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Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications 生理和疾病中的转录因子 ELF4：分子作用和临床意义
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-23 DOI: 10.1016/j.gendis.2024.101394
Dian Hu , Zerui Zhang , Yijun Wang , Siwen Li , Jiaqian Zhang , Zhangfan Wu , Mengyu Sun , Junqing Jiang , Danfei Liu , Xiaoyu Ji , Shuai Wang , Yufei Wang , Xiangyuan Luo , Wenjie Huang , Limin Xia
{"title":"Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications","authors":"Dian Hu ,&nbsp;Zerui Zhang ,&nbsp;Yijun Wang ,&nbsp;Siwen Li ,&nbsp;Jiaqian Zhang ,&nbsp;Zhangfan Wu ,&nbsp;Mengyu Sun ,&nbsp;Junqing Jiang ,&nbsp;Danfei Liu ,&nbsp;Xiaoyu Ji ,&nbsp;Shuai Wang ,&nbsp;Yufei Wang ,&nbsp;Xiangyuan Luo ,&nbsp;Wenjie Huang ,&nbsp;Limin Xia","doi":"10.1016/j.gendis.2024.101394","DOIUrl":"10.1016/j.gendis.2024.101394","url":null,"abstract":"<div><div>Transcription factor E74 like ETS transcription factor 4 (ELF4), a member of the ETS family, is highly expressed in normal human hematopoietic tissue, ovary, placenta, colon, and certain pathological cell lines. During normal physiological processes, ELF4 regulates differentiation in osteogenic, adipocyte, and neuronal types. It also exerts a critical impact on the development of the immune system. However, its function is dysregulated through posttranslational modifications, gene fusions, and complex signaling crosstalk under pathological conditions. Furthermore, serving as a double-edged sword in cancer, ELF4 exhibits both tumor-suppressing and tumor-promoting effects. Specifically, ELF4 plays a critical role in cancer metastasis, proliferation, and modulation of the tumor microenvironment. This review provides an in-depth overview of the molecular structure and post-translational modifications of ELF4. It also summarizes the hallmarks of ELF4 in physiology and diseases, with a particular focus on its significance in oncology. Notably, this review underscores the potential of ELF4 as a prognostic biomarker, highlighting its clinical relevance. Finally, it discusses unresolved questions and future research directions of ELF4. An in-depth understanding of ELF4 biology could facilitate its clinical translation and offer promising targeted therapeutic strategies.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101394"},"PeriodicalIF":6.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CARM1 accelerates the growth of liver cancer cells by enhancing ARAF CARM1 通过增强 ARAF 加速肝癌细胞的生长
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-23 DOI: 10.1016/j.gendis.2024.101395
Xiaoxue Jiang , Libo Xing , Yi Lu , Rushi Qin , Liyan Wang , Shuting Song , Xinlei Liu , Sijie Xie , Shujie Li , Dongdong Lu
{"title":"CARM1 accelerates the growth of liver cancer cells by enhancing ARAF","authors":"Xiaoxue Jiang ,&nbsp;Libo Xing ,&nbsp;Yi Lu ,&nbsp;Rushi Qin ,&nbsp;Liyan Wang ,&nbsp;Shuting Song ,&nbsp;Xinlei Liu ,&nbsp;Sijie Xie ,&nbsp;Shujie Li ,&nbsp;Dongdong Lu","doi":"10.1016/j.gendis.2024.101395","DOIUrl":"10.1016/j.gendis.2024.101395","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 1","pages":"Article 101395"},"PeriodicalIF":6.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERα expression in triple-negative breast cancer 通过诱导三阴性乳腺癌中ERα的表达，TMEM132E消融可抑制肿瘤进展并恢复他莫昔芬的敏感性
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-23 DOI: 10.1016/j.gendis.2024.101396
Shang Gao , Ping Sun , Zekun Wang , Yecheng Jin , Wenjie Sun , Xi Li , Ruonan Duan , Jiangxia Li , Qiji Liu
{"title":"TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERα expression in triple-negative breast cancer","authors":"Shang Gao ,&nbsp;Ping Sun ,&nbsp;Zekun Wang ,&nbsp;Yecheng Jin ,&nbsp;Wenjie Sun ,&nbsp;Xi Li ,&nbsp;Ruonan Duan ,&nbsp;Jiangxia Li ,&nbsp;Qiji Liu","doi":"10.1016/j.gendis.2024.101396","DOIUrl":"10.1016/j.gendis.2024.101396","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101396"},"PeriodicalIF":6.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling 克隆造血通过 PTX3/IL-1β 促炎信号调节结肠炎和白血病的协同进展
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-23 DOI: 10.1016/j.gendis.2024.101397
Hang He , Yuchen Wen , Qingran Huo , Hanzhi Yu , Jingjing Liu , Wenyan Jin , Zhiqin Wang , Huaquan Wang , Zhigang Zhao , Zhigang Cai
{"title":"Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling","authors":"Hang He ,&nbsp;Yuchen Wen ,&nbsp;Qingran Huo ,&nbsp;Hanzhi Yu ,&nbsp;Jingjing Liu ,&nbsp;Wenyan Jin ,&nbsp;Zhiqin Wang ,&nbsp;Huaquan Wang ,&nbsp;Zhigang Zhao ,&nbsp;Zhigang Cai","doi":"10.1016/j.gendis.2024.101397","DOIUrl":"10.1016/j.gendis.2024.101397","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101397"},"PeriodicalIF":6.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The MTMR11 variants identified in a short stature cohort compromise the dephosphorylation ability of MTM1 on SMAD5 to up-regulate BMP signaling 在矮身材人群中发现的 MTMR11 变异损害了 MTM1 在 SMAD5 上的去磷酸化能力，从而影响了 BMP 信号的上调
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-21 DOI: 10.1016/j.gendis.2024.101393
Kai Yang , Hongdou Li , Rui Peng , Bo Wu , Yiping Shen , Tongjin Zhao , Chentao Li , Weimin Wang , Hongyan Wang
{"title":"The MTMR11 variants identified in a short stature cohort compromise the dephosphorylation ability of MTM1 on SMAD5 to up-regulate BMP signaling","authors":"Kai Yang ,&nbsp;Hongdou Li ,&nbsp;Rui Peng ,&nbsp;Bo Wu ,&nbsp;Yiping Shen ,&nbsp;Tongjin Zhao ,&nbsp;Chentao Li ,&nbsp;Weimin Wang ,&nbsp;Hongyan Wang","doi":"10.1016/j.gendis.2024.101393","DOIUrl":"10.1016/j.gendis.2024.101393","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101393"},"PeriodicalIF":6.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to ‘CRISPR/Cas9 system and its applications in nervous system diseases’ [Genes & Diseases 11 (2024) 675–686] CRISPR/Cas9 系统及其在神经系统疾病中的应用"[《基因与疾病》11 (2024) 675-686] 更正
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-19 DOI: 10.1016/j.gendis.2024.101392
Haibin Jiang , Mengyan Tang , Zidi Xu , Yanan Wang , Mopu Li , Shuyin Zheng , Jianghu Zhu , Zhenlang Lin , Min Zhang
{"title":"Corrigendum to ‘CRISPR/Cas9 system and its applications in nervous system diseases’ [Genes & Diseases 11 (2024) 675–686]","authors":"Haibin Jiang ,&nbsp;Mengyan Tang ,&nbsp;Zidi Xu ,&nbsp;Yanan Wang ,&nbsp;Mopu Li ,&nbsp;Shuyin Zheng ,&nbsp;Jianghu Zhu ,&nbsp;Zhenlang Lin ,&nbsp;Min Zhang","doi":"10.1016/j.gendis.2024.101392","DOIUrl":"10.1016/j.gendis.2024.101392","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101392"},"PeriodicalIF":6.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001892/pdfft?md5=c910765c36207473a3c635a7466d2401&pid=1-s2.0-S2352304224001892-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of a prognostic model based on the cuproptosis-related genes in pancreatic cancer 基于胰腺癌杯突相关基因构建预后模型
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-14 DOI: 10.1016/j.gendis.2024.101391
Kaili Liao , Yuxin Fu , Shuman Guo , Tingyi Qian , Feifei Teng , Yuhan Xu , Bing Sun , Hanqing Zhao , Jingyan Zhang , Ranhao Fan , Jie Gao , Xiaozhong Wang
{"title":"Construction of a prognostic model based on the cuproptosis-related genes in pancreatic cancer","authors":"Kaili Liao ,&nbsp;Yuxin Fu ,&nbsp;Shuman Guo ,&nbsp;Tingyi Qian ,&nbsp;Feifei Teng ,&nbsp;Yuhan Xu ,&nbsp;Bing Sun ,&nbsp;Hanqing Zhao ,&nbsp;Jingyan Zhang ,&nbsp;Ranhao Fan ,&nbsp;Jie Gao ,&nbsp;Xiaozhong Wang","doi":"10.1016/j.gendis.2024.101391","DOIUrl":"10.1016/j.gendis.2024.101391","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101391"},"PeriodicalIF":6.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel mutation in KDR is associated with retinal venous beading and cerebral cavernous malformation KDR 的新型突变与视网膜静脉串珠和脑海绵畸形有关
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-13 DOI: 10.1016/j.gendis.2024.101390
Xiaonan Zhuang , Yuqiao Ju , Gezhi Xu , Xin Huang
{"title":"A novel mutation in KDR is associated with retinal venous beading and cerebral cavernous malformation","authors":"Xiaonan Zhuang ,&nbsp;Yuqiao Ju ,&nbsp;Gezhi Xu ,&nbsp;Xin Huang","doi":"10.1016/j.gendis.2024.101390","DOIUrl":"10.1016/j.gendis.2024.101390","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101390"},"PeriodicalIF":6.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinically relevant variants detected in Chinese children with global developmental delay/intellectual disability: An exome-wide sequencing study 在患有全球发育迟缓/智力障碍的中国儿童中检测到的临床相关变异：全外显子组测序研究
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-09 DOI: 10.1016/j.gendis.2024.101389
Yimeng Qiao , Nan Lv , Tongchuan Li , Ye Cheng , Yunqian Li , Jiqiang Dong , Meimei Han , Yang Gu , Qing Shang , Qinghe Xing
{"title":"Clinically relevant variants detected in Chinese children with global developmental delay/intellectual disability: An exome-wide sequencing study","authors":"Yimeng Qiao ,&nbsp;Nan Lv ,&nbsp;Tongchuan Li ,&nbsp;Ye Cheng ,&nbsp;Yunqian Li ,&nbsp;Jiqiang Dong ,&nbsp;Meimei Han ,&nbsp;Yang Gu ,&nbsp;Qing Shang ,&nbsp;Qinghe Xing","doi":"10.1016/j.gendis.2024.101389","DOIUrl":"10.1016/j.gendis.2024.101389","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101389"},"PeriodicalIF":6.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization 纤维支架上装载了来源于 BMSC 的凋亡囊泡，可通过诱导巨噬细胞极化促进伤口愈合
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-08-09 DOI: 10.1016/j.gendis.2024.101388
Xudong Su , Jianye Yang , Zhenghao Xu , Li Wei , Shuhao Yang , Feilong Li , Min Sun , Yingkun Hu , Wenge He , Chen Zhao , Li Chen , Yonghua Yuan , Leilei Qin , Ning Hu
{"title":"Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization","authors":"Xudong Su ,&nbsp;Jianye Yang ,&nbsp;Zhenghao Xu ,&nbsp;Li Wei ,&nbsp;Shuhao Yang ,&nbsp;Feilong Li ,&nbsp;Min Sun ,&nbsp;Yingkun Hu ,&nbsp;Wenge He ,&nbsp;Chen Zhao ,&nbsp;Li Chen ,&nbsp;Yonghua Yuan ,&nbsp;Leilei Qin ,&nbsp;Ning Hu","doi":"10.1016/j.gendis.2024.101388","DOIUrl":"10.1016/j.gendis.2024.101388","url":null,"abstract":"<div><div>Macrophages play a key role in wound healing. Dysfunction of their M0 polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation, which affects wound healing. Regulating the polarization of M0 macrophages to M2 macrophages is an effective strategy for treating wound healing. Mesenchymal stem cells (MSCs) deliver endogenous regulatory factors via paracrine extracellular vesicles, which may play a key role in wound healing, and previous studies have shown that apoptotic bodies (ABs) are closely associated with inflammation regression and macrophage polarization. However, the specific regulatory mechanisms involved in ABs remain unknown. In the present study, we designed an MSC-AB (MSC-derived AB)-loaded polycaprolactone (PCL) scaffold, evaluated the macrophage phenotype and skin wound inflammation <em>in vivo</em> and <em>in vitro</em>, and explored the ability of MSC-AB-loaded PCL scaffolds to promote wound healing. Our data suggest that the PCL scaffold regulates the expression of the CCL-1 gene by targeting the delivery of mmu-miR-21a-5p by local sustained-release MSC-ABs, and drives M0 macrophages to program M2 macrophages to regulate inflammation and angiogenesis, thereby synergistically promoting wound healing. This study provides a promising therapeutic strategy and experimental basis for treating various diseases associated with imbalances in proinflammatory and anti-inflammatory immune responses.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101388"},"PeriodicalIF":6.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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