Genes & Diseases最新文献_第9页

Epidermal second-hit mutation in MVK gene associated with linear porokeratosis 与线性角化病有关的 MVK 基因表皮二次突变

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-04-29 DOI: 10.1016/j.gendis.2024.101314

引用次数: 0

BBOX1, LACC1, MMP7 and SSTR1 as common predictors in obesity and non-alcoholic fatty liver disease BBOX1、LACC1、MMP7 和 SSTR1 是肥胖和非酒精性脂肪肝的共同预测因子

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-04-24 DOI: 10.1016/j.gendis.2024.101310

Chaoyuan Huang , Guoming Chen , Dongqiang Luo , Jiyuan Zheng , Nan Zhong , Danyun Li , Yang Luo , Peizhen Huang , Ning Wang , Yibin Feng , Yiyuan Zheng

引用次数: 0

ZIP4 inhibits Ephrin-B1 ubiquitination, activating Wnt5A/JNK/ZEB1 to promote liver cancer metastasis ZIP4 抑制 Ephrin-B1 泛素化，激活 Wnt5A/JNK/ZEB1 促进肝癌转移

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-04-24 DOI: 10.1016/j.gendis.2024.101312

Haijun Guo , Renyi Su , Xinfeng Lu , Hui Zhang , Xuyong Wei , Xiao Xu

引用次数: 0

Rare dentin defects: Understanding the pathophysiological mechanisms of COLXVA1 mutations 罕见的牙本质缺陷：了解 COLXVA1 基因突变的病理生理机制

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-04-20 DOI: 10.1016/j.gendis.2024.101303

Isaac Maximiliano Bugueno , Tristan Rey , Alexandra Jimenez-Armijo , Marzena Kawczynski , Naji Kharouf , Marie-Cécile Manière , Yann Herault , Agnès Bloch-Zupan , Virginie Haushalter-Laugel

引用次数: 0

Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment 精神和神经疾病中的维生素 D 结合蛋白：对诊断和治疗的影响

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-04-15 DOI: 10.1016/j.gendis.2024.101309

Ling Li , Bing Han , Yan Kong , Gaojia Zhang , Zhijun Zhang

{"title":"Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment","authors":"Ling Li , Bing Han , Yan Kong , Gaojia Zhang , Zhijun Zhang","doi":"10.1016/j.gendis.2024.101309","DOIUrl":"10.1016/j.gendis.2024.101309","url":null,"abstract":"<div><p>Vitamin D binding protein (VDBP) serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target organs. VDBP plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin degradation. Recent research has shed light on its potential role in various diseases, leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological disorders. The purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric disorders. By examining the intricate interplay between VDBP and these disorders, this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic avenues. Insights gained from the study of VDBP could pave the way for novel strategies in the diagnosis, prognosis, and treatment of psychiatric and neurological disorders.</p></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 5","pages":"Article 101309"},"PeriodicalIF":6.8,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001065/pdfft?md5=959d52b7b2ecc6dabca840639ce07d70&pid=1-s2.0-S2352304224001065-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling the cell diversity and tissue structure of aqueous humor circulatory system in human eyes using spatial single-cell RNA sequencing 利用空间单细胞 RNA 测序分析人眼眼房水循环系统的细胞多样性和组织结构

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-04-12 DOI: 10.1016/j.gendis.2024.101304

引用次数: 0

The crosstalk between non-coding RNAs and oxidative stress in cancer progression 非编码 RNA 与氧化应激在癌症进展中的相互影响

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-04-10 DOI: 10.1016/j.gendis.2024.101286

Qiqi Sun, Xiaoyong Lei, Xiaoyan Yang

引用次数: 0

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress 新型口服化合物 Z526 通过干预 NF-κB 信号传导和氧化应激减轻癌症相关恶病质

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-04-08 DOI: 10.1016/j.gendis.2024.101292

Xiaofan Gu, Shanshan Lu, Shuang Xu, Yiwei Li, Meng Fan, Guangyu Lin, Yiyuan Liu, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhang

{"title":"Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress","authors":"Xiaofan Gu, Shanshan Lu, Shuang Xu, Yiwei Li, Meng Fan, Guangyu Lin, Yiyuan Liu, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhang","doi":"10.1016/j.gendis.2024.101292","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101292","url":null,"abstract":"Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-κB signaling and oxidative stress play vital roles in both muscle atrophy and fat loss in CAC. Here, we showed that our developed oral compound Z526 exhibited potent anti-CAC efficacy by inhibiting NF-κB signaling and ameliorating oxidative stress. , Z526 alleviated C2C12 myotube atrophy and 3T3-L1 adipocyte lipolysis induced by conditioned mediums of multiple cachectic tumor cells or pro-cachectic inflammatory cytokines. , Z526 attenuated the cachectic symptoms of C26 or LLC tumor-bearing mice. Z526 treatment reduced weight loss without impacting tumor growth and improved muscle atrophy, fat loss, and impaired grip force. Besides, serum TNF-α and IL-6 levels were reduced after Z526 treatment in C26 tumor-bearing mice. Of note, Z526 significantly prolonged the survival of LLC tumor-bearing mice. Activated NF-κB signaling and oxidative stress in cachectic muscle and fat tissues were reversed by Z526. Furthermore, Z526 exhibited a promising preclinical safety profile. Thus, oral Z526, which exhibited potent anti-CAC activities and , multiple interventions in diverse pathogenic mechanisms (NF-κB signaling and oxidative stress), and a favorable preclinical safety profile, holds the promise to be developed into a novel and beneficial therapeutic option for CAC.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"7 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140582610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma 葡萄糖代谢紊乱通过 LINC01139 通路影响肿瘤微环境，促进肝细胞癌的免疫疗法

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-04-08 DOI: 10.1016/j.gendis.2024.101302

Yueying Gao , Jinyang Yu , Zhi Li , Kefan Liu , Jiwei Pan , Ya Zhang , Yanlin Ma , Jiwei Zhang , Zhigang Liu , Yongsheng Li

引用次数: 0

Novel heterozygous missense variants in the TOE1 gene linked to pontocerebellar hypoplasia type 7 与浮小脑发育不全 7 型有关的 TOE1 基因新杂合错义变体

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-04-08 DOI: 10.1016/j.gendis.2024.101290

引用次数: 0