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DARG: An integrated knowledge base for analyzing addictive drug-related genes DARG：分析成瘾药物相关基因的综合知识库
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-28 DOI: 10.1016/j.gendis.2024.101369
Xu Wang, Bei Yun, Zihan Zhang, Xiaoxi Wang, Yifan Wu, Yubo Hu, Shiyi Fang, Junjie Lv, Lina Chen, Wan Li
{"title":"DARG: An integrated knowledge base for analyzing addictive drug-related genes","authors":"Xu Wang, Bei Yun, Zihan Zhang, Xiaoxi Wang, Yifan Wu, Yubo Hu, Shiyi Fang, Junjie Lv, Lina Chen, Wan Li","doi":"10.1016/j.gendis.2024.101369","DOIUrl":"10.1016/j.gendis.2024.101369","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101369"},"PeriodicalIF":6.9,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SIK2 promotes malignant features of human osteosarcoma via up-regulating MMP2 and β-catenin expression SIK2 通过上调 MMP2 和 β-catenin 的表达促进人类骨肉瘤的恶性特征
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-26 DOI: 10.1016/j.gendis.2024.101325
Yutong Wang , Yulan Yao , Sen Kou , Shanshan Wang , Juntao Song , Siqi Yang , Hongwei Wang , Yunliang Wang
{"title":"SIK2 promotes malignant features of human osteosarcoma via up-regulating MMP2 and β-catenin expression","authors":"Yutong Wang , Yulan Yao , Sen Kou , Shanshan Wang , Juntao Song , Siqi Yang , Hongwei Wang , Yunliang Wang","doi":"10.1016/j.gendis.2024.101325","DOIUrl":"10.1016/j.gendis.2024.101325","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101325"},"PeriodicalIF":6.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia 视黄酸通路抑制诱导的 HOXB6 下调导致小耳症软骨细胞增殖抑制和凋亡
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-25 DOI: 10.1016/j.gendis.2024.101367
Run Yang , Xin Chen , Siyi Wu , Chenlong Li , Ying Chen , Yaoyao Fu , Aijuan He , Duan Ma , Jing Ma , Tianyu Zhang
{"title":"HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia","authors":"Run Yang , Xin Chen , Siyi Wu , Chenlong Li , Ying Chen , Yaoyao Fu , Aijuan He , Duan Ma , Jing Ma , Tianyu Zhang","doi":"10.1016/j.gendis.2024.101367","DOIUrl":"10.1016/j.gendis.2024.101367","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101367"},"PeriodicalIF":6.9,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein citrullination in gene transcription regulation and physiological implications 蛋白瓜氨酸化在基因转录调控中的作用及其生理意义
IF 6.8 2区 医学
Genes & Diseases Pub Date : 2024-06-22 DOI: 10.1016/j.gendis.2024.101355
Xiaoya Zhang, Guiqiu Xie, Lang Rao, Chaoguang Tian
{"title":"Protein citrullination in gene transcription regulation and physiological implications","authors":"Xiaoya Zhang, Guiqiu Xie, Lang Rao, Chaoguang Tian","doi":"10.1016/j.gendis.2024.101355","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101355","url":null,"abstract":"Protein citrullination involves the deimination of arginine or methylarginine residues in peptide chains to form citrulline by peptidyl arginine deiminases. This process is an important protein post-translational modification that affects molecular structure and function of various proteins, including histones. In recent years, protein citrullination has attracted widespread attention for its influence on gene transcription. Studies on the impact of protein citrullination modification on chromatin structure remodeling and the establishment of gene regulatory networks have made rapid progress. In this review, we briefly summarize the physiological functions of protein citrullination modification. Specifically, we comprehensively outline the latest progress in the study of the role of protein citrullination modification in gene transcription regulation, focusing on the interaction of protein citrullination with other post-translational modifications.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"24 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma: A novel gene fusion model report and mechanism research EWSR1-PSMC5融合基因在骨肉瘤耐药性中不同程度地激活自噬作用：新型基因融合模型报告及机制研究
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-21 DOI: 10.1016/j.gendis.2024.101358
Qing Pan , Wenbo Yang , Fuhua Huang , Wei Wu, Zengwu Shao, Zhicai Zhang
{"title":"EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma: A novel gene fusion model report and mechanism research","authors":"Qing Pan , Wenbo Yang , Fuhua Huang , Wei Wu, Zengwu Shao, Zhicai Zhang","doi":"10.1016/j.gendis.2024.101358","DOIUrl":"10.1016/j.gendis.2024.101358","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101358"},"PeriodicalIF":6.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells Shikonin 是一种新型前列腺素 E2 受体 4 拮抗剂，可靶向髓源性抑制细胞
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-20 DOI: 10.1016/j.gendis.2024.101356
Yang Wang , Naijipu Abuduaini , Wenjuan Liu , Yuanjun Song , Zunping Ke , Xilong Wang , Wei Jiao , Si Chen , Xianhua Lin , Weiwei Yu , Weiqiang Lu , Bo Feng , Jiacheng He
{"title":"Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells","authors":"Yang Wang , Naijipu Abuduaini , Wenjuan Liu , Yuanjun Song , Zunping Ke , Xilong Wang , Wei Jiao , Si Chen , Xianhua Lin , Weiwei Yu , Weiqiang Lu , Bo Feng , Jiacheng He","doi":"10.1016/j.gendis.2024.101356","DOIUrl":"10.1016/j.gendis.2024.101356","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101356"},"PeriodicalIF":6.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting MUC1 with fisetin in oral squamous cell carcinoma 用菲赛汀靶向治疗口腔鳞状细胞癌中的 MUC1
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-20 DOI: 10.1016/j.gendis.2024.101357
Qian Wang , Hongyan Zhang , Shuzhen Xiang , Lan Zhang , Jiajia Fan , Zengyan Xu , Fengfei Zhao , Minda Liu , Yanshu Li , Wei Dai
{"title":"Targeting MUC1 with fisetin in oral squamous cell carcinoma","authors":"Qian Wang , Hongyan Zhang , Shuzhen Xiang , Lan Zhang , Jiajia Fan , Zengyan Xu , Fengfei Zhao , Minda Liu , Yanshu Li , Wei Dai","doi":"10.1016/j.gendis.2024.101357","DOIUrl":"10.1016/j.gendis.2024.101357","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101357"},"PeriodicalIF":6.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GATA6 in pancreatic cancer initiation and progression GATA6 在胰腺癌发生和发展过程中的作用
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-17 DOI: 10.1016/j.gendis.2024.101353
Muyuan Ma, Jianhong An, Tingting Jiang, Keping Xie
{"title":"GATA6 in pancreatic cancer initiation and progression","authors":"Muyuan Ma,&nbsp;Jianhong An,&nbsp;Tingting Jiang,&nbsp;Keping Xie","doi":"10.1016/j.gendis.2024.101353","DOIUrl":"10.1016/j.gendis.2024.101353","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy characterized by insidious onset and lack of effective therapy. The molecular pathogenesis of PDA remains to be understood fully. Transcriptional factor GATA6 is an important transcriptional regulator in normal pancreas development, particularly in the initial specification and differentiation of the pancreas. Recent studies have linked pancreatic malignancy closely to GATA6. Increased levels of GATA6 expression enhance pancreatic cancer cell growth. GATA6 emerges as a lineage-specific oncogenic factor in PDA, augmenting the oncogenic phenotypes of PDA cells upon its overexpression. However, elevated GATA6 levels are correlated with well-differentiated tumors and a more favorable patient prognosis. Experimental evidence in genetic mouse models has revealed a tumor-suppressive role for GATA6. The circumstantial roles of GATA6 in pancreatic tumorigenesis remain to be defined. This review aims to elucidate recent advances in comprehending GATA6, emphasizing its crucial roles in both pancreas physiology and pathology. Special attention will be given to its involvement in PDA pathogenesis, exploring its potential as a novel biomarker and a promising therapeutic target for PDA.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101353"},"PeriodicalIF":6.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway HER3：揭开以前针对关键癌症生存途径的不成功疗法的曲折故事
IF 6.8 2区 医学
Genes & Diseases Pub Date : 2024-06-17 DOI: 10.1016/j.gendis.2024.101354
Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang
{"title":"HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway","authors":"Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang","doi":"10.1016/j.gendis.2024.101354","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101354","url":null,"abstract":"HER3, formally referred to as ERB-B2 receptor tyrosine kinase 3, is a member of the ErbB receptor tyrosine kinases (also known as EGFR) family. HER3 plays a significant pro-cancer role in various types of cancer due to its overexpression and abnormal activation, which initiates downstream signaling pathways crucial in cancer cell survival and progression. As a result, numerous monoclonal antibodies have been developed to block HER3 activation and subsequent signaling pathways. While pre-clinical investigations have effectively showcased significant anti-cancer effects of HER3-targeted therapies, these therapies have had little impact on cancer patient outcomes in the clinic, except for patients with rare fusion mutations. This review offers a comprehensive description of the oncogenic functions of HER3, encompassing its structure and mediating signaling pathways. More importantly, it provides an in-depth exploration of past and ongoing clinical trials investigating HER3-targeted therapies for distinct types of cancer and discusses the tumor microenvironment and other critical determinants that may contribute to the observed suboptimal outcomes in most clinical studies using HER3-targeted therapies. Lastly, we suggest alternative approaches and the exploration of novel strategies to potentially improve the efficacy of targeting the pivotal oncogenic HER3 signaling pathway in future translational investigations.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"40 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis” [Genes & Diseases 10 (2023) 554–567] 更正件
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-06-15 DOI: 10.1016/j.gendis.2024.101352
{"title":"Corrigendum to “N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis” [Genes & Diseases 10 (2023) 554–567]","authors":"","doi":"10.1016/j.gendis.2024.101352","DOIUrl":"10.1016/j.gendis.2024.101352","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101352"},"PeriodicalIF":6.9,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001491/pdfft?md5=7a0848e82ed067f8cf13392e2f4d5fe4&pid=1-s2.0-S2352304224001491-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141407913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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