自体条件血清用于退行性疾病及其前景。

IF 1.8 4区 生物学 Q4 CELL BIOLOGY
Growth factors Pub Date : 2021-02-01 Epub Date: 2021-12-09 DOI:10.1080/08977194.2021.2012467
Seyed Kazem Shakouri, Sanam Dolati, Jessica Santhakumar, Avnesh S Thakor, Reza Yarani
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引用次数: 2

摘要

自体条件血清(ACS)是一种血液衍生产品,由全血与医用级玻璃珠孵育而成,使血清中富集白细胞介素-1受体拮抗剂(IL-1Ra)、抗炎细胞因子(IL-4、IL-10和IL-13)和高浓度的生长因子。由于ACS能够靶向炎症级联减少软骨破坏和改善内源性修复机制,ACS在定性和定量上都比大多数现有的关节疾病药物治疗和手术治疗效果更好。ACS应用简单、安全,不良反应有限。鉴于其再生和免疫调节特性,本文综述了ACS在退行性关节疾病以及其他炎症和自身免疫性疾病中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autologous conditioned serum for degenerative diseases and prospects.

Autologous conditioned serum (ACS) is a blood-derived product that is prepared by the incubation of whole blood with medical-grade glass beads, resulting in serum enrichment in interleukin-1 receptor antagonist (IL-1Ra), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), and high concentrations of growth factors. ACS has shown qualitatively and quantitatively better therapeutic effects than most established pharmacological treatments and surgery for joint diseases given its ability to both target the inflammatory cascade to decrease cartilage destruction as well as improve endogenous repair mechanisms. ACS application is simple and safe with limited adverse effects. This article reviews the role of ACS in degenerative joint disease, in addition to other inflammatory and autoimmune diseases, given its regenerative and immune-modulating properties.

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来源期刊
Growth factors
Growth factors 生物-内分泌学与代谢
CiteScore
2.60
自引率
0.00%
发文量
20
审稿时长
>12 weeks
期刊介绍: Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications
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