Genes & Diseases最新文献_第7页

The significance of small noncoding RNAs in the pathogenesis of cardiovascular diseases 小非编码 RNA 在心血管疾病发病机制中的意义

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-05-30 DOI: 10.1016/j.gendis.2024.101342

Hemanyun Bai, Fanji Meng, Kangling Ke, Lingyan Fang, Weize Xu, Haitao Huang, Xiao Liang, Weiyan Li, Fengya Zeng, Can Chen

引用次数: 0

SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets 结直肠癌中的 SPP1+ 巨噬细胞：恶性肿瘤标志物和有希望的治疗靶点

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-05-30 DOI: 10.1016/j.gendis.2024.101340

Zhenyu Xie, Gaozan Zheng, Liaoran Niu, Kunli Du, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Songchen Dai, Fan Feng, Jian Zhang, Jianyong Zheng

{"title":"SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets","authors":"Zhenyu Xie, Gaozan Zheng, Liaoran Niu, Kunli Du, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Songchen Dai, Fan Feng, Jian Zhang, Jianyong Zheng","doi":"10.1016/j.gendis.2024.101340","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101340","url":null,"abstract":"macrophages have been identified as key players in the colorectal cancer (CRC) tumor microenvironment, but their function remains unclear. This study integrated single-cell and spatial transcriptomics with bulk sequencing to investigate the roles and mechanisms of macrophages in CRC. Our findings revealed a pronounced elevation of macrophages in CRC, especially within tumor territories. These macrophages served as markers for CRC initiation, progression, metastasis, and potential prognosis. Furthermore, they showed heightened transcriptional activity in genes linked to angiogenesis, epithelial–mesenchymal transition, glycolysis, hypoxia, and immunosuppression. protein amplified CRC cell migration and invasion, potentially mediating cellular crosstalk via the , , and complex axes. Patients with a high proportion of macrophages could benefit more from immune checkpoint blockade therapy. Interestingly, expression was significantly enriched in macrophages versus macrophages, possibly explaining limited anti-CSF1R monotherapy effects. In conclusion, we propose an macrophage model in CRC, highlighting such macrophages as a promising therapeutic target due to their malignancy markers.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"30 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy 人羊膜上皮细胞通过介导 PAK1/AMPK 依赖性自噬减轻脂肪肝的缺血再灌注损伤

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-29 DOI: 10.1016/j.gendis.2024.101343

Xun Qiu , Hanzhi Xu , Yawen Tan , Jinying Li , Zhoucheng Wang , Zhengxing Lian , Xuyong Wei , Luyang Yu , Kai Wang , Xiao Xu

引用次数: 0

Construction and validation of a novel SUMOylation-related lncRNAs signature for predicting the prognosis, tumor immune microenvironment, and therapeutic sensitivity of lung adenocarcinoma 构建并验证用于预测肺腺癌预后、肿瘤免疫微环境和治疗敏感性的新型 SUMOylation 相关 lncRNAs 标志

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-28 DOI: 10.1016/j.gendis.2024.101338

Jie Cai , Weizhong Ruan , Zida Wang , Gongzhe Liu , Bei Yang , Hao Wang , Deping Zhao , Chang Chen , Xiaogang Zhao

引用次数: 0

A novel nested gene Aff3ir participates in vascular remodeling by enhancing endothelial cell differentiation in mice 新型嵌套基因 Aff3ir 通过增强小鼠内皮细胞分化参与血管重塑

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-27 DOI: 10.1016/j.gendis.2024.101339

Yue Zhao , Mazdak Ehteramyan , Yi Li , Xuefeng Bai , Lei Huang , Yingtang Gao , Angshumonik Angbohang , Xiaoping Yang , Steven Lynham , Andriana Margariti , Ajay M. Shah , Yaling Tao , Ting Cai , Tong Li , Min Zhang , Lingfang Zeng

引用次数: 0

Concurrent PIK3CA and IDH1 variants in facial infiltrating lipomatosis with intracranial lesions 面部浸润性脂肪瘤伴颅内病变中同时存在的 PIK3CA 和 IDH1 变体

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-22 DOI: 10.1016/j.gendis.2024.101324

Hongrui Chen , Bin Sun , Lizhen Wang , Lei Chang , Zhang Yu , Wei Gao , Yajing Qiu , Hui Chen , Chen Hua , Xiaoxi Lin

引用次数: 0

Gene interactions analysis of brain spatial transcriptome for Alzheimer's disease 阿尔茨海默病大脑空间转录组基因相互作用分析

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-22 DOI: 10.1016/j.gendis.2024.101337

{"title":"Gene interactions analysis of brain spatial transcriptome for Alzheimer's disease","authors":"","doi":"10.1016/j.gendis.2024.101337","DOIUrl":"10.1016/j.gendis.2024.101337","url":null,"abstract":"<div><p>Recent studies have explored the spatial transcriptomics patterns of Alzheimer's disease (AD) brain by spatial sequencing in mouse models, enabling the identification of unique genome-wide transcriptomic features associated with different spatial regions and pathological status. However, the dynamics of gene interactions that occur during amyloid-β accumulation remain largely unknown. In this study, we performed analyses on ligand-receptor communication, transcription factor regulatory network, and spot-specific network to reveal the dependence and the dynamics of gene associations/interactions on spatial regions and pathological status with mouse and human brains. We first used a spatial transcriptomics dataset of the <em>App</em><sup><em>NL-G-F</em></sup> knock-in AD and wild-type mouse model. We revealed 17 ligand-receptor pairs with opposite tendencies throughout the amyloid-β accumulation process and showed the specific ligand-receptor interactions across the hippocampus layers at different extents of pathological changes. We then identified nerve function related transcription factors in the hippocampus and entorhinal cortex, as well as genes with different transcriptomic association degrees in AD versus wild-type mice. Finally, another independent spatial transcriptomics dataset from different AD mouse models and human single-nuclei RNA-seq data/AlzData database were used for validation. This is the first study to identify various gene associations throughout amyloid-β accumulation based on spatial transcriptomics, establishing the foundations to reveal advanced and in-depth AD etiology from a novel perspective based on the comprehensive analyses of gene interactions that are spatio-temporal dependent.</p></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101337"},"PeriodicalIF":6.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235230422400134X/pdfft?md5=1fbf3a2d47134eb845118f0f1e520f08&pid=1-s2.0-S235230422400134X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1 癌症相关成纤维细胞衍生的纤连蛋白外域 A 通过激活 SHMT1 促进肝癌细胞对索拉非尼的耐药性

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-20 DOI: 10.1016/j.gendis.2024.101330

{"title":"Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1","authors":"","doi":"10.1016/j.gendis.2024.101330","DOIUrl":"10.1016/j.gendis.2024.101330","url":null,"abstract":"<div><p>Resistance to sorafenib, an effective first-line treatment for advanced hepatocellular carcinoma (HCC), greatly compromised the prognosis of patients. The extracellular matrix is one of the most abundant components of the tumor microenvironment. Beyond acting as a physical barrier, it remains unclear whether cell interactions and signal transduction mediated by the extracellular matrix contribute to sorafenib resistance. With the analysis of primary HCC organoid RNA-seq data combined with <em>in vivo</em> and <em>in vitro</em> experiments validation, we discovered that fibronectin extra domain A (FN-EDA) derived from cancer-associated fibroblasts played a critical role in sorafenib resistance. Mechanistically, FN-EDA stimulates the up-regulation of the key one-carbon metabolism enzyme SHMT1 in HCC cells via the TLR4/NF-κB signaling pathway, thereby countering the oxidative stress induced by sorafenib. Moreover, we reinforced the clinical significance of our discoveries by conducting <em>in vivo</em> assays with an immunodeficiency subcutaneous xenograft tumor model, which was established using primary cancer-associated fibroblasts derived from clinical HCC tissues, and through the analysis of HCC samples obtained from The Cancer Genome Atlas (TCGA) database. Our findings suggest that targeting the FN-EDA/SHMT1 pathway could be a potential strategy to improve sorafenib responsiveness in HCC patients.</p></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101330"},"PeriodicalIF":6.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001272/pdfft?md5=6730558c8014bf0d03ae3760faddee2e&pid=1-s2.0-S2352304224001272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the genome-wide signatures underlying the micropapillary carcinoma components in colorectal cancers 大肠癌微乳头状癌成分的全基因组特征研究

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-19 DOI: 10.1016/j.gendis.2024.101331

Yingying Meng , Zhao Zhang , Tao Tang , Yanhong Yu , Dan Wang , Wei Sun

引用次数: 0

Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer 将映射到 LIFR 的高甲基化 CpG 位点鉴定为结肠癌的特异性诊断生物标志物

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-19 DOI: 10.1016/j.gendis.2024.101334

Ruizhi Chang , Ganxun Li , Guan-nan Jin , Bixiang Zhang, Ze-yang Ding

引用次数: 0