Growth factors最新文献_第9页

Platelet rich plasma efficiently substitutes the beneficial effects of serum during in vitro oocyte maturation and helps maintain the mitochondrial activity of maturing oocytes. 富血小板血浆有效地替代血清在卵母细胞体外成熟过程中的有益作用，并有助于维持成熟卵母细胞的线粒体活性。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-19 DOI: 10.1080/08977194.2021.1900168

F Moulavi, R T Akram, S Khorshid Sokhangouy, S M Hosseini

{"title":"Platelet rich plasma efficiently substitutes the beneficial effects of serum during in vitro oocyte maturation and helps maintain the mitochondrial activity of maturing oocytes.","authors":"F Moulavi, R T Akram, S Khorshid Sokhangouy, S M Hosseini","doi":"10.1080/08977194.2021.1900168","DOIUrl":"https://doi.org/10.1080/08977194.2021.1900168","url":null,"abstract":"Platelets contain most of the potent mitogenic factors present in serum and follicular fluid and intraovarian injection of autologous platelet rich plasma (PRP) was shown to improve ovarian function and development of preantral follicles. This study evaluated the effect of PRP on caprine oocyte maturation in vitro and subsequent fertilization and embryonic development. Cumulus oocyte complexes were cultured in a maturation medium supplemented with (1) fetal bovine serum (FBS, control), (2) PRP, extracted from healthy female goats, (3) polyvinyl alcohol (PVA), and (4) PVA plus PRP (PVA-PRP). The degree of cumulus expansion was scored, and denuded oocytes were used for assessment of nuclear maturation, mitochondrial activity, lipid content, redox status, yield and quality of in vitro embryo development, and cryosurvival of the resulting blastocysts. PRP supported the same beneficial effects of FBS on cumulus expansion, nuclear maturation, in vitro developmental competence of oocytes, and survival of vitrified-warmed blastocysts. Moreover, PRP protected oocytes from undesirable effects FBS exerted on the mitochondrial activity and intracytoplasmic lipid content of maturing oocyte. Although PVA could support the same beneficial effects of neither FBS nor PRP on oocyte maturation, its combined addition with PRP improved the yield and quality of oocyte maturation at rates closely similar to PRP. PRP efficiently substitutes beneficial effects of serum during in vitro oocyte maturation and helps maintain the mitochondrial activity of maturing oocytes.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"152-166"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1900168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25495880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Application of bioinformatics and molecular dynamics simulation approaches for identification of fibroblast growth factor 10 analogues with potentially improved thermostability. 应用生物信息学和分子动力学模拟方法鉴定具有潜在改善热稳定性的成纤维细胞生长因子10类似物。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 DOI: 10.1080/08977194.2021.1881501

Ali Akbar Alizadeh, Behzad Jafari, Siavoush Dastmalchi

{"title":"Application of bioinformatics and molecular dynamics simulation approaches for identification of fibroblast growth factor 10 analogues with potentially improved thermostability.","authors":"Ali Akbar Alizadeh, Behzad Jafari, Siavoush Dastmalchi","doi":"10.1080/08977194.2021.1881501","DOIUrl":"https://doi.org/10.1080/08977194.2021.1881501","url":null,"abstract":"Fibroblast growth factor 10 functions as a paracrine mesenchymal molecule to initiate signalling pathways regarding to cellular development and health. However, the low thermal stability restricts it's functionality in the human body and the shelf-life of FGF10-based formulations. The current study aimed to employ rational design and bioinformatics approaches to identify some point mutations which may improve the thermal stability of FGF10. Bioinformatics analyses resulted in N105D, C106F, K144R, K153M and I156R as the potential stability conferring mutations. The identified mutants were subjected to MD simulation indicating that all mutations are both structurally and energetically favoured. Finally, the effects of the identified mutations on receptor binding of FGF10 were predicted and the results showed that K144R and K153M mutations may increase the binding affinity relative to the wild type. The findings of the current study propose potentially improved FGF10 analogues for further experimental investigations.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"197-209"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1881501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39009210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative review of brain-derived neurotrophic factor (BDNF) on cognitive performance in Alzheimer's disease. 脑源性神经营养因子(BDNF)对阿尔茨海默病认知表现的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-01-11 DOI: 10.1080/08977194.2020.1864347

Noor Azila Ismail, Mohammad Farris Iman Leong Abdullah, Rohayu Hami, Hazwani Ahmad Yusof

引用次数: 9

Interactions between thymic endothelial cells and thymocytes are influenced by growth hormone. 胸腺内皮细胞和胸腺细胞之间的相互作用受生长激素的影响。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 Epub Date: 2021-05-24 DOI: 10.1080/08977194.2021.1924699

Marvin Paulo Lins, Iana Mayane Mendes Nicácio Viana, Salete Smaniotto, Maria Danielma Dos Santos Reis

{"title":"Interactions between thymic endothelial cells and thymocytes are influenced by growth hormone.","authors":"Marvin Paulo Lins, Iana Mayane Mendes Nicácio Viana, Salete Smaniotto, Maria Danielma Dos Santos Reis","doi":"10.1080/08977194.2021.1924699","DOIUrl":"https://doi.org/10.1080/08977194.2021.1924699","url":null,"abstract":"Growth hormone (GH), in addition to its classic actions on growth and metabolism in the body, exerts pleiotropic effects on the immune system, particularly on the thymus. The aim of this study was to evaluate the influence of GH on the interactions between mature thymocytes and the thymic endothelium involved in the migratory process. To this end, fresh thymocytes (C57BL/6 mice) and the thymic endothelial cell line (tEnd.1) were used. In the cell adhesion assay, the GH-treated thymocytes adhered more to tEnd.1 cells. Additionally, there was an improvement in the deposition of fibronectin by tEnd.1 cells when co-cultured with GH-pre-treated thymocytes. Furthermore, GH induced thymocyte F-actin polymerization. In the transendothelial migration assay, a large number of GH-treated thymocytes, mainly the CD4-CD8+ subset, migrated towards the endothelium under the stimulus of insulin-like growth factor 1. In conclusion, we demonstrated the positive actions of GH in thymocyte/thymic endothelium interactions, including transendothelial migration.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"177-188"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1924699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38930839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia. 慢性淋巴细胞白血病患者心血管疾病风险生物标志物GDF15和肌肉生长抑制素水平升高

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 DOI: 10.1080/08977194.2021.1932870

Karin Larsson, Martin Höglund, Anders Larsson, Måns Thulin, Torbjörn Karlsson

{"title":"Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia.","authors":"Karin Larsson, Martin Höglund, Anders Larsson, Måns Thulin, Torbjörn Karlsson","doi":"10.1080/08977194.2021.1932870","DOIUrl":"https://doi.org/10.1080/08977194.2021.1932870","url":null,"abstract":"Individuals suffering from cancer, including hematological malignancies, are at increased risk of cardiovascular disease (CVD). Elevated levels of several biomarkers in blood are associated with an increased risk of CVD. The aim of this study was to investigate whether a subset of such CVD risk biomarkers was elevated in patients with untreated chronic lymphocytic leukemia (CLL). Blood plasma and serum from 139 CLL patients and 71 healthy age-matched controls were analyzed for 11 proposed CVD risk biomarkers. The CLL cohort displayed a more heterogeneous pattern of biomarker expression compared to controls. The majority, eight out of 11, analyzed CVD risk biomarkers differed significantly in concentrations between CLL patients and controls. Increased levels of the biomarkers GDF15 and myostatin have not previously been reported in CLL. Further prospective studies are warranted to investigate whether these biomarkers predict future cardiovascular events in patients with CLL.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"189-196"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1932870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39009208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth. 尽管慢性缺血诱导血管生长，但成纤维细胞生长因子-2（FGF2）缺陷小鼠的肢体功能恢复受损。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-06-04 DOI: 10.1080/08977194.2020.1767612

Adeola Adeyemo, Christopher Johnson, Andrew Stiene, Kathleen LaSance, Zhihua Qi, Lisa Lemen, Jo El J Schultz

{"title":"Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth.","authors":"Adeola Adeyemo, Christopher Johnson, Andrew Stiene, Kathleen LaSance, Zhihua Qi, Lisa Lemen, Jo El J Schultz","doi":"10.1080/08977194.2020.1767612","DOIUrl":"10.1080/08977194.2020.1767612","url":null,"abstract":"FGF2 is a potent stimulator of vascular growth; however, even with a deficiency of FGF2 (Fgf2-/-), developmental vessel growth or ischaemia-induced revascularization still transpires. It remains to be elucidated as to what function, if any, FGF2 has during ischaemic injury. Wildtype (WT) or Fgf2-/- mice were subjected to hindlimb ischaemia for up to 42 days. Limb function, vascular growth, inflammatory- and angiogenesis-related proteins, and inflammatory cell infiltration were assessed in sham and ischaemic limbs at various timepoints. Recovery of ischaemic limb function was delayed in Fgf2-/- mice. Yet, vascular growth response to ischaemia was similar between WT and Fgf2-/- hindlimbs. Several angiogenesis- and inflammatory-related proteins (MCP-1, CXCL16, MMPs and PAI-1) were increased in Fgf2-/- ischaemic muscle. Neutrophil or monocyte recruitment/infiltration was elevated in Fgf2-/- ischaemic muscle. In summary, our study indicates that loss of FGF2 induces a pro-inflammatory microenvironment in skeletal muscle which exacerbates ischaemic injury and delays functional limb use.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 2","pages":"75-93"},"PeriodicalIF":1.8,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1767612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38012070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus. 肝素结合表皮生长因子(EGF)样生长因子在儿科1型糖尿病患者中的作用

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-10-30 DOI: 10.1080/08977194.2020.1841757

Dragana Kacarevic, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, Dragana Bojanin, Tatjana Milenkovic, Aleksandra Stefanovic, Marija Mihajlovic, Sanja Vujcic, Rade Vukovic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Ilijana Mazibrada, Jelena Vekic

{"title":"Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus.","authors":"Dragana Kacarevic, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, Dragana Bojanin, Tatjana Milenkovic, Aleksandra Stefanovic, Marija Mihajlovic, Sanja Vujcic, Rade Vukovic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Ilijana Mazibrada, Jelena Vekic","doi":"10.1080/08977194.2020.1841757","DOIUrl":"https://doi.org/10.1080/08977194.2020.1841757","url":null,"abstract":"Heparin-binding EGF-like growth factor (HB-EGF) is involved in atherosclerosis progression. We investigated association between plasma HB-EGF levels and lipid, oxidative stress and inflammatory biomarkers in pediatric patients with type 1 diabetes mellitus (T1DM). Levels of HB-EGF, high-sensitive C-reactive protein (hsCRP), prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), oxidized low-density lipoproteins (oxLDL), metabolic control and serum lipid parameters and paraoxonase 1 (PON1) activity were determined in 74 patients and 40 controls. In comparison to controls, patients had significantly higher levels (p < 0.01) of HB-EGF, hsCRP, PAB and oxLDL particles (p < 0.001), but lower levels of TAS and PON1 activity. In T1DM group, HB-EFG levels were positively associated with hsCRP, PAB and oxLDL levels. hsCRP and oxLDL levels were independent predictors of HB-EGF concentration. We demonstrated that oxidative modifications of LDL particles and low-grade inflammation are main determinants of increased plasma HB-EGF levels, which indicates an interactive role of oxidative stress, dyslipidemia and inflammation.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 2","pages":"120-126"},"PeriodicalIF":1.8,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1841757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38546236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors. 槲皮素通过调节不同细胞因子和生长因子促进大鼠皮肤伤口愈合。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-09-22 DOI: 10.1080/08977194.2020.1822830

Vinay Kant, Babu Lal Jangir, Vinod Kumar, Ankit Nigam, Vikash Sharma

{"title":"Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors.","authors":"Vinay Kant, Babu Lal Jangir, Vinod Kumar, Ankit Nigam, Vikash Sharma","doi":"10.1080/08977194.2020.1822830","DOIUrl":"https://doi.org/10.1080/08977194.2020.1822830","url":null,"abstract":"Quercetin on wounds could be favorable for healing based on its variety of biological effects. Eighty wounded rats were divided into four groups i.e. dimethyl sulfoxide, 0.03% quercetin, 0.1% quercetin, and 0.3% quercetin-treated. Different treatments were topically applied for 20 days. Quercetin (0.3%) caused the fastest wound closure and markedly improved the oxidative stress. Quercetin treatment increased the expressions of IL-10, VEGF, TGF-β1, CD31, α-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-α. Early infiltration of inflammatory cells and formation of good quality granulation tissue dominated by fibroblast proliferation, angiogenesis, and collagen deposition in quercetin treated groups was also evident. All these effects were more pronounced at 0.3% quercetin concentration. The earliest regeneration of epithelial layer was also observed in 0.3% quercetin-treated wounds. In conclusion, 0.3% quercetin accelerates wound healing efficiently by modulating antioxidant system of wound, cytokines, growth factors, other proteins and cells involved in healing.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 2","pages":"105-119"},"PeriodicalIF":1.8,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1822830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38404018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD. SIRT1减轻COPD大鼠模型内质网应激和细胞凋亡。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-08-20 DOI: 10.1080/08977194.2020.1810029

Li Zhang, Bailing Luo, Yuan Ting, Shengyang He, Lihua Xie, Shenghua Sun

引用次数: 6

Cyclosporin A suppresses Porphyromonas gingivalis lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1. 环孢素A抑制牙龈卟啉单胞菌脂多糖诱导的牙龈成纤维细胞和单核细胞THP-1共培养的基质金属蛋白酶活性。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-04-22 DOI: 10.1080/08977194.2020.1755280

Lei Jiang, Min Ni Liu, Guo Dong Wang, Qun Wu, Yun Fu Zhao

引用次数: 0