aberrant glycosylation in breast cancer (BC), but the mechanism is unclear. In this study, expression levels of GALNT6, GALNT14, and Gal-3 were assessed in BC, and their association with GDF-15, β-catenin, stemness (SOX2 and OCT4), and drug resistance marker (ABCC5) was evaluated. Gene expression of GALNT6, GALNT14, Gal-3, GDF-15, OCT4, SOX2, ABCC5, and β-catenin in tumor and adjacent non-tumor tissues (n = 30) was determined. The same was compared with GEO-microarray datasets. A significant increase in the expression of candidate genes was observed in BC tumor compared to adjacent non-tumor tissue; and in pre-therapeutic patients compared to post-therapeutic. GALNT6, GALNT14, Gal-3, and GDF-15 showed positive association with β-catenin, SOX2, OCT4, and ABCC5 and were significantly associated with poor Overall Survival. Our findings were also validated via in silico analysis. Our study suggests that GALNT6, GALNT14, and Gal-3 in association with GDF-15 promote stemness and intrinsic drug resistance in BC, possibly by β-catenin signaling pathway.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"84-100"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLA2G2D fosters angiogenesis in non-small cell lung cancer through aerobic glycolysis. PLA2G2D通过有氧糖酵解促进非小细胞肺癌的血管生成

IF 1.8 4区生物学

Growth factors Pub Date : 2024-05-01 Epub Date: 2024-01-01 DOI: 10.1080/08977194.2023.2297702

Huaizhong Zhang, Keng Chen, Yongqing Zhou, Zhuo Cao, Cunlai Xu, Lin Zhou, Gongzhi Wu, Congxiong Peng, Songqing Lai, Xuhui Wu

{"title":"PLA2G2D fosters angiogenesis in non-small cell lung cancer through aerobic glycolysis.","authors":"Huaizhong Zhang, Keng Chen, Yongqing Zhou, Zhuo Cao, Cunlai Xu, Lin Zhou, Gongzhi Wu, Congxiong Peng, Songqing Lai, Xuhui Wu","doi":"10.1080/08977194.2023.2297702","DOIUrl":"10.1080/08977194.2023.2297702","url":null,"abstract":"Non-small cell lung cancer (NSCLC) stands prominent among the prevailing and formidable oncological entities. The immune and metabolic-related molecule Phospholipase A2, group IID (PLA2G2D) exerts promotional effects on tumor progression. However, its involvement in cancer angiogenesis remains elusive. Therefore, this investigation delved into the functional significance of PLA2G2D concerning angiogenesis in NSCLC. This study analyzed the expression and enriched pathways of PLA2G2D in NSCLC tissues through bioinformatics analysis, and measured the expression of PLA2G2D in NSCLC cells using qRT-PCR and western blot (WB). Subsequently, the viability and angiogenic potential of NSCLC cells were assessed employing CCK-8 and angiogenesis assays, respectively. The expression profile of angiogenic factors was analyzed through WB. Finally, the expression of glycolysis pathway-related genes, extracellular acidification rate and oxygen consumption rate, and the levels of pyruvate, lactate, citrate, and malate were analyzed in NSCLC cells using qRT-PCR, Seahorse XF 96, and related kits. Bioinformatics analysis revealed the upregulation of PLA2G2D in NSCLC tissues and its association with VEGF and glycolysis signaling pathways. Molecular and cellular experiments demonstrated that upregulated PLA2G2D promoted the viability, angiogenic ability, and glycolysis pathway of NSCLC cells. Rescue assays revealed that the effects of high expression of PLA2G2D on the viability, angiogenic ability, and glycolysis of NSCLC cells were weakened after the addition of the glycolysis inhibitor 2-DG. In summary, PLA2G2D plays a key role in NSCLC angiogenesis through aerobic glycolysis, displaying great potential as a target for anti-angiogenesis therapy.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"74-83"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer 被确定为血清中新型生物标记物的 FOXN2 通过与分割缺陷 6 同源物 alpha 的相互作用调节转化生长因子-β 信号通路，从而促进胃癌的发病机制

IF 1.8 4区生物学

Growth factors Pub Date : 2024-03-04 DOI: 10.1080/08977194.2023.2297700

Liang Li, XueFeng Sun, Mei Zhang, BangShuo Zhang, Yi Yang, Sheng Wang

引用次数: 0

Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study. 评价注射富血小板纤维蛋白(i-PRF)对大鼠伤口愈合和生长因子释放的影响:一项裂口研究。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2289375

Aysan Lektemur Alpan, Gizem Torumtay Cin, Alper Kızıldağ, Necati Zavrak, Özlem Özmen, Şevki Arslan, Doğukan Mutlu

引用次数: 0

Fibroblast growth factor 23 and its role in bone diseases. 成纤维细胞生长因子23及其在骨疾病中的作用。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2274579

Andrija Jurina, Dino Kasumović, Valentina Delimar, Tajana Filipec Kanižaj, Mladen Japjec, Tomislav Dujmović, Marijana Vučić Lovrenčić, Mario Starešinić

引用次数: 0

Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke. 当归补血汤治疗缺血性脑卒中的网络药理学和分子对接研究。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2277755

Jinling Zhang, Ruiqing Li, Yang Yu, Weijia Sun, Chengshi Zhang, Haijun Wang

{"title":"Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke.","authors":"Jinling Zhang, Ruiqing Li, Yang Yu, Weijia Sun, Chengshi Zhang, Haijun Wang","doi":"10.1080/08977194.2023.2277755","DOIUrl":"10.1080/08977194.2023.2277755","url":null,"abstract":"Danggui blood-supplementing decoction (DBsD) is an herbal preparation treating several diseases including stroke. The present study sought to investigate the potential mechanism of DBsD in ischaemic stroke (IS) using network pharmacology, molecular docking, and cell experiment. Based on the protein-protein (PPI) network analysis, MAPK1 (0.51, 12), KNG1 (0.57, 28), and TNF (0.64, 39) were found with relatively good performance in degree and closeness centrality. The functional enrichment analysis revealed that DBsD contributed to IS-related biological processes, molecule function, and presynaptic/postsynaptic cellular components. Pathway enrichment indicated that DBsD might protect IS by modulating multi-signalling pathways including the sphingolipid signalling pathway. Molecular docking verified the stigmasterol-KNG1, bifendate-TNF, and formononetin-MAPK1 pairs. Cell experiments confirmed the involvement of KNG1 and sphingolipid signalling pathway in hippocampal neuronal cell apoptosis. This study showed that DBsD can protect neuronal cell injury after IS through multiple components, multiple targets, and multiple pathways.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"13-23"},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus. 12周高强度间歇训练和中等强度连续训练对2型糖尿病男性FGF21、鸢尾素和肌肉生长抑制素的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.1080/08977194.2023.2279163

Simin Riahy

{"title":"The effects of 12 weeks of high-intensity interval training and moderate-intensity continuous training on FGF21, irisin, and myostatin in men with type 2 diabetes mellitus.","authors":"Simin Riahy","doi":"10.1080/08977194.2023.2279163","DOIUrl":"10.1080/08977194.2023.2279163","url":null,"abstract":"This study investigated the influence of a 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on irisin, fibroblast growth factor 21 (FGF21), and myostatin (MSTN) among men with type 2 diabetes mellitus (T2DM). Forty-five adult men with T2DM were randomly selected and assigned to receive and perform HIIT (4 × 4 min at 85-95% HRmax with three min of active rest at 50-60% HRmax in between) and MICT (walking/running continuously for 47 min at 60-70% HRmax) three sessions per week for 12 weeks, or to act as a non-exercise control (CON) group. The subjects' blood samples were collected at baseline and 48 hours after the last intervention session. Our research revealed that both interventions resulted in similar decreases in FGF21 and MSTN when compared to the CON (p < .01). However, only the HIIT group showed a significant increase in irisin (p < .01) compared to the CON. Further, improvements in insulin resistance, body composition, and VO2 peak were noted in both intervention groups compared with those of the CON group (p < .01). It seems that while either aerobic exercise strategy could be seen as a therapy for men with T2DM, HIIT had a more advantageous effect on the irisin response.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":" ","pages":"24-35"},"PeriodicalIF":1.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of transforming growth factor β signaling and therapeutic efficacy. 转化生长因子β信号转导的动态及治疗效果。

IF 1.8 4区生物学

Growth factors Pub Date : 2023-10-01 Epub Date: 2023-05-25 DOI: 10.1080/08977194.2023.2215335

Siqi Wu, Rodney Brian Luwor, Hong-Jian Zhu

引用次数: 0