Genes & Diseases最新文献_第3页

Multi-omics approach reveals gene co-alterations and survival benefit in ovarian cancer patients under platinum-based adjuvant therapy 多组学方法揭示了铂类辅助治疗下卵巢癌患者的基因共改变和生存益处

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-04-04 DOI: 10.1016/j.gendis.2025.101628

Ning Ding , Jiahui Chen , Xiaotian Zhao , Minyi Zhu , Qiuxiang Ou , Jiaohui Pang , Luxi Ruan , Ying Zhang , Wei Sun , Xiaoxiang Chen

引用次数: 0

Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis 色氨酸通过调节肠道屏障完整性和肠道微生物群稳态来减轻急性缺氧应激诱导的肠道损伤

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-04-04 DOI: 10.1016/j.gendis.2025.101627

Jianhua Zheng , Jingqing Chen , Wensheng Zhang , Yunpeng Wu , Tongtong Qin , Yunzhi Fa , Qianyan Dong , Rui Zhang , Yefeng Qiu

引用次数: 0

miR-146b/Btg2 axis as a potential inducer of islet beta-cell decline during the progression of obesity to T2DM miR-146b/Btg2轴作为肥胖发展为T2DM过程中胰岛β细胞衰退的潜在诱导剂

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-04-02 DOI: 10.1016/j.gendis.2025.101621

Weixuan Wang , Dan Ma , Yong Chen , Rui Cheng , Ting Zhang , Qian Ge , Xi Li

{"title":"miR-146b/Btg2 axis as a potential inducer of islet beta-cell decline during the progression of obesity to T2DM","authors":"Weixuan Wang , Dan Ma , Yong Chen , Rui Cheng , Ting Zhang , Qian Ge , Xi Li","doi":"10.1016/j.gendis.2025.101621","DOIUrl":"10.1016/j.gendis.2025.101621","url":null,"abstract":"<div><div>We evaluated the potential mechanisms responsible for inducing beta-cell decline during the progression of obesity to type 2 diabetes mellitus (T2DM). Between February 2021 and February 2022, 25 subjects with non-diabetic obesity, 20 subjects with obesity and new-onset T2DM, and 25 healthy volunteers were recruited. Circulating exosome-contained miRNA expression profiling was performed by miRNA sequencing. The role of specific miRNA was analyzed by a gain-of-function approach in Min6 beta-cells, mouse islets, and human islets. Expression of 83 exosomal miRNAs was differently regulated in the circulation of subjects with non-diabetic obesity. We focused on miR-146b, which was mildly up-regulated in non-diabetic obesity and dramatically up-regulated in obese new-onset T2DM. Using an obese diabetic <em>db/db</em> mouse model, we found the expression of miR-146b to be mainly increased in islets. Overexpression of miR-146b in mouse beta-cells, mouse islets, and human islets <em>in vitro</em> facilitated beta-cell apoptosis yet inhibited its proliferation and insulin synthesis, leading to impaired insulin secretion. Eventually, miR-146b directly targeted the B cell translocation gene 2 (<em>Btg2</em>), an antiapoptotic transcriptional factor. Overexpression of <em>Btg2</em> reversed miR-146b-induced apoptosis and -suppressed proliferation in beta-cells. miR-146b that targets <em>Btg2</em> might be a predictive biomarker and an inducer of beta-cell decline.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101621"},"PeriodicalIF":6.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic analysis reveals the landscape of the shared gene network between ectopic pregnancy and early pregnancy loss 转录组学分析揭示了异位妊娠和早期妊娠丢失之间的共享基因网络的景观

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-27 DOI: 10.1016/j.gendis.2025.101616

Mengyu Jing , Ying Zhou , Shuyue Zheng , Yahui Xie , Xi Chen , Aixia Liu

引用次数: 0

Ribonucleases in Mendelian disease: Characterization and insight from model organisms 核糖核酸酶在孟德尔病：表征和洞察从模式生物

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-25 DOI: 10.1016/j.gendis.2025.101613

Annasha Dutta , Anastasiia Zaremba , Paulina Jackowiak

引用次数: 0

Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: Implications for autologous therapy 通过临床级方案，生物可降解支架上基因校正视网膜色素变性- hipsc衍生的RPE贴片恢复吞噬能力：对自体治疗的意义

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-22 DOI: 10.1016/j.gendis.2025.101609

Rodriguez-Jimenez Francisco Javier , Artero-Castro Ana , Studenovska Hana , Selles Francisca , Arteaga Claramunt Alba Maria , Brymova Anna , Jendelova Pavla , Motlik Jan , Petrovski Goran , Lytvynchuk Lyubomyr , Ardan Taras , Tichotová Lucie , Drutovič Saskia , Sharma Ruchi , Lukovic Dunja , Bharti Kapil , Erceg Slaven

引用次数: 0

Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy 转移rna衍生的小rna (tsrna)：液体活检中的新星

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-19 DOI: 10.1016/j.gendis.2025.101608

Qinglin Wang , Zehao Pan , Si Liang , Yuanjian Shi , Gaochao Dong , Lin Xu , Qixing Mao , Feng Jiang

引用次数: 0

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-19 DOI: 10.1016/j.gendis.2025.101606

Amin Ullah , Rajeev K. Singla , Dan Cao , Boyang Chen , Bairong Shen

{"title":"Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines","authors":"Amin Ullah , Rajeev K. Singla , Dan Cao , Boyang Chen , Bairong Shen","doi":"10.1016/j.gendis.2025.101606","DOIUrl":"10.1016/j.gendis.2025.101606","url":null,"abstract":"<div><div>Older age is one of the leading risk indicators for advanced breast cancer. It is critical to extensively investigate how aging affects breast cancer, considering the increasing rate of population aging. Human body aging and death are caused by cellular senescence and alterations in the aging microenvironment <em>in vivo</em>. Breast cancer cells may invade more easily with age due to the stiff extracellular matrix of the breast. Furthermore, growing evidence suggests that the massive release of inflammatory immune mediators, such as cytokines (interleukins) or CXC chemokines (CXCs), and their receptors (CXCRs), including interleukin (IL)-6, IL-8/CXCL8, tumor necrosis factor (TNF), interferon (INF), transforming growth factor (TGF), CXCL1, CXCL9, CXCL10, CXCL11/CXCR3, and CXCL12/CXCR4, plays a critical role in the development of breast cancer in elderly patients. Researchers are particularly interested in obesity-induced inflammation because it has been shown to raise the risk of breast cancer in postmenopausal women with higher body mass index. Obesity-triggered inflammation causes increased infiltration of proinflammatory cytokines, adipokines, immune cells, and tumor cells in the enlarged adipose tissue of postmenopausal women with breast cancer, thereby modulating the tumor's immune-mediated microenvironment. Therefore, in this review, we focus on the functional significance studies of proinflammatory cytokines, CXCs, and CXCRs and describe their roles in influencing breast cancer progression in older women and their factors, such as obesity in postmenopausal women. In addition, the current status and prospects of cytokine- and CXC-based theranostic interventions for breast cancer therapy in elderly and postmenopausal women are discussed.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101606"},"PeriodicalIF":6.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances 环状rna在乙型肝炎病毒诱导的肝细胞癌中的作用：综述和最新进展

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-18 DOI: 10.1016/j.gendis.2025.101605

Wenjun Quan , Kizito Eneye Bello , Rafidah Hanim Shueb , Nazri Mustaffa

引用次数: 0

Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines 五种广泛应用的肿瘤细胞系中MHC区域的单倍型分解组装

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-18 DOI: 10.1016/j.gendis.2025.101603

Haozhe Yuan , Mengping Jiang , Xingyu Xu , Jialiang Zhu , Shulong Dong , Weida Meng , Dandan Zhang , Jiakang Ma , Yicheng Lin , Ziqiang Chen , Shaoyang Sun , Wenqing Qiu , Yun Liu

{"title":"Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines","authors":"Haozhe Yuan , Mengping Jiang , Xingyu Xu , Jialiang Zhu , Shulong Dong , Weida Meng , Dandan Zhang , Jiakang Ma , Yicheng Lin , Ziqiang Chen , Shaoyang Sun , Wenqing Qiu , Yun Liu","doi":"10.1016/j.gendis.2025.101603","DOIUrl":"10.1016/j.gendis.2025.101603","url":null,"abstract":"<div><div>The major histocompatibility complex (MHC) region plays a crucial role in immune function and is implicated in various diseases and cancer immunoediting. However, its high polymorphism poses challenges for accurate genetic profiling using conventional reference genomes. Here, we present high-quality, haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines: A549, HeLa, HepG2, K562, and U2OS. Numerous oncological studies extensively employ these cell lines, ranging from basic molecular research to drug discovery and personalized medicine approaches. By integrating CRISPR-based targeted enrichment with 10 × Genomics linked-read and PacBio HiFi long-read sequencing, we constructed MHC haplotypes for each cell line, providing a valuable resource for the research community. Using these assembled haplotypes as references, we characterize the aneuploidy of the MHC region in these cell lines, offering insights into the genetic landscape of this critical immunological locus. Our work addresses the urgent need for accurate MHC profiling in these widely used cell line models, enabling more precise interpretation of existing and future genomic and epigenomic data. This resource is expected to significantly enhance our understanding of tumor biology, immune responses, and the development of targeted therapies.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101603"},"PeriodicalIF":6.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0