环状rna在乙型肝炎病毒诱导的肝细胞癌中的作用：综述和最新进展

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-03-18 DOI:10.1016/j.gendis.2025.101605

Wenjun Quan , Kizito Eneye Bello , Rafidah Hanim Shueb , Nazri Mustaffa

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引用次数: 0

摘要

环状rna （circRNAs）是一类稳定和通用的非编码rna，在一些疾病，特别是肿瘤的发生和发展中起着关键作用。乙型肝炎病毒（HBV）诱导的肝细胞癌（HCC）是一种具有重大全球影响的肝脏疾病。尽管努力进行适当的治疗，但hbv诱导的HCC患者的生存率一直很低。circRNAs调节hbv诱导的HCC的各种生理活动。本文旨在阐明circRNAs的生物发生机制和hbv诱导的HCC的病理生理机制，并综合分析circRNAs在肿瘤和治疗中的应用。此外，本文还对circrna在hbv诱导的HCC中的研究成果进行了综述。最后，讨论了现有方法和circRNA研究在hbv诱导的HCC中的局限性，为未来的研究提供了蓝图。

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Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances

Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a liver disease with substantial global impact. Despite efforts towards adequate management, the survival of patients with HBV-induced HCC has been consistently low. circRNAs regulate various physiological activities of HBV-induced HCC. This review aims to elucidate the biogenesis of circRNAs and the pathophysiology of HBV-induced HCC and comprehensively analyze the applications of circRNAs in oncology and therapeutics. In addition, this review summarizes past research achievements on circRNAs in HBV-induced HCC. Finally, the limitations of existing methodologies and circRNA research in HBV-induced HCC have been discussed to provide a blueprint for future investigations.

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.