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CRISPR/Cas9 screening reveals Zfp607b as a novel transcription factor regulating myogenesis CRISPR/Cas9筛选显示Zfp607b是一种新的调节肌肉发生的转录因子
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-30 DOI: 10.1016/j.gendis.2024.101444
Siyuan Liu , Wei Wang , Zishuai Wang , Chao Yan , Guohao Han , Weiwei Liu , Yuxing Huang , Wangchang Li , Shengsong Xie , Zhonglin Tang
{"title":"CRISPR/Cas9 screening reveals Zfp607b as a novel transcription factor regulating myogenesis","authors":"Siyuan Liu , Wei Wang , Zishuai Wang , Chao Yan , Guohao Han , Weiwei Liu , Yuxing Huang , Wangchang Li , Shengsong Xie , Zhonglin Tang","doi":"10.1016/j.gendis.2024.101444","DOIUrl":"10.1016/j.gendis.2024.101444","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101444"},"PeriodicalIF":6.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF144_07C) in Ganzhou, China 中国赣州一种新的HIV-1第二代循环重组形式（CRF144_07C）的特征
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-30 DOI: 10.1016/j.gendis.2024.101443
Xiaoyi Zhang , Hongmin Cao , Yating Chen , Chaoxian Lian , Ting Zeng , Junjie Liu , Junzhi Su , Qian Gao , Fengxiu Zhu , Yuning Zhang , Dandan Huang , Yanheng Zhou , Xin Chen
{"title":"Characterization of a novel HIV-1 second-generation circulating recombinant form (CRF144_07C) in Ganzhou, China","authors":"Xiaoyi Zhang , Hongmin Cao , Yating Chen , Chaoxian Lian , Ting Zeng , Junjie Liu , Junzhi Su , Qian Gao , Fengxiu Zhu , Yuning Zhang , Dandan Huang , Yanheng Zhou , Xin Chen","doi":"10.1016/j.gendis.2024.101443","DOIUrl":"10.1016/j.gendis.2024.101443","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101443"},"PeriodicalIF":6.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OSdream: An online survival and differential analysis tool of recurrence and metastasis of pan-cancers OSdream：泛癌复发和转移的在线生存和差异分析工具
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-30 DOI: 10.1016/j.gendis.2024.101446
Huimin Li , Qiang Wang , Yunyi Liu , Lin Chen , Qiwei Zhao , Longxiang Xie , Lu Zhang , Zhongyi Yan , Guosen Zhang , Yali Han , Wan Zhu , Xiangqian Guo
{"title":"OSdream: An online survival and differential analysis tool of recurrence and metastasis of pan-cancers","authors":"Huimin Li , Qiang Wang , Yunyi Liu , Lin Chen , Qiwei Zhao , Longxiang Xie , Lu Zhang , Zhongyi Yan , Guosen Zhang , Yali Han , Wan Zhu , Xiangqian Guo","doi":"10.1016/j.gendis.2024.101446","DOIUrl":"10.1016/j.gendis.2024.101446","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101446"},"PeriodicalIF":6.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis 溃疡性结肠炎炎症和非炎症结肠黏膜的炎症转录组特征和细胞类型组成
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-30 DOI: 10.1016/j.gendis.2024.101447
Eun Mi Song , Jahanzeb Saqib , Yang Hee Joo , Zehra Ramsha , Chang Mo Moon , Sung-Ae Jung , Junil Kim
{"title":"Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis","authors":"Eun Mi Song , Jahanzeb Saqib , Yang Hee Joo , Zehra Ramsha , Chang Mo Moon , Sung-Ae Jung , Junil Kim","doi":"10.1016/j.gendis.2024.101447","DOIUrl":"10.1016/j.gendis.2024.101447","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101447"},"PeriodicalIF":6.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy Ce6-GFFY是一种用于结直肠癌治疗的新型光敏剂。
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-28 DOI: 10.1016/j.gendis.2024.101441
Wei Qiao , Shuxin Li , Linna Luo , Meiling Chen , Xiaobin Zheng , Jiacong Ye , Zhaohui Liang , Qiaoli Wang , Ting Hu , Ling Zhou , Jing Wang , Xiaosong Ge , Guokai Feng , Fang Hu , Rongbin Liu , Jianjun Li , Jie Yang
{"title":"Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy","authors":"Wei Qiao ,&nbsp;Shuxin Li ,&nbsp;Linna Luo ,&nbsp;Meiling Chen ,&nbsp;Xiaobin Zheng ,&nbsp;Jiacong Ye ,&nbsp;Zhaohui Liang ,&nbsp;Qiaoli Wang ,&nbsp;Ting Hu ,&nbsp;Ling Zhou ,&nbsp;Jing Wang ,&nbsp;Xiaosong Ge ,&nbsp;Guokai Feng ,&nbsp;Fang Hu ,&nbsp;Rongbin Liu ,&nbsp;Jianjun Li ,&nbsp;Jie Yang","doi":"10.1016/j.gendis.2024.101441","DOIUrl":"10.1016/j.gendis.2024.101441","url":null,"abstract":"<div><div>Photodynamic therapy is an “old” strategy for cancer therapy featuring clinical safety and rapid working, but suitable photosensitizers for colorectal cancer therapy remain lacking. This study synthesized a novel photosensitizer termed Ce6-GFFY based on a self-assembling peptide GFFY and a photo-responsive molecule chlorin e6 (Ce6). Ce6-GFFY forms macroparticles with a diameter of ∼160 nm and possesses a half-life of 10 h, as well as an ideal tumor-targeting ability in mouse models. Ce6-GFFY effectively penetrates cells and generates numerous reactive oxygen species upon 660 nm laser irradiation. The reactive oxygen species promotes the accumulation of cytotoxic T cells and decrease of myeloid-derived suppressor cells in the tumor microenvironment through immunogenic cell death, thus prohibiting the growth of both primary and metastatic tumors after once treatment. This study not only provides a strategy for photosensitizer development but also confirms a promising application of Ce6-GFFY for colorectal cancer therapy.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101441"},"PeriodicalIF":6.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AUTS2 expression within mammalian lineage: A predictor of neural networks involved in autism spectrum disorders 哺乳动物谱系中的AUTS2表达：自闭症谱系障碍中涉及的神经网络的预测因子。
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-19 DOI: 10.1016/j.gendis.2024.101440
Aude-Marie Lepagnol-Bestel , Yann Loe-Mie , Mounia Bensaid , Michel Simonneau
{"title":"AUTS2 expression within mammalian lineage: A predictor of neural networks involved in autism spectrum disorders","authors":"Aude-Marie Lepagnol-Bestel ,&nbsp;Yann Loe-Mie ,&nbsp;Mounia Bensaid ,&nbsp;Michel Simonneau","doi":"10.1016/j.gendis.2024.101440","DOIUrl":"10.1016/j.gendis.2024.101440","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 3","pages":"Article 101440"},"PeriodicalIF":6.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
lncRNA POU3F3 promotes osteosarcoma progression through GPX4-modulated ferroptosis by interaction with IGF2BP2 to facilitate NRF2 mRNA stability lncRNA POU3F3通过与IGF2BP2相互作用促进NRF2 mRNA的稳定性，通过gpx4调节的铁凋亡促进骨肉瘤的进展
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-12 DOI: 10.1016/j.gendis.2024.101439
Suyang Xu , Yingjie Zhou , Ma Wan , Yikang Bi , Pengcheng Liu , Zixiang Li , Yafeng Xu , Hao Fang , Hai Hu , Chongshan Yang , Shenghui Lan
{"title":"lncRNA POU3F3 promotes osteosarcoma progression through GPX4-modulated ferroptosis by interaction with IGF2BP2 to facilitate NRF2 mRNA stability","authors":"Suyang Xu ,&nbsp;Yingjie Zhou ,&nbsp;Ma Wan ,&nbsp;Yikang Bi ,&nbsp;Pengcheng Liu ,&nbsp;Zixiang Li ,&nbsp;Yafeng Xu ,&nbsp;Hao Fang ,&nbsp;Hai Hu ,&nbsp;Chongshan Yang ,&nbsp;Shenghui Lan","doi":"10.1016/j.gendis.2024.101439","DOIUrl":"10.1016/j.gendis.2024.101439","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 5","pages":"Article 101439"},"PeriodicalIF":6.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis 韩国溃疡性结肠炎患者无名指蛋白186基因（RNF186）的疾病相关种系突变（A64T）的鉴定
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-10-06 DOI: 10.1016/j.gendis.2024.101438
Sang-Hun Park , Sae-Young Won , Yong-Chan Kim
{"title":"Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis","authors":"Sang-Hun Park ,&nbsp;Sae-Young Won ,&nbsp;Yong-Chan Kim","doi":"10.1016/j.gendis.2024.101438","DOIUrl":"10.1016/j.gendis.2024.101438","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101438"},"PeriodicalIF":6.9,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the mechanism and therapies of achondroplasia 软骨发育不全的机制及治疗进展
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-09-24 DOI: 10.1016/j.gendis.2024.101436
Hangang Chen , Ruobin Zhang , Min Jin , Jing Yang , Lin Chen , Yangli Xie
{"title":"Advances in the mechanism and therapies of achondroplasia","authors":"Hangang Chen ,&nbsp;Ruobin Zhang ,&nbsp;Min Jin ,&nbsp;Jing Yang ,&nbsp;Lin Chen ,&nbsp;Yangli Xie","doi":"10.1016/j.gendis.2024.101436","DOIUrl":"10.1016/j.gendis.2024.101436","url":null,"abstract":"<div><div>Achondroplasia (ACH), is the prevailing type of genetic dwarfism in humans, caused by mutations in fibroblast growth factor receptor 3 (FGFR3) that are inherited in an autosomal dominant manner. FGFR3 is mainly expressed in condensed mesenchyme, chondrocytes, and mature osteoblasts and osteoclasts, in which it regulates the formation, development, growth, and remodeling of the skeletal system. Mutations in FGFR3 causing ACH result in enhanced FGFR3 signaling through combined mechanisms including enhancing FGF dimerization and tyrosine kinase activity and stabilizing FGF receptors. In ACH, suppression of the proliferation and maturation of chondrocytes in the growth plate leads to a notable reduction in growth plate size, trabecular bone volume, and bone elongation through a profound enhancement of FGFR3 signaling. This review aims to comprehensively outline the cellular and molecular mechanisms contributing to the pathological process of ACH and its potential therapeutic interventions.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101436"},"PeriodicalIF":6.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases 线粒体DNA编辑：治疗神经退行性疾病的关键
IF 6.9 2区 医学
Genes & Diseases Pub Date : 2024-09-21 DOI: 10.1016/j.gendis.2024.101437
Ye Hong , Ying Song , Wenjun Wang , Jinghui Shi , Xi Chen
{"title":"Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases","authors":"Ye Hong ,&nbsp;Ying Song ,&nbsp;Wenjun Wang ,&nbsp;Jinghui Shi ,&nbsp;Xi Chen","doi":"10.1016/j.gendis.2024.101437","DOIUrl":"10.1016/j.gendis.2024.101437","url":null,"abstract":"<div><div>Neuronal death is associated with mitochondrial dysfunction caused by mutations in mitochondrial DNA. Mitochondrial DNA becomes damaged when processes such as replication, repair, and nucleotide synthesis are compromised. This extensive accumulation of damaged mitochondrial DNA subsequently disrupts the normal function of mitochondria, leading to aging, degeneration, or even death of neurons. Mitochondrial dysfunction stands as a pivotal factor in the development of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. Recognizing the intricate nature of their pathogenesis, there is an urgent need for more effective therapeutic interventions. In recent years, mitochondrial DNA editing tools such as zinc finger nucleases, double-stranded DNA deaminase toxin A-derived cytosine base editors, and transcription activator-like effector ligand deaminases have emerged. Their emergence will revolutionize the research and treatment of mitochondrial diseases. In this review, we summarize the advancements in mitochondrial base editing technology and anticipate its utilization in neurodegenerative diseases, offering insights that may inform preventive strategies and therapeutic interventions for disease phenotypes.</div></div>","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 4","pages":"Article 101437"},"PeriodicalIF":6.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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