Growth factors最新文献_第9页

Therapeutic approaches of trophic factors in animal models and in patients with spinal cord injury. 营养因子在动物模型和脊髓损伤患者中的治疗方法。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-01-01 Epub Date: 2020-04-17 DOI: 10.1080/08977194.2020.1753724

María Del Carmen Díaz-Galindo, Denisse Calderón-Vallejo, Carlos Olvera-Sandoval, J Luis Quintanar

{"title":"Therapeutic approaches of trophic factors in animal models and in patients with spinal cord injury.","authors":"María Del Carmen Díaz-Galindo, Denisse Calderón-Vallejo, Carlos Olvera-Sandoval, J Luis Quintanar","doi":"10.1080/08977194.2020.1753724","DOIUrl":"https://doi.org/10.1080/08977194.2020.1753724","url":null,"abstract":"Trophic factors are naturally produced by different tissues that participate in several functions such as the intercellular communication, in the development, stability, differentiation and regeneration at the cellular level. Specifically, in the case of spinal injuries, these factors can stimulate neuronal recovery. They are applied both in experimental models and in clinical trials in patients. The trophic factors analysed in this review include gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), growth hormone (GH), melatonin, oestrogens, the family of fibroblast growth factors (FGFs), the family of neurotrophins and the glial cell-derived neurotrophic factor (GDNF). There are some trophic (neurotrophic) factors that already been tested in patients with spinal cord injury (SCI), but only shown partial recovery effect. It is possible that, the administration of these trophic factors together with physical rehabilitation, act synergistically and, therefore, significantly improve the quality of life of patients with SCI.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1753724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37843139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Association between the serum concentrations of 12 cytokines and growth factors and metabolic syndrome in patients undergoing angiography. 血管造影患者血清12种细胞因子和生长因子浓度与代谢综合征的关系

IF 1.8 4区生物学

Growth factors Pub Date : 2019-12-01 Epub Date: 2020-03-12 DOI: 10.1080/08977194.2020.1737528

Seyed Reza Mirhafez, Mohamad Tajfard, Ahmadreza Zarifian, Ali Movahedi, Nazanin Amiri, Hamideh Ghazizadeh, Amir Avan, Gordon A Ferns, Majid Ghayour-Mobarhan

{"title":"Association between the serum concentrations of 12 cytokines and growth factors and metabolic syndrome in patients undergoing angiography.","authors":"Seyed Reza Mirhafez, Mohamad Tajfard, Ahmadreza Zarifian, Ali Movahedi, Nazanin Amiri, Hamideh Ghazizadeh, Amir Avan, Gordon A Ferns, Majid Ghayour-Mobarhan","doi":"10.1080/08977194.2020.1737528","DOIUrl":"https://doi.org/10.1080/08977194.2020.1737528","url":null,"abstract":"We aimed to compare the concentrations of serum cytokines in patients undergoing coronary angiography and finding their possible associations with metabolic syndrome. Twelve serum cytokines and growth factors (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, MCP-1, IFN-γ, EGF, and VEGF) were measured by sandwich chemiluminescence assays, on the Evidence Investigator® system. There were significant differences regarding sex, height, weight, BMI, WC, HC, FPG, TG and HDL-C between those with and without MetS in patients undergoing angiography (p < .05). Serum concentrations of IL-6 and INF-γ were significantly higher in subjects with MetS, compared to those without MetS (p = .031 and p = .035, respectively). However, only serum IL-6 was associated with the presence of MetS (β = 1.215, CI = 1.047-1.409, p = .010). From several serum cytokines and growth factors assessed in patients, IL-6 was the only serum cytokine that was significantly different between those with and without MetS after correction for confounding factors.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1737528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37727819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

IGF-1 regulate the expression of uncoupling protein 2 via FOXO1. IGF-1通过fox01调控解偶联蛋白2的表达。

IF 1.8 4区生物学

Growth factors Pub Date : 2019-12-01 Epub Date: 2020-03-10 DOI: 10.1080/08977194.2020.1739032

Yukiko Watamoto, Kumi Futawaka, Misa Hayashi, Midori Matsushita, Mana Mitsutani, Zilin Song, Rie Koyama, Yuki Fukuda, Ayaka Nushida, Syoko Nezu, Akiko Kuwahara, Kazusaburo Kataoka, Tetsuya Tagami, Kenji Moriyama

{"title":"IGF-1 regulate the expression of uncoupling protein 2 via FOXO1.","authors":"Yukiko Watamoto, Kumi Futawaka, Misa Hayashi, Midori Matsushita, Mana Mitsutani, Zilin Song, Rie Koyama, Yuki Fukuda, Ayaka Nushida, Syoko Nezu, Akiko Kuwahara, Kazusaburo Kataoka, Tetsuya Tagami, Kenji Moriyama","doi":"10.1080/08977194.2020.1739032","DOIUrl":"https://doi.org/10.1080/08977194.2020.1739032","url":null,"abstract":"Mitochondria uncoupling protein2 (UCP2) expressed ubiquitously is a key molecule of energy metabolism. Insulin-like growth factor-1 (IGF-1) is a hormone, a target molecule of growth hormone (GH) signal pathway, which is also known as the drug \"mecasermin\" for clinical usages. IGF-1 is seemed to be closely related to metabolic diseases, such as adult GH deficiency. However, there has not been reports depicted possible relationship with each other. So, we sought to elucidate the mechanisms by which expression of UCP2 is regulated by IGF-1 via FOXO1. The findings suggested that three sequences in the consensus UCP2 promoter play complementary functional roles in the functional expression of FOXO1. So, we found that FOXO1 is involved in IGF-1-mediated energy metabolism greater than that of direct action of GH via STAT5. Our findings suggested that IGF-1 was involved in energy metabolism by regulating the expression of UCP2 via the PI3K/Akt/FOXO1 pathway.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1739032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37724877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of single bout downhill running on the serum irisin concentrations in rats. 单次下坡跑对大鼠血清鸢尾素浓度的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2019-12-01 Epub Date: 2020-03-21 DOI: 10.1080/08977194.2020.1742118

Masanobu Murao, Tetsuo Imano, Junichi Akiyama, Teruhiko Kawakami, Masaaki Nakajima

{"title":"Effect of single bout downhill running on the serum irisin concentrations in rats.","authors":"Masanobu Murao, Tetsuo Imano, Junichi Akiyama, Teruhiko Kawakami, Masaaki Nakajima","doi":"10.1080/08977194.2020.1742118","DOIUrl":"https://doi.org/10.1080/08977194.2020.1742118","url":null,"abstract":"This study aimed to characterize the effect of different running modes on serum irisin concentrations in rats. A total of 18, 10-week-old rats were divided into three groups; control group, 16° uphill running group (concentric exercise; CON) and, -16° downhill running group (eccentric exercise; ECC). The running group's rats ran on the inclined treadmill at 16 m/min, for a total of 90 min. Blood was drawn from the rats, 48 h after running, after which the rats were anesthetized. The serum concentrations of irisin were measured using enzyme-linked immunosorbent assays. Vastus intermedius was collected for immunohistochemical analysis. After multiple comparisons, the ECC showed a significantly high serum irisin concentration (ECC: 28.42 ± 6.31 ng/ml, CON: 21.27 ± 3.03 ng/ml) and a larger irisin antibody reactive cross-sectional area in vastus intermedius compared to the CON (p < 0.05). This is the first study to reveal that single bout downhill running increases serum irisin concentrations in rats.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1742118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37761526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Epidermal growth factor receptor ligands: targets for optimizing treatment of metastatic colorectal cancer. 表皮生长因子受体配体:转移性结直肠癌优化治疗的靶点。

IF 1.8 4区生物学

Growth factors Pub Date : 2019-12-01 Epub Date: 2019-12-26 DOI: 10.1080/08977194.2019.1703702

Siavash Foroughi, Jeanne Tie, Peter Gibbs, Antony Wilks Burgess

引用次数: 6

Platelet-rich plasma improves impaired glucose hemostasis, disrupted insulin secretion, and pancreatic oxidative stress in streptozotocin-induced diabetic rat. 富血小板血浆改善链脲佐菌素诱导的糖尿病大鼠葡萄糖止血受损、胰岛素分泌紊乱和胰腺氧化应激。

IF 1.8 4区生物学

Growth factors Pub Date : 2019-12-01 Epub Date: 2020-03-10 DOI: 10.1080/08977194.2020.1735382

Marzieh Zarin, Narges Karbalaei, Sara Keshtgar, Marzieh Nemati

{"title":"Platelet-rich plasma improves impaired glucose hemostasis, disrupted insulin secretion, and pancreatic oxidative stress in streptozotocin-induced diabetic rat.","authors":"Marzieh Zarin, Narges Karbalaei, Sara Keshtgar, Marzieh Nemati","doi":"10.1080/08977194.2020.1735382","DOIUrl":"https://doi.org/10.1080/08977194.2020.1735382","url":null,"abstract":"Our study aimed to investigate the effects of platelet-rich plasma (PRP) on impaired glucose homeostasis, disrupted islet insulin secretion, and pancreatic oxidative status in streptozotocin (STZ)-diabetic rats. A total of 64 Sprague-Dawley male were randomized to four groups including controls, diabetes, control-PRP, and diabetes-PRP. The rats received the PRP (0.5 ml/kg, SC injection) twice weekly for 4 weeks. Plasma glucose and insulin levels, pancreatic oxidative stress markers and islet insulin secretion and content were measured. Compared with the control group, in the diabetic group, increased plasma glucose and malondialdehyde (MDA) levels and decreased plasma insulin level, islet insulin secretion, pancreatic superoxide dismutase (SOD), and catalase activities were observed. PRP treatment significantly reduced plasma glucose and MDA levels and enhanced plasma insulin, antioxidant enzyme activity, islet insulin secretion, and content in the diabetic rats. These findings showed that PRP can improve pancreatic islet insulin secretion, pancreatic oxidative stress and regulate plasma insulin and glucose levels in diabetic rats.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1735382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37720480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Granulocyte colony-stimulating factor downregulates interferon-gamma receptor expression and stimulates interleukin-6 production in activated human macrophages. 粒细胞集落刺激因子在活化的人巨噬细胞中下调干扰素受体的表达并刺激白细胞介素-6的产生

IF 1.8 4区生物学

Growth factors Pub Date : 2019-08-01 Epub Date: 2019-09-18 DOI: 10.1080/08977194.2019.1662418

V I Seledtsov, V V Malashchenko, M E Meniailo, N D Gazatova, G V Seledtsova

引用次数: 1

An oncogenic activity of PDGF-C and its splice variant in human breast cancer PDGF-C及其剪接变体在人乳腺癌中的致癌活性

IF 1.8 4区生物学

Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1662415

Alyssa Bottrell, Y. Meng, Abdo J. Najy, N. Hurst, Seongho Kim, C. Kim, Eun‐sook Kim, A. Moon, Eun Joo Kim, S. Y. Park, H. Kim

{"title":"An oncogenic activity of PDGF-C and its splice variant in human breast cancer","authors":"Alyssa Bottrell, Y. Meng, Abdo J. Najy, N. Hurst, Seongho Kim, C. Kim, Eun‐sook Kim, A. Moon, Eun Joo Kim, S. Y. Park, H. Kim","doi":"10.1080/08977194.2019.1662415","DOIUrl":"https://doi.org/10.1080/08977194.2019.1662415","url":null,"abstract":"Abstract Despite strong evidence for the involvement of PDGF signaling in breast cancer, little is known about the PDGF ligand responsible for PDGFR activation during breast cancer progression. Here, we found PDGF-C to be highly expressed in breast carcinoma cell lines. Immunohistochemical analysis of invasive breast cancer revealed an association between increased PDGF-C expression and lymph node metastases, Ki-67 proliferation index, and poor disease-free survival. We also identified a PDGF-C splice variant encoding truncated PDGF-C (t-PDGF-C) isoform lacking the signal peptide and the N-terminal CUB domain. While t-PDGF C homodimer is retained intracellularly, it can be secreted as a heterodimer with full-length PDGF-C (FL-PDGF-C). PDGF-C downregulation reduced anchorage-independent growth and matrigel invasion of MDA-MB-231 cells. Conversely, ectopic expression of t-PDGF-C enhanced phenotypic transformation and invasion in BT-549 cells expressing endogenous FL-PDGF-C. The present study provides new insights into the functional significance of PDGF-C and its splice variant in human breast cancer.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1662415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43550137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Growth differentiation factor 15 and its role in carcinogenesis: an update 生长分化因子15及其在癌变中的作用:最新进展

IF 1.8 4区生物学

Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1685988

A. Modi, Shailender Dwivedi, D. Roy, Manoj Khokhar, P. Purohit, Jeewan Ram Vishnoi, P. Pareek, Shailja Sharma, Praveen Sharma, S. Misra

引用次数: 26

Effects of hepatocyte growth factor gene-transfected mesenchymal stem cells on dimethylnitrosamine-induced liver fibrosis in rats 肝细胞生长因子基因转染间充质干细胞对二甲基亚硝胺诱导大鼠肝纤维化的影响

IF 1.8 4区生物学

Growth factors Pub Date : 2019-07-04 DOI: 10.1080/08977194.2019.1652399

S. Moon, C. Lee, See-Hyoung Park, Myeong Jin Nam

{"title":"Effects of hepatocyte growth factor gene-transfected mesenchymal stem cells on dimethylnitrosamine-induced liver fibrosis in rats","authors":"S. Moon, C. Lee, See-Hyoung Park, Myeong Jin Nam","doi":"10.1080/08977194.2019.1652399","DOIUrl":"https://doi.org/10.1080/08977194.2019.1652399","url":null,"abstract":"Abstract Nowadays, transplantation of human mesenchymal stem cells (MSCs) has emerged as a potential cellular therapy for liver cirrhosis. Hepatocyte growth factor (HGF) plays an important role in the regeneration of the liver. The objective of the study was to investigate the therapeutic effect of HGF-transfected human umbilical cord blood-derived MSCs on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. HGF-transfected MSCs were transplanted into rats with DMN-induced liver fibrosis. H2O2-induced cytotoxicity, apoptosis and intracellular reactive oxygen species were reduced in HGF-transfected MSCs in HGF-transfected MSCs. Pro-apoptotic proteins, such as cleaved poly (ADP-ribose) polymerase and cleaved caspase-3, were decreased in HGF-transfected MSCs. Biochemical analysis showed that the levels of aspartate aminotransferase and alanine aminotransferase were decreased after transplantation of HGF-transfected MSCs in rat fibrosis. Trichrome staining showed that HGF-transfected MSCs reduced liver damage. Taken together, our study indicated that HGF-transfected MSCs have therapeutic effects on DMN-induced liver fibrosis in rats.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2019-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2019.1652399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42649356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18