genesis最新文献

{"title":"Gretchen Lambert: taxonomist, explorer, and historian of the ascidian community. Active: 1968-present","authors":"Marie L. Nydam","doi":"10.1002/dvg.23540","DOIUrl":"10.1002/dvg.23540","url":null,"abstract":"<p>Gretchen Lambert (nee Shapiro) was born in Duluth, Minnesota, USA in 1941, and spent a large portion of her childhood at a wilderness fly-in fishing and hunting resort in Ontario, Canada. Her interest in marine biology was ignited in the 1950s when she visited the Florida Keys with her father. Lambert earned her Bachelor of Arts from the University of Minnesota in Zoology in 1963 (<i>magna cum laude</i>). From 1964 to 1965, Lambert worked at the University of Miami Institute of Marine Science in Miami, Florida, USA. In 1965, she moved to the University of Washington to start her Master's Degree in Zoology, which she obtained in 1967. She worked with the influential marine ecologist Robert Paine. During her time at the University of Washington, she met Charles Lambert, who became her partner in life and research. Very early on, Charles convinced her of the experimental advantages of ascidians as research animals. From 1970 to 1998, she and Charles worked at California State University, Fullerton (CSUF). Gretchen was a lecturer, a museum coordinator, a laboratory coordinator for introductory biology, a research associate and a senior research associate. She and Charles worked closely together on ascidian ecology and development.</p><p>In 1998, she and Charles retired from CSUF and moved to Seattle, Washington, USA. After retirement, the couple continued their research unabated. For most of the 2000s, they spent every summer at the Friday Harbor Laboratories in Washington State, USA. During the spring, summer and fall they worked on manuscripts together. In the 2000s, Gretchen took on an increasing number of leadership positions at the Friday Harbor Laboratories. She co-organized the International Tunicata Meeting twice, and has participated several times in the International Invasive Sea Squirt Conference and the International Conference on Marine Bioinvasions. Lambert has also been an instrumental editor of WoRMS (World Register of Marine Species), which is the definitive species list for ascidians. Since 1975, she has written “Ascidian News” twice a year. “Ascidian News” provides the ascidian community with research updates, conference abstracts, and citations for new publications.</p><p>For the last 45 years, Lambert has been one of the world's most active ascidian taxonomists. She has done taxonomic consulting for the Coral Reef Research Foundation, the Smithsonian Environmental Research Center, and fisheries departments in Australia, Canada, Singapore, and the United States. She has been on 21 taxonomic expeditions since 2003, focusing on the Eastern Pacific region but also in Guam, the Northeastern U.S., Florida, the Gulf Coast, the Caribbean, the English Channel and Singapore. Since 2001, she has organized and taught at least 25 workshops, training hundreds of researchers in ascidian taxonomy and identification. Lambert has closely mentored Jenn Dijkstra, a Research Associate Professor at the University of New Hampshire, and Lauren Stefan","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10414447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building hearts for undergraduate research with tunicates","authors":"Heather J. Evans Anderson","doi":"10.1002/dvg.23535","DOIUrl":"10.1002/dvg.23535","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10006532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascidian evolution and ecology","authors":"Marie L. Nydam","doi":"10.1002/dvg.23541","DOIUrl":"10.1002/dvg.23541","url":null,"abstract":"<p>I earned a Bachelor of Science degree in Evolution and Ecology (<i>summa cum laude</i>) from the University of California, Davis. At UC Davis, I worked with Jay Stachowicz to understand the recruitment patterns of fouling invertebrates and the role of predators in fouling community structure. At this time, I was introduced to ascidians because they were important members of the fouling community. I transitioned to evolutionary biology for my PhD at Cornell University, working with Rick Harrison on speciation and phylogenetics in the solitary ascidian genus <i>Ciona</i> (Nydam & Harrison, <span>2010</span>). I chose this genus because <i>Ciona robusta</i> was the only species in the fouling community with a sequenced genome. For my postdoctoral work at the University of California, Santa Barbara in the laboratory of Tony De Tomaso, I focused on the evolution of allorecognition in <i>Botryllus schlosseri</i> (Nydam, Taylor, & De Tomaso, <span>2013</span>).</p><p>Since 2012, I have been teaching and mentoring students in ascidian research at small liberal arts colleges: Centre College in Danville, KY, USA from 2012 to 2019 and Soka University of America in Aliso Viejo, CA, USA from 2019 to present. I have mentored ~20 female research students during this time, many of whom are co-authors on my publications. I have particularly enjoyed taking my students on collecting trips in England, France, Spain, and Florida.</p><p>While I have continued my work with <i>Ciona</i> introgression and <i>Botryllus schlosseri</i> allorecognition since becoming a faculty member (Nydam et al., <span>2017</span>; Nydam, Giesbrecht, & Stephenson, <span>2017</span>; Nydam, Stephenson, Waldman, & De Tomaso, <span>2017</span>), I have also developed four new research areas, all with female collaborators. First, building on the work of Gretchen and Charles Lambert, I compared the ascidian community composition in California and Florida marinas at two time points, ~20 years apart (Nichols, Lambert, & Nydam, <span>2023</span>; Nydam, Nichols, & Lambert, <span>2022</span>), and I continue to survey the ascidian communities in southern California with a particular emphasis on identifying newly arrived species (Nydam, Stefaniak, Lambert, Counts, & López-Legentil, <span>2022</span>; Figure 1). Second, I have worked with Lilian Palomino Alvarez and Rosana Rocha to describe 13 new species of ascidians in Mexico (Palomino-Alvarez, Nydam, Rocha, & Simoes, <span>2022</span>). Third, with C. Sarah Cohen and Carmela Gissi I created well-supported phylogenomic trees of the ascidian genera <i>Botrylloides</i> and <i>Botryllus</i>, generating new phylogenomic markers for these groups in the process (Nydam et al., <span>2021</span>; Nydam et al., 2023, in review; Figure 2). These trees are now being used to study the evolution of allorecognition in this group (Nydam et al., 2023, submitted for publication). Finally, I have received a grant from the National ","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A temporally-restricted pattern of endothelial cell collagen 4 alpha 1 expression during embryonic development determined with a novel knockin Col4a1-P2A-eGFP mouse line","authors":"Nathaniel L. Lartey,&nbsp;Martijn van der Ent,&nbsp;Roxann Alonzo,&nbsp;Di Chen,&nbsp;Philip D. King","doi":"10.1002/dvg.23539","DOIUrl":"10.1002/dvg.23539","url":null,"abstract":"<p>Classical collagen type IV comprising of a heterotrimer of two collagen IV alpha 1 chains and one collagen IV alpha 2 chain is the principal type of collagen synthesized by endothelial cells (EC) and is a major constituent of vascular basement membranes. In mouse and man, mutations in genes that encode collagen IV alpha 1 and alpha 2 result in vascular dysfunction. In addition, mutations in genes that encode the Ephrin receptor B4 (EPHB4) and the p120 Ras GTPase-activating protein (RASA1) that cause increased activation of the Ras mitogen-activated protein kinase (MAPK) signaling pathway in EC result in vascular dysfunction as a consequence of impaired export of collagen IV. To understand the pathogenesis of collagen IV-related vascular diseases and phenotypes it is necessary to identify at which times collagen IV is actively synthesized by EC. For this purpose, we used CRISPR/Cas9 targeting in mice to include immediately after the terminal <i>Col4a1</i> codon a sequence that specifies a P2A peptide followed by enhanced green fluorescent protein (eGFP). Analysis of eGFP expression in <i>Col4a1-P2A-eGFP</i> mice revealed active embryonic EC synthesis of collagen IV alpha 1 through mid to late gestation followed by a sharp decline before birth. These results provide a contextual framework for understanding the basis for the varied vascular abnormalities resulting from perturbation of EC expression and export of functional collagen IV.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10259891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Image, Volume 61, Issue 3–4","authors":"Vineet K. Maurya,&nbsp;Yan Ying,&nbsp;Denise G. Lanza,&nbsp;Jason D. Heaney,&nbsp;John P. Lydon","doi":"10.1002/dvg.23538","DOIUrl":"10.1002/dvg.23538","url":null,"abstract":"<p><b>Cover illustration:</b> The cover image is based on the Technical Note <i>A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor</i> by Vineet K. Maurya et al., https://doi.org/10.1002/dvg.23515.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 3-4","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47582984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular basis of ascidian whole body regeneration","authors":"Megan J. Wilson","doi":"10.1002/dvg.23537","DOIUrl":"10.1002/dvg.23537","url":null,"abstract":"&lt;p&gt;I studied Biochemistry and Genetics for my BSc, due to my keen interest in molecular biology. For my Hons and then PhD I studied, delving into exploring a sigma factor: a gene regulatory protein involved in infection and virulence in the pathogenic bacteria &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;My journey into developmental biology was rooted in personal curiosity. During my PhD, I sought to understand my brother's genetic disorder, Tuberous Sclerosis Complex (TSC), which manifests in benign tumor growth affecting various organ systems such as the kidney, brain, and skin. The puzzling occurrence of tumors in specific organs and the significant variability of symptoms among individuals drove me to delve into the field of developmental biology.&lt;/p&gt;&lt;p&gt;This led me to take a new path for a Post-doctoral position, as I joined the group of developmental biologist Prof Peter Koopman at the Institute for Molecular Biosciences, University of Queensland, Australia. There, I studied the molecular genetics of mammalian gonad development.&lt;/p&gt;&lt;p&gt;Subsequently, I returned to Otago in 2005 as a Postdoctoral Fellow, focusing on evolution and development. Under the mentorship of Professor Peter Dearden, I expanded my research interests to encompass gene regulation, development, and their evolutionary context, employing honeybee and &lt;i&gt;Drosophila&lt;/i&gt; models.&lt;/p&gt;&lt;p&gt;Originally, I was planning to study the evolution of developmental genes using &lt;i&gt;Ciona&lt;/i&gt;. Ascidians, representing the closest invertebrate group to the vertebrate lineage, offer valuable insights into the evolution of developmental pathways in early vertebrates (Heenan et al., &lt;span&gt;2016&lt;/span&gt;). While visiting a marine institute in Nelson, I was introduced to &lt;i&gt;Botrylloides&lt;/i&gt; and their impressive ability to regenerate a whole new adult from a small fragment of the vascular tunic in a short time (Figure 1).&lt;/p&gt;&lt;p&gt;Our research focuses on understanding the mechanisms that drive regenerative processes in a chordate model, specifically &lt;i&gt;Botrylloides&lt;/i&gt;. We started by exploring the molecular pathways involved in whole-body regeneration through de novo transcriptome analysis (Figure 2; Zondag et al., &lt;span&gt;2016&lt;/span&gt;; Meier &amp; Wilson, &lt;span&gt;2022&lt;/span&gt;). We then sequenced and annotated the genome to expand our knowledge of tunicate genome characteristics and evolutionary relationships (Blanchoud, Rutherford, et al., &lt;span&gt;2018&lt;/span&gt;). Additionally, we are studying the role of epigenetic regulation in whole-body regeneration and have found that histone deacetylase activity is essential for the regenerative process (Figure 2; Zondag et al., &lt;span&gt;2019&lt;/span&gt;).&lt;/p&gt;&lt;p&gt;More recently, we have utilized genomics tools, such as single-cell and ATAC sequencing, to unravel the intricate control of gene regulation during the regenerative process. Our work has been funded by the University of Otago Research Grant, Dean's bequest grant, and the Royal Society of New Zealand Marsden Fund.&lt;/p&gt;&lt;p&gt;One of the most fu","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascidians and their microbial symbionts","authors":"Susanna López-Legentil","doi":"10.1002/dvg.23534","DOIUrl":"10.1002/dvg.23534","url":null,"abstract":"<p>I obtained my PhD in Zoology in 2005 studying the biology and ecology of Mediterranean ascidians at both the University of Barcelona (UB; Spain) and the University of Perpignan (France). In 2006, I obtained a Fulbright postdoctoral fellowship to continue my studies at the University of North Carolina Wilmington (UNCW; USA). I returned to Spain in 2010 and joined the faculty at UB. While there, my husband Dr. Patrick Erwin (microbiologist) and I created the iMESA Lab, which stands for “integrated Molecular Ecology of Sponges and Ascidians.” A few years later, we returned to UNCW and continued the iMESA Lab work (Figure 1). Most recently, research at the iMESA Lab has focused on biological invasions (Figure 2).</p><p>Ascidians are ideally suited for the study of introduction processes because they rely on anthropogenic transport for their long-distance dispersal. There are many successfully introduced ascidians worldwide (e.g., López-Legentil* et al. <span>2015</span>, Villalobos* et al. <span>2017</span>, Streit* et al. <span>2021</span>, Nydam* et al. <span>2022</span>). Some of their success has been ascribed to rapid growth and high reproductive outputs (Pineda* et al. <span>2013</span>); however, ascidians also have hidden microbial allies. Historically, most studies of microbial symbionts in ascidians focused on cyanobacteria, until pioneering work at the iMESA Lab provided the most comprehensive characterization of the ascidian microbiome (Erwin et al. <span>2014</span>). This study revealed exceptional microbial biodiversity inhabiting the ascidian tunic and a high degree of host-specificity (Erwin et al. <span>2014</span>).</p><p>Furthermore, microbial symbionts may play a major role in facilitating the establishment of their hosts in a new habitat (Evans et al. <span>2017</span>, <span>2018</span>, Goddard-Dwyer* et al. <span>2021</span>). For example, we showed that microbiomes in a native ascidian differed across natural (reef) and artificial (harbor) habitats, while a non-native ascidian hosted stable microbial symbiont communities that may allow them to thrive in a wider range of habitats (Evans et al. <span>2018</span>). Across larger distances (inter-continental), spatial variation manifested in compositional and structural changes to the microbiome (beta-diversity) rather than changes in symbiont richness and evenness (alpha-diversity; Goddard-Dwyer* et al. <span>2021</span>, López-Legentil* et al. <span>2023</span>). Moreover, the comparative influence of host and location on microbiome similarity differed between colonial and solitary ascidians, with colonial ascidians hosting less diverse microbiomes but with greater distinctions from the seawater bacterioplankton than their solitary counterparts (López-Legentil* et al. <span>2023</span>). Further research will focus on achieving a greater understanding of the ascidian microbiome and its contributions to host invasiveness potential and evolution.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9834345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolving the mechanisms underlying epithelial-to-mesenchymal transition of the lateral plate mesoderm","authors":"Axel H. Newton,&nbsp;Craig A. Smith","doi":"10.1002/dvg.23531","DOIUrl":"10.1002/dvg.23531","url":null,"abstract":"<p>Formation of the vertebrate limb buds begins with a localized epithelial-to-mesenchymal transition (EMT) of the somatic lateral plate mesoderm (LPM). While the processes that drive proliferation and outgrowth of the limb mesenchyme are well established, the fundamental mechanisms that precede this process and initiate EMT are less understood. In this review, we outline putative drivers of EMT of the LPM, drawing from analyses across a range of vertebrates and developmental models. We detail the expression patterns of key EMT transcriptional regulators in the somatic LPM of the presumptive limb fields, and their potential role in producing a mesenchymal cell fate. These include a putative cooperative role between the EMT inducers PRRX1 and TWIST1, supported by evidence in zebrafish and chicken models but unconfirmed data from mice. As such, additional functional data are required to definitively determine the mechanisms that initiate and drive EMT of the somatic LPM, a critical transition preceding formation of the limb bud mesenchyme.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9777330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation and characterization of a Dkk4-Cre knock-in mouse line","authors":"Houda Khatif,&nbsp;Hisham Bazzi","doi":"10.1002/dvg.23532","DOIUrl":"10.1002/dvg.23532","url":null,"abstract":"<p>Ectodermal appendages in mammals, such as teeth, mammary glands, sweat glands and hair follicles, are generated during embryogenesis through a series of mesenchymal–epithelial interactions. Canonical Wnt signaling and its inhibitors are implicated in the early steps of ectodermal appendage development and patterning. To study the activation dynamics of the Wnt target and inhibitor <i>Dickkopf4</i> (<i>Dkk4</i>) in ectodermal appendages, we used CRSIPR/Cas9 to generate a <i>Dkk4-Cre</i> knock-in mouse (<i>Mus musculus</i>) line, where the Cre recombinase cDNA replaces the expression of endogenous <i>Dkk4</i>. Using Cre reporters, the <i>Dkk4-Cre</i> activity was evident at the prospective sites of ectodermal appendages, overlapping with the <i>Dkk4</i> mRNA expression. Unexpectedly, a predominantly mesenchymal cell population in the embryo posterior also showed <i>Dkk4-Cre</i> activity. Lineage-tracing suggested that these cells are likely derived from a few <i>Dkk4-Cre</i>-expressing cells in the epiblast at early gastrulation. Finally, our analyses of <i>Dkk4-Cre</i>-expressing cells in developing hair follicle epithelial placodes revealed intra- and inter-placodal cellular heterogeneity, supporting emerging data on the positional and transcriptional cellular variability in placodes. Collectively, we propose the new <i>Dkk4-Cre</i> knock-in mouse line as a suitable model to study Wnt and DKK4 inhibitor dynamics in early mouse development and ectodermal appendage morphogenesis.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10147566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunicate Eco-Evo-Devo laboratory in IMS-METU","authors":"Arzu Karahan","doi":"10.1002/dvg.23536","DOIUrl":"10.1002/dvg.23536","url":null,"abstract":"<p>I completed my undergraduate education in Atatürk University, Education Faculty, Biology Department. Then pursued my graduate education at the Biology Department of Mersin University. Both my master's and PhD theses were on the biological and population genetics features of various fish species. My initial encounter with tunicates dates back to my Postdoc at Israel Oceanographic and Limnologic Research Institute (IOLR) in 2011, where I was working on a DNA barcoding project. During that time, the entire institute was actively engaged in research on tunicates, and discussions during lunchtime often revolved around this fascinating group of organisms. Prof. Rinkevich usually only spoke seriously about tunicate biology but 1 day he told me “You know <i>Botryllus schlosseri</i> is riding horse in Black Sea coasts of Turkiye.” I was totally surprised and was trying to understand the meaning of this comment from a scientific perspective. He then showed me the picture of a <i>B. schlosseri</i> colony attached to a seahorse. Following several more Postdoc experiences, I began working as a Principal Investigator at Institute of Marine Sciences, Middle East Technical University (IMS-METU) in 2017. Since then, my team and I have been working on tunicate biodiversity, evolutionary biology, genomics, DNA barcoding, metabarcoding, metabolomics, whole-body regeneration (WBR) and aging related pathways.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"61 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}