发布求助
文献互助 智能选刊 最新文献

Future Neurology最新文献

筛选
英文 中文
A natural human monoclonal antibody protects from axonal injury in different CNS degenerative disease models 一种天然人单克隆抗体在不同中枢神经系统退行性疾病模型中保护轴突免受损伤
IF 1.3
Future Neurology Pub Date : 2018-02-01 DOI: 10.2217/FNL-2017-0027
Ahmad Kunbaz, A. Warrington, M. Perwein, Mahboobeh Fereidan-Esfahani, Moses Rodriguez
{"title":"A natural human monoclonal antibody protects from axonal injury in different CNS degenerative disease models","authors":"Ahmad Kunbaz, A. Warrington, M. Perwein, Mahboobeh Fereidan-Esfahani, Moses Rodriguez","doi":"10.2217/FNL-2017-0027","DOIUrl":"https://doi.org/10.2217/FNL-2017-0027","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"13 1","pages":"23-29"},"PeriodicalIF":1.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41912840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
What goes up must come down: homeostatic synaptic plasticity strategies in neurological disease. 上升的必然下降:神经系统疾病中的稳态突触可塑性策略。
IF 1.3
Future Neurology Pub Date : 2018-02-01 Epub Date: 2018-01-17 DOI: 10.2217/fnl-2017-0028
Emily A André, Patrick A Forcelli, Daniel Ts Pak
{"title":"What goes up must come down: homeostatic synaptic plasticity strategies in neurological disease.","authors":"Emily A André,&nbsp;Patrick A Forcelli,&nbsp;Daniel Ts Pak","doi":"10.2217/fnl-2017-0028","DOIUrl":"https://doi.org/10.2217/fnl-2017-0028","url":null,"abstract":"<p><p>Brain activity levels are tightly regulated to minimize imbalances in activity state. Deviations from the normal range of activity are deleterious and often associated with neurological disorders. To maintain optimal levels of activity, regulatory mechanisms termed homeostatic synaptic plasticity establish desired 'set points' for neural activity, monitor the network for deviations from the set point and initiate compensatory responses to return activity to the appropriate level that permits physiological function [1,2]. We speculate that impaired homeostatic control may contribute to the etiology of various neurological disorders including epilepsy and Alzheimer's disease, two disorders that exhibit hyperexcitability as a key feature during pathogenesis. Here, we will focus on recent progress in developing homeostatic regulation of neural activity as a therapeutic tool.</p>","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"13 1","pages":"13-21"},"PeriodicalIF":1.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/fnl-2017-0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35776204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Prehospital notification can effectively reduce in-hospital delay for thrombolysis in acute stroke 院前告知可有效减少急性脑卒中溶栓的住院延误
IF 1.3
Future Neurology Pub Date : 2018-02-01 DOI: 10.2217/FNL-2017-0031
Elyar Sadeghi-Hokmabadi, M. Farhoudi, A. Taheraghdam, R. Rikhtegar, R. Ghafouri, Rogayyeh Asadi, Elham Mehdizadeh Far, N. Ghaemian, Mehrdad Mehrara, Reshad Mirnour
{"title":"Prehospital notification can effectively reduce in-hospital delay for thrombolysis in acute stroke","authors":"Elyar Sadeghi-Hokmabadi, M. Farhoudi, A. Taheraghdam, R. Rikhtegar, R. Ghafouri, Rogayyeh Asadi, Elham Mehdizadeh Far, N. Ghaemian, Mehrdad Mehrara, Reshad Mirnour","doi":"10.2217/FNL-2017-0031","DOIUrl":"https://doi.org/10.2217/FNL-2017-0031","url":null,"abstract":"Aim: To reduce in-hospital intervals by developing a prehospital notification (PHN) protocol which directly notifies a neurologist to prepare for possible treatment. Methods: A 24/7 connection was established between emergency medical services dispatch and the on-call neurologist. A database of all patients with in-hospital stroke code activation was developed, door-to-computed tomography (CT) time and door-to-needle time was recorded from January 2013 to December 2016. The statistical results were considered significant at p < 0.05. Result: PHN resulted in a significant reduction in door-to-CT time (median 14 vs 20; p < 0.001). Among patients who were treated with intravenous thrombolysis, door-to-needle time was significantly shorter in patients with PHN compared with non-PHN group (median 42 vs 70; p < 0.001). Conclusion: PHN effectively reduced door-to-CT and door-to-needle times. © 2018 2018 Reshad Mirnour.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"13 1","pages":"5-11"},"PeriodicalIF":1.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42898121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Comorbid autism spectrum disorder and anxiety disorders: a brief review. 自闭症谱系障碍与焦虑症并发症：简要回顾。
IF 1.3
Future Neurology Pub Date : 2018-02-01 Epub Date: 2018-01-17 DOI: 10.2217/fnl-2017-0030
Brian A Zaboski, Eric A Storch
{"title":"Comorbid autism spectrum disorder and anxiety disorders: a brief review.","authors":"Brian A Zaboski, Eric A Storch","doi":"10.2217/fnl-2017-0030","DOIUrl":"10.2217/fnl-2017-0030","url":null,"abstract":"<p><p>Appearing in 40% of the cases of autism spectrum disorder (ASD), comorbid anxiety presents unique challenges for practitioners by amplifying problem behaviors such as social skills deficits, resistance to change and repetitive behaviors. Furthermore, comorbid ASD/anxiety strains familial relationships and increases parental stress. Research indicates that the neurobiological interactions between anxiety and ASD require comprehensive assessment approaches, modified cognitive behavioral therapy and carefully managed pharmacological interventions. Meta-analyses indicate that cognitive behavioral therapy with exposure is an effective treatment option when adequately accounting for social, familial and cognitive variables. The purpose of this focused review is to update readers on the latest research advances in comorbid ASD and anxiety, including prevalence, assessment, psychosocial and pharmacological treatment.</p>","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"13 1","pages":"31-37"},"PeriodicalIF":1.3,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772195/pdf/fnl-13-31.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35776205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic brain injuries in victims of intimate partner violence: an underappreciated source of neurological morbidity 亲密伴侣暴力受害者的创伤性脑损伤:一个未被重视的神经系统疾病来源
IF 1.3
Future Neurology Pub Date : 2017-12-01 DOI: 10.2217/FNL-2017-0026
K. Monahan, Andrew M. Goldfine, A. Biegon
{"title":"Traumatic brain injuries in victims of intimate partner violence: an underappreciated source of neurological morbidity","authors":"K. Monahan, Andrew M. Goldfine, A. Biegon","doi":"10.2217/FNL-2017-0026","DOIUrl":"https://doi.org/10.2217/FNL-2017-0026","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"12 1","pages":"189-191"},"PeriodicalIF":1.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46515038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Celebrating 50 years of neuroscience research at Lilly's Erl Wood site 庆祝礼来公司厄尔伍德基地神经科学研究50周年
IF 1.3
Future Neurology Pub Date : 2017-12-01 DOI: 10.2217/FNL-2017-0023
Adam Price-Evans
{"title":"Celebrating 50 years of neuroscience research at Lilly's Erl Wood site","authors":"Adam Price-Evans","doi":"10.2217/FNL-2017-0023","DOIUrl":"https://doi.org/10.2217/FNL-2017-0023","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"12 1","pages":"193-198"},"PeriodicalIF":1.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46298559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacotherapy of personality disorders: what we know and what we have to search for 人格障碍的药物治疗：我们所知道的和我们必须寻找的
IF 1.3
Future Neurology Pub Date : 2017-12-01 DOI: 10.2217/FNL-2017-0010
P. Bozzatello, Camilla Ghirardini, Maria Uscinska, P. Rocca, S. Bellino
{"title":"Pharmacotherapy of personality disorders: what we know and what we have to search for","authors":"P. Bozzatello, Camilla Ghirardini, Maria Uscinska, P. Rocca, S. Bellino","doi":"10.2217/FNL-2017-0010","DOIUrl":"https://doi.org/10.2217/FNL-2017-0010","url":null,"abstract":"Pharmacotherapy for personality disorders is in the early stage of development because the evidence base for effective drug treatment is insufficient, biased toward borderline personality disorder and rampant with methodological issues. In this paper, we reviewed randomized, placebo-controlled trials of drugs efficacy in patients with personality disorders published between 1990 and 2016. Overwhelming majority of studies focused on borderline personality disorder (BPD), and the accumulation of evidence resulted in 7 meta-analyses, which are interpreted into better strategies for evidence-based practice. Little research attention was given to schizotypal (SPTD) and antisocial (ASPD) personality disorders, with only indirect treatment efficacy evidence for the obsessive-compulsive (OCPD) and avoidant (AvPD) personality disorders. Some avenues for future efficacy research are indicated. respectively on a fair (level B) and minimal (level C) research-based evidence level. The main symptomatic targets of pharmacotherapy in personality disorders, according to WFSBP guidelines, are affective dysregulation, cognitive-perceptual symptoms, impulsivity and anger. The effects of pharmacotherapy in these patients can also be useful to increase response to combined psychosocial interventions.","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"12 1","pages":"199-222"},"PeriodicalIF":1.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45498492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Genetics of Alzheimer's disease: an update 阿尔茨海默病遗传学研究进展
IF 1.3
Future Neurology Pub Date : 2017-12-01 DOI: 10.2217/FNL-2017-0003
M. Tang, C. Reitz
{"title":"Genetics of Alzheimer's disease: an update","authors":"M. Tang, C. Reitz","doi":"10.2217/FNL-2017-0003","DOIUrl":"https://doi.org/10.2217/FNL-2017-0003","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"12 1","pages":"237-247"},"PeriodicalIF":1.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45529508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penumbral freeze: travel distance and delays provide an opportunity to study prerecanalization therapy neuroprotection 半影冻结:移动距离和延迟提供了研究预通管治疗神经保护的机会
IF 1.3
Future Neurology Pub Date : 2017-12-01 DOI: 10.2217/FNL-2017-0025
D. Blacker
{"title":"Penumbral freeze: travel distance and delays provide an opportunity to study prerecanalization therapy neuroprotection","authors":"D. Blacker","doi":"10.2217/FNL-2017-0025","DOIUrl":"https://doi.org/10.2217/FNL-2017-0025","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"12 1","pages":"185-188"},"PeriodicalIF":1.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42669288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fragile X–tremor/ataxia syndrome: five areas of new development 脆性震颤/共济失调综合征:五个新发展领域
IF 1.3
Future Neurology Pub Date : 2017-12-01 DOI: 10.2217/FNL-2017-0019
Ajal Dave, J. Hawley
{"title":"Fragile X–tremor/ataxia syndrome: five areas of new development","authors":"Ajal Dave, J. Hawley","doi":"10.2217/FNL-2017-0019","DOIUrl":"https://doi.org/10.2217/FNL-2017-0019","url":null,"abstract":"","PeriodicalId":12606,"journal":{"name":"Future Neurology","volume":"12 1","pages":"249-260"},"PeriodicalIF":1.3,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/FNL-2017-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48933807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信