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Anoikis-related gene signature associates with the immune infiltration and predicts the prognosis of glioma patients 免疫相关基因特征与免疫浸润有关，可预测胶质瘤患者的预后
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-04 DOI: 10.1016/j.gendis.2024.101346
Jianghua Lin , Junbao Wang , Junmiao Zhao , Xinyi Wu , Leiyu Hao , Xiao Tan , Lixue Yang , Lei-Lei Wu , Yuyang Xia , Xiaoling Zhang , Kaijun Zhao , Yu'e Liu
{"title":"Anoikis-related gene signature associates with the immune infiltration and predicts the prognosis of glioma patients","authors":"Jianghua Lin , Junbao Wang , Junmiao Zhao , Xinyi Wu , Leiyu Hao , Xiao Tan , Lixue Yang , Lei-Lei Wu , Yuyang Xia , Xiaoling Zhang , Kaijun Zhao , Yu'e Liu","doi":"10.1016/j.gendis.2024.101346","DOIUrl":"10.1016/j.gendis.2024.101346","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101346"},"PeriodicalIF":6.9,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells 泛素特异性蛋白酶在乳腺癌细胞程序性死亡中的作用
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-03 DOI: 10.1016/j.gendis.2024.101341
Wen Yan , Shasha Xiang , Jianbo Feng, Xuyu Zu
{"title":"Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells","authors":"Wen Yan ,&nbsp;Shasha Xiang ,&nbsp;Jianbo Feng,&nbsp;Xuyu Zu","doi":"10.1016/j.gendis.2024.101341","DOIUrl":"10.1016/j.gendis.2024.101341","url":null,"abstract":"<div><div>Breast cancer (BC) is the most common malignant tumor and the leading cause of cancer-related deaths among women worldwide. Great progress has been recently achieved in controlling breast cancer; however, mortality from breast cancer remains a substantial challenge, and new treatment mechanisms are being actively sought. Programmed cell death (PCD) is associated with the progression and treatment of many types of human cancers. PCD can be divided into multiple pathways including autophagy, apoptosis, mitotic catastrophe, necroptosis, ferroptosis, pyroptosis, and anoikis. Ubiquitination is a post-translational modification process in which ubiquitin, a 76-amino acid protein, is coupled to the lysine residues of other proteins. Ubiquitination is involved in many physiological events and promotes cancer development and progression. This review elaborates the role of ubiquitin-specific protease (USP) in programmed cell death, which is common in breast cancer cells, and lays the foundation for tumor diagnosis and targeted therapy.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101341"},"PeriodicalIF":6.9,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy 突变单核苷酸多态性 rs198389 和去甲基化促进扩张型心肌病所致心力衰竭中钠尿肽 B 基因的转录
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-31 DOI: 10.1016/j.gendis.2024.101345
Yulong Li , Mingzhi Shen , Ting Yang , Shui Yu , Jianyuan Yin , Leiming Luo , Yali Zhao , Ping Ping , Shihui Fu
{"title":"Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy","authors":"Yulong Li ,&nbsp;Mingzhi Shen ,&nbsp;Ting Yang ,&nbsp;Shui Yu ,&nbsp;Jianyuan Yin ,&nbsp;Leiming Luo ,&nbsp;Yali Zhao ,&nbsp;Ping Ping ,&nbsp;Shihui Fu","doi":"10.1016/j.gendis.2024.101345","DOIUrl":"10.1016/j.gendis.2024.101345","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101345"},"PeriodicalIF":6.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus GAPDH 可抑制腺病毒诱导的氧化应激，实现重组腺病毒的超快速生产
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-31 DOI: 10.1016/j.gendis.2024.101344
{"title":"GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus","authors":"","doi":"10.1016/j.gendis.2024.101344","DOIUrl":"10.1016/j.gendis.2024.101344","url":null,"abstract":"<div><p>Recombinant adenovirus (rAdV) is a commonly used vector system for gene transfer. Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive, possibly attributable to rAdV infection-associated oxidative stress and reactive oxygen species (ROS) production. Here, we show that exogenous GAPDH expression mitigates adenovirus-induced ROS-associated apoptosis in HEK293 cells, and expedites adenovirus production. By stably overexpressing GAPDH in HEK293 (293G) and 293pTP (293GP) cells, respectively, we demonstrated that rAdV-induced ROS production and cell apoptosis were significantly suppressed in 293G and 293GP cells. Transfection of 293G cells with adenoviral plasmid pAd-G2Luc yielded much higher titers of Ad-G2Luc at day 7 than that in HEK293 cells. Similarly, Ad-G2Luc was amplified more efficiently in 293G than in HEK293 cells. We further showed that transfection of 293GP cells with pAd-G2Luc produced much higher titers of Ad-G2Luc at day 5 than that of 293pTP cells. 293GP cells amplified the Ad-G2Luc much more efficiently than 293pTP cells, indicating that exogenous GAPDH can further augment pTP-enhanced adenovirus production. These results demonstrate that exogenous GAPDH can effectively suppress adenovirus-induced ROS and thus accelerate adenovirus production. Therefore, the engineered 293GP cells represent a superfast rAdV production system for adenovirus-based gene transfer and gene therapy.</p></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101344"},"PeriodicalIF":6.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001417/pdfft?md5=206897c8fce371b15f69ce30294d43f2&pid=1-s2.0-S2352304224001417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases 小非编码 RNA 在心血管疾病发病机制中的意义
IF 6.8 2区 医学
Genes & Diseases Pub Date : 2024-05-30 DOI: 10.1016/j.gendis.2024.101342
Hemanyun Bai, Fanji Meng, Kangling Ke, Lingyan Fang, Weize Xu, Haitao Huang, Xiao Liang, Weiyan Li, Fengya Zeng, Can Chen
{"title":"The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases","authors":"Hemanyun Bai, Fanji Meng, Kangling Ke, Lingyan Fang, Weize Xu, Haitao Huang, Xiao Liang, Weiyan Li, Fengya Zeng, Can Chen","doi":"10.1016/j.gendis.2024.101342","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101342","url":null,"abstract":"With the advancement of high-throughput sequencing and bioinformatics, an increasing number of overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived fragments (tsRNAs), PIWI-interacting RNAs (piRNAs), Ro-associated non-coding RNAs (RNYs or Y-RNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs). Each of these RNA types possesses distinct biological properties and plays specific roles in both physiological and pathological processes. The differential expression of sncRNAs substantially affects the occurrence and progression of various systemic diseases. However, their roles in the cardiovascular system remain unclear. Therefore, understanding the functionality and mechanisms of sncRNAs in the cardiovascular system holds promise for identifying novel targets and strategies for the diagnosis, prevention, and treatment of cardiovascular diseases. This review examines the biological characteristics of sncRNAs and their potential roles in cardiovascular diseases.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"4 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets 结直肠癌中的 SPP1+ 巨噬细胞：恶性肿瘤标志物和有希望的治疗靶点
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-30 DOI: 10.1016/j.gendis.2024.101340
Zhenyu Xie , Gaozan Zheng , Liaoran Niu , Kunli Du , Ruikai Li , Hanjun Dan , Lili Duan , Hongze Wu , Guangming Ren , Xinyu Dou , Songchen Dai , Fan Feng , Jian Zhang , Jianyong Zheng
{"title":"SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets","authors":"Zhenyu Xie ,&nbsp;Gaozan Zheng ,&nbsp;Liaoran Niu ,&nbsp;Kunli Du ,&nbsp;Ruikai Li ,&nbsp;Hanjun Dan ,&nbsp;Lili Duan ,&nbsp;Hongze Wu ,&nbsp;Guangming Ren ,&nbsp;Xinyu Dou ,&nbsp;Songchen Dai ,&nbsp;Fan Feng ,&nbsp;Jian Zhang ,&nbsp;Jianyong Zheng","doi":"10.1016/j.gendis.2024.101340","DOIUrl":"10.1016/j.gendis.2024.101340","url":null,"abstract":"<div><div><em>SPP1<sup>+</sup></em> macrophages have been identified as key players in the colorectal cancer (CRC) tumor microenvironment, but their function remains unclear. This study integrated single-cell and spatial transcriptomics with bulk sequencing to investigate the roles and mechanisms of <em>SPP1</em><sup>+</sup> macrophages in CRC. Our findings revealed a pronounced elevation of <em>SPP1</em><sup>+</sup> macrophages in CRC, especially within tumor territories. These macrophages served as markers for CRC initiation, progression, metastasis, and potential prognosis. Furthermore, they showed heightened transcriptional activity in genes linked to angiogenesis, epithelial–mesenchymal transition, glycolysis, hypoxia, and immunosuppression. <em>SPP1</em> protein amplified CRC cell migration and invasion, potentially mediating cellular crosstalk via the <em>SPP1-CD44</em>, <em>SPP1-PTGER4</em>, and <em>SPP1-a4b1</em> complex axes. Patients with a high proportion of <em>SPP1</em><sup>+</sup> macrophages could benefit more from immune checkpoint blockade therapy. Interestingly, <em>CSF1R</em> expression was significantly enriched in <em>C1QC</em><sup>+</sup> macrophages versus <em>SPP1</em><sup>+</sup> macrophages, possibly explaining limited anti-CSF1R monotherapy effects. In conclusion, we propose an <em>SPP1</em><sup>+</sup> macrophage model in CRC, highlighting such macrophages as a promising therapeutic target due to their malignancy markers.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101340"},"PeriodicalIF":6.9,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy 人羊膜上皮细胞通过介导 PAK1/AMPK 依赖性自噬减轻脂肪肝的缺血再灌注损伤
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-29 DOI: 10.1016/j.gendis.2024.101343
Xun Qiu , Hanzhi Xu , Yawen Tan , Jinying Li , Zhoucheng Wang , Zhengxing Lian , Xuyong Wei , Luyang Yu , Kai Wang , Xiao Xu
{"title":"Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy","authors":"Xun Qiu ,&nbsp;Hanzhi Xu ,&nbsp;Yawen Tan ,&nbsp;Jinying Li ,&nbsp;Zhoucheng Wang ,&nbsp;Zhengxing Lian ,&nbsp;Xuyong Wei ,&nbsp;Luyang Yu ,&nbsp;Kai Wang ,&nbsp;Xiao Xu","doi":"10.1016/j.gendis.2024.101343","DOIUrl":"10.1016/j.gendis.2024.101343","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101343"},"PeriodicalIF":6.9,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma 构建并验证用于预测肺腺癌预后、肿瘤免疫微环境和治疗敏感性的新型 SUMOylation 相关 lncRNAs 标志
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-28 DOI: 10.1016/j.gendis.2024.101338
Jie Cai , Weizhong Ruan , Zida Wang , Gongzhe Liu , Bei Yang , Hao Wang , Deping Zhao , Chang Chen , Xiaogang Zhao
{"title":"Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma","authors":"Jie Cai ,&nbsp;Weizhong Ruan ,&nbsp;Zida Wang ,&nbsp;Gongzhe Liu ,&nbsp;Bei Yang ,&nbsp;Hao Wang ,&nbsp;Deping Zhao ,&nbsp;Chang Chen ,&nbsp;Xiaogang Zhao","doi":"10.1016/j.gendis.2024.101338","DOIUrl":"10.1016/j.gendis.2024.101338","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101338"},"PeriodicalIF":6.9,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel nested gene Aff3ir participates in vascular remodeling by enhancing endothelial cell differentiation in mice 新型嵌套基因 Aff3ir 通过增强小鼠内皮细胞分化参与血管重塑
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-27 DOI: 10.1016/j.gendis.2024.101339
Yue Zhao , Mazdak Ehteramyan , Yi Li , Xuefeng Bai , Lei Huang , Yingtang Gao , Angshumonik Angbohang , Xiaoping Yang , Steven Lynham , Andriana Margariti , Ajay M. Shah , Yaling Tao , Ting Cai , Tong Li , Min Zhang , Lingfang Zeng
{"title":"A novel nested gene Aff3ir participates in vascular remodeling by enhancing endothelial cell differentiation in mice","authors":"Yue Zhao ,&nbsp;Mazdak Ehteramyan ,&nbsp;Yi Li ,&nbsp;Xuefeng Bai ,&nbsp;Lei Huang ,&nbsp;Yingtang Gao ,&nbsp;Angshumonik Angbohang ,&nbsp;Xiaoping Yang ,&nbsp;Steven Lynham ,&nbsp;Andriana Margariti ,&nbsp;Ajay M. Shah ,&nbsp;Yaling Tao ,&nbsp;Ting Cai ,&nbsp;Tong Li ,&nbsp;Min Zhang ,&nbsp;Lingfang Zeng","doi":"10.1016/j.gendis.2024.101339","DOIUrl":"10.1016/j.gendis.2024.101339","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101339"},"PeriodicalIF":6.9,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions 面部浸润性脂肪瘤伴颅内病变中同时存在的 PIK3CA 和 IDH1 变体
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-05-22 DOI: 10.1016/j.gendis.2024.101324
Hongrui Chen , Bin Sun , Lizhen Wang , Lei Chang , Zhang Yu , Wei Gao , Yajing Qiu , Hui Chen , Chen Hua , Xiaoxi Lin
{"title":"Concurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions","authors":"Hongrui Chen ,&nbsp;Bin Sun ,&nbsp;Lizhen Wang ,&nbsp;Lei Chang ,&nbsp;Zhang Yu ,&nbsp;Wei Gao ,&nbsp;Yajing Qiu ,&nbsp;Hui Chen ,&nbsp;Chen Hua ,&nbsp;Xiaoxi Lin","doi":"10.1016/j.gendis.2024.101324","DOIUrl":"10.1016/j.gendis.2024.101324","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101324"},"PeriodicalIF":6.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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