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The trigeminocardiac reflex: the course of the emerged definition over the last 21 years 三叉心反射:在过去的21年中出现的定义的过程
IF 1.3
Future Neurology Pub Date : 2020-08-17 DOI: 10.2217/fnl-2020-0013
T. Chowdhury, E. Golanov, R. Gelpi, R. Bayford, B. Schaller
{"title":"The trigeminocardiac reflex: the course of the emerged definition over the last 21 years","authors":"T. Chowdhury, E. Golanov, R. Gelpi, R. Bayford, B. Schaller","doi":"10.2217/fnl-2020-0013","DOIUrl":"https://doi.org/10.2217/fnl-2020-0013","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44240301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glioneuronal tumors: clinicopathological findings and treatment options 神经胶质瘤的临床病理学表现和治疗选择
IF 1.3
Future Neurology Pub Date : 2020-08-01 DOI: 10.2217/fnl-2020-0003
L. Gatto, E. Franceschi, V. D. Nunno, C. Tomasello, S. Bartolini, A. Brandes
{"title":"Glioneuronal tumors: clinicopathological findings and treatment options","authors":"L. Gatto, E. Franceschi, V. D. Nunno, C. Tomasello, S. Bartolini, A. Brandes","doi":"10.2217/fnl-2020-0003","DOIUrl":"https://doi.org/10.2217/fnl-2020-0003","url":null,"abstract":"Glioneuronal tumors are very rare CNS neoplasms that demonstrate neuronal differentiation, composed of mixed glial and neuronal cells. The majority of these lesions are low grade and their correct classification is crucial in order to avoid misidentification as ‘ordinary’ gliomas and prevent inappropriate aggressive treatment; nevertheless, precise diagnosis is a challenge due to phenotypic overlap across different histologic subtype. Surgery is the standard of therapeutic approach; literature concerning the benefit of adjuvant treatments is inconclusive and a globally accepted treatment of recurrence does not exist. Targetable mutations in the genes BRAF and FGFR1/2 are recurrently found in these tumors and could take a promising role in future treatment management.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2020-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45619649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson’s disease: new insights from a bioinformatics-based approach 鉴定α-突触核蛋白介导的帕金森病细胞毒性机制：基于生物信息学的新见解
IF 1.3
Future Neurology Pub Date : 2020-08-01 DOI: 10.2217/fnl-2020-0007
S. Chakrabarti, V. S. Sunder, Upinder Kaur, Sapna Bala, Priyanka Sharma, Manjari Kiran, R. Rawal, S. Chakrabarti
{"title":"Identifying the mechanisms of α-synuclein-mediated cytotoxicity in Parkinson’s disease: new insights from a bioinformatics-based approach","authors":"S. Chakrabarti, V. S. Sunder, Upinder Kaur, Sapna Bala, Priyanka Sharma, Manjari Kiran, R. Rawal, S. Chakrabarti","doi":"10.2217/fnl-2020-0007","DOIUrl":"https://doi.org/10.2217/fnl-2020-0007","url":null,"abstract":"Aim: A large body of evidence has implicated the cytotoxicity of α-synuclein in Parkinson’s disease (PD). We planned to use a bioinformatics-based approach to gain further insight into this process. Materials & methods: Using STRING version 10, we identified interacting proteins of α-synuclein. Using α-synuclein and one of these interactors involved in apoptosis as query proteins, we identified other linked proteins. We further analyzed the interactions between some of these proteins by Protein–Protein Docking using ClusPro. Results: We identified BAX as an interacting protein of α-synuclein. Interactions of α-synuclein and BAX as well as BAX and BCL2L1 were determined. Conclusion: The interaction of α-synuclein and BAX could play a crucial role in the cell death process of PD where apoptosis and mitochondrial permeability transition-driven necrosis may coexist.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2020-0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41786009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Percutaneous left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation 经皮左心耳封堵术预防心房颤动患者中风
IF 1.3
Future Neurology Pub Date : 2020-08-01 DOI: 10.2217/fnl-2020-0001
H. Diener, U. Landmesser
{"title":"Percutaneous left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation","authors":"H. Diener, U. Landmesser","doi":"10.2217/fnl-2020-0001","DOIUrl":"https://doi.org/10.2217/fnl-2020-0001","url":null,"abstract":"Patients with atrial fibrillation (AF) have a fivefold higher risk of stroke than persons in sinus rhythm. Effective stroke prevention is achieved with oral anticoagulants such as vitamin K antagonists or nonvitamin K oral anticoagulants. An alternative for stroke prevention in patients with AF is the closure of the left atrial appendage (LAA) with a percutaneously applied closure system. The two large randomized studies PROTECT-AF and PREVAIL failed to show superiority of LAA closure over anticoagulation in patients with AF. Meta-analyses of studies and registries, however, suggest that LAA closure has particular advantages with regard to the reduction of severe bleeding complications. Currently, several prospective randomized studies are being conducted in different patient populations to evaluate the benefit of LAA closure in comparison to standard of care. Currently, LAA closure is recommended in patients after intracranial hemorrhage, with advanced renal failure, after severe gastrointestinal bleeding, in patients with a high risk of recurrent ischemic stroke and elderly patients with high risk of bleeding and falling.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2020-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49077018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is new about somatosensory evoked potentials as neurological predictors of comatose survivors after cardiac arrest? 体感诱发电位作为心脏骤停后昏迷幸存者的神经预测指标有什么新进展？
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2020-0004
M. Scarpino, G. Lanzo, A. Amantini, A. Grippo
{"title":"What is new about somatosensory evoked potentials as neurological predictors of comatose survivors after cardiac arrest?","authors":"M. Scarpino, G. Lanzo, A. Amantini, A. Grippo","doi":"10.2217/fnl-2020-0004","DOIUrl":"https://doi.org/10.2217/fnl-2020-0004","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2020-0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45065219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Anticonvulsant drugs effects on sex hormone levels and sexual function in men with epilepsy 抗惊厥药物对男性癫痫患者性激素水平和性功能的影响
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2019-0028
M. Mazdeh, M. Heidari, M. Taheri, S. Ghafouri-Fard
{"title":"Anticonvulsant drugs effects on sex hormone levels and sexual function in men with epilepsy","authors":"M. Mazdeh, M. Heidari, M. Taheri, S. Ghafouri-Fard","doi":"10.2217/fnl-2019-0028","DOIUrl":"https://doi.org/10.2217/fnl-2019-0028","url":null,"abstract":"Aim: Sexual dysfunction is common in patients with epilepsy. The aim of this quasi-experimental study was to evaluate the effect of anticonvulsant drugs on hormonal and sexual function in men with epilepsy. Methods: Newly diagnosed patients with epilepsy were divided into three groups of 23 subjects who received monotherapy with sodium valproate, carbamazepine and levetiracetam, respectively. Findings: At the beginning of the study, sexual function and sexual hormones were comparable between the control group and the patient group (p > 0.05). After 6 months of treatment, patients who received sodium valproate had the weakest sexual function. Conclusion: According to the present findings, levetiracetam appears to be a good choice for sexually active patients compared with other conventional anticonvulsants.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"13 1","pages":"7-10"},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44471398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of propranolol with and without rosuvastatin on migraine attacks: a triple blind randomized clinical trial 普萘洛尔联合和不联合瑞舒伐他汀对偏头痛发作的影响：一项三盲随机临床试验
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2019-0029
M. Mazdeh, Rihane Mahmudian, S. Vafaei, M. Taheri, S. Ghafouri-Fard
{"title":"Effect of propranolol with and without rosuvastatin on migraine attacks: a triple blind randomized clinical trial","authors":"M. Mazdeh, Rihane Mahmudian, S. Vafaei, M. Taheri, S. Ghafouri-Fard","doi":"10.2217/fnl-2019-0029","DOIUrl":"https://doi.org/10.2217/fnl-2019-0029","url":null,"abstract":"Aim: To investigate the effect of rosuvastatin in combination with propranolol in reducing migraine attacks. Patients & methods: In a clinical trial study with census method, 120 patients with migraine headache were included. Patients were randomly assigned (using block randomization) to either propranolol (10 mg twice a day) with rosuvastatin (10 mg daily; intervention group [n = 60]) or propranolol (10 mg twice a day) with placebo (control [n = 60]). Results: The numbers of attacks were significantly decreased in the intervention group at the end of second, third and fourth weeks from the beginning of the intervention (p < 0.05). Conclusion: In patients with migraine, concomitant administration of propranolol (10 mg twice a day) and rosuvastatin (10 mg daily) is effective in reducing migraine attacks.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44165628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Predicting ambulatory recovery in acute ischemic stroke patients with thrombolytic therapy 溶栓治疗预测急性缺血性脑卒中患者的动态康复
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2020-0002
M. Scalise, L. Brechtel, Zach Conn, B. Bailes, Jordan C. Gainey, T. Nathaniel
{"title":"Predicting ambulatory recovery in acute ischemic stroke patients with thrombolytic therapy","authors":"M. Scalise, L. Brechtel, Zach Conn, B. Bailes, Jordan C. Gainey, T. Nathaniel","doi":"10.2217/fnl-2020-0002","DOIUrl":"https://doi.org/10.2217/fnl-2020-0002","url":null,"abstract":"Aim: The aim of this study was to determine the predictive value of clinical presentations on functional ambulation following thrombolytic therapy. Materials & methods: Logistic regression analysis was used to determine associations between functional ambulation and thrombolytic therapy. Results & conclusion: In the results, Hispanic ethnicity (odds ratio (OR): 2.808; p = 0.034; 95% CI: 1.08–7.30), high National Institute of Health Stroke Scale (NIHSS) (OR: 1.112; p ≤ 0.001; 95% CI: 1.06–1.17), weakness/paresis (OR: 1.796; p = 0.005; 95% CI: 1.19–2.71), Broca’s aphasia (OR: 1.571; p = 0.003; 95% CI = 1.16–2.12) and antihypertensive medication (OR: 1.530; p = 0.034; 95% CI: 1.03–2.26) were associated with an improved ambulation in patients without thrombolytic therapy. In thrombolytic treated patients, Broca’s aphasia was associated with improved functional outcome.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2020-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46424731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Open issues in antibody-mediated encephalitis 抗体介导的脑炎的开放性问题
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2019-0026
L. Zuliani, M. Zoccarato
{"title":"Open issues in antibody-mediated encephalitis","authors":"L. Zuliani, M. Zoccarato","doi":"10.2217/fnl-2019-0026","DOIUrl":"https://doi.org/10.2217/fnl-2019-0026","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41532200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Gender and functional outcomes in prestroke depressive patients treated with thrombolytic therapy 溶栓治疗脑卒中前抑郁患者的性别和功能结果
IF 1.3
Future Neurology Pub Date : 2020-05-01 DOI: 10.2217/fnl-2019-0030
M. Tate, R. Shugart, Robyn Moraney, L. Brechtel, Brice Blum, Thomas I Nathaniel
{"title":"Gender and functional outcomes in prestroke depressive patients treated with thrombolytic therapy","authors":"M. Tate, R. Shugart, Robyn Moraney, L. Brechtel, Brice Blum, Thomas I Nathaniel","doi":"10.2217/fnl-2019-0030","DOIUrl":"https://doi.org/10.2217/fnl-2019-0030","url":null,"abstract":"Aim: This study investigated the clinical factors associated with functional ambulatory outcomes and gender differences in prestroke depressive patients. Materials & methods: Clinical risk factors associated with improved functional outcomes with recombinant tissue plasminogen activator-treated cohorts were determined using binary logistic regression. Results: In the adjusted analysis, improvement in ambulation was associated with male patients that had higher National Institute of Health stroke scale score (p = 0.04), a stroke history (p = 0.026), lower serum creatinine levels (p = 0.049) and were taking cholesterol reducing medication (p = 0.014). Improvement in females was associated with taking antidepressants (p = 0.027) and having lower National Institute of Health stroke scale score (p = 0.002). Conclusion: Our findings indicate gender disparities between male and female prestroke depressive patients.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2019-0030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43454937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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