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CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left-Right Patterning in Xenopus tropicalis
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-26 DOI: 10.1002/dvg.70009
Valentyna Kostiuk, Rakib Kabir, Rashid Akbari, Amy Rushing, Delfina P. González, Angelina Kim, Ashley Kim, David Zenisek, Mustafa K. Khokha
{"title":"CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left-Right Patterning in Xenopus tropicalis","authors":"Valentyna Kostiuk,&nbsp;Rakib Kabir,&nbsp;Rashid Akbari,&nbsp;Amy Rushing,&nbsp;Delfina P. González,&nbsp;Angelina Kim,&nbsp;Ashley Kim,&nbsp;David Zenisek,&nbsp;Mustafa K. Khokha","doi":"10.1002/dvg.70009","DOIUrl":"https://doi.org/10.1002/dvg.70009","url":null,"abstract":"<div>\u0000 \u0000 <p>Heterotaxy (HTX) is characterized by an abnormality in the organ arrangement along the Left-Right (LR) axis and is caused by the disruption of LR patterning in early development. LR asymmetry is critical for multiple organs. Specifically, proper LR patterning is crucial for cardiac function and is a cause of congenital heart disease (CHD). <i>CACNA1G</i> is a candidate gene identified in patients with CHD and HTX. This gene encodes a T-type, low-voltage-activated calcium channel and is a member of the Cav3.1 channel family. However, its function in cardiac or embryonic development remains unknown. Here, we show that abnormal <i>cacna1g</i> expression in <i>Xenopus tropicalis</i> recapitulates the HTX phenotype found in the patient cohort. By examining early LR patterning markers, including <i>pitx2c</i> and <i>dand5</i>, we discovered that both markers are expressed abnormally, suggesting that LR patterning is disrupted at the earliest stages of the LR signaling cascade. Since cilia have been described as key regulators of LR asymmetry, we checked the process of cilia formation in <i>cacna1g</i> crispants. The LR Organizer (LRO) contained reduced cilia quantity in the <i>cacna1g</i> crispants, which may explain the LR defects. In conclusion, the abnormal expression of <i>cacna1g</i> affects cilia in the LRO, leading to abnormal LR patterning and cardiac looping.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"63 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Jun (Kelly) Liu, Cornell University, New York, USA 认识我们的编辑委员会--创世纪。美国纽约康奈尔大学刘俊（Kelly）访谈录
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-26 DOI: 10.1002/dvg.70006
Jun (Kelly) Liu, Paul Trevorrow
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引用次数: 0
Meet Our Editorial Board—Genesis: An Interview With Eric Bellefroid, University Libre de Bruxelles, Bruxelles, Belgium
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-26 DOI: 10.1002/dvg.70003
Paul Trevorrow, Eric Bellefroid
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引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With, Mark Lewandoski, National Cancer Institute, Maryland, USA
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-26 DOI: 10.1002/dvg.70007
Mark Lewandoski, Paul Trevorrow
{"title":"Meet Our Editorial Board—Genesis. An Interview With, Mark Lewandoski, National Cancer Institute, Maryland, USA","authors":"Mark Lewandoski,&nbsp;Paul Trevorrow","doi":"10.1002/dvg.70007","DOIUrl":"https://doi.org/10.1002/dvg.70007","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"63 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the Mechanisms That Regulate Osteoclast Differentiation: A Review of Current Advances
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-17 DOI: 10.1002/dvg.70012
Sai Zhang, Meng Gao, Shuzhe Song, Tongdan Zhao, Bianhua Zhou, Hongwei Wang, Weishun Tian, Wenpeng Zhao, Jing Zhao
{"title":"Unraveling the Mechanisms That Regulate Osteoclast Differentiation: A Review of Current Advances","authors":"Sai Zhang,&nbsp;Meng Gao,&nbsp;Shuzhe Song,&nbsp;Tongdan Zhao,&nbsp;Bianhua Zhou,&nbsp;Hongwei Wang,&nbsp;Weishun Tian,&nbsp;Wenpeng Zhao,&nbsp;Jing Zhao","doi":"10.1002/dvg.70012","DOIUrl":"https://doi.org/10.1002/dvg.70012","url":null,"abstract":"<div>\u0000 \u0000 <p>Osteoporosis is a metabolic bone disease primarily caused by a decreased bone formation and increased bone resorption. Osteoclasts are a special class of terminally differentiated cells that play an important role in normal bone remodeling and bone loss in osteoporosis as well as in a variety of osteolytic diseases. Osteoclasts can be differentiated from monocyte–macrophage cells of the hematopoietic system; they are the key cells in bone resorption. Osteoclast formation and differentiation are regulated by various cytokines and transcription factors. In this review, we summarize recent advances in research on the regulation of osteoclast differentiation and function by factors such as M-CSF, RANKL, AP-1, NFATC1, MITF, and PU.1. Understanding these cytokines and transcription factors can not only help identify targets for osteoclast differentiation but also aid in intervening in the treatment of osteoclast-related diseases.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"63 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Targeted Transgenic Mouse Line for the Study of Protocadherin γC4
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-09 DOI: 10.1002/dvg.70010
Cathy M. McLeod, Camille M. Hanes, Leah C. Fuller, Samjhana Bhandari, Hannah G. Lanthier, Robert W. Burgess, Joshua A. Weiner, Andrew M. Garrett
{"title":"A New Targeted Transgenic Mouse Line for the Study of Protocadherin γC4","authors":"Cathy M. McLeod,&nbsp;Camille M. Hanes,&nbsp;Leah C. Fuller,&nbsp;Samjhana Bhandari,&nbsp;Hannah G. Lanthier,&nbsp;Robert W. Burgess,&nbsp;Joshua A. Weiner,&nbsp;Andrew M. Garrett","doi":"10.1002/dvg.70010","DOIUrl":"https://doi.org/10.1002/dvg.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>The γ-protocadherins (γ-Pcdhs) comprise 22 homophilic cell adhesion molecule isoforms, expressed from the <i>Pcdhg</i> gene cluster via promoter choice mechanisms that serve many crucial functions during neural development. Emerging evidence supports the hypothesis that distinct isoforms have unique functions. The γC4 isoform, which is expressed from the <i>Pcdhgc4</i> promoter and includes its unique variable exon, is the sole γ-Pcdh isoform essential for the postnatal survival in mice. Here we describe a new mouse line (<i>C4-GFP</i>) in which <i>Pcdhgc4</i> with a C-terminal GFP tag is expressed from the <i>Rosa26</i> locus following excision of a lox-Stop-lox cassette by Cre recombinase. We report that restricted expression of this transgene in the nervous system using <i>Nestin-Cre</i> is sufficient to rescue the neonatal lethality of mice mutant for <i>Pcdhgc4</i>. This new line will be a vital tool for dissecting mechanisms underlying the functions of this essential cell adhesion molecule gene, mutations in which have been associated with neurodevelopmental disorders in humans.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"63 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With, Susan Mackem, National Cancer Institute, Maryland, USA
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-29 DOI: 10.1002/dvg.70011
Paul Trevorrow, Susan Mackem
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引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Yevgenya Grinblat, University of Wisconsin-Madison, Wisconsin, USA
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-27 DOI: 10.1002/dvg.70005
Paul Trevorrow, Yevgenya Grinblat
{"title":"Meet Our Editorial Board—Genesis. An Interview With Yevgenya Grinblat, University of Wisconsin-Madison, Wisconsin, USA","authors":"Paul Trevorrow,&nbsp;Yevgenya Grinblat","doi":"10.1002/dvg.70005","DOIUrl":"10.1002/dvg.70005","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Thomas Schimmang, Institute for Biomedicine and Molecular Genetics, Valladolid, Spain
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-27 DOI: 10.1002/dvg.70004
Paul Trevorrow, Thomas Schimmang
{"title":"Meet Our Editorial Board—Genesis. An Interview With Thomas Schimmang, Institute for Biomedicine and Molecular Genetics, Valladolid, Spain","authors":"Paul Trevorrow,&nbsp;Thomas Schimmang","doi":"10.1002/dvg.70004","DOIUrl":"10.1002/dvg.70004","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Paolo E. Forni, University at Albany, State University of New York, New York, USA
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-24 DOI: 10.1002/dvg.70002
Paul Trevorrow, Paolo E. Forni
{"title":"Meet Our Editorial Board—Genesis. An Interview With Paolo E. Forni, University at Albany, State University of New York, New York, USA","authors":"Paul Trevorrow,&nbsp;Paolo E. Forni","doi":"10.1002/dvg.70002","DOIUrl":"10.1002/dvg.70002","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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