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A gene regulatory system that directs gene expression at the 32-cell stage. 在 32 细胞阶段指导基因表达的基因调控系统。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-01 Epub Date: 2023-08-28 DOI: 10.1002/dvg.23545
Miki Tokuoka
{"title":"A gene regulatory system that directs gene expression at the 32-cell stage.","authors":"Miki Tokuoka","doi":"10.1002/dvg.23545","DOIUrl":"10.1002/dvg.23545","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10114172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversity and distribution of ascidians. 腹足类的多样性和分布。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-01 Epub Date: 2023-09-15 DOI: 10.1002/dvg.23548
Lauren M Stefaniak
{"title":"Diversity and distribution of ascidians.","authors":"Lauren M Stefaniak","doi":"10.1002/dvg.23548","DOIUrl":"10.1002/dvg.23548","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10317083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascidian evolution and ecology. 蛔虫的进化和生态学。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-01 Epub Date: 2023-08-16 DOI: 10.1002/dvg.23541
Marie L Nydam
{"title":"Ascidian evolution and ecology.","authors":"Marie L Nydam","doi":"10.1002/dvg.23541","DOIUrl":"10.1002/dvg.23541","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The colonial tunicate Botryllus schlosseri: A key species for evolutionary developmental studies. Botryllus schlosseri：进化发育研究的关键物种
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-01 Epub Date: 2023-08-28 DOI: 10.1002/dvg.23544
Lucia Manni
{"title":"The colonial tunicate Botryllus schlosseri: A key species for evolutionary developmental studies.","authors":"Lucia Manni","doi":"10.1002/dvg.23544","DOIUrl":"10.1002/dvg.23544","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10484868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gretchen Lambert: taxonomist, explorer, and historian of the ascidian community. Active: 1968-present. 格雷琴-兰伯特（Gretchen Lambert）：分类学家、探险家和 ascidian 社区历史学家。活跃时间：1968 年至今。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-01 Epub Date: 2023-08-21 DOI: 10.1002/dvg.23540
Marie L Nydam
{"title":"Gretchen Lambert: taxonomist, explorer, and historian of the ascidian community. Active: 1968-present.","authors":"Marie L Nydam","doi":"10.1002/dvg.23540","DOIUrl":"10.1002/dvg.23540","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10414447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascidians and their microbial symbionts. Ascidians and their microbial symbionts.
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-01 Epub Date: 2023-07-14 DOI: 10.1002/dvg.23534
Susanna López-Legentil
{"title":"Ascidians and their microbial symbionts.","authors":"Susanna López-Legentil","doi":"10.1002/dvg.23534","DOIUrl":"10.1002/dvg.23534","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9834345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
WntA and Wnt4 during the regeneration of internal organs in the holothurian Eupentacta fraudatrix WntA和Wnt4。
IF 1.5 4区 生物学
genesis Pub Date : 2023-10-17 DOI: 10.1002/dvg.23562
A. S. Girich
{"title":"WntA and Wnt4 during the regeneration of internal organs in the holothurian Eupentacta fraudatrix","authors":"A. S. Girich","doi":"10.1002/dvg.23562","DOIUrl":"10.1002/dvg.23562","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Over the past few years, it has been established that <i>wnt</i> genes are involved in the regenerative processes of holothurians. The <i>wnt4</i> gene was identified as one of the most active genes in <i>Eupentacta fraudatrix</i> regeneration using differential gene expression analysis and qPCR of individual genes. Also, the <i>wntA</i> gene was found in holothurians, which is present only in invertebrates and can perform unique functions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this regard, both these genes and proteins were studied in this work. During regeneration, the Wnt4 protein is found in the cells of the coelomic and ambulacral epithelium, retractor muscles, and radial nerves. Single cells with this protein are also found in the connective tissue of the developing aquapharyngeal bulb and in the hypoderm of the body wall. Cells with WntA are found exclusively in the hypoderm of the body wall.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We assume that both genes are involved in regeneration, but Wnt4 coordinates the formation of the epithelial tissue structure, while WntA maintains the state of the intercellular substance of the body wall.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engrailed: Pathological and physiological effects of a multifunctional developmental gene 雕刻：多功能发育基因的病理和生理作用。
IF 1.5 4区 生物学
genesis Pub Date : 2023-10-13 DOI: 10.1002/dvg.23557
Xiang Ma, Liang-Liang Zhao, Yi-Chun Yu, Yan Cheng
{"title":"Engrailed: Pathological and physiological effects of a multifunctional developmental gene","authors":"Xiang Ma,&nbsp;Liang-Liang Zhao,&nbsp;Yi-Chun Yu,&nbsp;Yan Cheng","doi":"10.1002/dvg.23557","DOIUrl":"10.1002/dvg.23557","url":null,"abstract":"<div>\u0000 \u0000 <p>Engrailed-1 (EN1) is a developmental gene that encodes En1, a highly conserved transcription factor involved in regionalization during early embryogenesis and in the later maintenance of normal neurons. After birth, EN1 still plays a role in the development and physiology of the body; for example, it exerts a protective effect on midbrain dopaminergic (mDA) neurons, and loss of EN1 causes mDA neurons in the ventral midbrain to gradually die approximately 6 weeks after birth, resulting in motor and nonmotor symptoms similar to those observed in Parkinson's disease. Notably, EN1 has been identified as a possible susceptibility gene for idiopathic Parkinson's disease in humans. EN1 is involved in the processes of wound-healing scar production and tissue and organ fibrosis. Additionally, EN1 can lead to tumorigenesis and thus provides a target for the treatment of some tumors. In this review, we summarize the effects of EN1 on embryonic organ development, describe the consequences of the deletion or overexpression of the EN1 gene, and discuss the pathways in which EN1 is involved. We hope to clarify the role of EN1 as a developmental gene and present potential therapeutic targets for diseases involving the EN1 gene.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antennapedia: The complexity of a master developmental transcription factor 触角足：主要发育转录因子的复杂性。
IF 1.5 4区 生物学
genesis Pub Date : 2023-10-13 DOI: 10.1002/dvg.23561
Marco Rosales-Vega, Diana Reséndez-Pérez, Martha Vázquez
{"title":"Antennapedia: The complexity of a master developmental transcription factor","authors":"Marco Rosales-Vega,&nbsp;Diana Reséndez-Pérez,&nbsp;Martha Vázquez","doi":"10.1002/dvg.23561","DOIUrl":"10.1002/dvg.23561","url":null,"abstract":"<p>Hox genes encode transcription factors that play an important role in establishing the basic body plan of animals. In <i>Drosophila</i>, <i>Antennapedia</i> is one of the five genes that make up the Antennapedia complex (ANT-C). Antennapedia determines the identity of the second thoracic segment, known as the mesothorax. Misexpression of <i>Antennapedia</i> at different developmental stages changes the identity of the mesothorax, including the muscles, nervous system, and cuticle. In <i>Drosophila</i>, <i>Antennapedia</i> has two distinct promoters highly regulated throughout development by several transcription factors. Antennapedia proteins are found with other transcription factors in different ANTENNAPEDIA transcriptional complexes to regulate multiple subsets of target genes. In this review, we describe the different mechanisms that regulate the expression and function of <i>Antennapedia</i> and the role of this Hox gene in the development of <i>Drosophila</i>.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41216946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor dormancy: EMT beyond invasion and metastasis 肿瘤休眠：EMT超越侵袭和转移。
IF 1.5 4区 生物学
genesis Pub Date : 2023-09-30 DOI: 10.1002/dvg.23552
Patrick Aouad, Hazel M. Quinn, Adeline Berger, Cathrin Brisken
{"title":"Tumor dormancy: EMT beyond invasion and metastasis","authors":"Patrick Aouad,&nbsp;Hazel M. Quinn,&nbsp;Adeline Berger,&nbsp;Cathrin Brisken","doi":"10.1002/dvg.23552","DOIUrl":"10.1002/dvg.23552","url":null,"abstract":"<p>More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from disseminated tumor cells (DTCs) that leave the primary tumor early on in tumor development, either as single cells or clusters, adapt to new environments, and reduce or shut down their proliferation entering a state of dormancy for prolonged periods of time. Dormancy has been difficult to track clinically and study experimentally. Recent advances in technology and disease modeling have provided new insights into the molecular mechanisms orchestrating dormancy and the switch to a proliferative state. A new role for epithelial-mesenchymal transition (EMT) in inducing plasticity and maintaining a dormant state in several cancer models has been revealed. In this review, we summarize the major findings linking EMT to dormancy control and highlight the importance of pre-clinical models and tumor/tissue context when designing studies. Understanding of the cellular and molecular mechanisms controlling dormant DTCs is pivotal in developing new therapeutic agents that prevent distant recurrence by maintaining a dormant state.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41135064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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