Genes & Diseases最新文献_第10页

GATA6 in pancreatic cancer initiation and progression GATA6 在胰腺癌发生和发展过程中的作用

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-17 DOI: 10.1016/j.gendis.2024.101353

Muyuan Ma, Jianhong An, Tingting Jiang, Keping Xie

{"title":"GATA6 in pancreatic cancer initiation and progression","authors":"Muyuan Ma, Jianhong An, Tingting Jiang, Keping Xie","doi":"10.1016/j.gendis.2024.101353","DOIUrl":"10.1016/j.gendis.2024.101353","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy characterized by insidious onset and lack of effective therapy. The molecular pathogenesis of PDA remains to be understood fully. Transcriptional factor GATA6 is an important transcriptional regulator in normal pancreas development, particularly in the initial specification and differentiation of the pancreas. Recent studies have linked pancreatic malignancy closely to GATA6. Increased levels of GATA6 expression enhance pancreatic cancer cell growth. GATA6 emerges as a lineage-specific oncogenic factor in PDA, augmenting the oncogenic phenotypes of PDA cells upon its overexpression. However, elevated GATA6 levels are correlated with well-differentiated tumors and a more favorable patient prognosis. Experimental evidence in genetic mouse models has revealed a tumor-suppressive role for GATA6. The circumstantial roles of GATA6 in pancreatic tumorigenesis remain to be defined. This review aims to elucidate recent advances in comprehending GATA6, emphasizing its crucial roles in both pancreas physiology and pathology. Special attention will be given to its involvement in PDA pathogenesis, exploring its potential as a novel biomarker and a promising therapeutic target for PDA.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101353"},"PeriodicalIF":6.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway HER3：揭开以前针对关键癌症生存途径的不成功疗法的曲折故事

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-06-17 DOI: 10.1016/j.gendis.2024.101354

Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang

{"title":"HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway","authors":"Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang","doi":"10.1016/j.gendis.2024.101354","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101354","url":null,"abstract":"HER3, formally referred to as ERB-B2 receptor tyrosine kinase 3, is a member of the ErbB receptor tyrosine kinases (also known as EGFR) family. HER3 plays a significant pro-cancer role in various types of cancer due to its overexpression and abnormal activation, which initiates downstream signaling pathways crucial in cancer cell survival and progression. As a result, numerous monoclonal antibodies have been developed to block HER3 activation and subsequent signaling pathways. While pre-clinical investigations have effectively showcased significant anti-cancer effects of HER3-targeted therapies, these therapies have had little impact on cancer patient outcomes in the clinic, except for patients with rare fusion mutations. This review offers a comprehensive description of the oncogenic functions of HER3, encompassing its structure and mediating signaling pathways. More importantly, it provides an in-depth exploration of past and ongoing clinical trials investigating HER3-targeted therapies for distinct types of cancer and discusses the tumor microenvironment and other critical determinants that may contribute to the observed suboptimal outcomes in most clinical studies using HER3-targeted therapies. Lastly, we suggest alternative approaches and the exploration of novel strategies to potentially improve the efficacy of targeting the pivotal oncogenic HER3 signaling pathway in future translational investigations.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"40 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis” [Genes & Diseases 10 (2023) 554–567] 更正件

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-15 DOI: 10.1016/j.gendis.2024.101352

引用次数: 0

Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes 褪黑素通过减轻内质网应激和软骨细胞凋亡改善 Slc26a2 相关软骨发育不良症

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-14 DOI: 10.1016/j.gendis.2024.101350

Pan Li , Chao Zheng , Jingyan Hu , Weiguang Lu , Dong Wang , Xue Hao , Chengxiang Zhao , Liu Yang , Zhuojing Luo , Qiang Jie

{"title":"Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes","authors":"Pan Li , Chao Zheng , Jingyan Hu , Weiguang Lu , Dong Wang , Xue Hao , Chengxiang Zhao , Liu Yang , Zhuojing Luo , Qiang Jie","doi":"10.1016/j.gendis.2024.101350","DOIUrl":"10.1016/j.gendis.2024.101350","url":null,"abstract":"<div><div>Although the pathogenesis and mechanism of congenital skeletal dysplasia are better understood, progress in drug development and intervention research remains limited. Here we report that melatonin treatment elicits a mitigating effect on skeletal abnormalities caused by <em>SLC26A2</em> deficiency. In addition to our previous finding of endoplasmic reticulum stress upon <em>SLC26A2</em> deficiency, we found calcium (Ca<sup>2+</sup>) overload jointly contributed to <em>SLC26A2</em>-associated chondrodysplasias. Continuous endoplasmic reticulum stress and cytosolic Ca<sup>2+</sup> overload in turn triggered apoptosis of growth plate chondrocytes. Melatonin, known for its anti-oxidant and anti-inflammatory properties, emerged as a promising therapeutic approach in our study, which enhanced survival, proliferation, and maturation of chondrocytes by attenuating endoplasmic reticulum stress and Ca<sup>2+</sup> overload. Our findings not only demonstrated the efficacy of melatonin in ameliorating abnormal function and cell fate of <em>SLC26A2</em>-deficient chondrocytes <em>in vitro</em> but also underscored its role in partially alleviating the skeletal dysplasia seen in <em>Col2a1-CreER</em><sup><em>T2</em></sup>; <em>Slc26a2</em><sup><em>fl/fl</em></sup> mice. As revealed by histology and micro-CT analyses, melatonin significantly improved retarded cartilage growth, defective trabecular bone formation, and tibial genu varum <em>in vivo</em>. Collectively, these data shed translational insights for drug development and support melatonin as a potential treatment for <em>SLC26A2</em>-related chondrodysplasias.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101350"},"PeriodicalIF":6.9,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141415883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration 免疫相关基因的交替剪接确定了具有不同免疫细胞浸润的乳腺癌亚型

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-14 DOI: 10.1016/j.gendis.2024.101349

Zhangxiang Zhao , Yuquan Wang , Zixin Jin , Huiming Han , Bo Chen , Mingyue Liu , Kaidong Liu , Shuping Zhuang , Haihai Liang , Yunyan Gu

引用次数: 0

Coding circular RNA in human cancer 人类癌症中的编码环状 RNA

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-14 DOI: 10.1016/j.gendis.2024.101347

Yuan Lin , Yawen Wang , Lixin Li, Kai Zhang

{"title":"Coding circular RNA in human cancer","authors":"Yuan Lin , Yawen Wang , Lixin Li, Kai Zhang","doi":"10.1016/j.gendis.2024.101347","DOIUrl":"10.1016/j.gendis.2024.101347","url":null,"abstract":"<div><div>circular RNA (circRNA) is a covalently closed single-stranded RNA that lacks 5' and 3' ends and has long been considered a noncoding RNA. With the development of high-throughput sequencing and bioinformatics technology, the understanding of circRNA has become increasingly advanced. Recent studies have shown that some cytoplasmic circRNAs can be effectively translated into detectable proteins, further indicating the importance of circRNA in cellular pathology and physiological functions. Internal ribosome entry site (IRES) and N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) mediated cap-independent translation initiation are considered potential mechanisms of circRNA translation. Multiple circRNAs have been shown to play crucial roles in human cancer. This paper provides an overview of the nature and functions of circRNA and describes the possible mechanisms underlying the initiation of circRNA translation. We summarized the emerging functions of circRNA-encoded proteins in human cancer. Finally, we discuss the therapeutic potential of circRNAs and the challenges of research in this field. This review on circRNA translation will reveal a hidden human proteome and enhance our understanding of the importance of circRNAs in human malignant tumors.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101347"},"PeriodicalIF":6.9,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141407423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene expression analysis in subcutaneous adipose tissue reveals a predominant influence of lncRNAs during growth 皮下脂肪组织的基因表达分析揭示了生长过程中 lncRNA 的主要影响因素

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-14 DOI: 10.1016/j.gendis.2024.101351

Federica Rey , Letizia Messa , Clarissa Berardo , Alessia Mauri , Gianvincenzo Zuccotti , Cristina Cereda , Stephana Carelli

引用次数: 0

Landscape of chimeric RNAs in COVID-19 patient blood COVID-19 患者血液中嵌合 RNA 的分布情况

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-06 DOI: 10.1016/j.gendis.2024.101348

Samuel Haddox , Ping Wu , Sandeep Singh , Fujun Qin , Jack Engel , Andrea Kian , Syed Ahmad , Hui Li , Peng Wu

{"title":"Landscape of chimeric RNAs in COVID-19 patient blood","authors":"Samuel Haddox , Ping Wu , Sandeep Singh , Fujun Qin , Jack Engel , Andrea Kian , Syed Ahmad , Hui Li , Peng Wu","doi":"10.1016/j.gendis.2024.101348","DOIUrl":"10.1016/j.gendis.2024.101348","url":null,"abstract":"<div><div>Despite the availability of efficacious vaccines, COVID-19 persists and our knowledge of how SARS-CoV-2 infection affects host transcriptomics remains incomplete. Transcriptome analysis, which has progressed our understanding of the patient response to SARS-CoV-2 infection, can be enhanced by considering chimeric transcript expression. Here we assess and characterize chimeric RNAs found in the whole blood of 178 COVID-19 patients. STAR-Fusion, SOAPfuse, and EricScript were used to detect chimeric RNAs resulting in over 30,000 predictions with approximately 500 high-confidence predictions that were found by more than one software and filtered based on exon annotations around the chimeric splice junction. GO term enrichment performed on the 5′ and 3′ parental genes of chimeric RNAs found in severe and critical patients resulted in pathways known to be affected in these patients, such as erythroid differentiation. Motif enrichment analysis of sequences proximal to chimeric splice junctions found in COVID-19 patients versus those found in GTEx whole blood revealed two RNA binding proteins previously implicated with coronavirus infection, PTBP1 and SFPQ. We discovered a chimeric RNA that correlated with COVID-19 disease status and appeared to be dependent upon a loss of PTBP1's function as a splicing repressor. Overall, we found over 350 novel COVID-19-specific chimeric RNAs not detectable in GTEx whole blood that may also serve as biomarkers for viral infection.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101348"},"PeriodicalIF":6.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141411817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-04 DOI: 10.1016/j.gendis.2024.101346

Jianghua Lin , Junbao Wang , Junmiao Zhao , Xinyi Wu , Leiyu Hao , Xiao Tan , Lixue Yang , Lei-Lei Wu , Yuyang Xia , Xiaoling Zhang , Kaijun Zhao , Yu'e Liu

引用次数: 0

Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells 泛素特异性蛋白酶在乳腺癌细胞程序性死亡中的作用

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-03 DOI: 10.1016/j.gendis.2024.101341

Wen Yan , Shasha Xiang , Jianbo Feng, Xuyu Zu

引用次数: 0