Quantile-specific heritability of serum growth factor concentrations.

IF 1.8 4区生物学 Q4 CELL BIOLOGY

Growth factors Pub Date : 2021-02-01 DOI:10.1080/08977194.2022.2049261

Paul T Williams

{"title":"Quantile-specific heritability of serum growth factor concentrations.","authors":"Paul T Williams","doi":"10.1080/08977194.2022.2049261","DOIUrl":null,"url":null,"abstract":"Background: \"Quantile-dependent expressivity\" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution.Methods: Quantile-regression analysis was applied to family sets from the Framingham Heart Study to determine whether the heritability (h2) of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), angiopoietin-2, and angiopoietin-2 (sTie-2) and VEGFR1 (sFlt-1) receptor concentrations were quantile-specific.Results: Quantile-specific h2 (±SE) increased with increasing percentiles of the age- and sex-adjusted VEGF (Ptrend<10-16), HGF (Ptrend=0.0004), angiopoietin-2 (Ptrend=0.0002), sTie-2 (Ptrend=1.2 × 10-5), and sFlt-1 distributions (Ptrend=0.04).Conclusion: Heritabilities of VEGF, HGF, angiopoitein-2, sTie-2 and sFlt-1 concentrations are quantile dependent. This may explain reported interactions of genetic loci (rs10738760, rs9472159, rs833061, rs3025039, rs2280789, rs1570360, rs2010963) with metabolic syndrome, diet, recurrent miscarriage, hepatocellular carcinoma, erysipelas, diabetic retinopathy, and bevacizumab treatment in their effect on VEGF concentrations.","PeriodicalId":12782,"journal":{"name":"Growth factors","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101221/pdf/nihms-1845547.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth factors","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/08977194.2022.2049261","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 1

Abstract

Background: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution.

Methods: Quantile-regression analysis was applied to family sets from the Framingham Heart Study to determine whether the heritability (h²) of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), angiopoietin-2, and angiopoietin-2 (sTie-2) and VEGFR1 (sFlt-1) receptor concentrations were quantile-specific.

Results: Quantile-specific h² (±SE) increased with increasing percentiles of the age- and sex-adjusted VEGF (P_trend<10^-16), HGF (P_trend=0.0004), angiopoietin-2 (P_trend=0.0002), sTie-2 (P_trend=1.2 × 10^-5), and sFlt-1 distributions (P_trend=0.04).

Conclusion: Heritabilities of VEGF, HGF, angiopoitein-2, sTie-2 and sFlt-1 concentrations are quantile dependent. This may explain reported interactions of genetic loci (rs10738760, rs9472159, rs833061, rs3025039, rs2280789, rs1570360, rs2010963) with metabolic syndrome, diet, recurrent miscarriage, hepatocellular carcinoma, erysipelas, diabetic retinopathy, and bevacizumab treatment in their effect on VEGF concentrations.

查看原文本刊更多论文

血清生长因子浓度的分位数特异性遗传力。

背景:当基因变异的效应大小取决于表型(如生长因子浓度)相对于其分布是高还是低时，就会出现“分位数依赖性表达性”。方法:对弗雷明汉心脏研究的家族集进行分位数回归分析，以确定血管内皮生长因子(VEGF)、肝细胞生长因子(HGF)、血管生成素-2、血管生成素-2 (sTie-2)和VEGFR1 (sFlt-1)受体浓度的遗传力(h2)是否具有分位数特异性。结果:分位数特异性h2(±SE)随年龄和性别调整的VEGF (Ptrend-16)、HGF (Ptrend=0.0004)、血管生成素-2 (Ptrend=0.0002)、sTie-2 (Ptrend=1.2 × 10-5)和sFlt-1分布(Ptrend=0.04)的百分位数增加而增加。结论:VEGF、HGF、血管生成素-2、sTie-2和sFlt-1浓度的遗传度呈分位数依赖性。这可以解释已报道的基因位点(rs10738760、rs9472159、rs833061、rs3025039、rs2280789、rs1570360、rs2010963)与代谢综合征、饮食、复发性流产、肝细胞癌、丹毒、糖尿病视网膜病变和贝伐单抗治疗对VEGF浓度的影响之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Growth factors 生物-内分泌学与代谢

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications