Genes & Diseases最新文献

Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation 肿瘤基质细胞中的半乳糖凝集素-3通过抑制氧化磷酸化增强胰腺癌患者对吉西他滨的耐药性

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-05-29 DOI: 10.1016/j.gendis.2025.101702

Yaheng Wu , Guo An , Jia Tong , Wenlong Zhang , Zhihua Tian , Bin Dong , Xijuan Liu , Lin Zhao , Chunxiang Ye , Jingtao Liu , Wei Zhao , Huachong Ma

{"title":"Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation","authors":"Yaheng Wu , Guo An , Jia Tong , Wenlong Zhang , Zhihua Tian , Bin Dong , Xijuan Liu , Lin Zhao , Chunxiang Ye , Jingtao Liu , Wei Zhao , Huachong Ma","doi":"10.1016/j.gendis.2025.101702","DOIUrl":"10.1016/j.gendis.2025.101702","url":null,"abstract":"<div><div>Galectin-3 (Gal-3) plays a multifaceted role in the development and progression of pancreatic adenocarcinoma (PAAD), which is associated with a poor prognosis. Its interaction with tumor microenvironment cells has been reported. However, the Gal-3-mediated tumor–stromal interaction and induced energy metabolism associated with drug resistance remain unknown. Our previous study has reported that Gal-3 secretion from tumor cells and inflammatory cytokine dependency are therapeutic targets. In this study, we revealed that the expression of Gal-3 was not only remarkably up-regulated in tumors but also significantly associated with the tumor-associated fibroblasts of PAAD patients. A coculture model of PAAD cells and pancreatic stellate cells revealed that Gal-3 mediated the Ca<sup>2+</sup>/−calcineurin–NFAT pathway to increase the transcription of CCL2 and BSG in tumor-associated fibroblasts. These findings ultimately lead to the observation of low energy metabolism in tumor cells. Particularly, mitochondrial oxidative phosphorylation was functionally arrested in Gal-3-high tumor cells, as demonstrated by a lower oxygen consumption rate and mitochondrial ATP production through abnormal mitochondrial morphology. The inhibition of the CCL2-CCR2 and PPIA-BSG pathways indicated the restoration of gemcitabine sensitivity when drug resistance was elicited by Gal-3. Oral administration of the natural Gal-3 inhibitor modified citrus pectin extract (MCP) showed therapeutic effect for Gal-3-activated tumors and stromal cells in orthotopic pancreatic xenograft models. Hence, our findings offer insights into the fact that low mitochondrial metabolism is dependent on Gal-3 activation-mediated gemcitabine resistance through tumor–stromal interactions.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101702"},"PeriodicalIF":6.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel oridonin analogue, CYD0682, suppresses breast cancer growth, angiogenesis, and metastasis by inhibiting the ANGPTL4/MAPK signaling axis 一种新的oridonin类似物CYD0682通过抑制ANGPTL4/MAPK信号轴抑制乳腺癌的生长、血管生成和转移

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-05-08 DOI: 10.1016/j.gendis.2025.101681

Xiaobin Mai , Le Wang , Juan Tu , Jialin Li , Jun Li , Yaping Zhan , Pei Tang , Ying Wang , Yan Wang , Lingyun Zheng , Qianqian Zhang , Jiangchao Li , Xiong Li , Lijing Wang , Jia Zhou , Cuiling Qi

引用次数: 0

MyoAAV-delivered sup-tRNA increases full-length dystrophin expression myoaav递送的sup-tRNA增加全长肌营养不良蛋白的表达

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-05-03 DOI: 10.1016/j.gendis.2025.101666

Xiuyi Ai , Yue Chang , Ruo Wu , Jie Liu , Pei Zhang , Yayu Wang , Zhuoyin Zheng , Shu Zhang , Yongchang Chen , Shiwen Wu

引用次数: 0

Glial subtype-specific modulation of disease pathogenesis in Drosophila models of ALS 肌萎缩侧索硬化症果蝇模型中神经胶质亚型特异性疾病发病机制的调节

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-04-08 DOI: 10.1016/j.gendis.2025.101631

Yanan Wei , Hayong Rhee , Hadi Najafi , Shane Blair , Nam Chul Kim , Woo Jae Kim

引用次数: 0

Ribonucleases in Mendelian disease: Characterization and insight from model organisms 核糖核酸酶在孟德尔病：表征和洞察从模式生物

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-25 DOI: 10.1016/j.gendis.2025.101613

Annasha Dutta , Anastasiia Zaremba , Paulina Jackowiak

引用次数: 0

Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy 转移rna衍生的小rna (tsrna)：液体活检中的新星

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-19 DOI: 10.1016/j.gendis.2025.101608

Qinglin Wang , Zehao Pan , Si Liang , Yuanjian Shi , Gaochao Dong , Lin Xu , Qixing Mao , Feng Jiang

引用次数: 0

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-19 DOI: 10.1016/j.gendis.2025.101606

Amin Ullah , Rajeev K. Singla , Dan Cao , Boyang Chen , Bairong Shen

{"title":"Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines","authors":"Amin Ullah , Rajeev K. Singla , Dan Cao , Boyang Chen , Bairong Shen","doi":"10.1016/j.gendis.2025.101606","DOIUrl":"10.1016/j.gendis.2025.101606","url":null,"abstract":"<div><div>Older age is one of the leading risk indicators for advanced breast cancer. It is critical to extensively investigate how aging affects breast cancer, considering the increasing rate of population aging. Human body aging and death are caused by cellular senescence and alterations in the aging microenvironment <em>in vivo</em>. Breast cancer cells may invade more easily with age due to the stiff extracellular matrix of the breast. Furthermore, growing evidence suggests that the massive release of inflammatory immune mediators, such as cytokines (interleukins) or CXC chemokines (CXCs), and their receptors (CXCRs), including interleukin (IL)-6, IL-8/CXCL8, tumor necrosis factor (TNF), interferon (INF), transforming growth factor (TGF), CXCL1, CXCL9, CXCL10, CXCL11/CXCR3, and CXCL12/CXCR4, plays a critical role in the development of breast cancer in elderly patients. Researchers are particularly interested in obesity-induced inflammation because it has been shown to raise the risk of breast cancer in postmenopausal women with higher body mass index. Obesity-triggered inflammation causes increased infiltration of proinflammatory cytokines, adipokines, immune cells, and tumor cells in the enlarged adipose tissue of postmenopausal women with breast cancer, thereby modulating the tumor's immune-mediated microenvironment. Therefore, in this review, we focus on the functional significance studies of proinflammatory cytokines, CXCs, and CXCRs and describe their roles in influencing breast cancer progression in older women and their factors, such as obesity in postmenopausal women. In addition, the current status and prospects of cytokine- and CXC-based theranostic interventions for breast cancer therapy in elderly and postmenopausal women are discussed.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101606"},"PeriodicalIF":6.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances 环状rna在乙型肝炎病毒诱导的肝细胞癌中的作用：综述和最新进展

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-18 DOI: 10.1016/j.gendis.2025.101605

Wenjun Quan , Kizito Eneye Bello , Rafidah Hanim Shueb , Nazri Mustaffa

引用次数: 0

Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines 五种广泛应用的肿瘤细胞系中MHC区域的单倍型分解组装

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-18 DOI: 10.1016/j.gendis.2025.101603

Haozhe Yuan , Mengping Jiang , Xingyu Xu , Jialiang Zhu , Shulong Dong , Weida Meng , Dandan Zhang , Jiakang Ma , Yicheng Lin , Ziqiang Chen , Shaoyang Sun , Wenqing Qiu , Yun Liu

{"title":"Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines","authors":"Haozhe Yuan , Mengping Jiang , Xingyu Xu , Jialiang Zhu , Shulong Dong , Weida Meng , Dandan Zhang , Jiakang Ma , Yicheng Lin , Ziqiang Chen , Shaoyang Sun , Wenqing Qiu , Yun Liu","doi":"10.1016/j.gendis.2025.101603","DOIUrl":"10.1016/j.gendis.2025.101603","url":null,"abstract":"<div><div>The major histocompatibility complex (MHC) region plays a crucial role in immune function and is implicated in various diseases and cancer immunoediting. However, its high polymorphism poses challenges for accurate genetic profiling using conventional reference genomes. Here, we present high-quality, haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines: A549, HeLa, HepG2, K562, and U2OS. Numerous oncological studies extensively employ these cell lines, ranging from basic molecular research to drug discovery and personalized medicine approaches. By integrating CRISPR-based targeted enrichment with 10 × Genomics linked-read and PacBio HiFi long-read sequencing, we constructed MHC haplotypes for each cell line, providing a valuable resource for the research community. Using these assembled haplotypes as references, we characterize the aneuploidy of the MHC region in these cell lines, offering insights into the genetic landscape of this critical immunological locus. Our work addresses the urgent need for accurate MHC profiling in these widely used cell line models, enabling more precise interpretation of existing and future genomic and epigenomic data. This resource is expected to significantly enhance our understanding of tumor biology, immune responses, and the development of targeted therapies.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101603"},"PeriodicalIF":6.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Otof gene transfer in DFNB9 mice carrying human founder non-truncating alleles 携带人类创始人非截断等位基因的DFNB9小鼠的Otof基因转移

IF 6.9 2区医学

Genes & Diseases Pub Date : 2025-03-06 DOI: 10.1016/j.gendis.2025.101590

Yehree Kim , Yoojin Chung , Ju Ang Kim , Kyu Hee Han , Kwon Woo Kang , Ngoc-Trinh Tran , Min Young Kim , Eunyoung Yi , Sangyong Jung , Bong Jik Kim , Quynh-Anh Artinian , Seth D. Koehler , Ning Pan , Tyler M. Gibson , Lars Becker , Joseph W. Goodliffe , Molly Kalker , Madeline Barnes , Luke A. Shaheen , Meghan C. Drummond , Byung Yoon Choi

引用次数: 0