The Application of scRNA-Seq in Heart Development and Regeneration

IF 2.4 4区 生物学 Q2 DEVELOPMENTAL BIOLOGY
genesis Pub Date : 2025-04-29 DOI:10.1002/dvg.70013
Junying Gao, Lindong Yu, Haoran Qi, Jun Qi, Zhaodi Zheng
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引用次数: 0

Abstract

Single-cell RNA sequencing (scRNA-seq) is a rapidly developing and useful technique for elucidating biological mechanisms and characterizing individual cells. Tens of millions of patients worldwide suffer from heart injuries and other types of heart disease. Neonatal mammalian hearts and certain adult vertebrate species, such as zebrafish, can fully regenerate after myocardial injury. However, the adult mammalian heart is unable to regenerate the damaged myocardium. scRNA-seq provides many new insights into pathological and normal hearts and facilitates our understanding of cellular responses to cardiac injury and repair at different stages, which may provide critical clues for effective therapies for adult heart regeneration. In this review, we summarize the application of scRNA-seq in heart development and regeneration and describe how important molecular mechanisms can be harnessed to promote heart regeneration.

scRNA-Seq在心脏发育和再生中的应用
单细胞RNA测序(scRNA-seq)是一项快速发展和有用的技术,用于阐明生物机制和表征单个细胞。全世界有数千万患者患有心脏损伤和其他类型的心脏病。新生哺乳动物的心脏和某些成年脊椎动物,如斑马鱼,在心肌损伤后可以完全再生。然而,成年哺乳动物的心脏不能再生受损的心肌。scRNA-seq提供了许多关于病理和正常心脏的新见解,有助于我们了解不同阶段心脏损伤和修复的细胞反应,这可能为成人心脏再生的有效治疗提供重要线索。本文综述了scRNA-seq在心脏发育和再生中的应用,并描述了如何利用重要的分子机制来促进心脏再生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
genesis
genesis 生物-发育生物学
CiteScore
3.60
自引率
0.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: As of January 2000, Developmental Genetics was renamed and relaunched as genesis: The Journal of Genetics and Development, with a new scope and Editorial Board. The journal focuses on work that addresses the genetics of development and the fundamental mechanisms of embryological processes in animals and plants. With increased awareness of the interplay between genetics and evolutionary change, particularly during developmental processes, we encourage submission of manuscripts from all ecological niches. The expanded numbers of genomes for which sequencing is being completed will facilitate genetic and genomic examination of developmental issues, even if the model system does not fit the “classical genetic” mold. Therefore, we encourage submission of manuscripts from all species. Other areas of particular interest include: 1) the roles of epigenetics, microRNAs and environment on developmental processes; 2) genome-wide studies; 3) novel imaging techniques for the study of gene expression and cellular function; 4) comparative genetics and genomics and 5) animal models of human genetic and developmental disorders. genesis presents reviews, full research articles, short research letters, and state-of-the-art technology reports that promote an understanding of the function of genes and the roles they play in complex developmental processes.
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