Growth factors最新文献_第8页

Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia. 慢性淋巴细胞白血病患者心血管疾病风险生物标志物GDF15和肌肉生长抑制素水平升高

IF 1.8 4区生物学

Growth factors Pub Date : 2020-06-01 DOI: 10.1080/08977194.2021.1932870

Karin Larsson, Martin Höglund, Anders Larsson, Måns Thulin, Torbjörn Karlsson

{"title":"Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia.","authors":"Karin Larsson, Martin Höglund, Anders Larsson, Måns Thulin, Torbjörn Karlsson","doi":"10.1080/08977194.2021.1932870","DOIUrl":"https://doi.org/10.1080/08977194.2021.1932870","url":null,"abstract":"Individuals suffering from cancer, including hematological malignancies, are at increased risk of cardiovascular disease (CVD). Elevated levels of several biomarkers in blood are associated with an increased risk of CVD. The aim of this study was to investigate whether a subset of such CVD risk biomarkers was elevated in patients with untreated chronic lymphocytic leukemia (CLL). Blood plasma and serum from 139 CLL patients and 71 healthy age-matched controls were analyzed for 11 proposed CVD risk biomarkers. The CLL cohort displayed a more heterogeneous pattern of biomarker expression compared to controls. The majority, eight out of 11, analyzed CVD risk biomarkers differed significantly in concentrations between CLL patients and controls. Increased levels of the biomarkers GDF15 and myostatin have not previously been reported in CLL. Further prospective studies are warranted to investigate whether these biomarkers predict future cardiovascular events in patients with CLL.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2021.1932870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39009208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth. 尽管慢性缺血诱导血管生长，但成纤维细胞生长因子-2（FGF2）缺陷小鼠的肢体功能恢复受损。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-06-04 DOI: 10.1080/08977194.2020.1767612

Adeola Adeyemo, Christopher Johnson, Andrew Stiene, Kathleen LaSance, Zhihua Qi, Lisa Lemen, Jo El J Schultz

{"title":"Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth.","authors":"Adeola Adeyemo, Christopher Johnson, Andrew Stiene, Kathleen LaSance, Zhihua Qi, Lisa Lemen, Jo El J Schultz","doi":"10.1080/08977194.2020.1767612","DOIUrl":"10.1080/08977194.2020.1767612","url":null,"abstract":"FGF2 is a potent stimulator of vascular growth; however, even with a deficiency of FGF2 (Fgf2-/-), developmental vessel growth or ischaemia-induced revascularization still transpires. It remains to be elucidated as to what function, if any, FGF2 has during ischaemic injury. Wildtype (WT) or Fgf2-/- mice were subjected to hindlimb ischaemia for up to 42 days. Limb function, vascular growth, inflammatory- and angiogenesis-related proteins, and inflammatory cell infiltration were assessed in sham and ischaemic limbs at various timepoints. Recovery of ischaemic limb function was delayed in Fgf2-/- mice. Yet, vascular growth response to ischaemia was similar between WT and Fgf2-/- hindlimbs. Several angiogenesis- and inflammatory-related proteins (MCP-1, CXCL16, MMPs and PAI-1) were increased in Fgf2-/- ischaemic muscle. Neutrophil or monocyte recruitment/infiltration was elevated in Fgf2-/- ischaemic muscle. In summary, our study indicates that loss of FGF2 induces a pro-inflammatory microenvironment in skeletal muscle which exacerbates ischaemic injury and delays functional limb use.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1767612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38012070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus. 肝素结合表皮生长因子(EGF)样生长因子在儿科1型糖尿病患者中的作用

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-10-30 DOI: 10.1080/08977194.2020.1841757

Dragana Kacarevic, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, Dragana Bojanin, Tatjana Milenkovic, Aleksandra Stefanovic, Marija Mihajlovic, Sanja Vujcic, Rade Vukovic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Ilijana Mazibrada, Jelena Vekic

{"title":"Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus.","authors":"Dragana Kacarevic, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, Dragana Bojanin, Tatjana Milenkovic, Aleksandra Stefanovic, Marija Mihajlovic, Sanja Vujcic, Rade Vukovic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Ilijana Mazibrada, Jelena Vekic","doi":"10.1080/08977194.2020.1841757","DOIUrl":"https://doi.org/10.1080/08977194.2020.1841757","url":null,"abstract":"Heparin-binding EGF-like growth factor (HB-EGF) is involved in atherosclerosis progression. We investigated association between plasma HB-EGF levels and lipid, oxidative stress and inflammatory biomarkers in pediatric patients with type 1 diabetes mellitus (T1DM). Levels of HB-EGF, high-sensitive C-reactive protein (hsCRP), prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), oxidized low-density lipoproteins (oxLDL), metabolic control and serum lipid parameters and paraoxonase 1 (PON1) activity were determined in 74 patients and 40 controls. In comparison to controls, patients had significantly higher levels (p < 0.01) of HB-EGF, hsCRP, PAB and oxLDL particles (p < 0.001), but lower levels of TAS and PON1 activity. In T1DM group, HB-EFG levels were positively associated with hsCRP, PAB and oxLDL levels. hsCRP and oxLDL levels were independent predictors of HB-EGF concentration. We demonstrated that oxidative modifications of LDL particles and low-grade inflammation are main determinants of increased plasma HB-EGF levels, which indicates an interactive role of oxidative stress, dyslipidemia and inflammation.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1841757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38546236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors. 槲皮素通过调节不同细胞因子和生长因子促进大鼠皮肤伤口愈合。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-09-22 DOI: 10.1080/08977194.2020.1822830

Vinay Kant, Babu Lal Jangir, Vinod Kumar, Ankit Nigam, Vikash Sharma

{"title":"Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors.","authors":"Vinay Kant, Babu Lal Jangir, Vinod Kumar, Ankit Nigam, Vikash Sharma","doi":"10.1080/08977194.2020.1822830","DOIUrl":"https://doi.org/10.1080/08977194.2020.1822830","url":null,"abstract":"Quercetin on wounds could be favorable for healing based on its variety of biological effects. Eighty wounded rats were divided into four groups i.e. dimethyl sulfoxide, 0.03% quercetin, 0.1% quercetin, and 0.3% quercetin-treated. Different treatments were topically applied for 20 days. Quercetin (0.3%) caused the fastest wound closure and markedly improved the oxidative stress. Quercetin treatment increased the expressions of IL-10, VEGF, TGF-β1, CD31, α-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-α. Early infiltration of inflammatory cells and formation of good quality granulation tissue dominated by fibroblast proliferation, angiogenesis, and collagen deposition in quercetin treated groups was also evident. All these effects were more pronounced at 0.3% quercetin concentration. The earliest regeneration of epithelial layer was also observed in 0.3% quercetin-treated wounds. In conclusion, 0.3% quercetin accelerates wound healing efficiently by modulating antioxidant system of wound, cytokines, growth factors, other proteins and cells involved in healing.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1822830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38404018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

SIRT1 attenuates endoplasmic reticulum stress and apoptosis in rat models of COPD. SIRT1减轻COPD大鼠模型内质网应激和细胞凋亡。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-08-20 DOI: 10.1080/08977194.2020.1810029

Li Zhang, Bailing Luo, Yuan Ting, Shengyang He, Lihua Xie, Shenghua Sun

引用次数: 6

Cyclosporin A suppresses Porphyromonas gingivalis lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1. 环孢素A抑制牙龈卟啉单胞菌脂多糖诱导的牙龈成纤维细胞和单核细胞THP-1共培养的基质金属蛋白酶活性。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-04-22 DOI: 10.1080/08977194.2020.1755280

Lei Jiang, Min Ni Liu, Guo Dong Wang, Qun Wu, Yun Fu Zhao

引用次数: 0

Statement of retraction: Interferon-α2b (IFN-α2b)-induced apoptosis is mediated by p38 MAPK in hepatocytes from rat preneoplastic liver via activation of NADPH oxidase. 撤回声明:干扰素α2b (IFN-α2b)诱导的大鼠肿瘤前肝细胞凋亡是由p38 MAPK通过激活NADPH氧化酶介导的。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-02-01 Epub Date: 2020-07-23 DOI: 10.1080/08977194.2020.1792624

引用次数: 0

Useful applications of growth factors for cardiovascular regenerative medicine. 生长因子在心血管再生医学中的有益应用。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-01-01 Epub Date: 2020-10-07 DOI: 10.1080/08977194.2020.1825410

Maria Rosaria De Pascale, Nunzia Della Mura, Michele Vacca, Claudio Napoli

{"title":"Useful applications of growth factors for cardiovascular regenerative medicine.","authors":"Maria Rosaria De Pascale, Nunzia Della Mura, Michele Vacca, Claudio Napoli","doi":"10.1080/08977194.2020.1825410","DOIUrl":"https://doi.org/10.1080/08977194.2020.1825410","url":null,"abstract":"Novel advances for cardiovascular diseases (CVDs) include regenerative approaches for fibrosis, hypertrophy, and neoangiogenesis. Studies indicate that growth factor (GF) signaling could promote heart repair since most of the evidence is derived from preclinical models. Observational studies have evaluated GF serum/plasma levels as feasible biomarkers for risk stratification of CVDs. Noteworthy, two clinical interventional published studies showed that the administration of growth factors (GFs) induced beneficial effect on left ventricular ejection fraction (LVEF), myocardial perfusion, end-systolic volume index (ESVI). To date, large scale ongoing studies are in Phase I-II and mostly focussed on intramyocardial (IM), intracoronary (IC) or intravenous (IV) administration of vascular endothelial growth factor (VEGF) and fibroblast growth factor-23 (FGF-23) which result in the most investigated GFs in the last 10 years. Future data of ongoing randomized controlled studies will be crucial in understanding whether GF-based protocols could be in a concrete way effective in the clinical setting.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1825410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38565934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cross talk of vascular endothelial growth factor and neurotrophins in mammary gland development. 血管内皮生长因子和神经营养因子在乳腺发育中的相互作用。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-01-01 Epub Date: 2020-07-09 DOI: 10.1080/08977194.2020.1792469

Kamini Dangat, Amrita Khaire, Sadhana Joshi

引用次数: 7

Prospects for the application of growth factors in wound healing. 生长因子在伤口愈合中的应用前景。

IF 1.8 4区生物学

Growth factors Pub Date : 2020-01-01 Epub Date: 2020-11-05 DOI: 10.1080/08977194.2020.1820499

Sanam Dolati, Mehdi Yousefi, Alireza Pishgahi, Salman Nourbakhsh, Behzad Pourabbas, Seyed Kazem Shakouri

{"title":"Prospects for the application of growth factors in wound healing.","authors":"Sanam Dolati, Mehdi Yousefi, Alireza Pishgahi, Salman Nourbakhsh, Behzad Pourabbas, Seyed Kazem Shakouri","doi":"10.1080/08977194.2020.1820499","DOIUrl":"https://doi.org/10.1080/08977194.2020.1820499","url":null,"abstract":"As the largest organ of the body, human skin is multifunctional and enjoys two layers, the epidermis and the dermis, the separation of which is performed by a basement membrane zone. Skin protects the body against mechanical forces and infections. Skin wounds represent large and growing challenges to the healthcare systems globally. Skin wound healing, as a protective shield for the body against the external environment, includes interactions among cell types, the neurovascular system, cytokines, and matrix remodeling. Growth factors (GFs) affect the microenvironment of the wound, and cause rises in cell differentiation, proliferation, and migration. Administrating exogenous GFs has revealed potential in enhancing wound healing outcomes. The use of human GFs in the field of wound healing is becoming gradually more interesting, because of the low-invasive techniques required for their use. Reviewed here are the literatures on the healing of skin wounds with emphasize on the role of GFs and their future prospects, containing profits, and probable long-standing side effects accompanied with their use.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/08977194.2020.1820499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38565710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12