Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: Implications for autologous therapy

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-03-22 DOI:10.1016/j.gendis.2025.101609

Rodriguez-Jimenez Francisco Javier , Artero-Castro Ana , Studenovska Hana , Selles Francisca , Arteaga Claramunt Alba Maria , Brymova Anna , Jendelova Pavla , Motlik Jan , Petrovski Goran , Lytvynchuk Lyubomyr , Ardan Taras , Tichotová Lucie , Drutovič Saskia , Sharma Ruchi , Lukovic Dunja , Bharti Kapil , Erceg Slaven

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通过临床级方案，生物可降解支架上基因校正视网膜色素变性- hipsc衍生的RPE贴片恢复吞噬能力：对自体治疗的意义

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.