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Meet Our Editorial Board—Genesis. An Interview With, Mark Lewandoski, National Cancer Institute, Maryland, USA 见见我们的编辑委员会——创世纪。采访马克·莱万多斯基，美国马里兰州国家癌症研究所
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-26 DOI: 10.1002/dvg.70007
Mark Lewandoski, Paul Trevorrow
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引用次数: 0
Unraveling the Mechanisms That Regulate Osteoclast Differentiation: A Review of Current Advances 揭示调节破骨细胞分化的机制：综述当前进展
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-17 DOI: 10.1002/dvg.70012
Sai Zhang, Meng Gao, Shuzhe Song, Tongdan Zhao, Bianhua Zhou, Hongwei Wang, Weishun Tian, Wenpeng Zhao, Jing Zhao
{"title":"Unraveling the Mechanisms That Regulate Osteoclast Differentiation: A Review of Current Advances","authors":"Sai Zhang,&nbsp;Meng Gao,&nbsp;Shuzhe Song,&nbsp;Tongdan Zhao,&nbsp;Bianhua Zhou,&nbsp;Hongwei Wang,&nbsp;Weishun Tian,&nbsp;Wenpeng Zhao,&nbsp;Jing Zhao","doi":"10.1002/dvg.70012","DOIUrl":"https://doi.org/10.1002/dvg.70012","url":null,"abstract":"<div>\u0000 \u0000 <p>Osteoporosis is a metabolic bone disease primarily caused by a decreased bone formation and increased bone resorption. Osteoclasts are a special class of terminally differentiated cells that play an important role in normal bone remodeling and bone loss in osteoporosis as well as in a variety of osteolytic diseases. Osteoclasts can be differentiated from monocyte–macrophage cells of the hematopoietic system; they are the key cells in bone resorption. Osteoclast formation and differentiation are regulated by various cytokines and transcription factors. In this review, we summarize recent advances in research on the regulation of osteoclast differentiation and function by factors such as M-CSF, RANKL, AP-1, NFATC1, MITF, and PU.1. Understanding these cytokines and transcription factors can not only help identify targets for osteoclast differentiation but also aid in intervening in the treatment of osteoclast-related diseases.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"63 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Targeted Transgenic Mouse Line for the Study of Protocadherin γC4 研究原钙粘蛋白γ - c4的新靶向转基因小鼠系
IF 2.4 4区 生物学
genesis Pub Date : 2025-02-09 DOI: 10.1002/dvg.70010
Cathy M. McLeod, Camille M. Hanes, Leah C. Fuller, Samjhana Bhandari, Hannah G. Lanthier, Robert W. Burgess, Joshua A. Weiner, Andrew M. Garrett
{"title":"A New Targeted Transgenic Mouse Line for the Study of Protocadherin γC4","authors":"Cathy M. McLeod,&nbsp;Camille M. Hanes,&nbsp;Leah C. Fuller,&nbsp;Samjhana Bhandari,&nbsp;Hannah G. Lanthier,&nbsp;Robert W. Burgess,&nbsp;Joshua A. Weiner,&nbsp;Andrew M. Garrett","doi":"10.1002/dvg.70010","DOIUrl":"https://doi.org/10.1002/dvg.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>The γ-protocadherins (γ-Pcdhs) comprise 22 homophilic cell adhesion molecule isoforms, expressed from the <i>Pcdhg</i> gene cluster via promoter choice mechanisms that serve many crucial functions during neural development. Emerging evidence supports the hypothesis that distinct isoforms have unique functions. The γC4 isoform, which is expressed from the <i>Pcdhgc4</i> promoter and includes its unique variable exon, is the sole γ-Pcdh isoform essential for the postnatal survival in mice. Here we describe a new mouse line (<i>C4-GFP</i>) in which <i>Pcdhgc4</i> with a C-terminal GFP tag is expressed from the <i>Rosa26</i> locus following excision of a lox-Stop-lox cassette by Cre recombinase. We report that restricted expression of this transgene in the nervous system using <i>Nestin-Cre</i> is sufficient to rescue the neonatal lethality of mice mutant for <i>Pcdhgc4</i>. This new line will be a vital tool for dissecting mechanisms underlying the functions of this essential cell adhesion molecule gene, mutations in which have been associated with neurodevelopmental disorders in humans.</p>\u0000 </div>","PeriodicalId":12718,"journal":{"name":"genesis","volume":"63 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With, Susan Mackem, National Cancer Institute, Maryland, USA 见见我们的编辑委员会——创世纪。采访美国马里兰州国家癌症研究所的苏珊·麦克姆。
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-29 DOI: 10.1002/dvg.70011
Paul Trevorrow, Susan Mackem
{"title":"Meet Our Editorial Board—Genesis. An Interview With, Susan Mackem, National Cancer Institute, Maryland, USA","authors":"Paul Trevorrow,&nbsp;Susan Mackem","doi":"10.1002/dvg.70011","DOIUrl":"10.1002/dvg.70011","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Yevgenya Grinblat, University of Wisconsin-Madison, Wisconsin, USA 见见我们的编辑委员会——创世纪。美国威斯康辛大学麦迪逊分校Yevgenya Grinblat访谈
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-27 DOI: 10.1002/dvg.70005
Paul Trevorrow, Yevgenya Grinblat
{"title":"Meet Our Editorial Board—Genesis. An Interview With Yevgenya Grinblat, University of Wisconsin-Madison, Wisconsin, USA","authors":"Paul Trevorrow,&nbsp;Yevgenya Grinblat","doi":"10.1002/dvg.70005","DOIUrl":"10.1002/dvg.70005","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Thomas Schimmang, Institute for Biomedicine and Molecular Genetics, Valladolid, Spain 见见我们的编辑委员会——创世纪。采访托马斯·希曼，西班牙巴利亚多利德生物医学和分子遗传学研究所。
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-27 DOI: 10.1002/dvg.70004
Paul Trevorrow, Thomas Schimmang
{"title":"Meet Our Editorial Board—Genesis. An Interview With Thomas Schimmang, Institute for Biomedicine and Molecular Genetics, Valladolid, Spain","authors":"Paul Trevorrow,&nbsp;Thomas Schimmang","doi":"10.1002/dvg.70004","DOIUrl":"10.1002/dvg.70004","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Paolo E. Forni, University at Albany, State University of New York, New York, USA 见见我们的编辑委员会——创世纪。采访美国纽约州立大学奥尔巴尼分校的保罗·e·福尼
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-24 DOI: 10.1002/dvg.70002
Paul Trevorrow, Paolo E. Forni
{"title":"Meet Our Editorial Board—Genesis. An Interview With Paolo E. Forni, University at Albany, State University of New York, New York, USA","authors":"Paul Trevorrow,&nbsp;Paolo E. Forni","doi":"10.1002/dvg.70002","DOIUrl":"10.1002/dvg.70002","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Yoh-suke Mukouyama, National Institutes of Health, Maryland, USA 见见我们的编辑委员会——创世纪。访美国马里兰州国立卫生研究院的佑介·慕山
IF 2.4 4区 生物学
genesis Pub Date : 2025-01-24 DOI: 10.1002/dvg.70008
Yoh-suke Mukouyama, Paul Trevorrow
{"title":"Meet Our Editorial Board—Genesis. An Interview With Yoh-suke Mukouyama, National Institutes of Health, Maryland, USA","authors":"Yoh-suke Mukouyama,&nbsp;Paul Trevorrow","doi":"10.1002/dvg.70008","DOIUrl":"10.1002/dvg.70008","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With, Sally Moody, The George Washington University School of Medicine and Health Sciences, USA 认识我们的编辑委员会--《创世纪》。专访美国乔治-华盛顿大学医学与健康科学学院莎莉-穆迪。
IF 2.4 4区 生物学
genesis Pub Date : 2024-12-31 DOI: 10.1002/dvg.70000
Paul Trevorrow, Sally A. Moody
{"title":"Meet Our Editorial Board—Genesis. An Interview With, Sally Moody, The George Washington University School of Medicine and Health Sciences, USA","authors":"Paul Trevorrow,&nbsp;Sally A. Moody","doi":"10.1002/dvg.70000","DOIUrl":"10.1002/dvg.70000","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meet Our Editorial Board—Genesis. An Interview With Margot L. K. Williams, Baylor College of Medicine, Texas, USA 见见我们的编辑委员会——创世纪。采访美国德克萨斯州贝勒医学院的玛格特·l·k·威廉姆斯。
IF 2.4 4区 生物学
genesis Pub Date : 2024-12-17 DOI: 10.1002/dvg.70001
Paul Trevorrow, Margot L. K. Williams
{"title":"Meet Our Editorial Board—Genesis. An Interview With Margot L. K. Williams, Baylor College of Medicine, Texas, USA","authors":"Paul Trevorrow,&nbsp;Margot L. K. Williams","doi":"10.1002/dvg.70001","DOIUrl":"10.1002/dvg.70001","url":null,"abstract":"","PeriodicalId":12718,"journal":{"name":"genesis","volume":"62 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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