The cellular and molecular mediators of metastasis to the lung.

IF 1.8 4区 生物学 Q4 CELL BIOLOGY
Growth factors Pub Date : 2022-08-01 Epub Date: 2022-07-21 DOI:10.1080/08977194.2022.2087520
Oliver Cucanic, Rae H Farnsworth, Steven A Stacker
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引用次数: 4

Abstract

Organ-specific metastasis to secondary organs is dependent on the formation of a supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought to be mediated by mutational and epigenetic changes to primary tumour cells resulting in altered cross-talk between cell types. This response is augmented through the release of tumour and stromal signalling mediators including cytokines, chemokines, exosomes and growth factors. Although researchers have elucidated some of the cancer-promoting features that are bespoke to organotropic metastasis to the lungs, it remains unclear if these are organ-specific or generic between organs. Understanding the mechanisms that mediate the metastasis-promoting synergy between the host microenvironment, immunity, and pulmonary structures may elucidate predictive, prognostic and therapeutic markers that could be targeted to reduce the metastatic burden of disease. Herein, we give an updated summary of the known cellular and molecular mechanisms that contribute to the formation of the lung pre-metastatic niche and tissue-specific metastasis.

肺转移的细胞和分子介质。
器官特异性转移到次要器官依赖于支持性转移前生态位的形成。这种组织特异性微环境反应被认为是由原发性肿瘤细胞的突变和表观遗传改变介导的,导致细胞类型之间的串扰改变。这种反应通过释放肿瘤和基质信号介质(包括细胞因子、趋化因子、外泌体和生长因子)而增强。尽管研究人员已经阐明了一些促癌特征,这些特征是为嗜器官转移到肺部而定制的,但尚不清楚这些特征是器官特异性的还是器官间的一般特征。了解宿主微环境、免疫和肺结构之间促进转移的协同作用的机制,可能有助于阐明可靶向减少疾病转移负担的预测性、预后性和治疗性标志物。在此,我们给出了一个最新的总结,已知的细胞和分子机制,有助于形成肺转移前生态位和组织特异性转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Growth factors
Growth factors 生物-内分泌学与代谢
CiteScore
2.60
自引率
0.00%
发文量
20
审稿时长
>12 weeks
期刊介绍: Growth Factors is an international and interdisciplinary vehicle publishing new knowledge and findings on the regulators of cell proliferation, differentiation and survival. The Journal will publish research papers, short communications and reviews on current developments in cell biology, biochemistry, physiology or pharmacology of growth factors, cytokines or hormones which improve our understanding of biology or medicine. Among the various fields of study topics of particular interest include: •Stem cell biology •Growth factor physiology •Structure-activity relationships •Drug development studies •Clinical applications
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