Genes & Diseases最新文献

{"title":"METTL16 in cancer: Roles and regulatory mechanisms","authors":"Kangjie Qiu ,&nbsp;Shuxin Zhong ,&nbsp;Jinyi Liu ,&nbsp;Weini Li ,&nbsp;Cunte Chen ,&nbsp;Yangqiu Li ,&nbsp;Chengwu Zeng","doi":"10.1016/j.gendis.2025.101758","DOIUrl":"10.1016/j.gendis.2025.101758","url":null,"abstract":"<div><div>The regulation of gene expression is pivotal in cancer development, with increasing emphasis on epigenetic modifications such as RNA methylation. N6-methyladenosine (m⁶A), the most abundant RNA modification, critically impacts RNA function and stability. METTL16, an m⁶A methyltransferase or “writer”, is essential in this modification process. Aberrant expression of METTL16 is closely linked to cancer cell proliferation, invasion, metastasis, and drug resistance, through modulation of RNA metabolism. Despite extensive research on RNA-modifying enzymes, the specific mechanisms and roles of METTL16 in cancer remain poorly understood. This review provides a detailed examination of METTL16's functions and regulatory mechanisms in cancer, emphasizing its m⁶A-dependent and m⁶A-independent roles in regulating RNA stability and function. Furthermore, it proposes that targeting METTL16 represents a promising avenue for cancer therapy.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101758"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"m6A modification erased by ALKBH5 promotes tumor growth and metastasis via regulation of YAP/ZEB1 axis in NSCLC","authors":"Dan Jin ,&nbsp;Weihua Di ,&nbsp;Rui Li ,&nbsp;Shuang Shao ,&nbsp;Jiwei Guo","doi":"10.1016/j.gendis.2025.101768","DOIUrl":"10.1016/j.gendis.2025.101768","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101768"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The differences in molecular profiles and survival outcomes between early-onset and late-onset glioblastoma multiforme","authors":"Yukui Wei ,&nbsp;Xiaolong Wu ,&nbsp;Hua Bao ,&nbsp;Yao Xiao ,&nbsp;Huantong Diao ,&nbsp;Siheng Liu ,&nbsp;Bingyang Shan ,&nbsp;Peng Ding ,&nbsp;Ye Cheng ,&nbsp;Xinru Xiao","doi":"10.1016/j.gendis.2025.101638","DOIUrl":"10.1016/j.gendis.2025.101638","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101638"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DUSP6 inhibitor (E/Z)-BCI hydrochloride stimulates glucose clearance and adipose lipolysis in diet-induced obese mice","authors":"Xiaohua Huang ,&nbsp;Wei Lu ,&nbsp;Dandan Jiang ,&nbsp;Zhengfeng Fang ,&nbsp;Bin Feng","doi":"10.1016/j.gendis.2025.101671","DOIUrl":"10.1016/j.gendis.2025.101671","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101671"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4+ resident macrophages","authors":"Dingyuan Tian ,&nbsp;Yingzi Pan ,&nbsp;Xiaoyue Lai ,&nbsp;Xinyu Bao ,&nbsp;Pan Zheng ,&nbsp;Yan Tan ,&nbsp;Chun Liu ,&nbsp;Ziyang Wang ,&nbsp;Qingyuan Yang ,&nbsp;Yang Liu ,&nbsp;Xiaoqin Wan ,&nbsp;Zhihui Zhang ,&nbsp;Fang Deng","doi":"10.1016/j.gendis.2025.101867","DOIUrl":"10.1016/j.gendis.2025.101867","url":null,"abstract":"<div><div>Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily implemented intervention, has previously been reported to exert cardioprotective effects by improving myocardial ischemia. However, whether intense light provides protective benefits against RV remodeling and the underlying mechanisms remain largely unexplored. In this study, we established mouse models exhibiting RV remodeling and dysfunction through long-term hypoxia to investigate the protective effects of intense light. Echocardiography, hemodynamic parameters measurements, and Fulton index assessments were employed to evaluate RV dysfunction and remodeling. Additionally, single-nuclei RNA sequencing, immunohistochemistry, immunofluorescence, and western blotting analyses were conducted to identify targeted genes in macrophage-associated inflammation within the heart. The results indicate that intense light significantly alleviates hypoxia-induced RV remodeling and dysfunction in mice. Intense light may mediate macrophage-associated inflammation through differentially expressed genes, including PF4, as well as the quantity of macrophages in the right ventricles (RVes). Resident macrophages (Res_Macro) demonstrate cardioprotective effects when intense light is applied, which mitigates RV remodeling. Our findings also suggest that PF4 expression and the presence of PF4⁺ resident macrophages (Res_PF4⁺_Macro) are linked to the attenuation of RV remodeling by intense light. Macrophage PF4 expression and the quantity of PF4⁺ macrophages in the RVes are closely associated with the levels of RV remodeling and dysfunction. This study unveils a novel noninvasive approach for the prevention of RV remodeling and dysfunction induced by hypoxia, and indicates that Res_PF4⁺_Macro and PF4 expression could be potential intervening targets.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101867"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fra2, a potential therapeutic target for silicosis","authors":"Yuanmeng Qi ,&nbsp;Jiarui Xia ,&nbsp;Xuesong Zhang ,&nbsp;Xiaoying Li ,&nbsp;Qimeng Li ,&nbsp;Zhenzhen Yang ,&nbsp;Wu Yao ,&nbsp;Changfu Hao ,&nbsp;Youliang Zhao","doi":"10.1016/j.gendis.2025.101723","DOIUrl":"10.1016/j.gendis.2025.101723","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101723"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering HSV-1 for oncolytic therapy: From molecular entry mechanisms to retargeting strategies","authors":"Yufang Zou ,&nbsp;Juan Tao ,&nbsp;Yingzheng Gao ,&nbsp;Jixuan Wang ,&nbsp;Pengfei Wang ,&nbsp;Jingyuan Yan ,&nbsp;Zuqing Nie ,&nbsp;Dewei Jiang ,&nbsp;Xinwei Huang","doi":"10.1016/j.gendis.2025.101797","DOIUrl":"10.1016/j.gendis.2025.101797","url":null,"abstract":"<div><div>Oncolytic viruses (OVs) represent a cutting-edge approach to cancer immunotherapy, characterized by their ability to selectively infect and eliminate tumor cells while sparing healthy tissues. Among the diverse OVs, type 1 herpes simplex virus (HSV-1) stands out due to its robust oncolytic activity, genetic malleability, broad cell tropism, and well-documented clinical safety. Advances in genetic engineering have further amplified the therapeutic efficacy of HSV-1 by enhancing tumor specificity, replication efficiency, and immunogenicity. Clinically significant HSV-1-based oncolytic viruses, such as T-VEC and G47Δ, have gained regulatory approvals for treating melanoma and malignant glioma, respectively, highlighting their transformative potential in cancer therapy. The attenuation strategies employed in most oncolytic HSV-1 (oHSV-1) strains, while ensuring safety, often reduce viral replication and cytotoxicity. To address this limitation, retargeting strategies focusing on HSV-1 glycoproteins (gD, gH/gL, and gB) have been developed. These modifications aim to abolish canonical receptor interactions and achieve tumor-specific targeting through ligand-receptor binding. Recent breakthroughs in understanding HSV entry mechanisms have enabled the creation of fully retargeted HSV vectors with enhanced specificity and efficacy. This review explores the molecular mechanisms underlying HSV glycoprotein-mediated cell entry, examines recent advances in receptor-retargeted oHSV-1 engineering, and discusses the challenges and future directions in the development of oncolytic HSV-based therapies.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101797"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges","authors":"Hanzheng Zhao ,&nbsp;Wentao Fu ,&nbsp;Xiaobao Yang ,&nbsp;Wenhui Zhang ,&nbsp;Si Wu ,&nbsp;Jingxin Ma ,&nbsp;Tianzhen Zhang ,&nbsp;Hongwei Yao ,&nbsp;Zhongtao Zhang","doi":"10.1016/j.gendis.2025.101742","DOIUrl":"10.1016/j.gendis.2025.101742","url":null,"abstract":"<div><div>Vitamin C, also known as ascorbic acid, has sparked controversy since it first emerged as a potential anti-cancer agent. However, an increasing number of preclinical studies have demonstrated that high-dose vitamin C exhibits selective anti-tumor effects, including “pro-oxidative cytotoxicity”, “anti-cancer epigenetic regulation”, and “immune modulation”. Consequently, vitamin C has reemerged as a promising anti-cancer therapy in the form of high-dose administration. Advancements in pharmacokinetic research have facilitated the development of clinical trials. Early clinical studies across various cancer types have confirmed the safety of high-dose vitamin C administered via intravenous injection. Moreover, its use as an adjuvant therapy in combination with standard treatments, such as chemotherapy and radiotherapy, has shown promising therapeutic potential. However, there remains a lack of consensus regarding optimal dosage, administration methods, tumor specificity, and patient selection. These factors have contributed to the inconsistent outcomes observed in phase II clinical trials and have hindered the widespread conduct of phase III trials. Without robust clinical evidence, high-dose vitamin C, despite being a non-toxic and promising anti-cancer agent, risks being “shelved” once again. In this review, we provide a comprehensive overview of the anti-tumor mechanisms of high-dose vitamin C and a detailed analysis of preclinical and clinical studies investigating its role as an anti-cancer agent. Additionally, we explore emerging trends in high-dose vitamin C therapy for cancer treatment and offer recommendations for future research in this field.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101742"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum-resistant ovarian cancer: From mechanisms to treatment strategies","authors":"He Li ,&nbsp;Jia-Jia Sheng ,&nbsp;Sheng-An Zheng ,&nbsp;Po-Wu Liu ,&nbsp;Nayiyuan Wu ,&nbsp;Wen-Jing Zeng ,&nbsp;Ying-Hua Li ,&nbsp;Jing Wang","doi":"10.1016/j.gendis.2025.101801","DOIUrl":"10.1016/j.gendis.2025.101801","url":null,"abstract":"<div><div>Over the last few decades, platinum-based chemotherapy has served as the standard chemotherapy in treating ovarian cancer (OC). While most patients initially respond well to platinum-based chemotherapy, approximately 70% of patients eventually relapse and confer resistance to platinum. Recent preclinical evidence on platinum-resistant ovarian cancer (PROC) is encouraging. Various potential mechanisms, such as genomic and epigenetic alterations, pharmacological alterations, DNA damage repair, metabolic reprogramming, the tumor microenvironment (TME) and programmed cell death, have been implicated in platinum resistance. In addition, clinical trials regarding the treatment of PROC have shown considerable success, and a multitude of promising therapies are in progress. In this review, we comprehensively summarized the underlying mechanisms of platinum resistance in OC and proposed the most promising novel therapeutics and strategies employed in the treatment of PROC.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101801"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated genomic analysis of EDNRB common and rare variants in Hirschsprung disease","authors":"Xiaoyu Zuo ,&nbsp;Jinglu Zhao ,&nbsp;Zipeng Liu ,&nbsp;Yuxiao Yao ,&nbsp;Dingyang Li ,&nbsp;Xiaogang Xu ,&nbsp;Huimin Xia ,&nbsp;Lihua Huang ,&nbsp;Jixiao Zeng ,&nbsp;Yan Zhang","doi":"10.1016/j.gendis.2025.101595","DOIUrl":"10.1016/j.gendis.2025.101595","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101595"},"PeriodicalIF":9.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145419793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}