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Unveiling the impact of DNA methylation machinery: Dnmt1 and Dnmt3a in orchestrating oocyte development and cellular homeostasis 揭示DNA甲基化机制的影响:Dnmt1和Dnmt3a在协调卵母细胞发育和细胞稳态中的作用。
IF 1.5 4区 生物学
genesis Pub Date : 2023-11-20 DOI: 10.1002/dvg.23579
Fatma Uysal, Gozde Sukur, Nazlican Bozdemir, Ozgur Cinar
{"title":"Unveiling the impact of DNA methylation machinery: Dnmt1 and Dnmt3a in orchestrating oocyte development and cellular homeostasis","authors":"Fatma Uysal,&nbsp;Gozde Sukur,&nbsp;Nazlican Bozdemir,&nbsp;Ozgur Cinar","doi":"10.1002/dvg.23579","DOIUrl":"10.1002/dvg.23579","url":null,"abstract":"<div>\u0000 \u0000 <p>DNA methylation can be considered the most prominent in controlling the gene expression responsible for the balance between cell proliferation and cell death. In this study, we aimed to analyze the distinct contributions of Dnmt1 and Dnmt3a enzymes in oocyte maturation, survival, autophagy, reactive oxygen species (ROS) production, and compensation capacity of Dnmt3b and Dnmt3l enzymes in mouse oocytes. Following confirming the suppression of Dnmt1or Dnmt3a through siRNA application, the assessment involved immunofluorescence staining for Dnmts, 5mC, p62, and ROS levels. Cell death rates showed a noticeable increase while oocyte maturation rates exhibited significant reduction. Global DNA methylation showed a decline, concomitant with elevated p62 and ROS levels upon Dnmt1 or Dnmt3a knockdown. Remarkably, silencing of Dnmt1 led to an upsurge in Dnmt3a expression, whereas Dnmt3a knockdown triggered an increase in Dnmt1 levels. Furthermore, Dnmt3l expression exhibited a notable decrease after silencing of either Dnmt1 or Dnmt3a, while Dnmt3b levels remained comparable between control and siRNA-treated groups. Collectively, this study underscores the pivotal roles of Dnmt1 and Dnmt3a in orchestrating various facets of oocyte development, encompassing maturation, survival, autophagy, and ROS production. These findings offer valuable insights into the intricate regulatory network governed by DNA methylation machinery within the context of oocyte physiology.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating cellular dynamics in tunicates 研究被囊动物的细胞动力学。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-20 DOI: 10.1002/dvg.23574
Christina D. Cota
{"title":"Investigating cellular dynamics in tunicates","authors":"Christina D. Cota","doi":"10.1002/dvg.23574","DOIUrl":"10.1002/dvg.23574","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bop1 is required to establish precursor domains of craniofacial tissues Bop1是颅面组织前体结构域建立所必需的。
IF 1.5 4区 生物学
genesis Pub Date : 2023-11-16 DOI: 10.1002/dvg.23580
Stephanie Keer, Karen M. Neilson, Helene Cousin, Himani D. Majumdar, Dominique Alfandari, Steven L. Klein, Sally A. Moody
{"title":"Bop1 is required to establish precursor domains of craniofacial tissues","authors":"Stephanie Keer,&nbsp;Karen M. Neilson,&nbsp;Helene Cousin,&nbsp;Himani D. Majumdar,&nbsp;Dominique Alfandari,&nbsp;Steven L. Klein,&nbsp;Sally A. Moody","doi":"10.1002/dvg.23580","DOIUrl":"10.1002/dvg.23580","url":null,"abstract":"<div>\u0000 \u0000 <p>Bop1 can promote cell proliferation and is a component of the Pes1-Bop1-WDR12 (PeBoW) complex that regulates ribosomal RNA processing and biogenesis. In embryos, however, <i>bop1</i> mRNA is highly enriched in the neural plate, cranial neural crest and placodes, and potentially may interact with Six1, which also is expressed in these tissues. Recent work demonstrated that during development, Bop1 is required for establishing the size of the tadpole brain, retina and cranial cartilages, as well as controlling neural tissue gene expression levels. Herein, we extend this work by assessing the effects of Bop1 knockdown at neural plate and larval stages. Loss of Bop1 expanded neural plate gene expression domains (<i>sox2</i>, <i>sox11</i>, <i>irx1</i>) and reduced neural crest (<i>foxd3</i>, <i>sox9</i>), placode (<i>six1</i>, <i>sox11</i>, <i>irx1</i>, <i>sox9</i>) and epidermal (<i>dlx5</i>) expression domains. At larval stages, Bop1 knockdown reduced the expression of several otic vesicle genes (<i>six1</i>, <i>pax2</i>, <i>irx1</i>, <i>sox9</i>, <i>dlx5</i>, <i>otx2</i>, <i>tbx1</i>) and branchial arch genes that are required for chondrogenesis (<i>sox9</i>, <i>tbx1</i>, <i>dlx5</i>). The latter was not the result of impaired neural crest migration. Together these observations indicate that Bop1 is a multifunctional protein that in addition to its well-known role in ribosomal biogenesis functions during early development to establish the craniofacial precursor domains.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Our motto: Ciona is beautiful! 我们的座右铭:乔娜是美丽的!
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-16 DOI: 10.1002/dvg.23564
Antonietta Spagnuolo, Nietta
{"title":"Our motto: Ciona is beautiful!","authors":"Antonietta Spagnuolo,&nbsp;Nietta","doi":"10.1002/dvg.23564","DOIUrl":"10.1002/dvg.23564","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women researchers in tunicate biology at the Stazione Zoologica Anton Dohrn in Napoli 那不勒斯安东·多恩动物学研究所的哺乳动物生物学女性研究人员。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-15 DOI: 10.1002/dvg.23573
Anna Di Gregorio, Annamaria Locascio, Filomena Ristoratore, Antonietta Spagnuolo
{"title":"Women researchers in tunicate biology at the Stazione Zoologica Anton Dohrn in Napoli","authors":"Anna Di Gregorio,&nbsp;Annamaria Locascio,&nbsp;Filomena Ristoratore,&nbsp;Antonietta Spagnuolo","doi":"10.1002/dvg.23573","DOIUrl":"10.1002/dvg.23573","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene regulatory networks in ascidian embryos 腹水胚胎中的基因调控网络。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-09 DOI: 10.1002/dvg.23570
Kaoru S. Imai
{"title":"Gene regulatory networks in ascidian embryos","authors":"Kaoru S. Imai","doi":"10.1002/dvg.23570","DOIUrl":"10.1002/dvg.23570","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections on forty years as a female tunicate researcher 女性束腰外衣研究者四十年的思考。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-09 DOI: 10.1002/dvg.23567
Billie J. Swalla
{"title":"Reflections on forty years as a female tunicate researcher","authors":"Billie J. Swalla","doi":"10.1002/dvg.23567","DOIUrl":"10.1002/dvg.23567","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EMT and primary ciliogenesis: For better or worse in sickness and in health EMT和原发性纤毛生成:无论疾病和健康状况如何。
IF 1.5 4区 生物学
genesis Pub Date : 2023-11-09 DOI: 10.1002/dvg.23568
Camille E. Tessier, Aurore M. M. Dupuy, Thomas Pelé, Philippe P. Juin, Jacqueline A. Lees, Vincent J. Guen
{"title":"EMT and primary ciliogenesis: For better or worse in sickness and in health","authors":"Camille E. Tessier,&nbsp;Aurore M. M. Dupuy,&nbsp;Thomas Pelé,&nbsp;Philippe P. Juin,&nbsp;Jacqueline A. Lees,&nbsp;Vincent J. Guen","doi":"10.1002/dvg.23568","DOIUrl":"10.1002/dvg.23568","url":null,"abstract":"<p>Epithelial-mesenchymal transition (EMT) and primary ciliogenesis are two cell-biological programs that are essential for development of multicellular organisms and whose abnormal regulation results in many diseases (i.e., developmental anomalies and cancers). Emerging studies suggest an intricate interplay between these two processes. Here, we discuss physiological and pathological contexts in which their interconnections promote normal development or disease progression. We describe underlying molecular mechanisms of the interplay and EMT/ciliary signaling axes that influence EMT-related processes (i.e., stemness, motility and invasion). Understanding the molecular and cellular mechanisms of the relationship between EMT and primary ciliogenesis may provide new insights in the etiology of diseases related to EMT and cilia dysfunction.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A journey with ascidians in the pigmentation world 与腹水在色素沉着世界的旅程。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-08 DOI: 10.1002/dvg.23569
Filomena Ristoratore
{"title":"A journey with ascidians in the pigmentation world","authors":"Filomena Ristoratore","doi":"10.1002/dvg.23569","DOIUrl":"10.1002/dvg.23569","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of transcription factors regulating ascidian embryogenesis 调节腹水胚胎发生的转录因子的动力学。
IF 2.4 4区 生物学
genesis Pub Date : 2023-11-07 DOI: 10.1002/dvg.23565
Izumi Oda-Ishii
{"title":"Dynamics of transcription factors regulating ascidian embryogenesis","authors":"Izumi Oda-Ishii","doi":"10.1002/dvg.23565","DOIUrl":"10.1002/dvg.23565","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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