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Role of angiogenesis-related lncRNAs in tumor microenvironment and prognosis of lung adenocarcinoma 血管生成相关lncrna在肺腺癌肿瘤微环境及预后中的作用
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-06-11 DOI: 10.1016/j.gendis.2025.101700
Lifeng Li , Yaqi Yang , Mengle Peng , Zhirui Fan , Xiaoran Duan , Ruyue Xue , Xuefeng Lv , Ming Cheng , Jie Zhao
{"title":"Role of angiogenesis-related lncRNAs in tumor microenvironment and prognosis of lung adenocarcinoma","authors":"Lifeng Li , Yaqi Yang , Mengle Peng , Zhirui Fan , Xiaoran Duan , Ruyue Xue , Xuefeng Lv , Ming Cheng , Jie Zhao","doi":"10.1016/j.gendis.2025.101700","DOIUrl":"10.1016/j.gendis.2025.101700","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 6","pages":"Article 101700"},"PeriodicalIF":6.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy TLR4与PIEZO1的相互作用促进了5- ht介导的妊娠期LPS暴露诱导的子代小鼠肠道运动功能障碍
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-06-05 DOI: 10.1016/j.gendis.2025.101707
Ruifang Luo , Yuan Miao , Riqiang Hu , Fang Lin , Junyan Yan , Ting Yang , Lu Xiao , Zhujun Sun , Yuting Wang , Jie Chen
{"title":"TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy","authors":"Ruifang Luo ,&nbsp;Yuan Miao ,&nbsp;Riqiang Hu ,&nbsp;Fang Lin ,&nbsp;Junyan Yan ,&nbsp;Ting Yang ,&nbsp;Lu Xiao ,&nbsp;Zhujun Sun ,&nbsp;Yuting Wang ,&nbsp;Jie Chen","doi":"10.1016/j.gendis.2025.101707","DOIUrl":"10.1016/j.gendis.2025.101707","url":null,"abstract":"<div><div>Several factors during pregnancy, such as changes in serotonin (5-HT) levels, can affect intestinal function in offspring mice. The role of 5-HT in regulating intestinal motility after lipopolysaccharide (LPS) exposure during pregnancy is unclear. In this study, <em>Tlr4</em><sup>fl/fl</sup> and <em>Tlr4</em><sup>▵IEC</sup> mice were injected with LPS or phosphate-buffered saline during pregnancy to obtain prenatal LPS-exposed or non-exposed offspring mice. Changes in intestinal morphology, motility, and the TLR4 and 5-HT signaling pathways were examined in male offspring mice. The role of TLR4 in regulating 5-HT secretion was investigated in the BON-1 enterochromaffin cell line. In the prenatal LPS-exposed <em>Tlr4</em><sup>fl/fl</sup> group, offspring mice exhibited colonic mucosal injury and faster intestinal motility, but these effects were absent when TLR4 was knocked out in intestinal epithelial cells. The TLR4 and 5-HT signaling pathways were activated in the colon of prenatal LPS-exposed <em>Tlr4</em><sup>fl/fl</sup> offspring mice but were inactivated in prenatal LPS-exposed <em>Tlr4</em> knockout offspring mice. In BON-1 cells, TLR4 interacted with the calcium ion channel PIEZO1, causing calcium influx and promoting 5-HT secretion. This process was disrupted by the TLR4 inhibitor TAK242. LPS exposure during pregnancy affected intestinal motility in offspring mice by activating TLR4 pathways in the colon and increasing 5-HT secretion from enterochromaffin cells. The effects of LPS on the intestine might be explained by the interaction between TLR4 and PIEZO1, suggesting that TLR4 is related to abnormal intestinal motility in offspring mice exposed to LPS during pregnancy.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101707"},"PeriodicalIF":6.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CMTM3 promotes adipocyte differentiation by regulating PPARγ in 3T3-L1 cells CMTM3通过调节3T3-L1细胞中的PPARγ促进脂肪细胞分化
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-30 DOI: 10.1016/j.gendis.2025.101699
Yanni Zhao , Meiyu Piao , Yuankuan Li , Sung Ho Lee , Seung-Joo Nho , Yujian Jin , Chang-Yeol Yeo , Kwang Youl Lee
{"title":"CMTM3 promotes adipocyte differentiation by regulating PPARγ in 3T3-L1 cells","authors":"Yanni Zhao ,&nbsp;Meiyu Piao ,&nbsp;Yuankuan Li ,&nbsp;Sung Ho Lee ,&nbsp;Seung-Joo Nho ,&nbsp;Yujian Jin ,&nbsp;Chang-Yeol Yeo ,&nbsp;Kwang Youl Lee","doi":"10.1016/j.gendis.2025.101699","DOIUrl":"10.1016/j.gendis.2025.101699","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 6","pages":"Article 101699"},"PeriodicalIF":6.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation 肿瘤基质细胞中的半乳糖凝集素-3通过抑制氧化磷酸化增强胰腺癌患者对吉西他滨的耐药性
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-29 DOI: 10.1016/j.gendis.2025.101702
Yaheng Wu , Guo An , Jia Tong , Wenlong Zhang , Zhihua Tian , Bin Dong , Xijuan Liu , Lin Zhao , Chunxiang Ye , Jingtao Liu , Wei Zhao , Huachong Ma
{"title":"Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation","authors":"Yaheng Wu ,&nbsp;Guo An ,&nbsp;Jia Tong ,&nbsp;Wenlong Zhang ,&nbsp;Zhihua Tian ,&nbsp;Bin Dong ,&nbsp;Xijuan Liu ,&nbsp;Lin Zhao ,&nbsp;Chunxiang Ye ,&nbsp;Jingtao Liu ,&nbsp;Wei Zhao ,&nbsp;Huachong Ma","doi":"10.1016/j.gendis.2025.101702","DOIUrl":"10.1016/j.gendis.2025.101702","url":null,"abstract":"<div><div>Galectin-3 (Gal-3) plays a multifaceted role in the development and progression of pancreatic adenocarcinoma (PAAD), which is associated with a poor prognosis. Its interaction with tumor microenvironment cells has been reported. However, the Gal-3-mediated tumor–stromal interaction and induced energy metabolism associated with drug resistance remain unknown. Our previous study has reported that Gal-3 secretion from tumor cells and inflammatory cytokine dependency are therapeutic targets. In this study, we revealed that the expression of Gal-3 was not only remarkably up-regulated in tumors but also significantly associated with the tumor-associated fibroblasts of PAAD patients. A coculture model of PAAD cells and pancreatic stellate cells revealed that Gal-3 mediated the Ca<sup>2+</sup>/−calcineurin–NFAT pathway to increase the transcription of CCL2 and BSG in tumor-associated fibroblasts. These findings ultimately lead to the observation of low energy metabolism in tumor cells. Particularly, mitochondrial oxidative phosphorylation was functionally arrested in Gal-3-high tumor cells, as demonstrated by a lower oxygen consumption rate and mitochondrial ATP production through abnormal mitochondrial morphology. The inhibition of the CCL2-CCR2 and PPIA-BSG pathways indicated the restoration of gemcitabine sensitivity when drug resistance was elicited by Gal-3. Oral administration of the natural Gal-3 inhibitor modified citrus pectin extract (MCP) showed therapeutic effect for Gal-3-activated tumors and stromal cells in orthotopic pancreatic xenograft models. Hence, our findings offer insights into the fact that low mitochondrial metabolism is dependent on Gal-3 activation-mediated gemcitabine resistance through tumor–stromal interactions.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101702"},"PeriodicalIF":6.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the temporal distribution of anti-VEGF drugs in the retina and the correlation with the distribution of FcR isoforms 抗vegf药物在视网膜的时间分布及其与FcR亚型分布的相关性研究
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-28 DOI: 10.1016/j.gendis.2025.101698
Jicai He , Yanping Jiang , Rongqin Yang , Ziwen Lu , Zhihuan Li , Zhigang Tu
{"title":"Investigation of the temporal distribution of anti-VEGF drugs in the retina and the correlation with the distribution of FcR isoforms","authors":"Jicai He ,&nbsp;Yanping Jiang ,&nbsp;Rongqin Yang ,&nbsp;Ziwen Lu ,&nbsp;Zhihuan Li ,&nbsp;Zhigang Tu","doi":"10.1016/j.gendis.2025.101698","DOIUrl":"10.1016/j.gendis.2025.101698","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 6","pages":"Article 101698"},"PeriodicalIF":6.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulated Krüppel-like factor 5 promotes hepatocellular carcinoma progression by activating Wnt3a signaling kr<s:1> ppel样因子5的上调通过激活Wnt3a信号通路促进肝细胞癌的进展
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-15 DOI: 10.1016/j.gendis.2025.101685
Wenli Sai , Jie Yang , Liwei Qiu , Min Xu , Min Yao , Dengfu Yao
{"title":"Upregulated Krüppel-like factor 5 promotes hepatocellular carcinoma progression by activating Wnt3a signaling","authors":"Wenli Sai ,&nbsp;Jie Yang ,&nbsp;Liwei Qiu ,&nbsp;Min Xu ,&nbsp;Min Yao ,&nbsp;Dengfu Yao","doi":"10.1016/j.gendis.2025.101685","DOIUrl":"10.1016/j.gendis.2025.101685","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 6","pages":"Article 101685"},"PeriodicalIF":6.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel oridonin analogue, CYD0682, suppresses breast cancer growth, angiogenesis, and metastasis by inhibiting the ANGPTL4/MAPK signaling axis 一种新的oridonin类似物CYD0682通过抑制ANGPTL4/MAPK信号轴抑制乳腺癌的生长、血管生成和转移
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-08 DOI: 10.1016/j.gendis.2025.101681
Xiaobin Mai , Le Wang , Juan Tu , Jialin Li , Jun Li , Yaping Zhan , Pei Tang , Ying Wang , Yan Wang , Lingyun Zheng , Qianqian Zhang , Jiangchao Li , Xiong Li , Lijing Wang , Jia Zhou , Cuiling Qi
{"title":"A novel oridonin analogue, CYD0682, suppresses breast cancer growth, angiogenesis, and metastasis by inhibiting the ANGPTL4/MAPK signaling axis","authors":"Xiaobin Mai ,&nbsp;Le Wang ,&nbsp;Juan Tu ,&nbsp;Jialin Li ,&nbsp;Jun Li ,&nbsp;Yaping Zhan ,&nbsp;Pei Tang ,&nbsp;Ying Wang ,&nbsp;Yan Wang ,&nbsp;Lingyun Zheng ,&nbsp;Qianqian Zhang ,&nbsp;Jiangchao Li ,&nbsp;Xiong Li ,&nbsp;Lijing Wang ,&nbsp;Jia Zhou ,&nbsp;Cuiling Qi","doi":"10.1016/j.gendis.2025.101681","DOIUrl":"10.1016/j.gendis.2025.101681","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101681"},"PeriodicalIF":6.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MyoAAV-delivered sup-tRNA increases full-length dystrophin expression myoaav递送的sup-tRNA增加全长肌营养不良蛋白的表达
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-03 DOI: 10.1016/j.gendis.2025.101666
Xiuyi Ai , Yue Chang , Ruo Wu , Jie Liu , Pei Zhang , Yayu Wang , Zhuoyin Zheng , Shu Zhang , Yongchang Chen , Shiwen Wu
{"title":"MyoAAV-delivered sup-tRNA increases full-length dystrophin expression","authors":"Xiuyi Ai ,&nbsp;Yue Chang ,&nbsp;Ruo Wu ,&nbsp;Jie Liu ,&nbsp;Pei Zhang ,&nbsp;Yayu Wang ,&nbsp;Zhuoyin Zheng ,&nbsp;Shu Zhang ,&nbsp;Yongchang Chen ,&nbsp;Shiwen Wu","doi":"10.1016/j.gendis.2025.101666","DOIUrl":"10.1016/j.gendis.2025.101666","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101666"},"PeriodicalIF":6.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of sodium-glucose cotransporter 2 inhibition mediated by blood metabolites in lymphocytic leukemia 血代谢物介导的钠-葡萄糖共转运蛋白2抑制在淋巴细胞白血病中的作用
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-02 DOI: 10.1016/j.gendis.2025.101664
Diguang Wen , Kai Lei , Xiang Ma, Jianchuan Deng
{"title":"The effect of sodium-glucose cotransporter 2 inhibition mediated by blood metabolites in lymphocytic leukemia","authors":"Diguang Wen ,&nbsp;Kai Lei ,&nbsp;Xiang Ma,&nbsp;Jianchuan Deng","doi":"10.1016/j.gendis.2025.101664","DOIUrl":"10.1016/j.gendis.2025.101664","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 6","pages":"Article 101664"},"PeriodicalIF":6.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
X26nt-mediated recruitment of eIF4A2 facilitates CCND1 translation to drive endothelial cell cycle progression x26nt介导的eIF4A2的募集促进了CCND1的翻译，从而驱动内皮细胞周期的进展
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2025-05-02 DOI: 10.1016/j.gendis.2025.101667
Xinghe Zhao , Xiaocui Chen , Zheyi Chen , Lisong Shen , Lingfang Zeng , Junyao Yang
{"title":"X26nt-mediated recruitment of eIF4A2 facilitates CCND1 translation to drive endothelial cell cycle progression","authors":"Xinghe Zhao ,&nbsp;Xiaocui Chen ,&nbsp;Zheyi Chen ,&nbsp;Lisong Shen ,&nbsp;Lingfang Zeng ,&nbsp;Junyao Yang","doi":"10.1016/j.gendis.2025.101667","DOIUrl":"10.1016/j.gendis.2025.101667","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 6","pages":"Article 101667"},"PeriodicalIF":6.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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