肝癌中长链非编码rna的表观遗传调控网络

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-01-20 DOI:10.1016/j.gendis.2025.101534

Zhaoqi Shi , Shengxi Jin , Xiaolong Liu , Mengting Jiang , Yifeng Fang , Parikshit Asutosh Khadaroo , Hui Lin , Xiaoxiao Fan

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引用次数: 0

摘要

长链非编码rna （Long noncoding RNAs, lncRNAs）是长度超过200个碱基的内源性非编码rna，普遍存在于恶性肿瘤中，与肝细胞癌的发生和进展密切相关。lncrna的合成与蛋白质编码转录本的合成相似，受表观遗传修饰的调节。最近的研究强调了表观遗传修饰在肝细胞癌中lncRNA基因转录中的重要调控作用。本文概述了表观遗传修饰，包括DNA甲基化、组蛋白修饰（甲基化和乙酰化）、RNA修饰和microrna对肝细胞癌中lncRNA基因转录的影响，并通过总结这些lncRNA基因如何促进肝细胞癌的发生和进展，深入探讨了潜在的机制。

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The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma

Long noncoding RNAs (lncRNAs) are endogenous noncoding RNAs exceeding 200 bases in length that are prevalent in malignant tumors and are closely associated with the onset and progression of hepatocellular carcinoma. The synthesis of lncRNAs exhibits similarities to that of protein-coding transcripts, which is regulated by epigenetic modifications. Recent research has highlighted the significant regulatory role of epigenetic modifications in the transcription of lncRNA genes in hepatocellular carcinoma. This review outlines the impact of epigenetic modifications, including DNA methylation, histone modification (methylation and acetylation), RNA modification, and microRNAs on the transcription of lncRNA genes in hepatocellular carcinoma and delves into the underlying mechanisms by summarizing how these lncRNA genes contribute to the development and progression of hepatocellular carcinoma.

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.