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« Hymne à Khôra » ou le fichier Diosperi " khola的赞美诗"或者Diosperi文件
IF 1.5 4区 生物学
genesis Pub Date : 2022-12-01 DOI: 10.4000/genesis.7589
J. Lebrave
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引用次数: 0
Pierre-Marc de Biasi et Anne Herschberg Pierrot (dir.), Flaubert et le moment théorique (1960-1980), Paris, CNRS Éditions, 2021, 198 p. Pierre-Marc de Biasi和Anne Herschberg Pierrot(编辑),《福楼拜与瞬间理论》(1960-1980年),巴黎,CNRS版,2021年,198页。
IF 1.5 4区 生物学
genesis Pub Date : 2022-12-01 DOI: 10.4000/genesis.7518
Anne-Claire Marpeau
{"title":"Pierre-Marc de Biasi et Anne Herschberg Pierrot (dir.), Flaubert et le moment théorique (1960-1980), Paris, CNRS Éditions, 2021, 198 p.","authors":"Anne-Claire Marpeau","doi":"10.4000/genesis.7518","DOIUrl":"https://doi.org/10.4000/genesis.7518","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42937372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Le toucher Touch/to touch him1 触摸/触摸/触摸他
IF 1.5 4区 生物学
genesis Pub Date : 2022-12-01 DOI: 10.4000/genesis.7747
A. Crasson, Jean-Louis Lebrave, Jérémy Pedrazzi, L. Alonso
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引用次数: 0
Cover Image, Volume 60, Issue 8-9 封面图片,第60卷,第8-9期
IF 1.5 4区 生物学
genesis Pub Date : 2022-09-21 DOI: 10.1002/dvg.23504
{"title":"Cover Image, Volume 60, Issue 8-9","authors":"","doi":"10.1002/dvg.23504","DOIUrl":"10.1002/dvg.23504","url":null,"abstract":"<p><b>Cover illustration</b>: The coronal sections of the mesial root of first molars in Osterix-cre mice crossed with R26-mTmG reporter mice atP21. GFP-positive cells are observed in pulp, periodontal ligaments, and alveolar bones. The dentinal tubules in root dentin are either GFP-positive or tomato-positive.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/dvg.23504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45272508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-wide analysis of bivalent histone modifications during Drosophila embryogenesis 果蝇胚胎发生过程中二价组蛋白修饰的全基因组分析
IF 1.5 4区 生物学
genesis Pub Date : 2022-09-20 DOI: 10.1002/dvg.23502
Qian Cheng, Hao Xie
{"title":"Genome-wide analysis of bivalent histone modifications during Drosophila embryogenesis","authors":"Qian Cheng,&nbsp;Hao Xie","doi":"10.1002/dvg.23502","DOIUrl":"10.1002/dvg.23502","url":null,"abstract":"<div>\u0000 \u0000 <p>In eukaryotes, histone modifications are key epigenetic regulators that are associated with distinct chromatin features. Bivalent histone modifications describe a situation where a subset of promoters have with both activating (H3K4me3) and repressive (H3K27me3) markers in pluripotent cells (e.g., ESCs). However, it remains to be understood whether bivalent histone modifications are stable throughout developmental stages. Here, by systematically analyzing ChIP-seq data of H3K4me3 and H3K27me3, we provided the first panoramic view of bivalent histone modifications in <i>Drosophila</i> from embryonic 0–4 to 20–24 hr. In our study, we found that bivalent histone modifications occur at other locations in the genome in addition to the promoter region. Additionally, the different genomic regions occupied by bivalent histone modifications exhibit spatiotemporal specificity at each stage. Furthermore, gene ontology and motif analysis reflected continuous and gradual changes of target genes during different developmental process. In summary, we suggest that bivalent histone modifications have potential regulatory functions throughout <i>Drosophila</i> embryonic stage.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10564476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced biomaterials for periodontal tissue regeneration 用于牙周组织再生的先进生物材料
IF 1.5 4区 生物学
genesis Pub Date : 2022-09-16 DOI: 10.1002/dvg.23501
Arwa Daghrery, Marco C. Bottino
{"title":"Advanced biomaterials for periodontal tissue regeneration","authors":"Arwa Daghrery,&nbsp;Marco C. Bottino","doi":"10.1002/dvg.23501","DOIUrl":"10.1002/dvg.23501","url":null,"abstract":"<p>The periodontium is a suitable target for regenerative intervention, since it does not functionally restore itself after disease. Importantly, the limited regeneration capacity of the periodontium could be improved with the development of novel biomaterials and therapeutic strategies. Of note, the regenerative potential of the periodontium depends not only on its tissue-specific architecture and function, but also on its ability to reconstruct distinct tissues and tissue interfaces, suggesting that the advancement of tissue engineering approaches can ultimately offer new perspectives to promote the organized reconstruction of soft and hard periodontal tissues. Here, we discuss material-based, biologically active cues, and the application of innovative biofabrication technologies to regenerate the multiple tissues that comprise the periodontium.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/51/DVG-60-e23501.PMC9557988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10436871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Medication-related osteonecrosis of the jaw: A literature review and update 颌骨药物相关性骨坏死:文献回顾与更新
IF 1.5 4区 生物学
genesis Pub Date : 2022-09-15 DOI: 10.1002/dvg.23500
Shinichiro Kuroshima, Farah A. Al-Omari, Muneteru Sasaki, Takashi Sawase
{"title":"Medication-related osteonecrosis of the jaw: A literature review and update","authors":"Shinichiro Kuroshima,&nbsp;Farah A. Al-Omari,&nbsp;Muneteru Sasaki,&nbsp;Takashi Sawase","doi":"10.1002/dvg.23500","DOIUrl":"10.1002/dvg.23500","url":null,"abstract":"<div>\u0000 \u0000 <p>Since the initial description of medication-related osteonecrosis of the jaw (MRONJ) almost two decades ago, the potential pathophysiology and risk factors have been elaborated on in many investigations and guidelines. However, the definitive pathophysiology based on scientific evidence remains lacking. Consequently, the optimal clinical treatment and prevention strategies for MRONJ have not been established. Despite their different mechanisms of action, many drugs, including bisphosphonates, denosumab, angiogenesis inhibitors, and other medications, have been reported to be associated with MRONJ lesions in cancer and osteoporosis patients. Importantly, MRONJ occurs predominantly in the jawbones and other craniofacial regions, but not in the appendicular skeleton. In this up-to-date review, the currently available information and theories regarding MRONJ are presented from both clinical and basic science perspectives. The definition and epidemiology of MRONJ, triggering medication, and histopathology are comprehensively summarized. The immunopathology and the potential pathophysiology based on immune cells such as neutrophils, T and B cells, macrophages, dendritic cells, and natural killer cells are also discussed. In addition, antiangiogenesis, soft tissue toxicity, necrotic bone, osteocyte death, and single-nucleotide polymorphisms are examined. Moreover, other possible mechanisms of MRONJ development are considered based on the unique embryological characteristics, different cell behaviors between jawbones and appendicular skeleton, unique anatomical structures, and sustained bacterial exposure in the oral cavity as a basis for MRONJ site specificity. Based on the literature review, it was concluded that multiple factors may contribute to the development of MRONJ, although which one is the key player triggering MRONJ in the craniofacial region remains unknown.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40360128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Novel approaches for periodontal tissue engineering 牙周组织工程的新方法
IF 1.5 4区 生物学
genesis Pub Date : 2022-09-10 DOI: 10.1002/dvg.23499
W. Benton Swanson, Yao Yao, Yuji Mishina
{"title":"Novel approaches for periodontal tissue engineering","authors":"W. Benton Swanson,&nbsp;Yao Yao,&nbsp;Yuji Mishina","doi":"10.1002/dvg.23499","DOIUrl":"10.1002/dvg.23499","url":null,"abstract":"<p>The periodontal complex involves the hard and soft tissues which support dentition, comprised of cementum, bone, and the periodontal ligament (PDL). Periodontitis, a prevalent infectious disease of the periodontium, threatens the integrity of these tissues and causes irreversible damage. Periodontal therapy aims to repair and ultimately regenerate these tissues toward preserving native dentition and improving the physiologic integration of dental implants. The PDL contains multipotent stem cells, which have a robust capacity to differentiate into various types of cells to form the PDL, cementum, and alveolar bone. Selection of appropriate growth factors and biomaterial matrices to facilitate periodontal regeneration are critical to recapitulate the physiologic organization and function of the periodontal complex. Herein, we discuss the current state of clinical periodontal regeneration including a review of FDA-approved growth factors. We will highlight advances in preclinical research toward identifying additional growth factors capable of robust repair and biomaterial matrices to augment regeneration similarly and synergistically, ultimately improving periodontal regeneration's predictability and long-term efficacy. This review should improve the readers' understanding of the molecular and cellular processes involving periodontal regeneration essential for designing comprehensive therapeutic approaches.</p>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Advances and challenges in intravital imaging of craniofacial and dental progenitor cells 颅面和牙齿祖细胞活体成像的进展和挑战
IF 1.5 4区 生物学
genesis Pub Date : 2022-08-18 DOI: 10.1002/dvg.23498
Dongwook Yang, Laura Ortinau, Youngjae Jeong, Dongsu Park
{"title":"Advances and challenges in intravital imaging of craniofacial and dental progenitor cells","authors":"Dongwook Yang,&nbsp;Laura Ortinau,&nbsp;Youngjae Jeong,&nbsp;Dongsu Park","doi":"10.1002/dvg.23498","DOIUrl":"10.1002/dvg.23498","url":null,"abstract":"<div>\u0000 \u0000 <p>Craniofacial and appendicular bone homeostasis is dynamically regulated by a balance between bone formation and resorption by osteoblasts and osteoclasts, respectively. Despite the developments in multiple imaging techniques in bone biology, there are still technical challenges and limitations in the investigation of spatial/anatomical location of rare stem/progenitor cells and their molecular regulation in tooth and craniofacial bones of living animals. Recent advances in live animal imaging techniques for the craniofacial and dental apparatus can provide new insights in real time into bone stem/progenitor cell dynamics and function in vivo. Here, we review the current inventions and applications of the noninvasive intravital imaging technique and its practical uses and limitations in the analysis of stem/progenitor cells in craniofacial and dental apparatus in vivo. Furthermore, we also explore the potential applications of intravital microscopy in the dental field.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9111171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of hyaluronic acid for regeneration of maxillofacial bones 透明质酸用于颌面骨再生
IF 1.5 4区 生物学
genesis Pub Date : 2022-08-11 DOI: 10.1002/dvg.23497
Giuseppe D'Albis, Vincenzo D'Albis, Micol Palma, Marianna Plantamura, Al krenawi Nizar
{"title":"Use of hyaluronic acid for regeneration of maxillofacial bones","authors":"Giuseppe D'Albis,&nbsp;Vincenzo D'Albis,&nbsp;Micol Palma,&nbsp;Marianna Plantamura,&nbsp;Al krenawi Nizar","doi":"10.1002/dvg.23497","DOIUrl":"10.1002/dvg.23497","url":null,"abstract":"<div>\u0000 \u0000 <p>Hyaluronic acid (HA) has been widely used in medicine and is currently of particular interest to maxillofacial surgeons. Several applications have been introduced, including those in which HA is used as a scaffold for bone regeneration, either alone or in combination with other grafting materials, to enhance bone growth. This review aims to analyze the available literature on the use of HA for maxillofacial bone regenerative procedures including socket preservation, sinus augmentation, and ridge augmentation. Medline and PubMed databases were searched for relevant reports published between January 2000 and April 2021. Nine publications describing the use of HA to augment bone volume were identified. Although further studies are needed, these findings are encouraging as they suggest that HA could be used effectively used, in combination with graft materials, in maxillofacial bone regenerative procedures. HA facilitates manipulation of bone grafts, improves handling characteristics and promotes osteoblast activity that stimulates bone regeneration and repair.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40602630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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