Genes & Diseases最新文献_第8页

The role of RNA binding proteins in cancer biology: A focus on FMRP RNA结合蛋白在癌症生物学中的作用：聚焦于FMRP

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-21 DOI: 10.1016/j.gendis.2024.101493

Yunlu Jia , Ruyin Jia , Yongxia Chen , Xuanyi Lin , Nadire Aishan , Han li , Linbo Wang , Xiaochen Zhang , Jian Ruan

{"title":"The role of RNA binding proteins in cancer biology: A focus on FMRP","authors":"Yunlu Jia , Ruyin Jia , Yongxia Chen , Xuanyi Lin , Nadire Aishan , Han li , Linbo Wang , Xiaochen Zhang , Jian Ruan","doi":"10.1016/j.gendis.2024.101493","DOIUrl":"10.1016/j.gendis.2024.101493","url":null,"abstract":"<div><div>RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such as RNA splicing, transport, localization, stability, and translation through their specific binding to RNA molecules. The diversity and complexity of RBPs are particularly significant in cancer biology, as they directly impact a multitude of RNA metabolic events closely associated with tumor initiation and progression. The fragile X mental retardation protein (FMRP), as a member of the RBP family, is central to the neurodevelopmental disorder fragile X syndrome and increasingly recognized in the modulation of cancer biology through its influence on RNA metabolism. The protein's versatility, stemming from its diverse RNA-binding domains, enables it to govern a wide array of transcript processing events. Modifications in FMRP's expression or localization have been associated with the regulation of mRNAs linked to various processes pertinent to cancer, including tumor proliferation, metastasis, epithelial–mesenchymal transition, cellular senescence, chemotherapy/radiotherapy resistance, and immunotherapy evasion. In this review, we emphasize recent findings and analyses that suggest contrasting functions of this protein family in tumorigenesis. Our knowledge of the proteins that are regulated by FMRP is rapidly growing, and this has led to the identification of multiple targets for therapeutic intervention of cancer, some of which have already moved into clinical trials or clinical practice.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101493"},"PeriodicalIF":6.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging roles for fatty acid oxidation in cancer 脂肪酸氧化在癌症中的新作用

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-20 DOI: 10.1016/j.gendis.2024.101491

Jialin Ma , Shuxian Wang , Pingfeng Zhang , Sihao Zheng , Xiangpan Li , Juanjuan Li , Huadong Pei

引用次数: 0

The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer 衰老过程及相关因子EMP1在促进可切除胰腺癌进展中的作用

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-15 DOI: 10.1016/j.gendis.2024.101490

Junfeng Zhang , Jianyou Gu , Tao Zhang , Renpei Xia , Jianbo Li , Mingda Tan , Yongjun Yang , Jifeng Xiang , Bin Xie , Rong Tang , Wangge Li , Xianxing Wang , Shixiang Guo , Huaizhi Wang

{"title":"The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer","authors":"Junfeng Zhang , Jianyou Gu , Tao Zhang , Renpei Xia , Jianbo Li , Mingda Tan , Yongjun Yang , Jifeng Xiang , Bin Xie , Rong Tang , Wangge Li , Xianxing Wang , Shixiang Guo , Huaizhi Wang","doi":"10.1016/j.gendis.2024.101490","DOIUrl":"10.1016/j.gendis.2024.101490","url":null,"abstract":"<div><div>Pancreatic cancer (PC) is a highly malignant neoplasm of the digestive system. The primary objective of this investigation is to elucidate the intricate mechanisms underlying the role of the aging process and the related factor Epithelial membrane protein 1 (EMP1) in PC progression. We established a prognostic model pertinent to the aging process that could be applied in postoperative PC patients. <em>In vitro</em> assays were employed to elucidate the impact of <em>EMP1</em> on PC cell function. We employed lentiviral vectors for both knockdown and overexpression of <em>EMP1</em> in Panc02 cells, followed by the establishment of subcutaneous, pulmonary metastasis, and orthotopic pancreatic liver metastasis models in mice. Using tissue microarrays, we evaluated the expression of <em>EMP1</em> and its downstream entities, and then conducted clinical correlation analysis. A predictive Age-Related Score (ARS) system based on age-associated prognostic genes was developed, offering precise prognostic predictions for postoperative PC patients, which could be applied well at the single-cell level, showing diverse aging, epithelial–mesenchymal transition (EMT), cell migration, cell proliferation, and <em>PI3K/AKT</em> signaling activity in high and low ARS risk cells. <em>EMP1</em> was identified as a pivotal molecule in the ARS system and is associated with poor prognosis. Besides, <em>EMP1</em> could enhance the proliferation, migration, and invasion of PC cells both <em>in vitro</em> and <em>in vivo</em> by augmenting the <em>PI3K/AKT</em> signaling cascade. In essence, this research formulated an aging-centric prognostic model for postoperative PC and pinpointed <em>EMP1</em> as an oncogenic factor facilitating tumor cell EMT during the aging trajectory in resectable PC patients.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101490"},"PeriodicalIF":6.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-17 signaling pathway in SPP1+ macrophages drives digestive tract cancer progression SPP1+巨噬细胞IL-17信号通路驱动消化道肿瘤进展

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-14 DOI: 10.1016/j.gendis.2024.101489

Yihong Wei , Ying Xu , Yanqiong Zeng , Amin Zhang , Xiangling Xing , Wancheng Liu

引用次数: 0

RNA-seq identifies Amd1 as a regulator of hepatocyte proliferation via Skp2 during liver development and hepatocellular carcinoma progression in zebrafish RNA-seq鉴定出Amd1在斑马鱼肝脏发育和肝细胞癌进展过程中通过Skp2调控肝细胞增殖

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-11 DOI: 10.1016/j.gendis.2024.101486

Ke Zhang , Botong Li , Zhiling Deng , Yong Dong , Yuanyuan Li , Bingyu Chen , Mao Lu , Liyan Wang , Xingdong Liu , Zhenhua Guo , Sizhou Huang

引用次数: 0

SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma SLC27A5在肝细胞癌中通过诱导METTL14的选择性多腺苷化抑制肿瘤干细胞

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-10 DOI: 10.1016/j.gendis.2024.101488

Xin Tang , Junji Tao , Yuanyuan Liu , Deao Gong , Xuefeng Shan , Kai Wang , Ni Tang

{"title":"SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma","authors":"Xin Tang , Junji Tao , Yuanyuan Liu , Deao Gong , Xuefeng Shan , Kai Wang , Ni Tang","doi":"10.1016/j.gendis.2024.101488","DOIUrl":"10.1016/j.gendis.2024.101488","url":null,"abstract":"<div><div>Solute carrier family 27 member 5 (SLC27A5/FATP5) is a liver-specific metabolic enzyme that plays a crucial role in fatty acid transport and bile acid metabolism. Deficiency of SLC27A5 promotes the progression of hepatocellular carcinoma (HCC) and is strongly associated with a poor prognosis. SLC27A5 exhibits noncanonical functions beyond its metabolic role; however, its specific mechanisms in hepatocarcinogenesis remain elusive and are therefore investigated in this study. Immunoprecipitation-mass spectrometry analysis showed that SLC27A5-interacting proteins were significantly enriched in alternative polyadenylation (APA). RNA-sequencing data provided evidence that SLC27A5 plays a global role in regulating APA events in HCC. Mechanistically, SLC27A5 facilitates the usage of the proximal polyadenylation site of <em>METTL14</em> by downregulating the expression of the APA-associated factor PABPC1, resulting in the shortening of the <em>METTL14</em>-3′UTR and the conversion of <em>METTL14</em>-UL to <em>METTL14</em>-US. In contrast to <em>METTL14</em>-UL, <em>METTL14</em>-US escapes the inhibitory effect of miRNA targeting, leading to increased METTL14 expression. <em>METTL14</em>-US upregulation by SLC27A5 suppressed the stemness of HCC. Therefore, low levels of SLC27A5 and METTL14 may serve as reliable biomarkers for identifying poor prognosis in patients with HCC. In conclusion, SLC27A5/PABPC1 inhibits HCC stemness via APA-regulated expression of METTL14, providing potential avenues for the development of novel therapeutic strategies.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101488"},"PeriodicalIF":6.9,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allele-specific methylation of the PSA promoter in prostate cells: A new translational marker for the differential diagnosis of prostate cancer 前列腺细胞中PSA启动子的等位基因特异性甲基化：前列腺癌鉴别诊断的一个新的翻译标记

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-09 DOI: 10.1016/j.gendis.2024.101487

Mikhail Baryshev, Irina Maksimova, Ilona Sasoveca

引用次数: 0

Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling engriled -1失活通过细胞外基质重塑导致无疤痕皮肤伤口愈合

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-09 DOI: 10.1016/j.gendis.2024.101484

Ailing Hao , Xiangyu Dong , Yannian Gou , Aohua Li , Jiajia Li , Han Xiang , Saidur Rahaman , Yi Zhu , Hui Zhang , Wulin You , Guowei Shen , Changqi Luo , Ou Mei , Xingye Wu , Lewis L. Shi , Russell R. Reid , Tong-Chuan He , Jiaming Fan

引用次数: 0

Epigenetic modulation of thyroid cancer metastasis and glycolysis through circSSU72-mediated ubiquitination of gamma-catenin and beta-catenin signaling 通过环cssu72介导的γ -连环蛋白和β -连环蛋白信号泛素化对甲状腺癌转移和糖酵解的表观遗传调节

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-07 DOI: 10.1016/j.gendis.2024.101485

Zeyu Zhang , Duntao Su , Xiangyuan Qiu , Lei Yao , Fada Xia , Xinying Li

引用次数: 0

Deciphering the roles of neddylation modification in hepatocellular carcinoma: Molecular mechanisms and targeted therapeutics 解读类化修饰在肝细胞癌中的作用：分子机制和靶向治疗

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-12-06 DOI: 10.1016/j.gendis.2024.101483

Wenxin Wu , Xuanyi Wang , Ruijie Ma , Shuhong Huang , Hongguang Li , Xinxing Lyu

{"title":"Deciphering the roles of neddylation modification in hepatocellular carcinoma: Molecular mechanisms and targeted therapeutics","authors":"Wenxin Wu , Xuanyi Wang , Ruijie Ma , Shuhong Huang , Hongguang Li , Xinxing Lyu","doi":"10.1016/j.gendis.2024.101483","DOIUrl":"10.1016/j.gendis.2024.101483","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is the most prevalent type of malignant liver tumor with high morbidity and mortality and severely threatens human health and life quality. Thus, it is of great significance to investigate the molecular mechanism underlying the pathogenesis of HCC and seek biomarkers for early diagnosis. Neddylation, one of the most conserved post-translational modification types in eukaryotes, plays vital roles in the progression of HCC. During the process of neddylation, NEDD8 is covalently conjugated to its substrate proteins, thereby modulating multiple necessary biological processes. Currently, increasing evidence shows that the aberrant activation of neddylation is positively correlated with the occurrence and development of tumors and the poor clinical prognosis of HCC patients. Based on the current investigations, neddylation modification has been reported to target both the cullins and non-cullin substrates and subsequently affect HCC progression, including the virus infection, malignant transformation, tumor cell proliferation, migration and invasion ability, and tumor microenvironment. Therefore, inhibitors targeting the neddylation cascade have been developed and entered clinical trials, indicating satisfactory anti-HCC treatment effects. This review aims to summarize the latest progress in the molecular mechanism of pathologically aberrant neddylation in HCC, as well as the advances of neddylation-targeted inhibitors as potential drugs for HCC treatment.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101483"},"PeriodicalIF":6.9,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0