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The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets lncRNA 在 AKI 和 CKD 中的作用：分子机制、生物标记物和潜在治疗靶点
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-30 DOI: 10.1016/j.gendis.2024.101509
Minhui Zheng , Zixuan Yang , Lei Shi , Liyuan Zhao , Kelan Liu , Naping Tang
{"title":"The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets","authors":"Minhui Zheng ,&nbsp;Zixuan Yang ,&nbsp;Lei Shi ,&nbsp;Liyuan Zhao ,&nbsp;Kelan Liu ,&nbsp;Naping Tang","doi":"10.1016/j.gendis.2024.101509","DOIUrl":"10.1016/j.gendis.2024.101509","url":null,"abstract":"<div><div>Exosomes, a type of extracellular vesicle, are commonly found in different body fluids and are rich in nucleic acids (circRNA, lncRNAs, miRNAs, mRNAs, tRNAs, <em>etc</em>.), proteins, and lipids. They are involved in intercellular communication. lncRNAs are responsible for the modulation of gene expression, thus affecting the pathological process of kidney injury. This review summarizes the latest knowledge on the roles of exosome lncRNAs and circulating lncRNAs in the pathogenesis, biomarker discovery, and treatment of chronic kidney disease, renal fibrosis, and acute kidney injury, providing an overview of novel regulatory approaches and lncRNA delivery systems.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101509"},"PeriodicalIF":6.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GATA2 up-regulation restores androgen receptor chromatin association and advances darolutamide resistance in prostate cancer GATA2上调恢复雄激素受体染色质关联并促进前列腺癌darolutamide耐药
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-28 DOI: 10.1016/j.gendis.2024.101508
Tianyi Zhou , Chengtai Yu , Yali Han , Bin He , Qin Feng
{"title":"GATA2 up-regulation restores androgen receptor chromatin association and advances darolutamide resistance in prostate cancer","authors":"Tianyi Zhou ,&nbsp;Chengtai Yu ,&nbsp;Yali Han ,&nbsp;Bin He ,&nbsp;Qin Feng","doi":"10.1016/j.gendis.2024.101508","DOIUrl":"10.1016/j.gendis.2024.101508","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101508"},"PeriodicalIF":6.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma Bcl6在头颈部鳞状细胞癌中控制调节性T细胞的稳定性和抑制功能
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-26 DOI: 10.1016/j.gendis.2024.101505
Shuqiong Wen , Xingxing Su , Junyi Guo , Zhanpeng Ou , Lisha Wang , Zhengliang Yue , Jing Zhao , Ling Ran , Jianjun Hu , Yuzhu Wang , Mengqu Ran , Qinyi He , Ping Ji , Lilin Ye , Zhiyu Chen , Lifan Xu , Qizhao Huang
{"title":"Bcl6 controls the stability and suppressive function of regulatory T cells in head and neck squamous cell carcinoma","authors":"Shuqiong Wen ,&nbsp;Xingxing Su ,&nbsp;Junyi Guo ,&nbsp;Zhanpeng Ou ,&nbsp;Lisha Wang ,&nbsp;Zhengliang Yue ,&nbsp;Jing Zhao ,&nbsp;Ling Ran ,&nbsp;Jianjun Hu ,&nbsp;Yuzhu Wang ,&nbsp;Mengqu Ran ,&nbsp;Qinyi He ,&nbsp;Ping Ji ,&nbsp;Lilin Ye ,&nbsp;Zhiyu Chen ,&nbsp;Lifan Xu ,&nbsp;Qizhao Huang","doi":"10.1016/j.gendis.2024.101505","DOIUrl":"10.1016/j.gendis.2024.101505","url":null,"abstract":"<div><div>Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common cancer globally. Most studies in HNSCC demonstrated that regulatory T (Treg) cells confine the anti-tumor activity of effector T cells which may contribute to the immune escape and uncontrolled tumor progression. Here, we uncovered that the specific abrogation of Bcl6 in Treg cells resulted in significantly delayed malignant transformation of 4NQO-induced tumorigenesis. Bcl6 deficiency impairs the lineage stability of Treg cells by down-regulating the histone H3K4 trimethylation. Importantly, Bcl6 inhibition repressed the tumor growth of murine HNSCC and exhibited synergistic effects with immune checkpoint blockade therapy. These findings suggest that Bcl6 can be exploited as a promising therapeutic target for HNSCC treatment.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101505"},"PeriodicalIF":6.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment and characterization of an induced pluripotent stem cell line from a Japanese cystic fibrosis patient with homozygous 1540del10 CFTR mutation 日本纯合子1540del10 CFTR突变囊性纤维化患者诱导多能干细胞系的建立和表征
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-25 DOI: 10.1016/j.gendis.2024.101506
Hitoshi Okumura , Mikio Hayashi , Hiromi Yamashita , Fumiyuki Hattori
{"title":"Establishment and characterization of an induced pluripotent stem cell line from a Japanese cystic fibrosis patient with homozygous 1540del10 CFTR mutation","authors":"Hitoshi Okumura ,&nbsp;Mikio Hayashi ,&nbsp;Hiromi Yamashita ,&nbsp;Fumiyuki Hattori","doi":"10.1016/j.gendis.2024.101506","DOIUrl":"10.1016/j.gendis.2024.101506","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101506"},"PeriodicalIF":6.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy 一种新的BCAT1抑制剂蟾毒灵使胰腺癌细胞对化疗敏感
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-24 DOI: 10.1016/j.gendis.2024.101503
Wei Zhang , Yibao Fan , Milad Ashrafizadeh , Dan Shi , Gautam Sethi , Yavuz Nuri Ertas , A.M. Abd El-Aty , Xianbin Zhang , Si Chen , Peng Gong
{"title":"A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy","authors":"Wei Zhang ,&nbsp;Yibao Fan ,&nbsp;Milad Ashrafizadeh ,&nbsp;Dan Shi ,&nbsp;Gautam Sethi ,&nbsp;Yavuz Nuri Ertas ,&nbsp;A.M. Abd El-Aty ,&nbsp;Xianbin Zhang ,&nbsp;Si Chen ,&nbsp;Peng Gong","doi":"10.1016/j.gendis.2024.101503","DOIUrl":"10.1016/j.gendis.2024.101503","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101503"},"PeriodicalIF":6.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization 探讨FTO在子痫前期发病机制中的作用：对m6A修饰和去个体化的见解
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-24 DOI: 10.1016/j.gendis.2024.101504
Jing Tong , Liang Zhang , Jing Bai , Cong Zhang
{"title":"Exploring the role of FTO in preeclampsia pathogenesis: Insights into m6A modification and decidualization","authors":"Jing Tong ,&nbsp;Liang Zhang ,&nbsp;Jing Bai ,&nbsp;Cong Zhang","doi":"10.1016/j.gendis.2024.101504","DOIUrl":"10.1016/j.gendis.2024.101504","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101504"},"PeriodicalIF":6.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of RNA binding proteins in cancer biology: A focus on FMRP RNA结合蛋白在癌症生物学中的作用：聚焦于FMRP
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-21 DOI: 10.1016/j.gendis.2024.101493
Yunlu Jia , Ruyin Jia , Yongxia Chen , Xuanyi Lin , Nadire Aishan , Han li , Linbo Wang , Xiaochen Zhang , Jian Ruan
{"title":"The role of RNA binding proteins in cancer biology: A focus on FMRP","authors":"Yunlu Jia ,&nbsp;Ruyin Jia ,&nbsp;Yongxia Chen ,&nbsp;Xuanyi Lin ,&nbsp;Nadire Aishan ,&nbsp;Han li ,&nbsp;Linbo Wang ,&nbsp;Xiaochen Zhang ,&nbsp;Jian Ruan","doi":"10.1016/j.gendis.2024.101493","DOIUrl":"10.1016/j.gendis.2024.101493","url":null,"abstract":"<div><div>RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such as RNA splicing, transport, localization, stability, and translation through their specific binding to RNA molecules. The diversity and complexity of RBPs are particularly significant in cancer biology, as they directly impact a multitude of RNA metabolic events closely associated with tumor initiation and progression. The fragile X mental retardation protein (FMRP), as a member of the RBP family, is central to the neurodevelopmental disorder fragile X syndrome and increasingly recognized in the modulation of cancer biology through its influence on RNA metabolism. The protein's versatility, stemming from its diverse RNA-binding domains, enables it to govern a wide array of transcript processing events. Modifications in FMRP's expression or localization have been associated with the regulation of mRNAs linked to various processes pertinent to cancer, including tumor proliferation, metastasis, epithelial–mesenchymal transition, cellular senescence, chemotherapy/radiotherapy resistance, and immunotherapy evasion. In this review, we emphasize recent findings and analyses that suggest contrasting functions of this protein family in tumorigenesis. Our knowledge of the proteins that are regulated by FMRP is rapidly growing, and this has led to the identification of multiple targets for therapeutic intervention of cancer, some of which have already moved into clinical trials or clinical practice.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101493"},"PeriodicalIF":6.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles for fatty acid oxidation in cancer 脂肪酸氧化在癌症中的新作用
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-20 DOI: 10.1016/j.gendis.2024.101491
Jialin Ma , Shuxian Wang , Pingfeng Zhang , Sihao Zheng , Xiangpan Li , Juanjuan Li , Huadong Pei
{"title":"Emerging roles for fatty acid oxidation in cancer","authors":"Jialin Ma ,&nbsp;Shuxian Wang ,&nbsp;Pingfeng Zhang ,&nbsp;Sihao Zheng ,&nbsp;Xiangpan Li ,&nbsp;Juanjuan Li ,&nbsp;Huadong Pei","doi":"10.1016/j.gendis.2024.101491","DOIUrl":"10.1016/j.gendis.2024.101491","url":null,"abstract":"<div><div>Fatty acid oxidation (FAO) denotes the mitochondrial aerobic process responsible for breaking down fatty acids (FAs) into acetyl-CoA units. This process holds a central position in the cancer metabolic landscape, with certain tumor cells relying primarily on FAO for energy production. Over the past decade, mounting evidence has underscored the critical role of FAO in various cellular processes such as cell growth, epigenetic modifications, tissue-immune homeostasis, cell signal transduction, and more. FAO is tightly regulated by multiple evolutionarily conserved mechanisms, and any dysregulation can predispose to cancer development. In this view, we summarize recent findings to provide an updated understanding of the multifaceted roles of FAO in tumor development, metastasis, and the response to cancer therapy. Additionally, we explore the regulatory mechanisms of FAO, laying the groundwork for potential therapeutic interventions targeting FAO in cancers within the metabolic landscape.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101491"},"PeriodicalIF":6.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer 衰老过程及相关因子EMP1在促进可切除胰腺癌进展中的作用
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-15 DOI: 10.1016/j.gendis.2024.101490
Junfeng Zhang , Jianyou Gu , Tao Zhang , Renpei Xia , Jianbo Li , Mingda Tan , Yongjun Yang , Jifeng Xiang , Bin Xie , Rong Tang , Wangge Li , Xianxing Wang , Shixiang Guo , Huaizhi Wang
{"title":"The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer","authors":"Junfeng Zhang ,&nbsp;Jianyou Gu ,&nbsp;Tao Zhang ,&nbsp;Renpei Xia ,&nbsp;Jianbo Li ,&nbsp;Mingda Tan ,&nbsp;Yongjun Yang ,&nbsp;Jifeng Xiang ,&nbsp;Bin Xie ,&nbsp;Rong Tang ,&nbsp;Wangge Li ,&nbsp;Xianxing Wang ,&nbsp;Shixiang Guo ,&nbsp;Huaizhi Wang","doi":"10.1016/j.gendis.2024.101490","DOIUrl":"10.1016/j.gendis.2024.101490","url":null,"abstract":"<div><div>Pancreatic cancer (PC) is a highly malignant neoplasm of the digestive system. The primary objective of this investigation is to elucidate the intricate mechanisms underlying the role of the aging process and the related factor Epithelial membrane protein 1 (EMP1) in PC progression. We established a prognostic model pertinent to the aging process that could be applied in postoperative PC patients. <em>In vitro</em> assays were employed to elucidate the impact of <em>EMP1</em> on PC cell function. We employed lentiviral vectors for both knockdown and overexpression of <em>EMP1</em> in Panc02 cells, followed by the establishment of subcutaneous, pulmonary metastasis, and orthotopic pancreatic liver metastasis models in mice. Using tissue microarrays, we evaluated the expression of <em>EMP1</em> and its downstream entities, and then conducted clinical correlation analysis. A predictive Age-Related Score (ARS) system based on age-associated prognostic genes was developed, offering precise prognostic predictions for postoperative PC patients, which could be applied well at the single-cell level, showing diverse aging, epithelial–mesenchymal transition (EMT), cell migration, cell proliferation, and <em>PI3K/AKT</em> signaling activity in high and low ARS risk cells. <em>EMP1</em> was identified as a pivotal molecule in the ARS system and is associated with poor prognosis. Besides, <em>EMP1</em> could enhance the proliferation, migration, and invasion of PC cells both <em>in vitro</em> and <em>in vivo</em> by augmenting the <em>PI3K/AKT</em> signaling cascade. In essence, this research formulated an aging-centric prognostic model for postoperative PC and pinpointed <em>EMP1</em> as an oncogenic factor facilitating tumor cell EMT during the aging trajectory in resectable PC patients.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101490"},"PeriodicalIF":6.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-17 signaling pathway in SPP1+ macrophages drives digestive tract cancer progression SPP1+巨噬细胞IL-17信号通路驱动消化道肿瘤进展
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-12-14 DOI: 10.1016/j.gendis.2024.101489
Yihong Wei , Ying Xu , Yanqiong Zeng , Amin Zhang , Xiangling Xing , Wancheng Liu
{"title":"IL-17 signaling pathway in SPP1+ macrophages drives digestive tract cancer progression","authors":"Yihong Wei ,&nbsp;Ying Xu ,&nbsp;Yanqiong Zeng ,&nbsp;Amin Zhang ,&nbsp;Xiangling Xing ,&nbsp;Wancheng Liu","doi":"10.1016/j.gendis.2024.101489","DOIUrl":"10.1016/j.gendis.2024.101489","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101489"},"PeriodicalIF":6.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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