融合基因在癌症中的作用：生物发生、功能和治疗意义

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-01-20 DOI:10.1016/j.gendis.2025.101536

Haiqiong Tang , Qiu Peng , Linda Oyang , Shiming Tan , Xianjie Jiang , Zongyao Ren , Xuemeng Xu , Mengzhou Shen , Haofan Li , Mingjing Peng , Longzheng Xia , Wenjuan Yang , Shizhen Li , Jiewen Wang , Yaqian Han , Nayiyuan Wu , Yanyan Tang , Jinguan Lin , Qianjin Liao , Yujuan Zhou

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引用次数: 0

摘要

肿瘤的发生和发展过程是复杂的，涉及许多基因和分子途径。融合基因是染色体异常重排的直接产物，是多种肿瘤形成的关键因素。近年来，随着测序技术和生物信息学的发展，人们发现了更多与特定类型肿瘤相关的融合基因。这篇综述的目的是对一系列癌症中存在的融合基因的发现和功能机制进行全面的研究。这将包括分析它们对肿瘤细胞生物学特性的影响。这篇综述将检查在代表性肿瘤类型中观察到的最普遍的融合基因类型，包括血液肿瘤、肺癌、软组织肉瘤、甲状腺癌和前列腺癌。本文综述了融合基因的作用和临床意义，并对融合基因的治疗策略进行了综述，包括靶向药物的应用和相关研究。本文综述了融合基因在肿瘤发生和治疗中的功能，为今后的研究和临床实践提供指导和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fusion genes in cancers: Biogenesis, functions, and therapeutic implications

The processes of tumorigenesis and development are intricate, involving numerous genes and molecular pathways. Fusion genes, direct products of abnormal chromosomal rearrangements, are key factors in the formation of many types of tumors. In recent years, the advent of sequencing technology and bioinformatics has led to the discovery of more fusion genes associated with specific types of tumors. The objective of this review is to undertake a comprehensive examination of the discovery and functional mechanisms of fusion genes present in a range of cancers. This will include an analysis of their impact on the biological properties of tumor cells. This review will examine the most prevalent types of fusion genes observed in representative tumor types, including hematological tumors, lung cancer, soft tissue sarcomas, thyroid cancer, and prostate cancer. We provide an overview of the roles and clinical significance of fusion genes, as well as a summarization of the therapeutic strategies for fusion genes, including the application of targeted drugs and related studies. This review presents a comprehensive analysis of the function of fusion genes in the development and treatment of tumors, providing guidance and insights for future research and clinical practice.

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.