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Actin polymerization regulates the osteogenesis of hASCs by influencing α-tubulin expression and Eg5 activity 肌动蛋白聚合通过影响α-微管蛋白的表达和Eg5的活性调节hASCs的成骨过程
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-26 DOI: 10.1016/j.gendis.2024.101380
Tingyu Fan , Wenqing Liu , Rongmei Qu , Jinhui Zhu , Yulian Shi , Jiaxuan Liu , Xiangtian Li , Zhitao Zhou , Yunbing Chang , Jun Ouyang , Jingxing Dai
{"title":"Actin polymerization regulates the osteogenesis of hASCs by influencing α-tubulin expression and Eg5 activity","authors":"Tingyu Fan , Wenqing Liu , Rongmei Qu , Jinhui Zhu , Yulian Shi , Jiaxuan Liu , Xiangtian Li , Zhitao Zhou , Yunbing Chang , Jun Ouyang , Jingxing Dai","doi":"10.1016/j.gendis.2024.101380","DOIUrl":"10.1016/j.gendis.2024.101380","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101380"},"PeriodicalIF":6.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin 异亮氨酰-tRNA合成酶2通过稳定β-catenin促进胰腺导管腺癌的增殖和转移
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-24 DOI: 10.1016/j.gendis.2024.101382
Yixun Jin , Xinyang Huang , Zhuoxin Wang, Berik Kouken, Qi Wang, Lifu Wang
{"title":"Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin","authors":"Yixun Jin ,&nbsp;Xinyang Huang ,&nbsp;Zhuoxin Wang,&nbsp;Berik Kouken,&nbsp;Qi Wang,&nbsp;Lifu Wang","doi":"10.1016/j.gendis.2024.101382","DOIUrl":"10.1016/j.gendis.2024.101382","url":null,"abstract":"<div><div>Isoleucyl-tRNA synthetase 2 (IARS2), originally regarded as an enzyme ligating isoleucine to the corresponding tRNA, has been identified as an oncogene recently. However, its function in pancreatic ductal adenocarcinoma (PDAC) remains to be discovered. Here we explored the biological role of IARS2 in PDAC. Up-regulated IARS2 was found in PDAC tissues and cell lines. Kaplan–Meier survival analysis indicated a worse prognosis in patients with high IARS2 expression. CCK-8, EdU, and colony formation assays showed IARS2 overexpression enhanced PDAC proliferation, which was reduced by IARS2 knockdown. Meanwhile, IARS2 down-regulation inhibited PDAC metastasis by impeding epithelial–mesenchymal transition. These results were also supported by subcutaneous xenograft and metastasis assays <em>in vivo</em>. To figure out underlying mechanisms, differential and enrichment analyses were conducted and the WNT signaling pathway was discovered. Our results demonstrated that there was no significant relationship between the WNT signaling pathway key factor CTNNB1 and IARS2 at the transcription level. However, cycloheximide assays showed that IARS2 reduced the β-catenin degradation rate. IARS2 inhibited the phosphorylation of β-catenin at the Ser33/37 site and regulated downstream targets of WNT signaling including c-MYC, c-JUN, and MMP7. The enhancement of proliferation and metastasis caused by IARS2 could be reversed by MSAB, an agent that promotes β-catenin degradation. In summary, IARS2 facilitates PDAC proliferation and metastasis by stabilizing β-catenin, which leads to WNT/β-catenin activation. IARS2 serves as an underlying prognosis marker and a potential therapeutic target for PDAC.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101382"},"PeriodicalIF":6.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterozygous deletion of Cul4b in female mice leads to ovulatory dysfunction and female infertility 雌性小鼠杂合子缺失 Cul4b 会导致排卵功能障碍和雌性不孕症
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-24 DOI: 10.1016/j.gendis.2024.101381
Yufeng Wang , Yuting Liu , Wei Jiang , Yu Song , Yongxin Zou , Molin Wang , Qiao Liu , Gongping Sun , Yaoqin Gong , Baichun Jiang
{"title":"Heterozygous deletion of Cul4b in female mice leads to ovulatory dysfunction and female infertility","authors":"Yufeng Wang ,&nbsp;Yuting Liu ,&nbsp;Wei Jiang ,&nbsp;Yu Song ,&nbsp;Yongxin Zou ,&nbsp;Molin Wang ,&nbsp;Qiao Liu ,&nbsp;Gongping Sun ,&nbsp;Yaoqin Gong ,&nbsp;Baichun Jiang","doi":"10.1016/j.gendis.2024.101381","DOIUrl":"10.1016/j.gendis.2024.101381","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 1","pages":"Article 101381"},"PeriodicalIF":6.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters 载脂蛋白 L1 风险等位基因加速高脂饮食诱导的 LDLR-/- 仓鼠动脉粥样硬化
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-23 DOI: 10.1016/j.gendis.2024.101379
Yitong Xu , Wenxi Zhang , Jiabao Guo , Jinxuan Chen , Guolin Miao , Lianxin Zhang , Yufei Han , Jingxuan Chen , Ying Zhao , Xunde Xian
{"title":"ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters","authors":"Yitong Xu ,&nbsp;Wenxi Zhang ,&nbsp;Jiabao Guo ,&nbsp;Jinxuan Chen ,&nbsp;Guolin Miao ,&nbsp;Lianxin Zhang ,&nbsp;Yufei Han ,&nbsp;Jingxuan Chen ,&nbsp;Ying Zhao ,&nbsp;Xunde Xian","doi":"10.1016/j.gendis.2024.101379","DOIUrl":"10.1016/j.gendis.2024.101379","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101379"},"PeriodicalIF":6.9,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive oxygen species mediate ovarian cancer development, platinum resistance, and angiogenesis via CXCL8 and GSK-3β/p70S6K1 axis 活性氧通过 CXCL8 和 GSK-3β/p70S6K1 轴介导卵巢癌的发展、铂类抗性和血管生成
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-17 DOI: 10.1016/j.gendis.2024.101378
Jiange Qiu , Qing Xu , Tahira Panah , A K M Helal Morshed , Xue Wang , Fengmei Zhou , Wenjing Liu , Jufeng Wang , Ye Zhang , Bingjie Liu , Bing-Hua Jiang
{"title":"Reactive oxygen species mediate ovarian cancer development, platinum resistance, and angiogenesis via CXCL8 and GSK-3β/p70S6K1 axis","authors":"Jiange Qiu ,&nbsp;Qing Xu ,&nbsp;Tahira Panah ,&nbsp;A K M Helal Morshed ,&nbsp;Xue Wang ,&nbsp;Fengmei Zhou ,&nbsp;Wenjing Liu ,&nbsp;Jufeng Wang ,&nbsp;Ye Zhang ,&nbsp;Bingjie Liu ,&nbsp;Bing-Hua Jiang","doi":"10.1016/j.gendis.2024.101378","DOIUrl":"10.1016/j.gendis.2024.101378","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101378"},"PeriodicalIF":6.9,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrative analysis of the metabolomes and transcriptomes of Ebola virus-infected cells: Uncovering pathways related to hepatic apoptosis 埃博拉病毒感染细胞代谢组和转录组的综合分析：揭示与肝细胞凋亡相关的途径
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-16 DOI: 10.1016/j.gendis.2024.101377
Chenchen Liu , Zengguo Cao , Cheng Peng , Fangxu Li , Zixi Chen , Xinghai Zhang , Xiaoying Jia , Jinge Zhou , Wenting Mao , Entao Li , Gengfu Xiao , Sandra Chiu
{"title":"Integrative analysis of the metabolomes and transcriptomes of Ebola virus-infected cells: Uncovering pathways related to hepatic apoptosis","authors":"Chenchen Liu ,&nbsp;Zengguo Cao ,&nbsp;Cheng Peng ,&nbsp;Fangxu Li ,&nbsp;Zixi Chen ,&nbsp;Xinghai Zhang ,&nbsp;Xiaoying Jia ,&nbsp;Jinge Zhou ,&nbsp;Wenting Mao ,&nbsp;Entao Li ,&nbsp;Gengfu Xiao ,&nbsp;Sandra Chiu","doi":"10.1016/j.gendis.2024.101377","DOIUrl":"10.1016/j.gendis.2024.101377","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101377"},"PeriodicalIF":6.9,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid metabolism involved in progression and drug resistance of breast cancer 乳腺癌进展和耐药性与脂质代谢有关
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-15 DOI: 10.1016/j.gendis.2024.101376
Wenxiang Fu , Aijun Sun , Huijuan Dai
{"title":"Lipid metabolism involved in progression and drug resistance of breast cancer","authors":"Wenxiang Fu ,&nbsp;Aijun Sun ,&nbsp;Huijuan Dai","doi":"10.1016/j.gendis.2024.101376","DOIUrl":"10.1016/j.gendis.2024.101376","url":null,"abstract":"<div><div>Breast cancer is the most common malignant tumor threatening women's health. Alteration in lipid metabolism plays an important role in the occurrence and development of many diseases, including breast cancer. The uptake, synthesis, and catabolism of lipids in breast cancer cells are significantly altered, among which the metabolism of fatty acids, cholesterols, sphingolipids, and glycolipids are most significantly changed. The growth, progression, metastasis, and drug resistance of breast cancer cells are tightly correlated with the increased uptake and biosynthesis of fatty acids and cholesterols and the up-regulation of fatty acid oxidation. Cholesterol and its metabolite 27-hydroxycholesterol promote the progression of breast cancer in a variety of ways. The alteration of lipid metabolism could promote the epithelial–mesenchymal transition of breast cancer cells and lead to changes in the tumor immune microenvironment that are conducive to the survival of cancer cells. While the accumulation of ceramide in cancer cells shows an inhibitory effect on breast cancer. This review focuses on lipid metabolism and elaborates on the research progress of the correlation between different lipid metabolism and the growth, progression, and drug resistance of breast cancer.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101376"},"PeriodicalIF":6.9,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel homozygous intronic variant affecting splicing in the RYR1 gene contributes to fetal hydrops 影响 RYR1 基因剪接的新型同卵内含子变异导致胎儿肾积水
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-14 DOI: 10.1016/j.gendis.2024.101375
Wei Hou , Guifang Huang , Hongyu Wei , Wenwei Li , Houfeng Huang , Yuling Qiu , Hengying Zhu , Huifeng Han , Ping Chen , Xue Zhang
{"title":"A novel homozygous intronic variant affecting splicing in the RYR1 gene contributes to fetal hydrops","authors":"Wei Hou ,&nbsp;Guifang Huang ,&nbsp;Hongyu Wei ,&nbsp;Wenwei Li ,&nbsp;Houfeng Huang ,&nbsp;Yuling Qiu ,&nbsp;Hengying Zhu ,&nbsp;Huifeng Han ,&nbsp;Ping Chen ,&nbsp;Xue Zhang","doi":"10.1016/j.gendis.2024.101375","DOIUrl":"10.1016/j.gendis.2024.101375","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101375"},"PeriodicalIF":6.9,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001727/pdfft?md5=cdf11e4954ffcdbe2575704ac5252ecc&pid=1-s2.0-S2352304224001727-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences between lung adenocarcinoma and lung squamous cell carcinoma: Driver genes, therapeutic targets, and clinical efficacy 肺腺癌和肺鳞癌的区别：驱动基因、治疗目标和临床疗效
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-11 DOI: 10.1016/j.gendis.2024.101374
Yue Shen , Jie-Qi Chen , Xiang-Ping Li
{"title":"Differences between lung adenocarcinoma and lung squamous cell carcinoma: Driver genes, therapeutic targets, and clinical efficacy","authors":"Yue Shen ,&nbsp;Jie-Qi Chen ,&nbsp;Xiang-Ping Li","doi":"10.1016/j.gendis.2024.101374","DOIUrl":"10.1016/j.gendis.2024.101374","url":null,"abstract":"<div><div>With the rapid advancements in second-generation gene sequencing technologies, a growing number of driver genes and associated therapeutic targets have been unveiled for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). While they are clinically classified as non-small cell lung cancer (NSCLC), they display distinct genomic features and substantial variations in clinical efficacy, underscoring the need for particular attention. Hence, this review provides a comprehensive overview of the latest advancements in driver genes, epigenetic targets, chemotherapy, targeted therapy, and immunotherapy for LUAD and LUSC. Additionally, it delves into the distinctions in signaling pathways and pivotal facets of clinical management specific to these two categories of lung cancer. Moreover, we furnish pertinent details regarding clinical trials pertaining to driver genes and epigenetics, thus establishing a theoretical foundation for the realization of precision treatments for LUAD and LUSC.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101374"},"PeriodicalIF":6.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of synonymous mutations in m6A modification sites in human cancers 人类癌症中 m6A 修饰位点同义突变的发生率
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-07-06 DOI: 10.1016/j.gendis.2024.101373
{"title":"Prevalence of synonymous mutations in m6A modification sites in human cancers","authors":"","doi":"10.1016/j.gendis.2024.101373","DOIUrl":"10.1016/j.gendis.2024.101373","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 1","pages":"Article 101373"},"PeriodicalIF":6.9,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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