溶栓治疗脑卒中前抑郁患者的性别和功能结果

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2020-05-01 DOI:10.2217/fnl-2019-0030

M. Tate, R. Shugart, Robyn Moraney, L. Brechtel, Brice Blum, Thomas I Nathaniel

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引用次数: 6

摘要

目的：本研究调查了与卒中前抑郁患者的功能性动态结果和性别差异相关的临床因素。材料与方法：使用二元逻辑回归确定与重组组织纤溶酶原激活剂治疗组功能结果改善相关的临床危险因素。结果：在调整后的分析中，行走能力的改善与国家卫生研究所卒中量表评分较高（p=0.04）、有卒中史（p=0.026）、，较低的血清肌酸酐水平（p=0.049）和正在服用降胆固醇药物（p=0.014）。女性的改善与服用抗抑郁药（p=0.027）和国家卫生研究所卒中量表评分较低（p=0.002）有关。结论：我们的研究结果表明，男性和女性卒中前抑郁患者之间存在性别差异。

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Gender and functional outcomes in prestroke depressive patients treated with thrombolytic therapy

Aim: This study investigated the clinical factors associated with functional ambulatory outcomes and gender differences in prestroke depressive patients. Materials & methods: Clinical risk factors associated with improved functional outcomes with recombinant tissue plasminogen activator-treated cohorts were determined using binary logistic regression. Results: In the adjusted analysis, improvement in ambulation was associated with male patients that had higher National Institute of Health stroke scale score (p = 0.04), a stroke history (p = 0.026), lower serum creatinine levels (p = 0.049) and were taking cholesterol reducing medication (p = 0.014). Improvement in females was associated with taking antidepressants (p = 0.027) and having lower National Institute of Health stroke scale score (p = 0.002). Conclusion: Our findings indicate gender disparities between male and female prestroke depressive patients.

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.