Genes & Diseases最新文献

DNA damage-induced nuclear STING translocation orchestrates innate immune activation and chromatin remodeling DNA损伤诱导的核STING易位协调先天免疫激活和染色质重塑

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-09 DOI: 10.1016/j.gendis.2025.101851

Yihao Wang , Zan Shen , Lingjie Li , Jianfeng Shen

引用次数: 0

Serum tRF-4575 may regulate osteoclast differentiation and serve as a promising biomarker for enthesitis-related arthritis diagnosis 血清tRF-4575可能调节破骨细胞的分化，并作为一种有前景的生物标志物用于关节炎的诊断

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-10 DOI: 10.1016/j.gendis.2025.101848

Jing Jin, Lingzhi Qiu, Yuting Pan, Yifan Xie, Xiaoyan Shao, Zhidan Fan, Haiguo Yu

引用次数: 0

The role of immunoproteasome in diabetes and diabetes-related complications 免疫蛋白酶体在糖尿病及其相关并发症中的作用。

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-20 DOI: 10.1016/j.gendis.2025.101861

Mengwen Wang , Lingyun Luo , Lei Dai , Hesong Zeng , Hongjie Wang

{"title":"The role of immunoproteasome in diabetes and diabetes-related complications","authors":"Mengwen Wang , Lingyun Luo , Lei Dai , Hesong Zeng , Hongjie Wang","doi":"10.1016/j.gendis.2025.101861","DOIUrl":"10.1016/j.gendis.2025.101861","url":null,"abstract":"<div><div>The immunoproteasome represents a specialized isoform of the proteasome that is integral to the processes of antigen presentation and protein degradation. While it is primarily expressed in hematopoietic cells, its expression can also be induced in non-hematopoietic cells in response to various inflammatory stimuli. Recent research has highlighted the role of the immunoproteasome in modulating islet β-cell apoptosis and glycolipid metabolism, both of which are critical mechanisms in the pathogenesis of diabetes. Furthermore, the immunoproteasome has been demonstrated to play a significant role in the development of diabetic complications through the activation of various downstream cytokines. Investigating how the immunoproteasome is activated and involved in the pathophysiological processes of diabetes and its complications may provide innovative and promising approaches for diabetes treatment. This review aims to present a comprehensive summary of current research on the role of immunoproteasome in diabetes and its associated complications, ultimately identifying novel strategies for diabetes management and therapy.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 3","pages":"Article 101861"},"PeriodicalIF":9.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YTHDF2 in inflammation: Mechanisms and therapeutic strategies 炎症中的YTHDF2：机制和治疗策略。

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-10-28 DOI: 10.1016/j.gendis.2025.101909

Junxiu Liu , Senxu Lu , Chuanhuai Chen , Xiaobo Lin , Lijuan Xia , Pansheng Xu , Jinjin Shao , Luxi Yang , Wenhai Huang , Lijiang Zhang

{"title":"YTHDF2 in inflammation: Mechanisms and therapeutic strategies","authors":"Junxiu Liu , Senxu Lu , Chuanhuai Chen , Xiaobo Lin , Lijuan Xia , Pansheng Xu , Jinjin Shao , Luxi Yang , Wenhai Huang , Lijiang Zhang","doi":"10.1016/j.gendis.2025.101909","DOIUrl":"10.1016/j.gendis.2025.101909","url":null,"abstract":"<div><div>Inflammation is a double-edged sword in biology. Moderate immune responses effectively eliminate pathogens and promote tissue repair, while excessive or persistent inflammation drives acute and chronic diseases. N6-methyladenosine (m<sup>6</sup>A), a central RNA epigenetic modification, dynamically regulates inflammatory initiation, amplification, and resolution. Among m<sup>6</sup>A-binding proteins, YTHDF2—the first identified mammalian m<sup>6</sup>A reader—modulates inflammatory responses by recognizing m<sup>6</sup>A/m<sup>5</sup>C sites to control RNA stability and translation. This review reports novel insights into the role of YTHDF2 in regulating immune cell functions and inflammatory signaling pathways across various disease contexts. Specifically, it systematically summarizes the molecular mechanisms through which YTHDF2 contributes to the pathogenesis of inflammatory diseases and reviews recent advances in the development of selective therapeutic agents targeting YTHDF2. Additionally, the functional complexity of YTHDF2 within specific pathological environments is discussed, and the current challenges facing the translation of these findings into targeted therapies are outlined. This review is expected to serve as a theoretical foundation for prospective therapeutic strategies employing novel epigenomic regulation-based approaches to treat inflammatory diseases.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 3","pages":"Article 101909"},"PeriodicalIF":9.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis and experimental verification of the role of mitochondrial dynamics-related genes in liver hepatocellular carcinoma 线粒体动力学相关基因在肝癌中的作用的综合分析和实验验证

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-26 DOI: 10.1016/j.gendis.2025.101872

Yuchen Zhang , Jing Yuan , Ning Zhang , Yang Yang , Chang Liu , Xingyu Jiang , Yue Wu , Xingxing Ma , Yinyin Xie

引用次数: 0

EEF1AKMT4-eEF1A2 synergistically facilitates the progression of GBC by promoting ribosomal protein output EEF1AKMT4-eEF1A2通过促进核糖体蛋白输出协同促进GBC的进展

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-04-02 DOI: 10.1016/j.gendis.2025.101619

Yun-cheng Li , Qiang Gao , Yong-chang Tang , Zhen-yu Shao , Jia-ming Hu , Zeng-li Liu , An-da Shi , Shao-hui Huang , Yun-fei Xu , Zong-li Zhang , Kang-shuai Li

{"title":"EEF1AKMT4-eEF1A2 synergistically facilitates the progression of GBC by promoting ribosomal protein output","authors":"Yun-cheng Li , Qiang Gao , Yong-chang Tang , Zhen-yu Shao , Jia-ming Hu , Zeng-li Liu , An-da Shi , Shao-hui Huang , Yun-fei Xu , Zong-li Zhang , Kang-shuai Li","doi":"10.1016/j.gendis.2025.101619","DOIUrl":"10.1016/j.gendis.2025.101619","url":null,"abstract":"<div><div>Gallbladder cancer (GBC) is prone to lymph node metastasis. Lymph node (LN) metastasis is correlated with abysmal patient prognosis, but the underlying mechanism remains elusive. In this study, transcriptome sequencing of 6 paired GBC tumors and metastatic LNs was performed and identified eEF1A2 as key genes associated with GBC LN metastasis. qPCR, Western blotting and immunohistochemistry (IHC) were performed to assess the expression of eEF1A2 and relating proteins in GBC. The function of eEF1A2 and its regulators were demonstrated in different GBC cell lines as well as in xenograft models. Two independent cohorts of GBC patients were used to reveal the clinical significance. The results revealed that eEF1A2 is tightly correlated with lymph node metastasis and poor prognosis in patients with GBC. In two GBC cell lines, eEF1A2 knockdown impaired cell proliferation, migration, and invasion <em>in vitro</em> and inhibited tumor growth and lymph node metastasis <em>in vivo</em>, whereas overexpression of eEF1A2 promoted these processes. EEF1AKMT4 trimethylates eEF1A2 at K36 site in GBC and is essential for the tumor-promoting effect of eEF1A2. Mechanistically, trimethylation at the K36 site of eEF1A2 increased the GTPase activity of eEF1A2 and enhanced tumor promoting signals including ERK1/2 and AKT by promoting the ribosome total protein synthesis. In conclusion, the evolutionarily conserved EEF1AKMT4-eEF1A2K36me3-ribosome protein synthesis-tumor promoting signals axis acts as a mechanism that promotes GBC progression and may be a potential therapeutic target for GBC lymph node metastasis.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 3","pages":"Article 101619"},"PeriodicalIF":9.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The functions of FXYD family members in human health and disease FXYD家族成员在人类健康和疾病中的作用

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-10 DOI: 10.1016/j.gendis.2025.101847

Xi Li , Min Long , Shangwei Zhong , Jun-Li Luo

{"title":"The functions of FXYD family members in human health and disease","authors":"Xi Li , Min Long , Shangwei Zhong , Jun-Li Luo","doi":"10.1016/j.gendis.2025.101847","DOIUrl":"10.1016/j.gendis.2025.101847","url":null,"abstract":"<div><div>The FXYD family (FXYD domain-containing ion transport regulators) proteins consist of short, single-pass transmembrane proteins that primarily regulate the Na<sup>+</sup>/K<sup>+</sup>-ATPase (NKA) pump, a key player in maintaining cellular ion homeostasis. Ranging from 60 to 160 amino acids in length, FXYD proteins display tissue-specific expression patterns and influence not only NKA activity but also the function of other ion channels, including potassium, sodium, and chloride channels. These proteins interact with NKA in diverse ways, modulating its activity to meet the specific needs of different tissues. In addition to their physiological roles, FXYD proteins are implicated in the development and progression of various diseases, such as cancer, cardiovascular disorders, renal diseases, and neurological conditions. This review offers an overview of the structures, biological functions, and molecular mechanisms through which FXYD proteins regulate ion transport. Furthermore, we explore their emerging roles in disease pathogenesis and discuss potential therapeutic strategies for targeting FXYD proteins in disease management.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 3","pages":"Article 101847"},"PeriodicalIF":9.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deubiquitinase USP17 negatively regulates 3T3-L1 adipocyte differentiation via HDAC1 去泛素酶USP17通过HDAC1负向调控3T3-L1脂肪细胞分化

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-11-12 DOI: 10.1016/j.gendis.2025.101930

Yuankuan Li , Meiyu Piao , Yujian Jin , Sung Ho Lee , Kwang Youl Lee

引用次数: 0

eQTL analysis: A bridge from genome to mechanism eQTL分析：从基因组到机制的桥梁

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-17 DOI: 10.1016/j.gendis.2025.101850

Zhe Jia , Jing Xu , Yingnan Ma , Siyu Wei , Chen Sun , Xingyu Chen , Jingxuan Kang , Haiyan Chen , Chen Zhang , Yu Dong , Junxian Tao , Xuying Guo , Hongchao Lv , Guoping Tang , Yongshuai Jiang , Mingming Zhang

引用次数: 0

Lactylation-driven METTL3 regulates wound healing by enhancing m6A/HNRNPA2B1/DNMT1 signaling in keratinocytes 乳酸化驱动的METTL3通过增强角质形成细胞中的m6A/HNRNPA2B1/DNMT1信号来调节伤口愈合

IF 9.4 2区医学

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-07-28 DOI: 10.1016/j.gendis.2025.101787

Xue-ting Hu , Lu-min Sui , Cheng-xiu Pu , Luo-quan Ao , Mu Yuan , Li Deng , Qing Zhao , Xiao-feng Wu , Xiang Xu

引用次数: 0