Genes & Diseases最新文献_第6页

Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells Shikonin 是一种新型前列腺素 E2 受体 4 拮抗剂，可靶向髓源性抑制细胞

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-06-20 DOI: 10.1016/j.gendis.2024.101356

Yang Wang, Naijipu Abuduaini, Wenjuan Liu, Yuanjun Song, Zunping Ke, Xilong Wang, Wei Jiao, Si Chen, Xianhua Lin, Weiwei Yu, Weiqiang Lu, Bo Feng, Jiacheng He

引用次数: 0

Targeting MUC1 with fisetin in oral squamous cell carcinoma 用菲赛汀靶向治疗口腔鳞状细胞癌中的 MUC1

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-06-20 DOI: 10.1016/j.gendis.2024.101357

Qian Wang, Hongyan Zhang, Shuzhen Xiang, Lan Zhang, Jiajia Fan, Zengyan Xu, Fengfei Zhao, Minda Liu, Yanshu Li, Wei Dai

引用次数: 0

GATA6 in pancreatic cancer initiation and progression GATA6 在胰腺癌发生和发展过程中的作用

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-06-17 DOI: 10.1016/j.gendis.2024.101353

Muyuan Ma, Jianhong An, Tingting Jiang, Keping Xie

{"title":"GATA6 in pancreatic cancer initiation and progression","authors":"Muyuan Ma, Jianhong An, Tingting Jiang, Keping Xie","doi":"10.1016/j.gendis.2024.101353","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101353","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy characterized by insidious onset and lack of effective therapy. The molecular pathogenesis of PDA remains to be understood fully. Transcriptional factor GATA6 is an important transcriptional regulator in normal pancreas development, particularly in the initial specification and differentiation of the pancreas. Recent studies have linked pancreatic malignancy closely to GATA6. Increased levels of GATA6 expression enhance pancreatic cancer cell growth. GATA6 emerges as a lineage-specific oncogenic factor in PDA, augmenting the oncogenic phenotypes of PDA cells upon its overexpression. However, elevated GATA6 levels are correlated with well-differentiated tumors and a more favorable patient prognosis. Experimental evidence in genetic mouse models has revealed a tumor-suppressive role for GATA6. The circumstantial roles of GATA6 in pancreatic tumorigenesis remain to be defined. This review aims to elucidate recent advances in comprehending GATA6, emphasizing its crucial roles in both pancreas physiology and pathology. Special attention will be given to its involvement in PDA pathogenesis, exploring its potential as a novel biomarker and a promising therapeutic target for PDA.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"59 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway HER3：揭开以前针对关键癌症生存途径的不成功疗法的曲折故事

IF 6.8 2区医学

Genes & Diseases Pub Date : 2024-06-17 DOI: 10.1016/j.gendis.2024.101354

Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang

{"title":"HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway","authors":"Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang","doi":"10.1016/j.gendis.2024.101354","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101354","url":null,"abstract":"HER3, formally referred to as ERB-B2 receptor tyrosine kinase 3, is a member of the ErbB receptor tyrosine kinases (also known as EGFR) family. HER3 plays a significant pro-cancer role in various types of cancer due to its overexpression and abnormal activation, which initiates downstream signaling pathways crucial in cancer cell survival and progression. As a result, numerous monoclonal antibodies have been developed to block HER3 activation and subsequent signaling pathways. While pre-clinical investigations have effectively showcased significant anti-cancer effects of HER3-targeted therapies, these therapies have had little impact on cancer patient outcomes in the clinic, except for patients with rare fusion mutations. This review offers a comprehensive description of the oncogenic functions of HER3, encompassing its structure and mediating signaling pathways. More importantly, it provides an in-depth exploration of past and ongoing clinical trials investigating HER3-targeted therapies for distinct types of cancer and discusses the tumor microenvironment and other critical determinants that may contribute to the observed suboptimal outcomes in most clinical studies using HER3-targeted therapies. Lastly, we suggest alternative approaches and the exploration of novel strategies to potentially improve the efficacy of targeting the pivotal oncogenic HER3 signaling pathway in future translational investigations.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"40 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis” [Genes & Diseases 10 (2023) 554–567] 更正件

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-15 DOI: 10.1016/j.gendis.2024.101352

引用次数: 0

Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration 免疫相关基因的交替剪接确定了具有不同免疫细胞浸润的乳腺癌亚型

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-14 DOI: 10.1016/j.gendis.2024.101349

Zhangxiang Zhao , Yuquan Wang , Zixin Jin , Huiming Han , Bo Chen , Mingyue Liu , Kaidong Liu , Shuping Zhuang , Haihai Liang , Yunyan Gu

引用次数: 0

Gene expression analysis in subcutaneous adipose tissue reveals a predominant influence of lncRNAs during growth 皮下脂肪组织的基因表达分析揭示了生长过程中 lncRNA 的主要影响因素

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-14 DOI: 10.1016/j.gendis.2024.101351

Federica Rey , Letizia Messa , Clarissa Berardo , Alessia Mauri , Gianvincenzo Zuccotti , Cristina Cereda , Stephana Carelli

引用次数: 0

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-06-04 DOI: 10.1016/j.gendis.2024.101346

Jianghua Lin , Junbao Wang , Junmiao Zhao , Xinyi Wu , Leiyu Hao , Xiao Tan , Lixue Yang , Lei-Lei Wu , Yuyang Xia , Xiaoling Zhang , Kaijun Zhao , Yu'e Liu

引用次数: 0

Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy 突变单核苷酸多态性 rs198389 和去甲基化促进扩张型心肌病所致心力衰竭中钠尿肽 B 基因的转录

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-31 DOI: 10.1016/j.gendis.2024.101345

Yulong Li , Mingzhi Shen , Ting Yang , Shui Yu , Jianyuan Yin , Leiming Luo , Yali Zhao , Ping Ping , Shihui Fu

引用次数: 0

GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus GAPDH 可抑制腺病毒诱导的氧化应激，实现重组腺病毒的超快速生产

IF 6.9 2区医学

Genes & Diseases Pub Date : 2024-05-31 DOI: 10.1016/j.gendis.2024.101344

{"title":"GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus","authors":"","doi":"10.1016/j.gendis.2024.101344","DOIUrl":"10.1016/j.gendis.2024.101344","url":null,"abstract":"<div><p>Recombinant adenovirus (rAdV) is a commonly used vector system for gene transfer. Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive, possibly attributable to rAdV infection-associated oxidative stress and reactive oxygen species (ROS) production. Here, we show that exogenous GAPDH expression mitigates adenovirus-induced ROS-associated apoptosis in HEK293 cells, and expedites adenovirus production. By stably overexpressing GAPDH in HEK293 (293G) and 293pTP (293GP) cells, respectively, we demonstrated that rAdV-induced ROS production and cell apoptosis were significantly suppressed in 293G and 293GP cells. Transfection of 293G cells with adenoviral plasmid pAd-G2Luc yielded much higher titers of Ad-G2Luc at day 7 than that in HEK293 cells. Similarly, Ad-G2Luc was amplified more efficiently in 293G than in HEK293 cells. We further showed that transfection of 293GP cells with pAd-G2Luc produced much higher titers of Ad-G2Luc at day 5 than that of 293pTP cells. 293GP cells amplified the Ad-G2Luc much more efficiently than 293pTP cells, indicating that exogenous GAPDH can further augment pTP-enhanced adenovirus production. These results demonstrate that exogenous GAPDH can effectively suppress adenovirus-induced ROS and thus accelerate adenovirus production. Therefore, the engineered 293GP cells represent a superfast rAdV production system for adenovirus-based gene transfer and gene therapy.</p></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101344"},"PeriodicalIF":6.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001417/pdfft?md5=206897c8fce371b15f69ce30294d43f2&pid=1-s2.0-S2352304224001417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0