genesisPub Date : 2023-11-20DOI: 10.1002/dvg.23574
Christina D. Cota
{"title":"Investigating cellular dynamics in tunicates","authors":"Christina D. Cota","doi":"10.1002/dvg.23574","DOIUrl":"10.1002/dvg.23574","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
genesisPub Date : 2023-11-16DOI: 10.1002/dvg.23580
Stephanie Keer, Karen M. Neilson, Helene Cousin, Himani D. Majumdar, Dominique Alfandari, Steven L. Klein, Sally A. Moody
{"title":"Bop1 is required to establish precursor domains of craniofacial tissues","authors":"Stephanie Keer, Karen M. Neilson, Helene Cousin, Himani D. Majumdar, Dominique Alfandari, Steven L. Klein, Sally A. Moody","doi":"10.1002/dvg.23580","DOIUrl":"10.1002/dvg.23580","url":null,"abstract":"<div>\u0000 \u0000 <p>Bop1 can promote cell proliferation and is a component of the Pes1-Bop1-WDR12 (PeBoW) complex that regulates ribosomal RNA processing and biogenesis. In embryos, however, <i>bop1</i> mRNA is highly enriched in the neural plate, cranial neural crest and placodes, and potentially may interact with Six1, which also is expressed in these tissues. Recent work demonstrated that during development, Bop1 is required for establishing the size of the tadpole brain, retina and cranial cartilages, as well as controlling neural tissue gene expression levels. Herein, we extend this work by assessing the effects of Bop1 knockdown at neural plate and larval stages. Loss of Bop1 expanded neural plate gene expression domains (<i>sox2</i>, <i>sox11</i>, <i>irx1</i>) and reduced neural crest (<i>foxd3</i>, <i>sox9</i>), placode (<i>six1</i>, <i>sox11</i>, <i>irx1</i>, <i>sox9</i>) and epidermal (<i>dlx5</i>) expression domains. At larval stages, Bop1 knockdown reduced the expression of several otic vesicle genes (<i>six1</i>, <i>pax2</i>, <i>irx1</i>, <i>sox9</i>, <i>dlx5</i>, <i>otx2</i>, <i>tbx1</i>) and branchial arch genes that are required for chondrogenesis (<i>sox9</i>, <i>tbx1</i>, <i>dlx5</i>). The latter was not the result of impaired neural crest migration. Together these observations indicate that Bop1 is a multifunctional protein that in addition to its well-known role in ribosomal biogenesis functions during early development to establish the craniofacial precursor domains.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
genesisPub Date : 2023-11-15DOI: 10.1002/dvg.23573
Anna Di Gregorio, Annamaria Locascio, Filomena Ristoratore, Antonietta Spagnuolo
{"title":"Women researchers in tunicate biology at the Stazione Zoologica Anton Dohrn in Napoli","authors":"Anna Di Gregorio, Annamaria Locascio, Filomena Ristoratore, Antonietta Spagnuolo","doi":"10.1002/dvg.23573","DOIUrl":"10.1002/dvg.23573","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
genesisPub Date : 2023-11-09DOI: 10.1002/dvg.23570
Kaoru S. Imai
{"title":"Gene regulatory networks in ascidian embryos","authors":"Kaoru S. Imai","doi":"10.1002/dvg.23570","DOIUrl":"10.1002/dvg.23570","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
genesisPub Date : 2023-11-09DOI: 10.1002/dvg.23567
Billie J. Swalla
{"title":"Reflections on forty years as a female tunicate researcher","authors":"Billie J. Swalla","doi":"10.1002/dvg.23567","DOIUrl":"10.1002/dvg.23567","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
genesisPub Date : 2023-11-09DOI: 10.1002/dvg.23568
Camille E. Tessier, Aurore M. M. Dupuy, Thomas Pelé, Philippe P. Juin, Jacqueline A. Lees, Vincent J. Guen
{"title":"EMT and primary ciliogenesis: For better or worse in sickness and in health","authors":"Camille E. Tessier, Aurore M. M. Dupuy, Thomas Pelé, Philippe P. Juin, Jacqueline A. Lees, Vincent J. Guen","doi":"10.1002/dvg.23568","DOIUrl":"10.1002/dvg.23568","url":null,"abstract":"<p>Epithelial-mesenchymal transition (EMT) and primary ciliogenesis are two cell-biological programs that are essential for development of multicellular organisms and whose abnormal regulation results in many diseases (i.e., developmental anomalies and cancers). Emerging studies suggest an intricate interplay between these two processes. Here, we discuss physiological and pathological contexts in which their interconnections promote normal development or disease progression. We describe underlying molecular mechanisms of the interplay and EMT/ciliary signaling axes that influence EMT-related processes (i.e., stemness, motility and invasion). Understanding the molecular and cellular mechanisms of the relationship between EMT and primary ciliogenesis may provide new insights in the etiology of diseases related to EMT and cilia dysfunction.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
genesisPub Date : 2023-11-08DOI: 10.1002/dvg.23569
Filomena Ristoratore
{"title":"A journey with ascidians in the pigmentation world","authors":"Filomena Ristoratore","doi":"10.1002/dvg.23569","DOIUrl":"10.1002/dvg.23569","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}