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Effect of autologous growth factors on apoptosis and thickness of the outer nuclear layer in an experimental retinal degeneration model. 自体生长因子对实验性视网膜变性模型外核层细胞凋亡及厚度的影响。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-12-01 Epub Date: 2021-07-08 DOI: 10.1080/08977194.2021.1948842
Emin Ozmert, Sibel Demirel, Umut Arslan, Özlem Biçer, Ozan Ahlat, Figen Şermet
{"title":"Effect of autologous growth factors on apoptosis and thickness of the outer nuclear layer in an experimental retinal degeneration model.","authors":"Emin Ozmert,&nbsp;Sibel Demirel,&nbsp;Umut Arslan,&nbsp;Özlem Biçer,&nbsp;Ozan Ahlat,&nbsp;Figen Şermet","doi":"10.1080/08977194.2021.1948842","DOIUrl":"https://doi.org/10.1080/08977194.2021.1948842","url":null,"abstract":"<p><p>Retinal pigment epithelium and photoreceptor cells are a microenvironment where 90 different peptides are synthesized for transduction, visual cycle, intracellular electron transport chain, and removal of metabolic wastes. Depending on the inheritance pattern, either mutant proteins accumulate inside the cells or the energy cycle is disrupted. Disruption of homeostasis causes the cells to switch to the dormant phase; if the improper conditions last longer, then apoptosis eventually develops resulting in a loss of visual function. In neural tissues, growth factors such as neural growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor, and insulin-like growth factor are regulatory peptides for intracellular energy cycle and intracellular digestion. In this study, it has been shown histopathologically that autologous growth factors can prevent apoptosis and prevent loss of outer retinal thickness in the retinal degeneration model created with sodium iodate.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 5-6","pages":"247-258"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1948842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of fasting on body composition and proteolysis gene expression in skeletal muscles and liver of BEH+/+ and BEL mice. 禁食对BEH+/+和BEL小鼠体组成及骨骼肌和肝脏蛋白水解基因表达的影响。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-12-01 Epub Date: 2021-08-06 DOI: 10.1080/08977194.2021.1960831
Edgaras Lapinskas, Raulas Krusnauskas, Agne Cekanauskaite, Aivaras Ratkevicius
{"title":"Effect of fasting on body composition and proteolysis gene expression in skeletal muscles and liver of BEH+/+ and BEL mice.","authors":"Edgaras Lapinskas,&nbsp;Raulas Krusnauskas,&nbsp;Agne Cekanauskaite,&nbsp;Aivaras Ratkevicius","doi":"10.1080/08977194.2021.1960831","DOIUrl":"https://doi.org/10.1080/08977194.2021.1960831","url":null,"abstract":"<p><p>Fasting improves health, but can cause muscle weakness. We assessed body composition in 21-week old males of Berlin high (BEH+/+) and Berlin low (BEL) strains after two bouts of 48-h or 40-h of fasting with 5-day refeeding in between, respectively. BEH+/+ mice tended to loose less weight than BEL in bout 1 and 2 (16.0 ± 2.7 versus 23.5 ± 2.9%, <i>p</i> < 0.001 and 17.1 ± 3.4 versus 20.4 ± 3.4%, <i>p</i> = 0.17, respectively). In spite of greater serum IGF-1 and body fat levels, BEH+/+ mice showed more severe muscle atrophy, but less marked liver wasting and fat depletion than BEL mice. BEH+/+ mice also showed smaller increases in expression of <i>p62</i>, <i>Atrogin-1,</i> and <i>Mstn</i> genes in skeletal muscles. In summary, BEL mice show resistance to fasting-induced muscle wasting in spite of low serum IGF-1 levels and high expression of genes associated with muscle atrophy.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 5-6","pages":"259-268"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1960831","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39281613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue. 胰岛素和IGF-2支持大鼠角膜内皮细胞生长和器官培养组织的伤口修复。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-12-01 Epub Date: 2021-08-13 DOI: 10.1080/08977194.2021.1963721
Sheldon R Gordon, Darryl R Reaume, Thomas R Perkins
{"title":"Insulin and IGF-2 support rat corneal endothelial cell growth and wound repair in the organ cultured tissue.","authors":"Sheldon R Gordon,&nbsp;Darryl R Reaume,&nbsp;Thomas R Perkins","doi":"10.1080/08977194.2021.1963721","DOIUrl":"https://doi.org/10.1080/08977194.2021.1963721","url":null,"abstract":"<p><p>The ability of insulin and IGF-2 to support wound repair in the organ-cultured rat corneal endothelium was investigated. Corneas given a circular transcorneal freeze injury, were explanted into organ cultures containing either insulin or IGF-2 and cultured up to72 h. Both factors increased [<sup>3</sup>H]-thymidine incorporation and mitotic levels compared to controls. Insulin's ability to mediate wound closure without serum was dependent on its continuous presence in the medium. PKC was also investigated in endothelial repair using the PKC promoter phorbol 12-myristate 13-acetate (PMA). Concentrations between 10<sup>-6</sup> and 10<sup>-8</sup> M, PMA failed to accelerate wound closure. When injured endothelia were cultured in the presence of insulin and the PKC inhibitor H-7, wound closure was also unaffected. These results indicate that insulin and IGF-2 stimulate cell growth in injured rat corneal endothelium and that insulin without the benefit of serum promotes wound closure <i>in situ</i> independent of the PKC pathway.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 5-6","pages":"269-281"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39307697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miRNA-26-5p inhibits cyclosporine A-induced overgrowth of gingival fibroblasts by regulating PTEN/PI3K/AKT pathway. miRNA-26-5p通过调控PTEN/PI3K/AKT通路抑制环孢素a诱导的牙龈成纤维细胞过度生长。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-12-01 Epub Date: 2021-08-24 DOI: 10.1080/08977194.2021.1967343
Qiyong Hu, Nadan Guo, Yuting Zhao, Yi Chen, Peng Zhang, Wei Shen, Ziya Gu
{"title":"miRNA-26-5p inhibits cyclosporine A-induced overgrowth of gingival fibroblasts by regulating PTEN/PI3K/AKT pathway.","authors":"Qiyong Hu,&nbsp;Nadan Guo,&nbsp;Yuting Zhao,&nbsp;Yi Chen,&nbsp;Peng Zhang,&nbsp;Wei Shen,&nbsp;Ziya Gu","doi":"10.1080/08977194.2021.1967343","DOIUrl":"https://doi.org/10.1080/08977194.2021.1967343","url":null,"abstract":"<p><p>We evaluated the effect of cyclosporine A (CsA) administration on the level of miR-26-5p in rat gingival tissues and human gingival fibroblasts (HGFs) by qRT-PCR assay. Further, we conducted Western blotting and immunohistochemical analysis to assess the expressions of PTEN, PI3K, and p-AKT, and evaluated cell proliferation of HGFs by MTT assay. CsA treatment significantly downregulated the expressions of miR-26-5p and PTEN and upregulated the expressions of PI3K and p-AKT in both rat gingival tissues and HGFs. Overexpression of miR-26-5p inhibited CsA-induced overgrowth of HGFs, whereas knockdown of miR-26-5p promoted the overgrowth. PTEN knockdown not only promoted CsA-induced overgrowth of human HGFs but also reversed the repressive effects of miR-26-5p on CsA-induced overgrowth of HGFs. Our results revealed that miRNA-26-5p could repress CsA-induced overgrowth of human HGFs by regulating PTEN/PI3K/AKT pathway.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 5-6","pages":"291-301"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39339036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells. 半乳糖凝集素-1对人单核细胞源性树突状细胞免疫调节特性的影响。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-12-01 Epub Date: 2021-07-05 DOI: 10.1080/08977194.2021.1947267
Tanja Džopalić, Miloš Kostić, Milena Kostić, Goran Marjanović, Jelena Guzina, Vladimir Jurišić, Biljana Božić Nedeljković
{"title":"Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells.","authors":"Tanja Džopalić,&nbsp;Miloš Kostić,&nbsp;Milena Kostić,&nbsp;Goran Marjanović,&nbsp;Jelena Guzina,&nbsp;Vladimir Jurišić,&nbsp;Biljana Božić Nedeljković","doi":"10.1080/08977194.2021.1947267","DOIUrl":"https://doi.org/10.1080/08977194.2021.1947267","url":null,"abstract":"<p><p>Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs <i>in-vitro</i>. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4<sup>+</sup>T cells. Gal-1 reduced the expression of CD80 and CD86 molecules on MoDCs compared to untreated MoDCs. Gal-1 at concentrations of 1 and 6 μg/mL significantly reduced IL-12 production, while the concentration of 3 μg/mL led to its significant increase. Gal-1 in all concentrations induced a significant increase in the production of IL-10. Treatment of MoDCs with 3 and 6 μg/mL of Gal-1 stimulated the production of IL-2 and IFN-γ in the co-culture with CD4<sup>+</sup>T lymphocytes. This study demonstrated a dual immunomodulatory effect of Gal-1 on MoDCs in terms of immune stimulation and immune suppression, depending on the applied concentration.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 5-6","pages":"235-246"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1947267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39151611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2. 重组人成纤维细胞生长因子2治疗三度烧伤小鼠。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-12-01 Epub Date: 2021-08-20 DOI: 10.1080/08977194.2021.1967342
Thu-Minh Tran-Nguyen, Khanh-Thien Le, Le-Giang Thi Nguyen, Thanh-Loan Thi Tran, Phuong-Cac Hoang-Thai, Thuoc Linh Tran, Sik-Loo Tan, Hieu Tran-Van
{"title":"Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2.","authors":"Thu-Minh Tran-Nguyen,&nbsp;Khanh-Thien Le,&nbsp;Le-Giang Thi Nguyen,&nbsp;Thanh-Loan Thi Tran,&nbsp;Phuong-Cac Hoang-Thai,&nbsp;Thuoc Linh Tran,&nbsp;Sik-Loo Tan,&nbsp;Hieu Tran-Van","doi":"10.1080/08977194.2021.1967342","DOIUrl":"https://doi.org/10.1080/08977194.2021.1967342","url":null,"abstract":"<p><p>Fibroblast growth factor 2 (FGF-2) is a multifunctional protein that has major roles in wound healing, tissue repair, and regeneration. This therapeutic protein is widely used for burn treatment because it can stimulate cell proliferation and differentiation, angiogenesis, and extracellular matrix remodeling. In this study, we developed a simple method using a controlled heated brass rod to create a homogenous third-degree burn murine model and evaluated the treatment using recombinant human FGF-2 (rhFGF-2). The results indicated that the wound area was 0.83 ± 0.05 cm<sup>2</sup> and wound depth was 573.42 ± 147.82 μm. Mice treated with rhFGF-2 showed higher rates of wound closure, granulation tissue formation, angiogenesis, and re-epithelialization than that of phosphate-buffered saline (PBS)-treated group. In conclusion, our lab-made rhFGF-2 could be a potentially therapeutic protein for burn treatment as well as a bioequivalent drug for other commercial applications using FGF-2.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 5-6","pages":"282-290"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39329436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Exploring the role of oxidative stress, fatty acids and neurotrophins in gestational diabetes mellitus. 探讨氧化应激、脂肪酸和神经营养因子在妊娠期糖尿病中的作用。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-11 DOI: 10.1080/08977194.2021.1895143
Anjali Jadhav, Amrita Khaire, Sadhana Joshi
{"title":"Exploring the role of oxidative stress, fatty acids and neurotrophins in gestational diabetes mellitus.","authors":"Anjali Jadhav,&nbsp;Amrita Khaire,&nbsp;Sadhana Joshi","doi":"10.1080/08977194.2021.1895143","DOIUrl":"https://doi.org/10.1080/08977194.2021.1895143","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) constitutes an unfavorable intrauterine environment for embryonic and feto-placental development. Women with GDM are at higher risk for materno-fetal complications and placental abnormalities. The placenta acts as an interface between the maternal and fetal circulations and also plays an important role in protecting the fetus from adverse effects of maternal metabolic conditions. One of the earliest abnormalities observed in GDM pregnancies is increased oxidative stress in the placenta which affects fetal development. Imbalances in maternal nutrition particularly long-chain polyunsaturated fatty acid (LCPUFA) intake and/or metabolism lead to increased oxidative stress. Reports indicate that oxidative stress and LCPUFA such as docosahexaenoic acid affect the levels of neurotrophins. The present review aims to provide insights into a mechanistic link between oxidative stress, LCPUFA and neurotrophin in the placenta in women with GDM and its implications for neurodevelopmental outcomes in children.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"226-234"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1895143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25462907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Attenuating influenza a virus infection by heparin binding EGF-like growth factor. 肝素结合egf样生长因子减毒甲型流感病毒感染。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-15 DOI: 10.1080/08977194.2021.1895144
K M Lai, B H Goh, W L Lee
{"title":"Attenuating influenza a virus infection by heparin binding EGF-like growth factor.","authors":"K M Lai,&nbsp;B H Goh,&nbsp;W L Lee","doi":"10.1080/08977194.2021.1895144","DOIUrl":"https://doi.org/10.1080/08977194.2021.1895144","url":null,"abstract":"<p><p>Cell entry of influenza A virus (IAV) was reported to be promoted by epidermal growth factor receptor (EGFR). On the other hand, binding of heparin-binding EGF-like growth factor (HB-EGF) to EGFR leads to internalisation and degradation of the receptors. This study aimed to testify whether or not HB-EGF-induced downregulation of EGFR could attenuate IAV cell entry and subsequently diminish the infection. Immunoblotting and plaque assay revealed that HB-EGF-induced degradation of EGFR led to reduction of viral matrix 1 protein level and suppressed virion production. In addition, immunoblotting and imaging flow cytometric analysis demonstrated that IAV-induced phosphorylation of STAT1 and its localisation to nucleus in the early stage of infection were inhibited by HB-EGF treatment. This suggested the potential of HB-EGF in modulating uncontrolled and exaggerated inflammatory response caused by IAV infection. Together these findings attest the potential of HB-EGF mediated endocytosis and degradation of EGFR as a novel anti-IAV strategy.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"167-176"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1895144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25480439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Effects of platelet-rich plasma on the pancreatic islet survival and function, islet transplantation outcome and pancreatic pdx1 and insulin gene expression in streptozotocin-induced diabetic rats. 富血小板血浆对链脲佐菌素诱导的糖尿病大鼠胰岛存活和功能、胰岛移植结局及胰腺pdx1和胰岛素基因表达的影响。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-06-01 Epub Date: 2021-02-11 DOI: 10.1080/08977194.2021.1881502
Marzieh Nemati, Narges Karbalaei, Pooneh Mokarram, Farzaneh Dehghani
{"title":"Effects of platelet-rich plasma on the pancreatic islet survival and function, islet transplantation outcome and pancreatic pdx<sub>1</sub> and insulin gene expression in streptozotocin-induced diabetic rats.","authors":"Marzieh Nemati,&nbsp;Narges Karbalaei,&nbsp;Pooneh Mokarram,&nbsp;Farzaneh Dehghani","doi":"10.1080/08977194.2021.1881502","DOIUrl":"https://doi.org/10.1080/08977194.2021.1881502","url":null,"abstract":"<p><p>Platelet-rich plasma (PRP) is a therapeutic option in different fields based on its growth factors. We investigated influence of PRP on islet survival, function, transplantation outcomes, and pancreatic genes expression in diabetic rats. <i>In vitro</i>: pancreatic isolated islets were incubated with/without PRP then viability, insulin secretion, and content were assessed. <i>In vivo</i>: Series 1 were designed to determine whether islet treatment with PRP improves transplantation outcome in diabetic rats by evaluating plasma glucose and insulin concentrations and oxidative parameters. Series 2, effects of PRP subcutaneous injection were evaluated on pancreatic genes expression and glucose tolerance test in diabetic rats. PRP enhanced viability and secretary function of islet. Reduced glucose and malondialdehyde levels as well as increased insulin levels, superoxide dismutase activity, and expressions of pdx1 and insulin were observed in diabetic rats. PRP treatment has positive effects on islet viability, function, transplantation outcome, and pancreatic genes expression in diabetic rats.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"137-151"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1881502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25355874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer. 转移性结直肠癌患者表皮生长因子受体配体水平的预后和预测能力的免疫组织化学评估。
IF 1.8 4区 生物学
Growth factors Pub Date : 2020-06-01 Epub Date: 2021-03-27 DOI: 10.1080/08977194.2021.1878166
Siavash Foroughi, Ryan A Hutchinson, Hui-Li Wong, Michael Christie, Ahida Batrouney, Rachel Wong, Margaret Lee, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs
{"title":"Immunohistochemical evaluation of the prognostic and predictive power of epidermal growth factor receptor ligand levels in patients with metastatic colorectal cancer.","authors":"Siavash Foroughi,&nbsp;Ryan A Hutchinson,&nbsp;Hui-Li Wong,&nbsp;Michael Christie,&nbsp;Ahida Batrouney,&nbsp;Rachel Wong,&nbsp;Margaret Lee,&nbsp;Jeanne Tie,&nbsp;Antony Wilks Burgess,&nbsp;Peter Gibbs","doi":"10.1080/08977194.2021.1878166","DOIUrl":"https://doi.org/10.1080/08977194.2021.1878166","url":null,"abstract":"<p><p>For patients with metastatic colorectal cancer (mCRC), epidermal growth factor receptor (EGFR) inhibitors are limited to patients with <i>RAS</i> wild-type tumours. Not all patients will benefit from treatment and better predictive biomarkers are needed. Here we investigated the prognostic and predictive impact of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG). Expression levels were assessed by immunohistochemistry on 99 <i>KRAS</i> wild-type tumours. AREG and EREG positivity was seen in 49% and 50% of cases, respectively. No difference in expression was observed by primary tumour side. There was no significant difference in OS by AREG or EREG expression. In the subset of patients who received an EGFR inhibitor, EREG positivity was associated with longer OS (median 34.0 vs. 27.0 months, <i>p</i> = 0.033), driven by a difference in patients with a left-sided primary (HR 0.37, <i>p</i> = 0.015). Our study supports further investigation into EREG as a predictive biomarker in mCRC.</p>","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":"38 3-4","pages":"127-136"},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1878166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25523180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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