Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-03-19 DOI:10.1016/j.gendis.2025.101608

Qinglin Wang , Zehao Pan , Si Liang , Yuanjian Shi , Gaochao Dong , Lin Xu , Qixing Mao , Feng Jiang

引用次数: 0

Abstract

Liquid biopsy has emerged as a valuable clinical tool due to its non-invasive nature and real-time molecular profiling capabilities. Transfer RNA-derived small RNAs (tsRNAs) are a group of small non-coding RNAs generated from mature tRNAs or tRNA precursors. Recently, increasing studies have reported tsRNAs' potential to serve as promising biomarkers in various diseases, especially cancers. Notably, tsRNAs can be detected in various kinds of body fluids, such as seminal fluid plasma, blood plasma, saliva, and urine, and have been demonstrated to exist stably in body fluids. In this mini-review, we will summarize the recent discoveries on the role of tsRNAs in body fluids as biomarkers, hoping to provide new insights for disease diagnosis and therapeutic strategies.

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转移rna衍生的小rna (tsrna)：液体活检中的新星

液体活检由于其非侵入性和实时分子分析能力而成为一种有价值的临床工具。转移rna衍生的小rna （Transfer RNA-derived small rna, tsrna）是一组由成熟tRNA或tRNA前体产生的非编码小rna。最近，越来越多的研究报道了tsRNAs在各种疾病，特别是癌症中作为有前途的生物标志物的潜力。值得注意的是，tsRNAs可以在各种体液中检测到，如精液血浆、血浆、唾液和尿液，并且已被证明在体液中稳定存在。在这篇综述中，我们将总结tsRNAs在体液中作为生物标志物作用的最新发现，希望为疾病的诊断和治疗策略提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.