2 型绒毛受体-A4 亚家族：小鼠潜在的捕食者传感器

IF 2.4 4区生物学 Q2 DEVELOPMENTAL BIOLOGY

genesis Pub Date : 2024-04-08 DOI:10.1002/dvg.23597

Andrea Rocha, Quynh Anh Thi Nguyen, Sachiko Haga-Yamanaka

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引用次数: 0

摘要

嗅觉器官检测到的感觉信号是动物行为的关键调节器。小鼠的附属嗅觉器官--绒毛器官能检测到来自其他动物的信号，并在小鼠种内和种间互动中发挥关键作用。然而，如何通过约 350 个绒毛感觉受体蛋白控制小鼠行为的伦理相关线索在很大程度上仍然是个谜。2型绒毛膜感觉受体-A4（V2R-A4）亚家族成员被反复从对捕食者线索有反应的绒毛膜感觉神经元中检测到，这表明该受体亚家族可能扮演捕食者传感器的角色。本综述将重点探讨这一引人入胜的亚家族，深入研究其受体功能和遗传特征。

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Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice

Sensory signals detected by olfactory sensory organs are critical regulators of animal behavior. An accessory olfactory organ, the vomeronasal organ, detects cues from other animals and plays a pivotal role in intra- and inter-species interactions in mice. However, how ethologically relevant cues control mouse behavior through approximately 350 vomeronasal sensory receptor proteins largely remains elusive. The type 2 vomeronasal receptor-A4 (V2R-A4) subfamily members have been repeatedly detected from vomeronasal sensory neurons responsive to predator cues, suggesting a potential role of this receptor subfamily as a sensor for predators. This review focuses on this intriguing subfamily, delving into its receptor functions and genetic characteristics.

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来源期刊

genesis 生物-发育生物学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： As of January 2000, Developmental Genetics was renamed and relaunched as genesis: The Journal of Genetics and Development, with a new scope and Editorial Board. The journal focuses on work that addresses the genetics of development and the fundamental mechanisms of embryological processes in animals and plants. With increased awareness of the interplay between genetics and evolutionary change, particularly during developmental processes, we encourage submission of manuscripts from all ecological niches. The expanded numbers of genomes for which sequencing is being completed will facilitate genetic and genomic examination of developmental issues, even if the model system does not fit the “classical genetic” mold. Therefore, we encourage submission of manuscripts from all species. Other areas of particular interest include: 1) the roles of epigenetics, microRNAs and environment on developmental processes; 2) genome-wide studies; 3) novel imaging techniques for the study of gene expression and cellular function; 4) comparative genetics and genomics and 5) animal models of human genetic and developmental disorders. genesis presents reviews, full research articles, short research letters, and state-of-the-art technology reports that promote an understanding of the function of genes and the roles they play in complex developmental processes.